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Fusion gene ID: 18171 |
FusionGeneSummary for KAT6A_FCGR1B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: KAT6A_FCGR1B | Fusion gene ID: 18171 | Hgene | Tgene | Gene symbol | KAT6A | FCGR1B | Gene ID | 7994 | 2210 |
| Gene name | lysine acetyltransferase 6A | Fc fragment of IgG receptor Ib | |
| Synonyms | MOZ|MRD32|MYST-3|MYST3|RUNXBP2|ZC2HC6A|ZNF220 | CD64b|IGFRB | |
| Cytomap | 8p11.21 | 1p11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | histone acetyltransferase KAT6AK(lysine) acetyltransferase 6AMOZ, YBF2/SAS3, SAS2 and TIP60 protein 3MYST histone acetyltransferase (monocytic leukemia) 3histone acetyltransferase MYST3monocytic leukemia zinc finger proteinrunt-related transcription | high affinity immunoglobulin gamma Fc receptor IBFc fragment of IgG, high affinity Ib, receptor (CD64)Fc gamma receptor IbFc-gamma receptor I B2fc-gamma RIBfcRIBhFcgammaRIBigG Fc receptor IB | |
| Modification date | 20180523 | 20180329 | |
| UniProtAcc | Q92794 | Q92637 | |
| Ensembl transtripts involved in fusion gene | ENST00000406337, ENST00000265713, ENST00000396930, ENST00000485568, | ENST00000369384, ENST00000369383, ENST00000472543, | |
| Fusion gene scores | * DoF score | 16 X 12 X 6=1152 | 1 X 1 X 1=1 |
| # samples | 26 | 1 | |
| ** MAII score | log2(26/1152*10)=-2.14755718841386 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: KAT6A [Title/Abstract] AND FCGR1B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | KAT6A | GO:0006473 | protein acetylation | 23431171 |
| Hgene | KAT6A | GO:0016573 | histone acetylation | 11742995|17925393 |
| Hgene | KAT6A | GO:0030099 | myeloid cell differentiation | 11742995 |
| Hgene | KAT6A | GO:0043966 | histone H3 acetylation | 16387653 |
| Hgene | KAT6A | GO:0045892 | negative regulation of transcription, DNA-templated | 11742995 |
| Hgene | KAT6A | GO:0045893 | positive regulation of transcription, DNA-templated | 11742995|11965546|18794358 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-VP-A875-01A | KAT6A | chr8 | 41905896 | - | FCGR1B | chr1 | 149759922 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000406337 | ENST00000369384 | KAT6A | chr8 | 41905896 | - | FCGR1B | chr1 | 149759922 | + |
| 5CDS-intron | ENST00000406337 | ENST00000369383 | KAT6A | chr8 | 41905896 | - | FCGR1B | chr1 | 149759922 | + |
| 5CDS-intron | ENST00000406337 | ENST00000472543 | KAT6A | chr8 | 41905896 | - | FCGR1B | chr1 | 149759922 | + |
| 5CDS-intron | ENST00000265713 | ENST00000369384 | KAT6A | chr8 | 41905896 | - | FCGR1B | chr1 | 149759922 | + |
| 5CDS-intron | ENST00000265713 | ENST00000369383 | KAT6A | chr8 | 41905896 | - | FCGR1B | chr1 | 149759922 | + |
| 5CDS-intron | ENST00000265713 | ENST00000472543 | KAT6A | chr8 | 41905896 | - | FCGR1B | chr1 | 149759922 | + |
| 5CDS-intron | ENST00000396930 | ENST00000369384 | KAT6A | chr8 | 41905896 | - | FCGR1B | chr1 | 149759922 | + |
| 5CDS-intron | ENST00000396930 | ENST00000369383 | KAT6A | chr8 | 41905896 | - | FCGR1B | chr1 | 149759922 | + |
| 5CDS-intron | ENST00000396930 | ENST00000472543 | KAT6A | chr8 | 41905896 | - | FCGR1B | chr1 | 149759922 | + |
| 5CDS-intron | ENST00000485568 | ENST00000369384 | KAT6A | chr8 | 41905896 | - | FCGR1B | chr1 | 149759922 | + |
| 5CDS-intron | ENST00000485568 | ENST00000369383 | KAT6A | chr8 | 41905896 | - | FCGR1B | chr1 | 149759922 | + |
| 5CDS-intron | ENST00000485568 | ENST00000472543 | KAT6A | chr8 | 41905896 | - | FCGR1B | chr1 | 149759922 | + |
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FusionProtFeatures for KAT6A_FCGR1B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KAT6A | FCGR1B |
| Histone acetyltransferase that acetylates lysineresidues in histone H3 and histone H4 (in vitro). Component of theMOZ/MORF complex which has a histone H3 acetyltransferaseactivity. May act as a transcriptional coactivator for RUNX1 andRUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controlsits transcriptional activity via association with PML.{ECO:0000269|PubMed:11742995, ECO:0000269|PubMed:11965546,ECO:0000269|PubMed:12771199, ECO:0000269|PubMed:16387653,ECO:0000269|PubMed:17925393, ECO:0000269|PubMed:23431171}. | May bind to the Fc region of immunoglobulins gamma witha low affinity compared to FCGR1A. May function in the humoralimmune response. {ECO:0000269|PubMed:1430234,ECO:0000269|PubMed:9881690}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for KAT6A_FCGR1B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for KAT6A_FCGR1B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| KAT6A | ING5, UBE2U, MAFK, BRPF1, HSPA4, TP53, EP300, MEAF6, HIST1H3A, HIST1H4A, RUNX1, CREBBP, ESR1, KMT2A, WDR5, HIST2H3C, ELAVL1, ATN1, ATXN1, RERE, H3F3C, HIST1H4I, HIST3H3, PML, SYMPK, AKT1, HIST4H4, CCNB1, CRK, RPL10, RNPS1, L1TD1, PHF14, TNRC6B, PNPLA8, RSF1, HEMGN | FCGR1B |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for KAT6A_FCGR1B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for KAT6A_FCGR1B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | KAT6A | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
| Hgene | KAT6A | C0025149 | Medulloblastoma | 1 | CTD_human |
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