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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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Fusion gene ID: 18202

FusionGeneSummary for KATNAL1_CUL4A

check button Fusion gene summary
Fusion gene informationFusion gene name: KATNAL1_CUL4A
Fusion gene ID: 18202
HgeneTgene
Gene symbol

KATNAL1

CUL4A

Gene ID

84056

8451

Gene namekatanin catalytic subunit A1 like 1cullin 4A
Synonyms--
Cytomap

13q12.3

13q34

Type of geneprotein-codingprotein-coding
Descriptionkatanin p60 ATPase-containing subunit A-like 1katanin catalytic subunit A like 1katanin p60 subunit A like 1p60 katanin-like 1cullin-4ACUL-4A
Modification date2018052320180523
UniProtAcc

Q9BW62

Q13619

Ensembl transtripts involved in fusion geneENST00000380615, ENST00000380617, 
ENST00000375441, ENST00000451881, 
ENST00000326335, ENST00000375440, 
ENST00000463426, 
Fusion gene scores* DoF score2 X 2 X 2=85 X 7 X 5=175
# samples 28
** MAII scorelog2(2/8*10)=1.32192809488736log2(8/175*10)=-1.12928301694497
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KATNAL1 [Title/Abstract] AND CUL4A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationDDR (DNA damage repair) gene involved fusion gene, retained protein feature but frameshift.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKATNAL1

GO:0051013

microtubule severing

26929214


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-D3-A5GR-06AKATNAL1chr13

30857753

-CUL4Achr13

113907396

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000380615ENST00000375441KATNAL1chr13

30857753

-CUL4Achr13

113907396

+
Frame-shiftENST00000380615ENST00000451881KATNAL1chr13

30857753

-CUL4Achr13

113907396

+
Frame-shiftENST00000380615ENST00000326335KATNAL1chr13

30857753

-CUL4Achr13

113907396

+
Frame-shiftENST00000380615ENST00000375440KATNAL1chr13

30857753

-CUL4Achr13

113907396

+
5CDS-intronENST00000380615ENST00000463426KATNAL1chr13

30857753

-CUL4Achr13

113907396

+
In-frameENST00000380617ENST00000375441KATNAL1chr13

30857753

-CUL4Achr13

113907396

+
In-frameENST00000380617ENST00000451881KATNAL1chr13

30857753

-CUL4Achr13

113907396

+
In-frameENST00000380617ENST00000326335KATNAL1chr13

30857753

-CUL4Achr13

113907396

+
In-frameENST00000380617ENST00000375440KATNAL1chr13

30857753

-CUL4Achr13

113907396

+
5CDS-intronENST00000380617ENST00000463426KATNAL1chr13

30857753

-CUL4Achr13

113907396

+

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FusionProtFeatures for KATNAL1_CUL4A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KATNAL1

Q9BW62

CUL4A

Q13619

Regulates microtubule dynamics in Sertoli cells, aprocess that is essential for spermiogenesis and male fertility.Severs microtubules in an ATP-dependent manner, promoting rapidreorganization of cellular microtubule arrays (By similarity). Hasmicrotubule-severing activity in vitro (PubMed:26929214).{ECO:0000250|UniProtKB:Q8K0T4, ECO:0000269|PubMed:26929214}. Core component of multiple cullin-RING-based E3ubiquitin-protein ligase complexes which mediate theubiquitination of target proteins. As a scaffold protein maycontribute to catalysis through positioning of the substrate andthe ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligaseactivity of the complex is dependent on the neddylation of thecullin subunit and is inhibited by the association of thedeneddylated cullin subunit with TIP120A/CAND1. The functionalspecificity of the E3 ubiquitin-protein ligase complex depends onthe variable substrate recognition component. DCX(DET1-COP1)directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination ofXPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required forefficient histone deposition during replication-coupled (H3.1) andreplication-independent (H3.3) nucleosome assembly, probably byfacilitating the transfer of H3 from ASF1A/ASF1B to otherchaperones involved in histone deposition. DCX(DTL) plays a rolein PCNA-dependent polyubiquitination of CDT1 and MDM2-dependentubiquitination of TP53 in response to radiation-induced DNA damageand during DNA replication. In association with DDB1 and SKP2probably is involved in ubiquitination of CDKN1B/p27kip. Isinvolved in ubiquitination of HOXA9. DCX(DTL) directsautoubiquitination of DTL. {ECO:0000269|PubMed:14578910,ECO:0000269|PubMed:14609952, ECO:0000269|PubMed:15448697,ECO:0000269|PubMed:15548678, ECO:0000269|PubMed:16537899,ECO:0000269|PubMed:16678110, ECO:0000269|PubMed:23478445,ECO:0000269|PubMed:24209620}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KATNAL1_CUL4A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_KATNAL1_ENST00000380617_chr13_30857753_-_CUL4A_ENST00000375441_chr13_113907396_+_268aa
MNLAEICDNAKKGREYALLGNYDSSMVYYQGVMQQIQRHCQSVRDPAIKGKWQQMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEF
KEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQI

>In-frame_KATNAL1_ENST00000380617_chr13_30857753_-_CUL4A_ENST00000451881_chr13_113907396_+_268aa
MNLAEICDNAKKGREYALLGNYDSSMVYYQGVMQQIQRHCQSVRDPAIKGKWQQMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEF
KEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQI

>In-frame_KATNAL1_ENST00000380617_chr13_30857753_-_CUL4A_ENST00000326335_chr13_113907396_+_268aa
MNLAEICDNAKKGREYALLGNYDSSMVYYQGVMQQIQRHCQSVRDPAIKGKWQQMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEF
KEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQI

>In-frame_KATNAL1_ENST00000380617_chr13_30857753_-_CUL4A_ENST00000375440_chr13_113907396_+_268aa
MNLAEICDNAKKGREYALLGNYDSSMVYYQGVMQQIQRHCQSVRDPAIKGKWQQMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEF
KEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQI


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_KATNAL1_ENST00000380617_chr13_30857753_-_CUL4A_ENST00000375441_chr13_113907396_+_804nt
ATGAATTTGGCTGAGATTTGTGATAATGCAAAGAAAGGAAGAGAATATGCCCTTCTTGGAAATTACGACTCATCAATGGTATATTACCAG
GGGGTGATGCAGCAGATTCAGAGACATTGCCAGTCAGTCAGAGATCCAGCTATCAAAGGCAAATGGCAACAGATGATTAAACTTCAGGAA
GTATTTAAGGCATTTTATCTTGGAAAGCACAGTGGTCGAAAACTTCAGTGGCAAACTACTTTGGGACATGCTGTTTTAAAAGCGGAGTTT
AAAGAAGGGAAGAAGGAATTCCAGGTGTCCCTCTTCCAGACACTGGTGCTCCTCATGTTCAACGAGGGAGATGGCTTCAGCTTTGAGGAG
ATAAAAATGGCCACGGGGATAGAGGATAGTGAATTGCGCAGAACGCTGCAGTCCCTGGCCTGTGGCAAAGCACGTGTGCTGATTAAAAGT
CCCAAAGGAAAGGAAGTGGAAGATGGAGACAAGTTCATTTTTAATGGAGAGTTCAAGCACAAGTTGTTTAGAATAAAGATCAATCAAATT
CAGATGAAGGAAACTGTTGAGGAACAGGTTAGCACCACTGAGAGAGTGTTTCAGGATAGACAATATCAGATTGATGCTGCTATCGTCAGA
ATAATGAAGATGAGAAAGACTCTTGGTCATAATCTTCTAGTTTCTGAATTATATAATCAGCTGAAATTTCCAGTAAAGCCTGGAGATTTG

>In-frame_KATNAL1_ENST00000380617_chr13_30857753_-_CUL4A_ENST00000451881_chr13_113907396_+_804nt
ATGAATTTGGCTGAGATTTGTGATAATGCAAAGAAAGGAAGAGAATATGCCCTTCTTGGAAATTACGACTCATCAATGGTATATTACCAG
GGGGTGATGCAGCAGATTCAGAGACATTGCCAGTCAGTCAGAGATCCAGCTATCAAAGGCAAATGGCAACAGATGATTAAACTTCAGGAA
GTATTTAAGGCATTTTATCTTGGAAAGCACAGTGGTCGAAAACTTCAGTGGCAAACTACTTTGGGACATGCTGTTTTAAAAGCGGAGTTT
AAAGAAGGGAAGAAGGAATTCCAGGTGTCCCTCTTCCAGACACTGGTGCTCCTCATGTTCAACGAGGGAGATGGCTTCAGCTTTGAGGAG
ATAAAAATGGCCACGGGGATAGAGGATAGTGAATTGCGCAGAACGCTGCAGTCCCTGGCCTGTGGCAAAGCACGTGTGCTGATTAAAAGT
CCCAAAGGAAAGGAAGTGGAAGATGGAGACAAGTTCATTTTTAATGGAGAGTTCAAGCACAAGTTGTTTAGAATAAAGATCAATCAAATT
CAGATGAAGGAAACTGTTGAGGAACAGGTTAGCACCACTGAGAGAGTGTTTCAGGATAGACAATATCAGATTGATGCTGCTATCGTCAGA
ATAATGAAGATGAGAAAGACTCTTGGTCATAATCTTCTAGTTTCTGAATTATATAATCAGCTGAAATTTCCAGTAAAGCCTGGAGATTTG

>In-frame_KATNAL1_ENST00000380617_chr13_30857753_-_CUL4A_ENST00000326335_chr13_113907396_+_804nt
ATGAATTTGGCTGAGATTTGTGATAATGCAAAGAAAGGAAGAGAATATGCCCTTCTTGGAAATTACGACTCATCAATGGTATATTACCAG
GGGGTGATGCAGCAGATTCAGAGACATTGCCAGTCAGTCAGAGATCCAGCTATCAAAGGCAAATGGCAACAGATGATTAAACTTCAGGAA
GTATTTAAGGCATTTTATCTTGGAAAGCACAGTGGTCGAAAACTTCAGTGGCAAACTACTTTGGGACATGCTGTTTTAAAAGCGGAGTTT
AAAGAAGGGAAGAAGGAATTCCAGGTGTCCCTCTTCCAGACACTGGTGCTCCTCATGTTCAACGAGGGAGATGGCTTCAGCTTTGAGGAG
ATAAAAATGGCCACGGGGATAGAGGATAGTGAATTGCGCAGAACGCTGCAGTCCCTGGCCTGTGGCAAAGCACGTGTGCTGATTAAAAGT
CCCAAAGGAAAGGAAGTGGAAGATGGAGACAAGTTCATTTTTAATGGAGAGTTCAAGCACAAGTTGTTTAGAATAAAGATCAATCAAATT
CAGATGAAGGAAACTGTTGAGGAACAGGTTAGCACCACTGAGAGAGTGTTTCAGGATAGACAATATCAGATTGATGCTGCTATCGTCAGA
ATAATGAAGATGAGAAAGACTCTTGGTCATAATCTTCTAGTTTCTGAATTATATAATCAGCTGAAATTTCCAGTAAAGCCTGGAGATTTG

>In-frame_KATNAL1_ENST00000380617_chr13_30857753_-_CUL4A_ENST00000375440_chr13_113907396_+_804nt
ATGAATTTGGCTGAGATTTGTGATAATGCAAAGAAAGGAAGAGAATATGCCCTTCTTGGAAATTACGACTCATCAATGGTATATTACCAG
GGGGTGATGCAGCAGATTCAGAGACATTGCCAGTCAGTCAGAGATCCAGCTATCAAAGGCAAATGGCAACAGATGATTAAACTTCAGGAA
GTATTTAAGGCATTTTATCTTGGAAAGCACAGTGGTCGAAAACTTCAGTGGCAAACTACTTTGGGACATGCTGTTTTAAAAGCGGAGTTT
AAAGAAGGGAAGAAGGAATTCCAGGTGTCCCTCTTCCAGACACTGGTGCTCCTCATGTTCAACGAGGGAGATGGCTTCAGCTTTGAGGAG
ATAAAAATGGCCACGGGGATAGAGGATAGTGAATTGCGCAGAACGCTGCAGTCCCTGGCCTGTGGCAAAGCACGTGTGCTGATTAAAAGT
CCCAAAGGAAAGGAAGTGGAAGATGGAGACAAGTTCATTTTTAATGGAGAGTTCAAGCACAAGTTGTTTAGAATAAAGATCAATCAAATT
CAGATGAAGGAAACTGTTGAGGAACAGGTTAGCACCACTGAGAGAGTGTTTCAGGATAGACAATATCAGATTGATGCTGCTATCGTCAGA
ATAATGAAGATGAGAAAGACTCTTGGTCATAATCTTCTAGTTTCTGAATTATATAATCAGCTGAAATTTCCAGTAAAGCCTGGAGATTTG


* Fusion transcript sequences (Full-length transcript).
>In-frame_KATNAL1_ENST00000380617_chr13_30857753_-_CUL4A_ENST00000375441_chr13_113907396_+_905nt
GACAGAAAAAAAAATCTCTCTTTGTCTTGAGGGGGCTGTTGAGTGGTCGCGGACCTGGGCTCTGTGCGTTGGGAAAGGGAAGTGGAGGTC
TCTGAAAGAAGATGAATTTGGCTGAGATTTGTGATAATGCAAAGAAAGGAAGAGAATATGCCCTTCTTGGAAATTACGACTCATCAATGG
TATATTACCAGGGGGTGATGCAGCAGATTCAGAGACATTGCCAGTCAGTCAGAGATCCAGCTATCAAAGGCAAATGGCAACAGATGATTA
AACTTCAGGAAGTATTTAAGGCATTTTATCTTGGAAAGCACAGTGGTCGAAAACTTCAGTGGCAAACTACTTTGGGACATGCTGTTTTAA
AAGCGGAGTTTAAAGAAGGGAAGAAGGAATTCCAGGTGTCCCTCTTCCAGACACTGGTGCTCCTCATGTTCAACGAGGGAGATGGCTTCA
GCTTTGAGGAGATAAAAATGGCCACGGGGATAGAGGATAGTGAATTGCGCAGAACGCTGCAGTCCCTGGCCTGTGGCAAAGCACGTGTGC
TGATTAAAAGTCCCAAAGGAAAGGAAGTGGAAGATGGAGACAAGTTCATTTTTAATGGAGAGTTCAAGCACAAGTTGTTTAGAATAAAGA
TCAATCAAATTCAGATGAAGGAAACTGTTGAGGAACAGGTTAGCACCACTGAGAGAGTGTTTCAGGATAGACAATATCAGATTGATGCTG
CTATCGTCAGAATAATGAAGATGAGAAAGACTCTTGGTCATAATCTTCTAGTTTCTGAATTATATAATCAGCTGAAATTTCCAGTAAAGC
CTGGAGATTTGAAAAAGAGAATTGAATCTCTGATAGACAGAGACTATATGGAGAGAGACAAAGACAATCCGAATCAGTACCACTACGTGG

>In-frame_KATNAL1_ENST00000380617_chr13_30857753_-_CUL4A_ENST00000451881_chr13_113907396_+_2400nt
GACAGAAAAAAAAATCTCTCTTTGTCTTGAGGGGGCTGTTGAGTGGTCGCGGACCTGGGCTCTGTGCGTTGGGAAAGGGAAGTGGAGGTC
TCTGAAAGAAGATGAATTTGGCTGAGATTTGTGATAATGCAAAGAAAGGAAGAGAATATGCCCTTCTTGGAAATTACGACTCATCAATGG
TATATTACCAGGGGGTGATGCAGCAGATTCAGAGACATTGCCAGTCAGTCAGAGATCCAGCTATCAAAGGCAAATGGCAACAGATGATTA
AACTTCAGGAAGTATTTAAGGCATTTTATCTTGGAAAGCACAGTGGTCGAAAACTTCAGTGGCAAACTACTTTGGGACATGCTGTTTTAA
AAGCGGAGTTTAAAGAAGGGAAGAAGGAATTCCAGGTGTCCCTCTTCCAGACACTGGTGCTCCTCATGTTCAACGAGGGAGATGGCTTCA
GCTTTGAGGAGATAAAAATGGCCACGGGGATAGAGGATAGTGAATTGCGCAGAACGCTGCAGTCCCTGGCCTGTGGCAAAGCACGTGTGC
TGATTAAAAGTCCCAAAGGAAAGGAAGTGGAAGATGGAGACAAGTTCATTTTTAATGGAGAGTTCAAGCACAAGTTGTTTAGAATAAAGA
TCAATCAAATTCAGATGAAGGAAACTGTTGAGGAACAGGTTAGCACCACTGAGAGAGTGTTTCAGGATAGACAATATCAGATTGATGCTG
CTATCGTCAGAATAATGAAGATGAGAAAGACTCTTGGTCATAATCTTCTAGTTTCTGAATTATATAATCAGCTGAAATTTCCAGTAAAGC
CTGGAGATTTGAAAAAGAGAATTGAATCTCTGATAGACAGAGACTATATGGAGAGAGACAAAGACAATCCGAATCAGTACCACTACGTGG
CCTGACGCATCTGCAGACGGTTCCCCTTCATGAAACACTAGAATGTACCCTCAGAGCAGGAAGCACACCTGTGCCATTTCTGGGACTCTG
ATTGATCCAGCTGTGGACATTGGAAGGCGAAGGAAGGGAGGTGGCTCCTGGGTCATCTTTCACAAGGCTCAAGACTTCAACCTGCAGATG
TATCTTTTTCCCTCCAGTTTTTCCTCTAGTTCTTTTAGGCATTTAAATTGTTTCTGTTACTCTGTGCAAAATAACTTTGAGATTGGACAA
GAAGATGTTACTAAAGAGAAGTTCCTTTAAAAGGTCTTGTTCTTGTGTCAAAAAGCTGCAAGTTTGGTTTGTTCTCGTGTGTGATCATGA
GTGCACAATGAAGAAGACCCTAGATGCTGCATTTTTTAGCTCTGAAGATTCCTTAGGTATCCCTGAAGACAGCTCGCTCAGATGATCAGC
ATTTAGAGTGAAAACAAGGGCCCTTCATGGGTGAACATTAGAAAGAGCCAGGGTTCAAAGCTGGCGAATGGATGACGCACCCTAGCCACT
GGCCCCTCTCTGTTTCATGTATTTCCAAAAGTTGTAAACTTTGATGGCTGATTTTTCGTAAGTCAGGTTTCTAAGTGAGCTCCCTGAGGT
GCCAAGGCCATGGTGTCCGCCCTGCTGCGTCTGTTCGTCAGCTGAGTTCCTTGTGAATCTCTGTTTTAGGGTTTGGGGCTAGTGTGTTTG
TGTTTCCATTCTAAGATTGAGTCTGGCAGTCCCTGTTTTTTTGCATTGGGGTAACTGCTCTTTGATTTTTTTTAATTGCAGTATTTGTGT
GATTGCAATAATAAAGTTTGGTTTGGTTTTTACAGTCATGCGCAGGGACGATCCTTGTTCTCTGCTGTAAACTGTAAAAAGTTTATGGAG
ACTTAAAGTCTTGATGTTGTGAAGCAGAGGTTATTTTGTGGAAAGATTAAAAGGATTTTGTTGGTACCTGGTTTTGTGTTGTGTATATAT
ACATGAGGTTGAACAGTGAAAGGAAAGTTCAGTAGTGATGTTAGAAGGGTAACTATGACAAAGATACTTTTGAGATAACATTTAAAAGTA
CTTTATATTTTACATAATAGCATGTTTCATTTTGATTAAAAGCTACCAAAGGAATTTTGATCATGGCATAAGTGTTTAAAGCAATATTTT
CTGGAATATACCAAGTTTATATAATTTGATTTTGTGCTAAATTATTAAGAGTCTCTTTTTGAAACATGCGGGTTTGAAATATGACACCTT
GTGGGTTTCCATATTAAAATCCTCACTCTTTAATTGTCATTTCTATCTTTGAAAATTTTCATTTATGAGTTCCATGATATGTGGTCTAAG
AAAGACCAAACAGATTTCTATTTTTTTTTTCTTATAAGTTCGTTGTGTCTAGAGATTGTTAATATTGTAATTTAATGTAGACTTACTTTG

>In-frame_KATNAL1_ENST00000380617_chr13_30857753_-_CUL4A_ENST00000326335_chr13_113907396_+_2408nt
GACAGAAAAAAAAATCTCTCTTTGTCTTGAGGGGGCTGTTGAGTGGTCGCGGACCTGGGCTCTGTGCGTTGGGAAAGGGAAGTGGAGGTC
TCTGAAAGAAGATGAATTTGGCTGAGATTTGTGATAATGCAAAGAAAGGAAGAGAATATGCCCTTCTTGGAAATTACGACTCATCAATGG
TATATTACCAGGGGGTGATGCAGCAGATTCAGAGACATTGCCAGTCAGTCAGAGATCCAGCTATCAAAGGCAAATGGCAACAGATGATTA
AACTTCAGGAAGTATTTAAGGCATTTTATCTTGGAAAGCACAGTGGTCGAAAACTTCAGTGGCAAACTACTTTGGGACATGCTGTTTTAA
AAGCGGAGTTTAAAGAAGGGAAGAAGGAATTCCAGGTGTCCCTCTTCCAGACACTGGTGCTCCTCATGTTCAACGAGGGAGATGGCTTCA
GCTTTGAGGAGATAAAAATGGCCACGGGGATAGAGGATAGTGAATTGCGCAGAACGCTGCAGTCCCTGGCCTGTGGCAAAGCACGTGTGC
TGATTAAAAGTCCCAAAGGAAAGGAAGTGGAAGATGGAGACAAGTTCATTTTTAATGGAGAGTTCAAGCACAAGTTGTTTAGAATAAAGA
TCAATCAAATTCAGATGAAGGAAACTGTTGAGGAACAGGTTAGCACCACTGAGAGAGTGTTTCAGGATAGACAATATCAGATTGATGCTG
CTATCGTCAGAATAATGAAGATGAGAAAGACTCTTGGTCATAATCTTCTAGTTTCTGAATTATATAATCAGCTGAAATTTCCAGTAAAGC
CTGGAGATTTGAAAAAGAGAATTGAATCTCTGATAGACAGAGACTATATGGAGAGAGACAAAGACAATCCGAATCAGTACCACTACGTGG
CCTGACGCATCTGCAGACGGTTCCCCTTCATGAAACACTAGAATGTACCCTCAGAGCAGGAAGCACACCTGTGCCATTTCTGGGACTCTG
ATTGATCCAGCTGTGGACATTGGAAGGCGAAGGAAGGGAGGTGGCTCCTGGGTCATCTTTCACAAGGCTCAAGACTTCAACCTGCAGATG
TATCTTTTTCCCTCCAGTTTTTCCTCTAGTTCTTTTAGGCATTTAAATTGTTTCTGTTACTCTGTGCAAAATAACTTTGAGATTGGACAA
GAAGATGTTACTAAAGAGAAGTTCCTTTAAAAGGTCTTGTTCTTGTGTCAAAAAGCTGCAAGTTTGGTTTGTTCTCGTGTGTGATCATGA
GTGCACAATGAAGAAGACCCTAGATGCTGCATTTTTTAGCTCTGAAGATTCCTTAGGTATCCCTGAAGACAGCTCGCTCAGATGATCAGC
ATTTAGAGTGAAAACAAGGGCCCTTCATGGGTGAACATTAGAAAGAGCCAGGGTTCAAAGCTGGCGAATGGATGACGCACCCTAGCCACT
GGCCCCTCTCTGTTTCATGTATTTCCAAAAGTTGTAAACTTTGATGGCTGATTTTTCGTAAGTCAGGTTTCTAAGTGAGCTCCCTGAGGT
GCCAAGGCCATGGTGTCCGCCCTGCTGCGTCTGTTCGTCAGCTGAGTTCCTTGTGAATCTCTGTTTTAGGGTTTGGGGCTAGTGTGTTTG
TGTTTCCATTCTAAGATTGAGTCTGGCAGTCCCTGTTTTTTTGCATTGGGGTAACTGCTCTTTGATTTTTTTTAATTGCAGTATTTGTGT
GATTGCAATAATAAAGTTTGGTTTGGTTTTTACAGTCATGCGCAGGGACGATCCTTGTTCTCTGCTGTAAACTGTAAAAAGTTTATGGAG
ACTTAAAGTCTTGATGTTGTGAAGCAGAGGTTATTTTGTGGAAAGATTAAAAGGATTTTGTTGGTACCTGGTTTTGTGTTGTGTATATAT
ACATGAGGTTGAACAGTGAAAGGAAAGTTCAGTAGTGATGTTAGAAGGGTAACTATGACAAAGATACTTTTGAGATAACATTTAAAAGTA
CTTTATATTTTACATAATAGCATGTTTCATTTTGATTAAAAGCTACCAAAGGAATTTTGATCATGGCATAAGTGTTTAAAGCAATATTTT
CTGGAATATACCAAGTTTATATAATTTGATTTTGTGCTAAATTATTAAGAGTCTCTTTTTGAAACATGCGGGTTTGAAATATGACACCTT
GTGGGTTTCCATATTAAAATCCTCACTCTTTAATTGTCATTTCTATCTTTGAAAATTTTCATTTATGAGTTCCATGATATGTGGTCTAAG
AAAGACCAAACAGATTTCTATTTTTTTTTTCTTATAAGTTCGTTGTGTCTAGAGATTGTTAATATTGTAATTTAATGTAGACTTACTTTG

>In-frame_KATNAL1_ENST00000380617_chr13_30857753_-_CUL4A_ENST00000375440_chr13_113907396_+_905nt
GACAGAAAAAAAAATCTCTCTTTGTCTTGAGGGGGCTGTTGAGTGGTCGCGGACCTGGGCTCTGTGCGTTGGGAAAGGGAAGTGGAGGTC
TCTGAAAGAAGATGAATTTGGCTGAGATTTGTGATAATGCAAAGAAAGGAAGAGAATATGCCCTTCTTGGAAATTACGACTCATCAATGG
TATATTACCAGGGGGTGATGCAGCAGATTCAGAGACATTGCCAGTCAGTCAGAGATCCAGCTATCAAAGGCAAATGGCAACAGATGATTA
AACTTCAGGAAGTATTTAAGGCATTTTATCTTGGAAAGCACAGTGGTCGAAAACTTCAGTGGCAAACTACTTTGGGACATGCTGTTTTAA
AAGCGGAGTTTAAAGAAGGGAAGAAGGAATTCCAGGTGTCCCTCTTCCAGACACTGGTGCTCCTCATGTTCAACGAGGGAGATGGCTTCA
GCTTTGAGGAGATAAAAATGGCCACGGGGATAGAGGATAGTGAATTGCGCAGAACGCTGCAGTCCCTGGCCTGTGGCAAAGCACGTGTGC
TGATTAAAAGTCCCAAAGGAAAGGAAGTGGAAGATGGAGACAAGTTCATTTTTAATGGAGAGTTCAAGCACAAGTTGTTTAGAATAAAGA
TCAATCAAATTCAGATGAAGGAAACTGTTGAGGAACAGGTTAGCACCACTGAGAGAGTGTTTCAGGATAGACAATATCAGATTGATGCTG
CTATCGTCAGAATAATGAAGATGAGAAAGACTCTTGGTCATAATCTTCTAGTTTCTGAATTATATAATCAGCTGAAATTTCCAGTAAAGC
CTGGAGATTTGAAAAAGAGAATTGAATCTCTGATAGACAGAGACTATATGGAGAGAGACAAAGACAATCCGAATCAGTACCACTACGTGG


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FusionGenePPI for KATNAL1_CUL4A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KATNAL1COX17, ELAVL1, SIAH1, ZNF69, C1orf109, KATNBL1, KATNAL1, KLC4, CEP57L1, FBXW7CUL4ARNF7, DET1, RFWD2, CAND1, RBX1, HSPA1A, HSP90AA1, NEDD8, TUBA1B, CDKN1A, DDB1, DDB2, CUL4B, FBXW5, NF2, SAP130, CDKN1B, COPS5, COPS6, PTGS2, UBC, PCNA, TRPC4AP, DDA1, CRBN, COPS3, COPS4, COPS2, COPS8, COPS7B, COPS7A, DCAF11, DCAF5, BRWD1, PHIP, DCAF6, DCAF12, DCAF10, DCAF4, WDTC1, SKP2, TOR1AIP2, BANF1, EMD, DTL, WDR26, GRWD1, RBBP5, WDR5B, POC1B, SNRNP40, WDR61, WDR76, WDR82, WDR5, TLE2, EED, HIST1H3A, CDT1, CHEK1, COMMD1, DNMT3B, VPRBP, UBXN7, MYC, KAT2A, RASSF1, RAG1, SALL2, RAD21, HOXA9, HOXB4, GPS1, GLMN, MCM10, NACC1, CTNNB1, TP53, MDM2, CUL1, RBBP7, FBXW8, WSB1, WSB2, NUP43, BTRC, PWP1, RBBP4, ERCC8, CUL4A, DCUN1D1, AK9, DCST1, DCAF8, AMBRA1, DCAF12L2, DCAF16, CUL5, DCAF4L1, IGF2BP1, IGHV3OR15-7, MYEOV2, ANAPC5, CDY2B, CDY2A, OTULIN, LOC285556, NXPH3, RGS12, SCAF11, SH3RF2, SLA, TCHP, USP7, MAP4, ABCA10, XXYLT1, SYNM, ZNF407, ZNF525, CSRP2BP, RPL26, SLC25A22, SFXN1, HSPA8, TFG, CUL3, KRT10, DCAF7, CA2, KLHL9, KRT1, TUBA4B, FUS, HSPA1B, KRT9, TUBB4B, HSP90B1, PSMC6, SKP1, TUBA4A, EWSR1, H2AFV, HAX1, HNRNPA2B1, HNRNPUL1, HSPA1L, IARS, KRT2, KRT24, PCBD1, SNRPD1, TUBA1C, TUBB1, HNRNPH1, HNRNPH3, HSPA5, LGALS3BP, NCL, PABPC1, PPP2R1A, SNRPA, SNRPB, CCT5, DNAJC10, EEF1A1, EEF1A2, ENO1, HNRNPAB, HNRNPF, HNRNPDL, HSPA7, HSPA9, KRT76, PRDX1, QPCT, RPL15, RPL7A, RPLP2, RPS2, SRSF3, SLC25A5, SLC25A6, SSBP1, TAF15, TUBB, BAG4, C1QBP, DDX21, DDX5, DHX15, DHX9, HIST1H2AB, HIST1H2AE, HIST1H2AG, HIST1H2AL, HIST1H2AJ, HIST1H2AK, HIST1H2AI, HIST1H2AM, HNRNPD, HSP90AB1, HSPD1, KRT75, NFKB1, NPM1, PABPC4, RPL10A, RPL11, RPL19, RPL22, RPL23A, RPL38, RPL4, RPL7AP27, RPLP1, RPS14, RPS15A, RPS18, RPS20, RPS3, SDHA, SNRNP70, SNRPD3, SNRPE, TIA1, TIAL1, CSN1S1, MYB, LRWD1, ERCC6, UBE2E3, GRK5, SENP8, DCAF15, SUGT1, CHEK2, RPTOR, DCUN1D2, DCUN1D3, DCUN1D4, DCUN1D5, DDIT4, SF3B3, DICER1, DLC1, CAST, PRMT5, ASB4, HIST1H1C, DAB2IP, DCAF17, IP6K1, HIST1H1A, VCP, ARIH1, ABCE1, CLCN1, DCAF4L2, C9orf41, MRPS11, CCNG1, TUBG1, SAMHD1, UNK, MTM1, IFI16, CENPA, HIST1H2BG, PYGO2, GNB2, GNB1, GNB3, GNB4, GNB5, MCM2, DPPA4, NANOG, POU5F1, UVRAG, SLBP, FKBP8, IKZF3, ATP6V0D1, TMCO3, CRYBA4, TRIM16, TRIM25, LATS1, TWIST1, TES, SIRT7


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KATNAL1_CUL4A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KATNAL1_CUL4A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCUL4AC0038325Stevens-Johnson Syndrome1CTD_human