|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 1818 |
FusionGeneSummary for ANKRD26_MCM10 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ANKRD26_MCM10 | Fusion gene ID: 1818 | Hgene | Tgene | Gene symbol | ANKRD26 | MCM10 | Gene ID | 22852 | 55388 |
| Gene name | ankyrin repeat domain 26 | minichromosome maintenance 10 replication initiation factor | |
| Synonyms | THC2|bA145E8.1 | CNA43|DNA43|PRO2249 | |
| Cytomap | 10p12.1 | 10p13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ankyrin repeat domain-containing protein 26GNS/ANKRD26/NCKAP1L fusion | protein MCM10 homologMCM10 minichromosome maintenance deficient 10homolog of yeast MCM10hsMCM10minichromosome maintenance complex component 10 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9UPS8 | Q7L590 | |
| Ensembl transtripts involved in fusion gene | ENST00000376070, ENST00000376087, ENST00000436985, ENST00000466890, | ENST00000378714, ENST00000484800, ENST00000378694, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 2 X 2 X 2=8 |
| # samples | 2 | 2 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: ANKRD26 [Title/Abstract] AND MCM10 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-XF-A8HD-01A | ANKRD26 | chr10 | 27389014 | - | MCM10 | chr10 | 13251091 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000376070 | ENST00000378714 | ANKRD26 | chr10 | 27389014 | - | MCM10 | chr10 | 13251091 | + |
| intron-3CDS | ENST00000376070 | ENST00000484800 | ANKRD26 | chr10 | 27389014 | - | MCM10 | chr10 | 13251091 | + |
| intron-3CDS | ENST00000376070 | ENST00000378694 | ANKRD26 | chr10 | 27389014 | - | MCM10 | chr10 | 13251091 | + |
| Frame-shift | ENST00000376087 | ENST00000378714 | ANKRD26 | chr10 | 27389014 | - | MCM10 | chr10 | 13251091 | + |
| Frame-shift | ENST00000376087 | ENST00000484800 | ANKRD26 | chr10 | 27389014 | - | MCM10 | chr10 | 13251091 | + |
| In-frame | ENST00000376087 | ENST00000378694 | ANKRD26 | chr10 | 27389014 | - | MCM10 | chr10 | 13251091 | + |
| Frame-shift | ENST00000436985 | ENST00000378714 | ANKRD26 | chr10 | 27389014 | - | MCM10 | chr10 | 13251091 | + |
| Frame-shift | ENST00000436985 | ENST00000484800 | ANKRD26 | chr10 | 27389014 | - | MCM10 | chr10 | 13251091 | + |
| In-frame | ENST00000436985 | ENST00000378694 | ANKRD26 | chr10 | 27389014 | - | MCM10 | chr10 | 13251091 | + |
| intron-3CDS | ENST00000466890 | ENST00000378714 | ANKRD26 | chr10 | 27389014 | - | MCM10 | chr10 | 13251091 | + |
| intron-3CDS | ENST00000466890 | ENST00000484800 | ANKRD26 | chr10 | 27389014 | - | MCM10 | chr10 | 13251091 | + |
| intron-3CDS | ENST00000466890 | ENST00000378694 | ANKRD26 | chr10 | 27389014 | - | MCM10 | chr10 | 13251091 | + |
Top |
FusionProtFeatures for ANKRD26_MCM10 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ANKRD26 | MCM10 |
| Acts as a regulator of adipogenesis. Involved in theregulation of the feeding behavior.{ECO:0000250|UniProtKB:Q811D2}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for ANKRD26_MCM10 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ANKRD26_ENST00000376087_chr10_27389014_-_MCM10_ENST00000378694_chr10_13251091_+_104aa MKKIFSKKGESPLGSFARRQRSSAGGGGEPGEGAYSQPGYHVRDRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNSNCGLYKWER >In-frame_ANKRD26_ENST00000436985_chr10_27389014_-_MCM10_ENST00000378694_chr10_13251091_+_104aa MKKIFSKKGESPLGSFARRQRSSAGGGGEPGEGAYSQPGYHVRDRDLGKIHKAASAGNVAKVQQILLLRKNGLNDRDKMNSNCGLYKWER |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ANKRD26_ENST00000376087_chr10_27389014_-_MCM10_ENST00000378694_chr10_13251091_+_312nt ATGAAGAAGATTTTTAGTAAGAAGGGCGAGTCGCCCTTGGGCTCCTTCGCGCGGCGGCAGAGGAGCAGCGCGGGAGGCGGGGGCGAGCCG GGGGAGGGCGCCTACTCGCAGCCCGGCTACCACGTCCGAGACCGAGATCTCGGCAAGATCCACAAAGCTGCCAGCGCGGGTAATGTGGCG AAAGTGCAGCAGATCCTTTTGCTCAGGAAGAATGGCTTGAACGATAGAGACAAGATGAACAGTAACTGTGGCCTCTACAAATGGGAACGG >In-frame_ANKRD26_ENST00000436985_chr10_27389014_-_MCM10_ENST00000378694_chr10_13251091_+_312nt ATGAAGAAGATTTTTAGTAAGAAGGGCGAGTCGCCCTTGGGCTCCTTCGCGCGGCGGCAGAGGAGCAGCGCGGGAGGCGGGGGCGAGCCG GGGGAGGGCGCCTACTCGCAGCCCGGCTACCACGTCCGAGACCGAGATCTCGGCAAGATCCACAAAGCTGCCAGCGCGGGTAATGTGGCG AAAGTGCAGCAGATCCTTTTGCTCAGGAAGAATGGCTTGAACGATAGAGACAAGATGAACAGTAACTGTGGCCTCTACAAATGGGAACGG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ANKRD26_ENST00000376087_chr10_27389014_-_MCM10_ENST00000378694_chr10_13251091_+_2422nt GTCTAGCGGGATCGCTTGCTTGGTAACCCGGAGGGAGAGATTGGAAACCGCGGAGTTTCCTTTGGGAGGCTGCGGCCAGCCGGGGCTGAC TTGTTATGTTGGGCTCCGGAGGCCGTTAAGAGCCGAGAGAGACATGAGGTGTCTCTGAAGCCCGGTCGCCTGGGCCATGAAGAAGATTTT TAGTAAGAAGGGCGAGTCGCCCTTGGGCTCCTTCGCGCGGCGGCAGAGGAGCAGCGCGGGAGGCGGGGGCGAGCCGGGGGAGGGCGCCTA CTCGCAGCCCGGCTACCACGTCCGAGACCGAGATCTCGGCAAGATCCACAAAGCTGCCAGCGCGGGTAATGTGGCGAAAGTGCAGCAGAT CCTTTTGCTCAGGAAGAATGGCTTGAACGATAGAGACAAGATGAACAGTAACTGTGGCCTCTACAAATGGGAACGGGACGGAATGCTAAA GGTATGCCATTTGCGTACTAATTTTTGACTCCTTTTAGTGACCCATGCTAATAATGTGGAACCATCTCCTATTAAAATATTTTCATTTTT CTAGGAAAAGACTGGTCCAAAGATAGGAGGAGAAACTCTGTTACCAAGAGGAGAAGAACATGCTAAATTTCTGAACAGCCTTAAATAACC CGAACTTCAGACATTTTCCCACAGACTTCCTGGCCTCCTGTGACTCTGGAAAGCAAAGGATTGGCTGTGTATTGTCCATTGATTCCTGAT TGACGCCGTCAAAAACAAATGCTTGTTAAGCCCATAAGCTTTGCCTGCTTACTTTCTGCCATTGGGTTGGTTTGATACCACATTTAACAT TGACATTTAAGTGGAAAACCAAGTTATCATTGTCTTTTCTAAGCTCAGTGTGGATGATTGCATTACTTCATTCACTGAAGTTTTTGCCCA AAAATTGGAAGGTAAACAGAGAGCTATGTTTCTGTATCTTTTGGTTATAGAGTGTTCACTTCTTTATCATAACAAAATTCTAGTGTTTAT ACGAACACCCAGAGGCAAAAGAATTTGGCTTAATTCTCACTCCAGGTAAGTAGCTTAACTTCTGGGCTTCAGTTTTCTCATCTGTAAAAT CAGGAAGATTGGACTAAGTGATCCTGAAATGTATTTTTTAGCACTGGATTTCTACAAATAATAAAACTTTCCCATCTAGATAATGATGAT CACATAGTCTTGATGTACGGACATTAAAAGCCAGATTTCTTCATTCAATTCTGTTATCTCTGTTTTACTCTTTGAAATTGATCAAGCCAC TGAATCACTTTGCATTTCAGTTTATATATATAGAGAGAAAGAAGGTGTCTGCTCTTACATTATTGTGGAGCCCTGTGATAGAAATATGTA AAATCTCATATTATTTTTTTTTTAATTTTTTTATTTTTTATGACAGGGTCTCACTATGTCACCCTGGCTGGAGTGCAGTAGTGCGATCGC GGCACACTGCAGCCTTGGCTTCCCTGGGCTCAAGCAGTCCTCCCACCTCAGTCTCCCAAATAGCTAGGACTACAGGCGTGCGTGACCAAG CCCAGCTAATTTTTGCATTTTTTGTAGAGATGGGGTTTTGCCATGTTGCTCAGGCTGGTCTCAAACTCCTGAGCACTAGCAATCCACCCA CCTCTGTTTCCAAAAAAAAAAAAAAAATGAAAGGTCAACCCCTATGCAAATTACCACAGCAAAGGTTTCATTCAGGAGATTCTTCCATCT GGGCAACCTGGTTTTCCAAATATCATTTGACCTAAGTGAATGTTGATACTAGCTAAAGATTGGGTAAATTGGTTGAATTATTGTATTGAA GCTTGAGCTGTAGCTAAAAGTAATTTAGGTTTCCCCTAAGATGTTATTATGTTAGGGACATAACACTTTTGGGAGGTTGTTGTGGGAGAT GGTTGATTTAGGTTTTCAAAAGCTAGAAATAAAATTTACATGCCTTAGATTTCATAAAATTCTGCTCTAATTGGGTGGAAGGTGCTGTAT CTAACTTGTGTTCCTCCTAAGGTTATGTCCTAATAACTATTCTTTTAGGAGTATACTTCTACTTTATAGAAGGTTGCTTTTCTTTTTAAT TTTTTCTAACAAAGAAAAGAATAAAGTATTTATTAATAAGAACCAGAAAGCACTTGAAACTGATGTTTTTAATGGCTCATTTAGGGTAGA TTTATTTATCTCATTAACTTAAAACAGCTATGTGTATGAAATAGGTCACAACAGAACTTGAACACCAGGTTGGTGTCTGAGCAATCCCTT TCTTATGGGAAAAACAATGTTCTTGTTTGAACAGAGGGTATCATTGCAGTCAGTATTCACGTGTATATTGTTATATAAGTTGTATAATAT >In-frame_ANKRD26_ENST00000436985_chr10_27389014_-_MCM10_ENST00000378694_chr10_13251091_+_2321nt GGCTCCGGAGGCCGTTAAGAGCCGAGAGAGACATGAGGTGTCTCTGAAGCCCGGTCGCCTGGGCCATGAAGAAGATTTTTAGTAAGAAGG GCGAGTCGCCCTTGGGCTCCTTCGCGCGGCGGCAGAGGAGCAGCGCGGGAGGCGGGGGCGAGCCGGGGGAGGGCGCCTACTCGCAGCCCG GCTACCACGTCCGAGACCGAGATCTCGGCAAGATCCACAAAGCTGCCAGCGCGGGTAATGTGGCGAAAGTGCAGCAGATCCTTTTGCTCA GGAAGAATGGCTTGAACGATAGAGACAAGATGAACAGTAACTGTGGCCTCTACAAATGGGAACGGGACGGAATGCTAAAGGTATGCCATT TGCGTACTAATTTTTGACTCCTTTTAGTGACCCATGCTAATAATGTGGAACCATCTCCTATTAAAATATTTTCATTTTTCTAGGAAAAGA CTGGTCCAAAGATAGGAGGAGAAACTCTGTTACCAAGAGGAGAAGAACATGCTAAATTTCTGAACAGCCTTAAATAACCCGAACTTCAGA CATTTTCCCACAGACTTCCTGGCCTCCTGTGACTCTGGAAAGCAAAGGATTGGCTGTGTATTGTCCATTGATTCCTGATTGACGCCGTCA AAAACAAATGCTTGTTAAGCCCATAAGCTTTGCCTGCTTACTTTCTGCCATTGGGTTGGTTTGATACCACATTTAACATTGACATTTAAG TGGAAAACCAAGTTATCATTGTCTTTTCTAAGCTCAGTGTGGATGATTGCATTACTTCATTCACTGAAGTTTTTGCCCAAAAATTGGAAG GTAAACAGAGAGCTATGTTTCTGTATCTTTTGGTTATAGAGTGTTCACTTCTTTATCATAACAAAATTCTAGTGTTTATACGAACACCCA GAGGCAAAAGAATTTGGCTTAATTCTCACTCCAGGTAAGTAGCTTAACTTCTGGGCTTCAGTTTTCTCATCTGTAAAATCAGGAAGATTG GACTAAGTGATCCTGAAATGTATTTTTTAGCACTGGATTTCTACAAATAATAAAACTTTCCCATCTAGATAATGATGATCACATAGTCTT GATGTACGGACATTAAAAGCCAGATTTCTTCATTCAATTCTGTTATCTCTGTTTTACTCTTTGAAATTGATCAAGCCACTGAATCACTTT GCATTTCAGTTTATATATATAGAGAGAAAGAAGGTGTCTGCTCTTACATTATTGTGGAGCCCTGTGATAGAAATATGTAAAATCTCATAT TATTTTTTTTTTAATTTTTTTATTTTTTATGACAGGGTCTCACTATGTCACCCTGGCTGGAGTGCAGTAGTGCGATCGCGGCACACTGCA GCCTTGGCTTCCCTGGGCTCAAGCAGTCCTCCCACCTCAGTCTCCCAAATAGCTAGGACTACAGGCGTGCGTGACCAAGCCCAGCTAATT TTTGCATTTTTTGTAGAGATGGGGTTTTGCCATGTTGCTCAGGCTGGTCTCAAACTCCTGAGCACTAGCAATCCACCCACCTCTGTTTCC AAAAAAAAAAAAAAAATGAAAGGTCAACCCCTATGCAAATTACCACAGCAAAGGTTTCATTCAGGAGATTCTTCCATCTGGGCAACCTGG TTTTCCAAATATCATTTGACCTAAGTGAATGTTGATACTAGCTAAAGATTGGGTAAATTGGTTGAATTATTGTATTGAAGCTTGAGCTGT AGCTAAAAGTAATTTAGGTTTCCCCTAAGATGTTATTATGTTAGGGACATAACACTTTTGGGAGGTTGTTGTGGGAGATGGTTGATTTAG GTTTTCAAAAGCTAGAAATAAAATTTACATGCCTTAGATTTCATAAAATTCTGCTCTAATTGGGTGGAAGGTGCTGTATCTAACTTGTGT TCCTCCTAAGGTTATGTCCTAATAACTATTCTTTTAGGAGTATACTTCTACTTTATAGAAGGTTGCTTTTCTTTTTAATTTTTTCTAACA AAGAAAAGAATAAAGTATTTATTAATAAGAACCAGAAAGCACTTGAAACTGATGTTTTTAATGGCTCATTTAGGGTAGATTTATTTATCT CATTAACTTAAAACAGCTATGTGTATGAAATAGGTCACAACAGAACTTGAACACCAGGTTGGTGTCTGAGCAATCCCTTTCTTATGGGAA AAACAATGTTCTTGTTTGAACAGAGGGTATCATTGCAGTCAGTATTCACGTGTATATTGTTATATAAGTTGTATAATATGCTTGTAAAGG |
Top |
FusionGenePPI for ANKRD26_MCM10 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ANKRD26 | BRCA1, CBX2, CBX4, AMOT, PRKAR1A, MED4, PCM1, CEP128, CEP89, CNTRL, CCDC40, NDEL1, RALBP1 | MCM10 | KRT15, CEP70, HOOK2, ZBTB43, CCDC85B, CALCOCO2, CEP72, DPPA2, TRIM37, NINL, MCM6, CCND3, ZBTB8A, MCM7, ORC2, RPAP1, IKBKG, DDB1, RBX1, CUL4A, VPRBP, APP, ORC4, CDC45, MCM2, CDC7, MCM3, CDC5L, CDC6, CCND1, CDK6, ORC3, CDKN2A, CDKN1A, GOLGA2, TEX264, TMEM171, MCMBP, MCM4, SIRT1, NTRK1, HIST1H2BG, PCM1, TNIP1, POLR2G, SUPT5H, OFD1, CCDC14, USP37, YWHAE, IKZF5, CAV3, KLHL40, TPH1, RELL2, CACNG5 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for ANKRD26_MCM10 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for ANKRD26_MCM10 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|