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Fusion gene ID: 18266 |
FusionGeneSummary for KCNIP4_FLRT2 |
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Fusion gene information | Fusion gene name: KCNIP4_FLRT2 | Fusion gene ID: 18266 | Hgene | Tgene | Gene symbol | KCNIP4 | FLRT2 | Gene ID | 80333 | 23768 |
Gene name | potassium voltage-gated channel interacting protein 4 | fibronectin leucine rich transmembrane protein 2 | |
Synonyms | CALP|KCHIP4 | - | |
Cytomap | 4p15.31-p15.2 | 14q31.3 | |
Type of gene | protein-coding | protein-coding | |
Description | Kv channel-interacting protein 4Kv channel interacting protein 4a-type potassium channel modulatory protein 4calsenilin-like protein | leucine-rich repeat transmembrane protein FLRT2fibronectin-like domain-containing leucine-rich transmembrane protein 2 | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | Q6PIL6 | O43155 | |
Ensembl transtripts involved in fusion gene | ENST00000382148, ENST00000447367, ENST00000382150, ENST00000382152, ENST00000509207, ENST00000382149, ENST00000359001, | ENST00000330753, ENST00000557419, ENST00000554746, | |
Fusion gene scores | * DoF score | 5 X 5 X 2=50 | 2 X 2 X 1=4 |
# samples | 5 | 2 | |
** MAII score | log2(5/50*10)=0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: KCNIP4 [Title/Abstract] AND FLRT2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AB007865 | KCNIP4 | chr4 | 21781637 | + | FLRT2 | chr14 | 86087721 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000382148 | ENST00000330753 | KCNIP4 | chr4 | 21781637 | + | FLRT2 | chr14 | 86087721 | + |
intron-intron | ENST00000382148 | ENST00000557419 | KCNIP4 | chr4 | 21781637 | + | FLRT2 | chr14 | 86087721 | + |
intron-5UTR | ENST00000382148 | ENST00000554746 | KCNIP4 | chr4 | 21781637 | + | FLRT2 | chr14 | 86087721 | + |
intron-5UTR | ENST00000447367 | ENST00000330753 | KCNIP4 | chr4 | 21781637 | + | FLRT2 | chr14 | 86087721 | + |
intron-intron | ENST00000447367 | ENST00000557419 | KCNIP4 | chr4 | 21781637 | + | FLRT2 | chr14 | 86087721 | + |
intron-5UTR | ENST00000447367 | ENST00000554746 | KCNIP4 | chr4 | 21781637 | + | FLRT2 | chr14 | 86087721 | + |
intron-5UTR | ENST00000382150 | ENST00000330753 | KCNIP4 | chr4 | 21781637 | + | FLRT2 | chr14 | 86087721 | + |
intron-intron | ENST00000382150 | ENST00000557419 | KCNIP4 | chr4 | 21781637 | + | FLRT2 | chr14 | 86087721 | + |
intron-5UTR | ENST00000382150 | ENST00000554746 | KCNIP4 | chr4 | 21781637 | + | FLRT2 | chr14 | 86087721 | + |
intron-5UTR | ENST00000382152 | ENST00000330753 | KCNIP4 | chr4 | 21781637 | + | FLRT2 | chr14 | 86087721 | + |
intron-intron | ENST00000382152 | ENST00000557419 | KCNIP4 | chr4 | 21781637 | + | FLRT2 | chr14 | 86087721 | + |
intron-5UTR | ENST00000382152 | ENST00000554746 | KCNIP4 | chr4 | 21781637 | + | FLRT2 | chr14 | 86087721 | + |
intron-5UTR | ENST00000509207 | ENST00000330753 | KCNIP4 | chr4 | 21781637 | + | FLRT2 | chr14 | 86087721 | + |
intron-intron | ENST00000509207 | ENST00000557419 | KCNIP4 | chr4 | 21781637 | + | FLRT2 | chr14 | 86087721 | + |
intron-5UTR | ENST00000509207 | ENST00000554746 | KCNIP4 | chr4 | 21781637 | + | FLRT2 | chr14 | 86087721 | + |
intron-5UTR | ENST00000382149 | ENST00000330753 | KCNIP4 | chr4 | 21781637 | + | FLRT2 | chr14 | 86087721 | + |
intron-intron | ENST00000382149 | ENST00000557419 | KCNIP4 | chr4 | 21781637 | + | FLRT2 | chr14 | 86087721 | + |
intron-5UTR | ENST00000382149 | ENST00000554746 | KCNIP4 | chr4 | 21781637 | + | FLRT2 | chr14 | 86087721 | + |
intron-5UTR | ENST00000359001 | ENST00000330753 | KCNIP4 | chr4 | 21781637 | + | FLRT2 | chr14 | 86087721 | + |
intron-intron | ENST00000359001 | ENST00000557419 | KCNIP4 | chr4 | 21781637 | + | FLRT2 | chr14 | 86087721 | + |
intron-5UTR | ENST00000359001 | ENST00000554746 | KCNIP4 | chr4 | 21781637 | + | FLRT2 | chr14 | 86087721 | + |
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FusionProtFeatures for KCNIP4_FLRT2 |
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Hgene | Tgene |
KCNIP4 | FLRT2 |
Functions in cell-cell adhesion, cell migration and axonguidance. Mediates cell-cell adhesion via its interactions withADGRL3 and probably also other latrophilins that are expressed atthe surface of adjacent cells. May play a role in the migration ofcortical neurons during brain development via its interaction withUNC5D. Mediates axon growth cone collapse and plays a repulsiverole in neuron guidance via its interaction with UNC5D, andpossibly also other UNC-5 family members. Plays a role infibroblast growth factor-mediated signaling cascades. Required fornormal organization of the cardiac basement membrane duringembryogenesis, and for normal embryonic epicardium and heartmorphogenesis. {ECO:0000250|UniProtKB:Q8BLU0}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for KCNIP4_FLRT2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for KCNIP4_FLRT2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for KCNIP4_FLRT2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KCNIP4_FLRT2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |