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Fusion gene ID: 18174 |
FusionGeneSummary for KAT6A_MSR1 |
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Fusion gene information | Fusion gene name: KAT6A_MSR1 | Fusion gene ID: 18174 | Hgene | Tgene | Gene symbol | KAT6A | MSR1 | Gene ID | 7994 | 4481 |
Gene name | lysine acetyltransferase 6A | macrophage scavenger receptor 1 | |
Synonyms | MOZ|MRD32|MYST-3|MYST3|RUNXBP2|ZC2HC6A|ZNF220 | CD204|SCARA1|SR-A|SR-AI|SR-AII|SR-AIII|SRA|phSR1|phSR2 | |
Cytomap | 8p11.21 | 8p22 | |
Type of gene | protein-coding | protein-coding | |
Description | histone acetyltransferase KAT6AK(lysine) acetyltransferase 6AMOZ, YBF2/SAS3, SAS2 and TIP60 protein 3MYST histone acetyltransferase (monocytic leukemia) 3histone acetyltransferase MYST3monocytic leukemia zinc finger proteinrunt-related transcription | macrophage scavenger receptor types I and IImacrophage acetylated LDL receptor I and IImacrophage scavenger receptor type IIIscavenger receptor class A member 1 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q92794 | P21757 | |
Ensembl transtripts involved in fusion gene | ENST00000406337, ENST00000265713, ENST00000396930, ENST00000485568, | ENST00000350896, ENST00000262101, ENST00000445506, ENST00000355282, ENST00000518343, ENST00000381998, ENST00000536385, | |
Fusion gene scores | * DoF score | 16 X 12 X 6=1152 | 3 X 2 X 1=6 |
# samples | 26 | 3 | |
** MAII score | log2(26/1152*10)=-2.14755718841386 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/6*10)=2.32192809488736 | |
Context | PubMed: KAT6A [Title/Abstract] AND MSR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | KAT6A | GO:0006473 | protein acetylation | 23431171 |
Hgene | KAT6A | GO:0016573 | histone acetylation | 11742995|17925393 |
Hgene | KAT6A | GO:0030099 | myeloid cell differentiation | 11742995 |
Hgene | KAT6A | GO:0043966 | histone H3 acetylation | 16387653 |
Hgene | KAT6A | GO:0045892 | negative regulation of transcription, DNA-templated | 11742995 |
Hgene | KAT6A | GO:0045893 | positive regulation of transcription, DNA-templated | 11742995|11965546|18794358 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-BH-A202-01A | KAT6A | chr8 | 41905896 | - | MSR1 | chr8 | 16035501 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000406337 | ENST00000350896 | KAT6A | chr8 | 41905896 | - | MSR1 | chr8 | 16035501 | - |
5CDS-5UTR | ENST00000406337 | ENST00000262101 | KAT6A | chr8 | 41905896 | - | MSR1 | chr8 | 16035501 | - |
5CDS-5UTR | ENST00000406337 | ENST00000445506 | KAT6A | chr8 | 41905896 | - | MSR1 | chr8 | 16035501 | - |
5CDS-5UTR | ENST00000406337 | ENST00000355282 | KAT6A | chr8 | 41905896 | - | MSR1 | chr8 | 16035501 | - |
5CDS-intron | ENST00000406337 | ENST00000518343 | KAT6A | chr8 | 41905896 | - | MSR1 | chr8 | 16035501 | - |
5CDS-5UTR | ENST00000406337 | ENST00000381998 | KAT6A | chr8 | 41905896 | - | MSR1 | chr8 | 16035501 | - |
5CDS-5UTR | ENST00000406337 | ENST00000536385 | KAT6A | chr8 | 41905896 | - | MSR1 | chr8 | 16035501 | - |
5CDS-5UTR | ENST00000265713 | ENST00000350896 | KAT6A | chr8 | 41905896 | - | MSR1 | chr8 | 16035501 | - |
5CDS-5UTR | ENST00000265713 | ENST00000262101 | KAT6A | chr8 | 41905896 | - | MSR1 | chr8 | 16035501 | - |
5CDS-5UTR | ENST00000265713 | ENST00000445506 | KAT6A | chr8 | 41905896 | - | MSR1 | chr8 | 16035501 | - |
5CDS-5UTR | ENST00000265713 | ENST00000355282 | KAT6A | chr8 | 41905896 | - | MSR1 | chr8 | 16035501 | - |
5CDS-intron | ENST00000265713 | ENST00000518343 | KAT6A | chr8 | 41905896 | - | MSR1 | chr8 | 16035501 | - |
5CDS-5UTR | ENST00000265713 | ENST00000381998 | KAT6A | chr8 | 41905896 | - | MSR1 | chr8 | 16035501 | - |
5CDS-5UTR | ENST00000265713 | ENST00000536385 | KAT6A | chr8 | 41905896 | - | MSR1 | chr8 | 16035501 | - |
5CDS-5UTR | ENST00000396930 | ENST00000350896 | KAT6A | chr8 | 41905896 | - | MSR1 | chr8 | 16035501 | - |
5CDS-5UTR | ENST00000396930 | ENST00000262101 | KAT6A | chr8 | 41905896 | - | MSR1 | chr8 | 16035501 | - |
5CDS-5UTR | ENST00000396930 | ENST00000445506 | KAT6A | chr8 | 41905896 | - | MSR1 | chr8 | 16035501 | - |
5CDS-5UTR | ENST00000396930 | ENST00000355282 | KAT6A | chr8 | 41905896 | - | MSR1 | chr8 | 16035501 | - |
5CDS-intron | ENST00000396930 | ENST00000518343 | KAT6A | chr8 | 41905896 | - | MSR1 | chr8 | 16035501 | - |
5CDS-5UTR | ENST00000396930 | ENST00000381998 | KAT6A | chr8 | 41905896 | - | MSR1 | chr8 | 16035501 | - |
5CDS-5UTR | ENST00000396930 | ENST00000536385 | KAT6A | chr8 | 41905896 | - | MSR1 | chr8 | 16035501 | - |
5CDS-5UTR | ENST00000485568 | ENST00000350896 | KAT6A | chr8 | 41905896 | - | MSR1 | chr8 | 16035501 | - |
5CDS-5UTR | ENST00000485568 | ENST00000262101 | KAT6A | chr8 | 41905896 | - | MSR1 | chr8 | 16035501 | - |
5CDS-5UTR | ENST00000485568 | ENST00000445506 | KAT6A | chr8 | 41905896 | - | MSR1 | chr8 | 16035501 | - |
5CDS-5UTR | ENST00000485568 | ENST00000355282 | KAT6A | chr8 | 41905896 | - | MSR1 | chr8 | 16035501 | - |
5CDS-intron | ENST00000485568 | ENST00000518343 | KAT6A | chr8 | 41905896 | - | MSR1 | chr8 | 16035501 | - |
5CDS-5UTR | ENST00000485568 | ENST00000381998 | KAT6A | chr8 | 41905896 | - | MSR1 | chr8 | 16035501 | - |
5CDS-5UTR | ENST00000485568 | ENST00000536385 | KAT6A | chr8 | 41905896 | - | MSR1 | chr8 | 16035501 | - |
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FusionProtFeatures for KAT6A_MSR1 |
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Hgene | Tgene |
KAT6A | MSR1 |
Histone acetyltransferase that acetylates lysineresidues in histone H3 and histone H4 (in vitro). Component of theMOZ/MORF complex which has a histone H3 acetyltransferaseactivity. May act as a transcriptional coactivator for RUNX1 andRUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controlsits transcriptional activity via association with PML.{ECO:0000269|PubMed:11742995, ECO:0000269|PubMed:11965546,ECO:0000269|PubMed:12771199, ECO:0000269|PubMed:16387653,ECO:0000269|PubMed:17925393, ECO:0000269|PubMed:23431171}. | Membrane glycoproteins implicated in the pathologicdeposition of cholesterol in arterial walls during atherogenesis.Two types of receptor subunits exist. These receptors mediate theendocytosis of a diverse group of macromolecules, includingmodified low density lipoproteins (LDL) (PubMed:2251254). IsoformIII does not internalize acetylated LDL (PubMed:9548586).{ECO:0000269|PubMed:2251254, ECO:0000269|PubMed:9548586}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for KAT6A_MSR1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for KAT6A_MSR1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
KAT6A | ING5, UBE2U, MAFK, BRPF1, HSPA4, TP53, EP300, MEAF6, HIST1H3A, HIST1H4A, RUNX1, CREBBP, ESR1, KMT2A, WDR5, HIST2H3C, ELAVL1, ATN1, ATXN1, RERE, H3F3C, HIST1H4I, HIST3H3, PML, SYMPK, AKT1, HIST4H4, CCNB1, CRK, RPL10, RNPS1, L1TD1, PHF14, TNRC6B, PNPLA8, RSF1, HEMGN | MSR1 | HSPA1A, TRAF6, IQCB1, ATP6V0C, NKG7, MALL, LEPROTL1, SEC22A, IKBIP, COL4A2, COLGALT2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for KAT6A_MSR1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KAT6A_MSR1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | KAT6A | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
Hgene | KAT6A | C0025149 | Medulloblastoma | 1 | CTD_human |
Tgene | MSR1 | C0022661 | Kidney Failure, Chronic | 1 | CTD_human |
Tgene | MSR1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |