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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 18183

FusionGeneSummary for KAT6B_CREBBP

check button Fusion gene summary
Fusion gene informationFusion gene name: KAT6B_CREBBP
Fusion gene ID: 18183
HgeneTgene
Gene symbol

KAT6B

CREBBP

Gene ID

23522

1387

Gene namelysine acetyltransferase 6BCREB binding protein
SynonymsGTPTS|MORF|MOZ2|MYST4|ZC2HC6B|qkf|querkopfCBP|KAT3A|RSTS|RSTS1
Cytomap

10q22.2

16p13.3

Type of geneprotein-codingprotein-coding
Descriptionhistone acetyltransferase KAT6BK(lysine) acetyltransferase 6BMOZ, YBF2/SAS3, SAS2 and TIP60 protein 4MOZ-related factorMYST histone acetyltransferase (monocytic leukemia) 4MYST-4histone acetyltransferase MORFhistone acetyltransferase MOZ2histone aCREB-binding protein
Modification date2018052320180522
UniProtAcc

Q8WYB5

Q92793

Ensembl transtripts involved in fusion geneENST00000372725, ENST00000372724, 
ENST00000287239, ENST00000372714, 
ENST00000372711, ENST00000490365, 
ENST00000262367, ENST00000382070, 
Fusion gene scores* DoF score11 X 9 X 4=3968 X 17 X 3=408
# samples 1118
** MAII scorelog2(11/396*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/408*10)=-1.18057224564182
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: KAT6B [Title/Abstract] AND CREBBP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Tumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKAT6B

GO:0016573

histone acetylation

11965546

HgeneKAT6B

GO:0043966

histone H3 acetylation

16387653

HgeneKAT6B

GO:0045892

negative regulation of transcription, DNA-templated

10497217

HgeneKAT6B

GO:0045893

positive regulation of transcription, DNA-templated

10497217|11965546

TgeneCREBBP

GO:0000122

negative regulation of transcription by RNA polymerase II

21539536

TgeneCREBBP

GO:0006355

regulation of transcription, DNA-templated

12169688

TgeneCREBBP

GO:0006473

protein acetylation

15273251|24939902

TgeneCREBBP

GO:0016573

histone acetylation

11742995

TgeneCREBBP

GO:0018076

N-terminal peptidyl-lysine acetylation

12435739

TgeneCREBBP

GO:0034644

cellular response to UV

24939902

TgeneCREBBP

GO:0045893

positive regulation of transcription, DNA-templated

11742995


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AJ299261KAT6Bchr10

76785007

+CREBBPchr16

3901010

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000372725ENST00000262367KAT6Bchr10

76785007

+CREBBPchr16

3901010

-
In-frameENST00000372725ENST00000382070KAT6Bchr10

76785007

+CREBBPchr16

3901010

-
In-frameENST00000372724ENST00000262367KAT6Bchr10

76785007

+CREBBPchr16

3901010

-
In-frameENST00000372724ENST00000382070KAT6Bchr10

76785007

+CREBBPchr16

3901010

-
In-frameENST00000287239ENST00000262367KAT6Bchr10

76785007

+CREBBPchr16

3901010

-
In-frameENST00000287239ENST00000382070KAT6Bchr10

76785007

+CREBBPchr16

3901010

-
In-frameENST00000372714ENST00000262367KAT6Bchr10

76785007

+CREBBPchr16

3901010

-
In-frameENST00000372714ENST00000382070KAT6Bchr10

76785007

+CREBBPchr16

3901010

-
In-frameENST00000372711ENST00000262367KAT6Bchr10

76785007

+CREBBPchr16

3901010

-
In-frameENST00000372711ENST00000382070KAT6Bchr10

76785007

+CREBBPchr16

3901010

-
3UTR-3CDSENST00000490365ENST00000262367KAT6Bchr10

76785007

+CREBBPchr16

3901010

-
3UTR-3CDSENST00000490365ENST00000382070KAT6Bchr10

76785007

+CREBBPchr16

3901010

-

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FusionProtFeatures for KAT6B_CREBBP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KAT6B

Q8WYB5

CREBBP

Q92793

Histone acetyltransferase which may be involved in bothpositive and negative regulation of transcription. Required forRUNX2-dependent transcriptional activation. May be involved incerebral cortex development. Component of the MOZ/MORF complexwhich has a histone H3 acetyltransferase activity.{ECO:0000269|PubMed:10497217, ECO:0000269|PubMed:11965546,ECO:0000269|PubMed:16387653}. Acetylates histones, giving a specific tag fortranscriptional activation. Also acetylates non-histone proteins,like NCOA3 and FOXO1. Binds specifically to phosphorylated CREBand enhances its transcriptional activity toward cAMP-responsivegenes. Acts as a coactivator of ALX1. Acts as a circadiantranscriptional coactivator which enhances the activity of thecircadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers. Acetylates PCNA; acetylation promotesremoval of chromatin-bound PCNA and its degradation duringnucleotide excision repair (NER) (PubMed:24939902).{ECO:0000269|PubMed:11154691, ECO:0000269|PubMed:12738767,ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221,ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:9707565}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000287239+17181070_110412212074Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000287239+17181204_120712212074Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000287239+1718492_53312212074Compositional biasNote=Ser-rich
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000287239+1718521_52412212074Compositional biasNote=Poly-Ser
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000287239+1718599_60512212074Compositional biasNote=Poly-Ser
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372711+1617492_53310381891Compositional biasNote=Ser-rich
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372711+1617521_52410381891Compositional biasNote=Poly-Ser
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372711+1617599_60510381891Compositional biasNote=Poly-Ser
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372714+1617492_5339291782Compositional biasNote=Ser-rich
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372714+1617521_5249291782Compositional biasNote=Poly-Ser
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372714+1617599_6059291782Compositional biasNote=Poly-Ser
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372724+1718492_5339291782Compositional biasNote=Ser-rich
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372724+1718521_5249291782Compositional biasNote=Poly-Ser
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372724+1718599_6059291782Compositional biasNote=Poly-Ser
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372725+1617492_5339291782Compositional biasNote=Ser-rich
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372725+1617521_5249291782Compositional biasNote=Poly-Ser
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372725+1617599_6059291782Compositional biasNote=Poly-Ser
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000287239+1718103_17612212074DomainH15
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000287239+1718715_98912212074DomainMYST-type HAT
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372711+1617103_17610381891DomainH15
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372711+1617715_98910381891DomainMYST-type HAT
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372714+1617103_1769291782DomainH15
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372724+1718103_1769291782DomainH15
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372725+1617103_1769291782DomainH15
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000287239+1718361_71712212074RegionNote=Negatively regulates HAT activity
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000287239+1718718_100812212074RegionNote=Catalytic
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000287239+1718856_86012212074RegionAcetyl-CoA binding
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000287239+1718865_87112212074RegionAcetyl-CoA binding
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372711+1617361_71710381891RegionNote=Negatively regulates HAT activity
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372711+1617718_100810381891RegionNote=Catalytic
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372711+1617856_86010381891RegionAcetyl-CoA binding
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372711+1617865_87110381891RegionAcetyl-CoA binding
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372714+1617361_7179291782RegionNote=Negatively regulates HAT activity
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372714+1617856_8609291782RegionAcetyl-CoA binding
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372714+1617865_8719291782RegionAcetyl-CoA binding
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372724+1718361_7179291782RegionNote=Negatively regulates HAT activity
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372724+1718856_8609291782RegionAcetyl-CoA binding
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372724+1718865_8719291782RegionAcetyl-CoA binding
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372725+1617361_7179291782RegionNote=Negatively regulates HAT activity
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372725+1617856_8609291782RegionAcetyl-CoA binding
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372725+1617865_8719291782RegionAcetyl-CoA binding
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000287239+1718213_27212212074Zinc fingerPHD-type 1
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000287239+1718269_32012212074Zinc fingerPHD-type 2
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000287239+1718748_77312212074Zinc fingerC2HC MYST-type
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372711+1617213_27210381891Zinc fingerPHD-type 1
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372711+1617269_32010381891Zinc fingerPHD-type 2
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372711+1617748_77310381891Zinc fingerC2HC MYST-type
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372714+1617213_2729291782Zinc fingerPHD-type 1
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372714+1617269_3209291782Zinc fingerPHD-type 2
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372714+1617748_7739291782Zinc fingerC2HC MYST-type
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372724+1718213_2729291782Zinc fingerPHD-type 1
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372724+1718269_3209291782Zinc fingerPHD-type 2
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372724+1718748_7739291782Zinc fingerC2HC MYST-type
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372725+1617213_2729291782Zinc fingerPHD-type 1
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372725+1617269_3209291782Zinc fingerPHD-type 2
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372725+1617748_7739291782Zinc fingerC2HC MYST-type
TgeneCREBBPchr10:76785007chr16:3901010ENST00000262367-0311061_1064282443Compositional biasNote=Poly-Glu
TgeneCREBBPchr10:76785007chr16:3901010ENST00000262367-0311199_1487282443Compositional biasNote=Cys/His-rich
TgeneCREBBPchr10:76785007chr16:3901010ENST00000262367-0311555_1562282443Compositional biasNote=Poly-Glu
TgeneCREBBPchr10:76785007chr16:3901010ENST00000262367-0311943_1948282443Compositional biasNote=Poly-Pro
TgeneCREBBPchr10:76785007chr16:3901010ENST00000262367-0311967_1970282443Compositional biasNote=Poly-Gln
TgeneCREBBPchr10:76785007chr16:3901010ENST00000262367-0312081_2085282443Compositional biasNote=Poly-Gln
TgeneCREBBPchr10:76785007chr16:3901010ENST00000262367-0312199_2216282443Compositional biasNote=Poly-Gln
TgeneCREBBPchr10:76785007chr16:3901010ENST00000262367-0312245_2248282443Compositional biasNote=Poly-Gln
TgeneCREBBPchr10:76785007chr16:3901010ENST00000262367-0312297_2300282443Compositional biasNote=Poly-Gln
TgeneCREBBPchr10:76785007chr16:3901010ENST00000382070-0301061_1064282405Compositional biasNote=Poly-Glu
TgeneCREBBPchr10:76785007chr16:3901010ENST00000382070-0301199_1487282405Compositional biasNote=Cys/His-rich
TgeneCREBBPchr10:76785007chr16:3901010ENST00000382070-0301555_1562282405Compositional biasNote=Poly-Glu
TgeneCREBBPchr10:76785007chr16:3901010ENST00000382070-0301943_1948282405Compositional biasNote=Poly-Pro
TgeneCREBBPchr10:76785007chr16:3901010ENST00000382070-0301967_1970282405Compositional biasNote=Poly-Gln
TgeneCREBBPchr10:76785007chr16:3901010ENST00000382070-0302081_2085282405Compositional biasNote=Poly-Gln
TgeneCREBBPchr10:76785007chr16:3901010ENST00000382070-0302199_2216282405Compositional biasNote=Poly-Gln
TgeneCREBBPchr10:76785007chr16:3901010ENST00000382070-0302245_2248282405Compositional biasNote=Poly-Gln
TgeneCREBBPchr10:76785007chr16:3901010ENST00000382070-0302297_2300282405Compositional biasNote=Poly-Gln
TgeneCREBBPchr10:76785007chr16:3901010ENST00000262367-0311103_1175282443DomainBromo
TgeneCREBBPchr10:76785007chr16:3901010ENST00000262367-0311323_1700282443DomainCBP/p300-type HAT
TgeneCREBBPchr10:76785007chr16:3901010ENST00000262367-031587_666282443DomainKIX
TgeneCREBBPchr10:76785007chr16:3901010ENST00000382070-0301103_1175282405DomainBromo
TgeneCREBBPchr10:76785007chr16:3901010ENST00000382070-0301323_1700282405DomainCBP/p300-type HAT
TgeneCREBBPchr10:76785007chr16:3901010ENST00000382070-030587_666282405DomainKIX
TgeneCREBBPchr10:76785007chr16:3901010ENST00000262367-0311434_1436282443RegionAcetyl-CoA binding
TgeneCREBBPchr10:76785007chr16:3901010ENST00000262367-0311446_1447282443RegionAcetyl-CoA binding
TgeneCREBBPchr10:76785007chr16:3901010ENST00000382070-0301434_1436282405RegionAcetyl-CoA binding
TgeneCREBBPchr10:76785007chr16:3901010ENST00000382070-0301446_1447282405RegionAcetyl-CoA binding
TgeneCREBBPchr10:76785007chr16:3901010ENST00000262367-0311701_1744282443Zinc fingerZZ-type
TgeneCREBBPchr10:76785007chr16:3901010ENST00000262367-0311765_1846282443Zinc fingerTAZ-type 2
TgeneCREBBPchr10:76785007chr16:3901010ENST00000262367-031347_433282443Zinc fingerTAZ-type 1
TgeneCREBBPchr10:76785007chr16:3901010ENST00000382070-0301701_1744282405Zinc fingerZZ-type
TgeneCREBBPchr10:76785007chr16:3901010ENST00000382070-0301765_1846282405Zinc fingerTAZ-type 2
TgeneCREBBPchr10:76785007chr16:3901010ENST00000382070-030347_433282405Zinc fingerTAZ-type 1

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000287239+17181351_137312212074Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000287239+17181409_141712212074Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000287239+17181594_176312212074Compositional biasNote=Ser-rich
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000287239+17181961_206112212074Compositional biasNote=Met-rich
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372711+16171070_110410381891Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372711+16171204_120710381891Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372711+16171351_137310381891Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372711+16171409_141710381891Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372711+16171594_176310381891Compositional biasNote=Ser-rich
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372711+16171961_206110381891Compositional biasNote=Met-rich
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372714+16171070_11049291782Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372714+16171204_12079291782Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372714+16171351_13739291782Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372714+16171409_14179291782Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372714+16171594_17639291782Compositional biasNote=Ser-rich
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372714+16171961_20619291782Compositional biasNote=Met-rich
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372724+17181070_11049291782Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372724+17181204_12079291782Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372724+17181351_13739291782Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372724+17181409_14179291782Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372724+17181594_17639291782Compositional biasNote=Ser-rich
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372724+17181961_20619291782Compositional biasNote=Met-rich
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372725+16171070_11049291782Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372725+16171204_12079291782Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372725+16171351_13739291782Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372725+16171409_14179291782Compositional biasNote=Poly-Glu
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372725+16171594_17639291782Compositional biasNote=Ser-rich
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372725+16171961_20619291782Compositional biasNote=Met-rich
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372714+1617715_9899291782DomainMYST-type HAT
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372724+1718715_9899291782DomainMYST-type HAT
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372725+1617715_9899291782DomainMYST-type HAT
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372714+1617718_10089291782RegionNote=Catalytic
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372724+1718718_10089291782RegionNote=Catalytic
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372725+1617718_10089291782RegionNote=Catalytic


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FusionGeneSequence for KAT6B_CREBBP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for KAT6B_CREBBP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KAT6BRUNX2, RUNX1, ING5, ATN1, HIST3H3, UBE2I, SGOL1, MEAF6CREBBPEGR1, HNF4A, NFE2L2, TDG, AIRE, NCOA6, BRCA1, CREB1, AR, N4BP2, CTNNB1, RELA, SS18L1, PIAS3, NPAS2, EBF1, E2F1, E2F3, KLF5, PML, SRF, TP53, KLF1, ING1, SMAD1, CSNK2A1, CUX1, ATF1, EWSR1, NR3C1, HNF1A, HOXB7, MSX1, HTT, TCF3, MGMT, KMT2A, MYOD1, ATF2, JUN, MECOM, GLI3, DDX5, PTMA, MYB, FOXO1, FOXO4, RPS6KA3, CITED1, STAT1, STAT6, MAF, PELP1, RPS6KA2, RBBP4, RBBP7, ONECUT1, SERTAD1, SREBF1, SREBF2, NFATC2, TRIP4, HIF1A, NFE2, STAT2, SMARCA4, NCOA1, ESR1, MAML1, MYBL2, KAT2B, GTF2B, CITED2, IRF3, NUP98, TRERF1, TGS1, KLF4, STAT3, NEUROG1, HIPK2, KHDRBS1, GATA1, PHOX2A, SNIP1, NFATC4, KLF13, XRCC6, FOS, POLR2A, SMARCB1, CCNC, CDK8, MED21, NKX2-1, NCOA3, PPARG, ATF4, RPA2, PPARGC1A, HIST3H3, HIST4H4, EP300, ANAPC7, ANAPC5, CDC16, ANAPC2, CDH1, CDC20, REL, DDX17, GCM1, MAP3K5, MAPK10, MKNK1, APC, PAPOLA, CPSF6, TBX21, NCOR1, NCOR2, CARM1, ESR2, YY1, MYC, PLAGL1, MIER1, HDAC1, SP1, SP3, HDAC3, VDR, DAXX, CEBPB, CEBPD, PARP1, PTMS, ATXN3, CTBP1, HIST1H3A, MTF1, SETD1A, MYBL1, NLK, SMAD3, DEK, FGFR1, RPS6KA1, CDKN1A, SND1, NCOA2, KAT6A, SRCAP, TAF6L, ETS1, ETS2, RUNX2, MAFK, TCF12, HDAC2, HOXB6, KPNA2, KPNA6, NR5A1, HMGA1, FOXO3, HIST1H4A, HES6, RUVBL1, FOSL1, FOSB, JUNB, FOXM1, HMGB1, HMGB2, POU1F1, IRF1, SMAD2, RARA, SH3GL1, BCL6, GRIP1, KLF8, NFYB, TRIM28, POT1, WDR5, IRF5, AKT1, CDC27, ATF3, ATG3, MDM2, HOXB2, HOXB3, HOXB9, HOXD12, HOXD13, HOXD10, HOXD4, HOXB4, HOXA10, HOXA9, PBX1, SMARCA2, MYH9, MSH6, MSH2, ZBTB2, ZNF639, ACTA2, CSNK2A2, TP73, PRLR, MED25, PTOV1, IFNAR2, IRF9, TBP, RPS6KA5, IRF7, KAT5, PYGO2, HBP1, TACC2, NPAT, CCNE1, ELAVL1, KDM3B, PSMC5, MDC1, LYN, HCK, SRC, ZCCHC12, RAD23A, RUNX1, CHUK, IKBKB, IKBKG, HIST2H2BE, LIG4, TLR2, EPAS1, MTDH, MEIS1, LDLR, DYRK1B, DYRK1A, CDK2, EID1, COPS2, PSME3, WRN, KLF2, UBE2D1, CREBBP, UBE2I, MAPK3, FHL1, HIST1H2BB, EID3, POU2F3, ELK1, MAPK1, TFDP1, CREM, ZEB1, CRTC1, MAML2, CENPJ, HSF1, FHL2, CDH2, PHOX2B, DDIT3, XAF1, BMI1, CCND3, TXNDC11, CCNA2, C3orf62, PPP1R13L, BRMS1, PCNA, UBE2S, TLE3, MUS81, PTTG1, MED23, SNAI1, TFAP2B, SMAD4, NR3C2, ARNTL, CLOCK, SUMO1, NFATC1, CPSF4, RFPL3, CTGF, NFYA, KIAA0430, HELZ, NISCH, SOWAHA, PCGF3, EIF4ENIF1, PAN2, JUP, HSPA8, LAMP2, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000287239+1718752_100812212074BRPF1
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372711+1617752_100810381891BRPF1
TgeneCREBBPchr10:76785007chr16:3901010ENST00000262367-0311162_1180282443ASF1A
TgeneCREBBPchr10:76785007chr16:3901010ENST00000382070-0301162_1180282405ASF1A
TgeneCREBBPchr10:76785007chr16:3901010ENST00000262367-0311433_1435282443histone
TgeneCREBBPchr10:76785007chr16:3901010ENST00000382070-0301433_1435282405histone
TgeneCREBBPchr10:76785007chr16:3901010ENST00000262367-0311124_1170282443histone
TgeneCREBBPchr10:76785007chr16:3901010ENST00000382070-0301124_1170282405histone
TgeneCREBBPchr10:76785007chr16:3901010ENST00000262367-031227_410282443SRCAP
TgeneCREBBPchr10:76785007chr16:3901010ENST00000382070-030227_410282405SRCAP
TgeneCREBBPchr10:76785007chr16:3901010ENST00000262367-0311460_1891282443TRERF1
TgeneCREBBPchr10:76785007chr16:3901010ENST00000382070-0301460_1891282405TRERF1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372714+1617752_10089291782BRPF1
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372724+1718752_10089291782BRPF1
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372725+1617752_10089291782BRPF1
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000287239+17181560_207312212074RUNX1 and RUNX2
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372711+16171560_207310381891RUNX1 and RUNX2
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372714+16171560_20739291782RUNX1 and RUNX2
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372724+17181560_20739291782RUNX1 and RUNX2
HgeneKAT6Bchr10:76785007chr16:3901010ENST00000372725+16171560_20739291782RUNX1 and RUNX2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KAT6B_CREBBP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KAT6B_CREBBP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKAT6BC0853193Bipolar I disorder1PSYGENET
HgeneKAT6BC3495559Juvenile arthritis1CTD_human
TgeneCREBBPC0035934Rubinstein-Taybi Syndrome3CTD_human;ORPHANET;UNIPROT
TgeneCREBBPC0033578Prostatic Neoplasms2CTD_human
TgeneCREBBPC0005586Bipolar Disorder1PSYGENET
TgeneCREBBPC0005695Bladder Neoplasm1CTD_human
TgeneCREBBPC0007137Squamous cell carcinoma1CTD_human
TgeneCREBBPC0007138Carcinoma, Transitional Cell1CTD_human
TgeneCREBBPC0010606Adenoid Cystic Carcinoma1CTD_human
TgeneCREBBPC0011573Endogenous depression1PSYGENET
TgeneCREBBPC0024301Lymphoma, Follicular1CTD_human
TgeneCREBBPC0036341Schizophrenia1PSYGENET
TgeneCREBBPC0036920Sezary Syndrome1CTD_human
TgeneCREBBPC0149925Small cell carcinoma of lung1CTD_human
TgeneCREBBPC0152013Adenocarcinoma of lung (disorder)1CTD_human
TgeneCREBBPC0279626Squamous cell carcinoma of esophagus1CTD_human
TgeneCREBBPC1862939AMYOTROPHIC LATERAL SCLEROSIS 11CTD_human