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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18194

FusionGeneSummary for KAT7_IGF2BP1

check button Fusion gene summary
Fusion gene informationFusion gene name: KAT7_IGF2BP1
Fusion gene ID: 18194
HgeneTgene
Gene symbol

KAT7

IGF2BP1

Gene ID

11143

10642

Gene namelysine acetyltransferase 7insulin like growth factor 2 mRNA binding protein 1
SynonymsHBO1|HBOA|MYST2|ZC2HC7CRD-BP|CRDBP|IMP-1|IMP1|VICKZ1|ZBP1
Cytomap

17q21.33

17q21.32

Type of geneprotein-codingprotein-coding
Descriptionhistone acetyltransferase KAT7K(lysine) acetyltransferase 7MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2MYST histone acetyltransferase 2histone acetyltransferase MYST2histone acetyltransferase binding to ORC1insulin-like growth factor 2 mRNA-binding protein 1IGF-II mRNA-binding protein 1IGF2 mRNA-binding protein 1VICKZ family member 1ZBP-1coding region determinant-binding proteininsulin-like growth factor 2 mRNA binding protein 1 deltaN CRDBPzipcode-bi
Modification date2018052320180519
UniProtAcc

O95251

Q9NZI8

Ensembl transtripts involved in fusion geneENST00000259021, ENST00000454930, 
ENST00000509773, ENST00000510819, 
ENST00000424009, ENST00000503935, 
ENST00000435742, ENST00000513980, 
ENST00000290341, ENST00000431824, 
ENST00000515586, 
Fusion gene scores* DoF score5 X 4 X 4=807 X 6 X 3=126
# samples 56
** MAII scorelog2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/126*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KAT7 [Title/Abstract] AND IGF2BP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKAT7

GO:0006260

DNA replication

16387653

HgeneKAT7

GO:0031098

stress-activated protein kinase signaling cascade

21856198

HgeneKAT7

GO:0043966

histone H3 acetylation

16387653

HgeneKAT7

GO:0043981

histone H4-K5 acetylation

16387653

HgeneKAT7

GO:0043982

histone H4-K8 acetylation

16387653

HgeneKAT7

GO:0043983

histone H4-K12 acetylation

16387653

HgeneKAT7

GO:0043984

histone H4-K16 acetylation

16387653

HgeneKAT7

GO:1900182

positive regulation of protein localization to nucleus

24739512

TgeneIGF2BP1

GO:0017148

negative regulation of translation

9891060

TgeneIGF2BP1

GO:0070934

CRD-mediated mRNA stabilization

19029303


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDTHCATCGA-EM-A2CM-01AKAT7chr17

47886570

+IGF2BP1chr17

47076471

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000259021ENST00000290341KAT7chr17

47886570

+IGF2BP1chr17

47076471

+
Frame-shitENST00000259021ENST00000431824KAT7chr17

47886570

+IGF2BP1chr17

47076471

+
5CDS-3UTRENST00000259021ENST00000515586KAT7chr17

47886570

+IGF2BP1chr17

47076471

+
Frame-shitENST00000454930ENST00000290341KAT7chr17

47886570

+IGF2BP1chr17

47076471

+
Frame-shitENST00000454930ENST00000431824KAT7chr17

47886570

+IGF2BP1chr17

47076471

+
5CDS-3UTRENST00000454930ENST00000515586KAT7chr17

47886570

+IGF2BP1chr17

47076471

+
intron-3CDSENST00000509773ENST00000290341KAT7chr17

47886570

+IGF2BP1chr17

47076471

+
intron-3CDSENST00000509773ENST00000431824KAT7chr17

47886570

+IGF2BP1chr17

47076471

+
intron-3UTRENST00000509773ENST00000515586KAT7chr17

47886570

+IGF2BP1chr17

47076471

+
intron-3CDSENST00000510819ENST00000290341KAT7chr17

47886570

+IGF2BP1chr17

47076471

+
intron-3CDSENST00000510819ENST00000431824KAT7chr17

47886570

+IGF2BP1chr17

47076471

+
intron-3UTRENST00000510819ENST00000515586KAT7chr17

47886570

+IGF2BP1chr17

47076471

+
intron-3CDSENST00000424009ENST00000290341KAT7chr17

47886570

+IGF2BP1chr17

47076471

+
intron-3CDSENST00000424009ENST00000431824KAT7chr17

47886570

+IGF2BP1chr17

47076471

+
intron-3UTRENST00000424009ENST00000515586KAT7chr17

47886570

+IGF2BP1chr17

47076471

+
Frame-shitENST00000503935ENST00000290341KAT7chr17

47886570

+IGF2BP1chr17

47076471

+
Frame-shitENST00000503935ENST00000431824KAT7chr17

47886570

+IGF2BP1chr17

47076471

+
5CDS-3UTRENST00000503935ENST00000515586KAT7chr17

47886570

+IGF2BP1chr17

47076471

+
intron-3CDSENST00000435742ENST00000290341KAT7chr17

47886570

+IGF2BP1chr17

47076471

+
intron-3CDSENST00000435742ENST00000431824KAT7chr17

47886570

+IGF2BP1chr17

47076471

+
intron-3UTRENST00000435742ENST00000515586KAT7chr17

47886570

+IGF2BP1chr17

47076471

+
intron-3CDSENST00000513980ENST00000290341KAT7chr17

47886570

+IGF2BP1chr17

47076471

+
intron-3CDSENST00000513980ENST00000431824KAT7chr17

47886570

+IGF2BP1chr17

47076471

+
intron-3UTRENST00000513980ENST00000515586KAT7chr17

47886570

+IGF2BP1chr17

47076471

+

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FusionProtFeatures for KAT7_IGF2BP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KAT7

O95251

IGF2BP1

Q9NZI8

Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity towardhistone H3 and is responsible for the bulk of histone H4acetylation in vivo. Involved in H3K14 (histone H3 lysine 14)acetylation and cell proliferation (By similarity). Throughchromatin acetylation it may regulate DNA replication and act as acoactivator of TP53-dependent transcription. Acts as a coactivatorof the licensing factor CDT1 (PubMed:18832067). Specificallyrepresses AR-mediated transcription.{ECO:0000250|UniProtKB:Q5SVQ0, ECO:0000269|PubMed:10438470,ECO:0000269|PubMed:10930412, ECO:0000269|PubMed:11278932,ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:18832067}. RNA-binding factor that recruits target transcripts tocytoplasmic protein-RNA complexes (mRNPs). This transcript'caging' into mRNPs allows mRNA transport and transient storage.It also modulates the rate and location at which targettranscripts encounter the translational apparatus and shields themfrom endonuclease attacks or microRNA-mediated degradation. Playsa direct role in the transport and translation of transcriptsrequired for axonal regeneration in adult sensory neurons (Bysimilarity). Regulates localized beta-actin/ACTB mRNA translation,a crucial process for cell polarity, cell migration and neuriteoutgrowth. Co-transcriptionally associates with the ACTB mRNA inthe nucleus. This binding involves a conserved 54-nucleotideelement in the ACTB mRNA 3'-UTR, known as the 'zipcode'. The RNPthus formed is exported to the cytoplasm, binds to a motor proteinand is transported along the cytoskeleton to the cell periphery.During transport, prevents ACTB mRNA from being translated intoprotein. When the RNP complex reaches its destination near theplasma membrane, IGF2BP1 is phosphorylated. This releases themRNA, allowing ribosomal 40S and 60S subunits to assemble andinitiate ACTB protein synthesis. Monomeric ACTB then assemblesinto the subcortical actin cytoskeleton (By similarity). Duringneuronal development, key regulator of neurite outgrowth, growthcone guidance and neuronal cell migration, presumably through thespatiotemporal fine tuning of protein synthesis, such as that ofACTB (By similarity). May regulate mRNA transport to activatedsynapses (By similarity). Binds to and stabilizes ABCB1/MDR-1 mRNA(By similarity). During interstinal wound repair, interacts withand stabilizes PTGS2 transcript. PTGS2 mRNA stabilization may becrucial for colonic mucosal wound healing (By similarity). Bindsto the 3'-UTR of IGF2 mRNA by a mechanism of cooperative andsequential dimerization and regulates IGF2 mRNA subcellularlocalization and translation. Binds to MYC mRNA, in the codingregion instability determinant (CRD) of the open reading frame(ORF), hence prevents MYC cleavage by endonucleases and possiblymicroRNA targeting to MYC-CRD. Binds to the 3'-UTR of CD44 mRNAand stabilizes it, hence promotes cell adhesion and invadopodiaformation in cancer cells. Binds to the oncofetal H19 transcriptand to the neuron-specific TAU mRNA and regulates theirlocalizations. Binds to and stabilizes BTRC/FBW1A mRNA. Binds tothe adenine-rich autoregulatory sequence (ARS) located in PABPC1mRNA and represses its translation. PABPC1 mRNA-binding isstimulated by PABPC1 protein. Prevents BTRC/FBW1A mRNA degradationby disrupting microRNA-dependent interaction with AGO2. Promotesthe directed movement of tumor-derived cells by fine-tuningintracellular signaling networks. Binds to MAPK4 3'-UTR andinhibits its translation. Interacts with PTEN transcript openreading frame (ORF) and prevents mRNA decay. This combined actionon MAPK4 (down-regulation) and PTEN (up-regulation) antagonizesHSPB1 phosphorylation, consequently it prevents G-actinsequestration by phosphorylated HSPB1, allowing F-actinpolymerization. Hence enhances the velocity of cell migration andstimulates directed cell migration by PTEN-modulated polarization.Interacts with Hepatitis C virus (HCV) 5'-UTR and 3'-UTR andspecifically enhances translation at the HCV IRES, but not 5'-cap-dependent translation, possibly by recruiting eIF3. Interacts withHIV-1 GAG protein and blocks the formation of infectious HIV-1particles. Reduces HIV-1 assembly by inhibiting viral RNApackaging, as well as assembly and processing of GAG protein oncellular membranes. During cellular stress, such as oxidativestress or heat shock, stabilizes target mRNAs that are recruitedto stress granules, including CD44, IGF2, MAPK4, MYC, PTEN,RAPGEF2 and RPS6KA5 transcripts. {ECO:0000250,ECO:0000269|PubMed:10875929, ECO:0000269|PubMed:16356927,ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:16778892,ECO:0000269|PubMed:17101699, ECO:0000269|PubMed:17255263,ECO:0000269|PubMed:17893325, ECO:0000269|PubMed:18385235,ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:19541769,ECO:0000269|PubMed:19647520, ECO:0000269|PubMed:20080952,ECO:0000269|PubMed:22279049, ECO:0000269|PubMed:8132663,ECO:0000269|PubMed:9891060}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for KAT7_IGF2BP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KAT7_IGF2BP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KAT7VIM, CEP70, ZNF165, HOOK2, DVL3, CALCOCO2, NINL, KCTD13, ZBTB8A, AR, ORC1, KATNBL1, PACSIN1, CAAP1, SEPT5, PPID, RGL2, RPS10, WDR33, CBX8, DDX11, ATN1, POLB, SAT1, SNAPIN, ING4, ING5, JADE1, JADE2, JADE3, MEAF6, TP53, HIST1H4A, CDT1, JUN, GMNN, CDC6, ORC2, MCM2, CDK11B, HIST1H3A, HIST2H2AC, CSNK1E, DYNC1I1, HAP1, BARD1, LRIF1, APP, EZH2, RNF2, IFI16, HIST1H2BG, XPO1, DAXX, S100A4, TMPO, ING3, DDB2, POU5F1, BRPF3, BRD1, FOXA1IGF2BP1CNBP, PUF60, PRKRA, GSK3B, ARHGDIA, SMYD2, ILK, MEPCE, HNRNPA1, RPAP1, KHDRBS2, CDK9, TP53, TP63, TP73, MYC, AGO4, HDAC5, NOP56, ARRB2, BTRC, CUL3, CUL4A, CUL4B, CUL5, CUL2, CUL1, COPS5, CAND1, NEDD8, BIRC2, SYNCRIP, FN1, VCAM1, IFIT1, GRB2, ITGA4, CBX6, CBX8, PAN2, BAG3, FBXO6, PARK2, WWOX, IVNS1ABP, STAU1, AURKA, CDKN1A, CEP250, HAUS2, TUBGCP2, TUBGCP3, TUBGCP4, MOV10, NXF1, CUL7, OBSL1, CCDC8, RPS6KB2, IGF2BP2, IGF2BP3, RAB2A, RPL37A, XPO1, HNRNPU, MKRN1, ELAVL1, NF2, ZNF746, ELAVL4, ELAVL2, RRS1, MRPS34, GSPT2, NCL, TRIM25, G3BP1, UBE2S, MTF1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KAT7_IGF2BP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KAT7_IGF2BP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource