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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionGeneSequence

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Fusion gene ID: 18165

FusionGeneSummary for KAT6A_ADAM2

check button Fusion gene summary
Fusion gene informationFusion gene name: KAT6A_ADAM2
Fusion gene ID: 18165
HgeneTgene
Gene symbol

KAT6A

ADAM2

Gene ID

7994

2515

Gene namelysine acetyltransferase 6AADAM metallopeptidase domain 2
SynonymsMOZ|MRD32|MYST-3|MYST3|RUNXBP2|ZC2HC6A|ZNF220CRYN1|CRYN2|CT15|FTNB|PH-30b|PH30|PH30-beta
Cytomap

8p11.21

8p11.22

Type of geneprotein-codingprotein-coding
Descriptionhistone acetyltransferase KAT6AK(lysine) acetyltransferase 6AMOZ, YBF2/SAS3, SAS2 and TIP60 protein 3MYST histone acetyltransferase (monocytic leukemia) 3histone acetyltransferase MYST3monocytic leukemia zinc finger proteinrunt-related transcriptiondisintegrin and metalloproteinase domain-containing protein 2cancer/testis antigen 15fertilin subunit beta
Modification date2018052320180519
UniProtAcc

Q92794

Q99965

Ensembl transtripts involved in fusion geneENST00000406337, ENST00000265713, 
ENST00000396930, ENST00000485568, 
ENST00000347580, ENST00000379853, 
ENST00000265708, ENST00000521880, 
ENST00000523181, 
Fusion gene scores* DoF score16 X 12 X 6=11526 X 3 X 3=54
# samples 266
** MAII scorelog2(26/1152*10)=-2.14755718841386
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/54*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: KAT6A [Title/Abstract] AND ADAM2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKAT6A

GO:0006473

protein acetylation

23431171

HgeneKAT6A

GO:0016573

histone acetylation

11742995|17925393

HgeneKAT6A

GO:0030099

myeloid cell differentiation

11742995

HgeneKAT6A

GO:0043966

histone H3 acetylation

16387653

HgeneKAT6A

GO:0045892

negative regulation of transcription, DNA-templated

11742995

HgeneKAT6A

GO:0045893

positive regulation of transcription, DNA-templated

11742995|11965546|18794358


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AR-A1AR-01AKAT6Achr8

41812814

-ADAM2chr8

39694731

-
TCGALDBRCATCGA-E2-A15A-01AKAT6Achr8

41905896

-ADAM2chr8

39627094

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000406337ENST00000347580KAT6Achr8

41812814

-ADAM2chr8

39694731

-
In-frameENST00000406337ENST00000379853KAT6Achr8

41812814

-ADAM2chr8

39694731

-
In-frameENST00000406337ENST00000265708KAT6Achr8

41812814

-ADAM2chr8

39694731

-
In-frameENST00000406337ENST00000521880KAT6Achr8

41812814

-ADAM2chr8

39694731

-
5CDS-5UTRENST00000406337ENST00000523181KAT6Achr8

41812814

-ADAM2chr8

39694731

-
Frame-shiftENST00000265713ENST00000347580KAT6Achr8

41812814

-ADAM2chr8

39694731

-
Frame-shiftENST00000265713ENST00000379853KAT6Achr8

41812814

-ADAM2chr8

39694731

-
Frame-shiftENST00000265713ENST00000265708KAT6Achr8

41812814

-ADAM2chr8

39694731

-
Frame-shiftENST00000265713ENST00000521880KAT6Achr8

41812814

-ADAM2chr8

39694731

-
5CDS-5UTRENST00000265713ENST00000523181KAT6Achr8

41812814

-ADAM2chr8

39694731

-
Frame-shiftENST00000396930ENST00000347580KAT6Achr8

41812814

-ADAM2chr8

39694731

-
Frame-shiftENST00000396930ENST00000379853KAT6Achr8

41812814

-ADAM2chr8

39694731

-
Frame-shiftENST00000396930ENST00000265708KAT6Achr8

41812814

-ADAM2chr8

39694731

-
Frame-shiftENST00000396930ENST00000521880KAT6Achr8

41812814

-ADAM2chr8

39694731

-
5CDS-5UTRENST00000396930ENST00000523181KAT6Achr8

41812814

-ADAM2chr8

39694731

-
Frame-shiftENST00000485568ENST00000347580KAT6Achr8

41812814

-ADAM2chr8

39694731

-
Frame-shiftENST00000485568ENST00000379853KAT6Achr8

41812814

-ADAM2chr8

39694731

-
Frame-shiftENST00000485568ENST00000265708KAT6Achr8

41812814

-ADAM2chr8

39694731

-
Frame-shiftENST00000485568ENST00000521880KAT6Achr8

41812814

-ADAM2chr8

39694731

-
5CDS-5UTRENST00000485568ENST00000523181KAT6Achr8

41812814

-ADAM2chr8

39694731

-
Frame-shiftENST00000406337ENST00000347580KAT6Achr8

41905896

-ADAM2chr8

39627094

-
Frame-shiftENST00000406337ENST00000379853KAT6Achr8

41905896

-ADAM2chr8

39627094

-
Frame-shiftENST00000406337ENST00000265708KAT6Achr8

41905896

-ADAM2chr8

39627094

-
Frame-shiftENST00000406337ENST00000521880KAT6Achr8

41905896

-ADAM2chr8

39627094

-
5CDS-intronENST00000406337ENST00000523181KAT6Achr8

41905896

-ADAM2chr8

39627094

-
Frame-shiftENST00000265713ENST00000347580KAT6Achr8

41905896

-ADAM2chr8

39627094

-
Frame-shiftENST00000265713ENST00000379853KAT6Achr8

41905896

-ADAM2chr8

39627094

-
Frame-shiftENST00000265713ENST00000265708KAT6Achr8

41905896

-ADAM2chr8

39627094

-
Frame-shiftENST00000265713ENST00000521880KAT6Achr8

41905896

-ADAM2chr8

39627094

-
5CDS-intronENST00000265713ENST00000523181KAT6Achr8

41905896

-ADAM2chr8

39627094

-
Frame-shiftENST00000396930ENST00000347580KAT6Achr8

41905896

-ADAM2chr8

39627094

-
Frame-shiftENST00000396930ENST00000379853KAT6Achr8

41905896

-ADAM2chr8

39627094

-
Frame-shiftENST00000396930ENST00000265708KAT6Achr8

41905896

-ADAM2chr8

39627094

-
Frame-shiftENST00000396930ENST00000521880KAT6Achr8

41905896

-ADAM2chr8

39627094

-
5CDS-intronENST00000396930ENST00000523181KAT6Achr8

41905896

-ADAM2chr8

39627094

-
Frame-shiftENST00000485568ENST00000347580KAT6Achr8

41905896

-ADAM2chr8

39627094

-
Frame-shiftENST00000485568ENST00000379853KAT6Achr8

41905896

-ADAM2chr8

39627094

-
Frame-shiftENST00000485568ENST00000265708KAT6Achr8

41905896

-ADAM2chr8

39627094

-
Frame-shiftENST00000485568ENST00000521880KAT6Achr8

41905896

-ADAM2chr8

39627094

-
5CDS-intronENST00000485568ENST00000523181KAT6Achr8

41905896

-ADAM2chr8

39627094

-

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FusionProtFeatures for KAT6A_ADAM2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KAT6A

Q92794

ADAM2

Q99965

Histone acetyltransferase that acetylates lysineresidues in histone H3 and histone H4 (in vitro). Component of theMOZ/MORF complex which has a histone H3 acetyltransferaseactivity. May act as a transcriptional coactivator for RUNX1 andRUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controlsits transcriptional activity via association with PML.{ECO:0000269|PubMed:11742995, ECO:0000269|PubMed:11965546,ECO:0000269|PubMed:12771199, ECO:0000269|PubMed:16387653,ECO:0000269|PubMed:17925393, ECO:0000269|PubMed:23431171}. Sperm surface membrane protein that may be involved insperm-egg plasma membrane adhesion and fusion duringfertilization. Could have a direct role in sperm-zona binding ormigration of sperm from the uterus into the oviduct. Interactionswith egg membrane could be mediated via binding between itsdisintegrin-like domain to one or more integrins receptors on theegg. This is a non catalytic metalloprotease-like protein.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKAT6Achr8:41812814chr8:39694731ENST00000265713-917371_3795322005Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41812814chr8:39694731ENST00000396930-1018371_3795322005Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41812814chr8:39694731ENST00000406337-1018371_3795322005Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41812814chr8:39694731ENST00000265713-91795_1715322005DomainH15
HgeneKAT6Achr8:41812814chr8:39694731ENST00000396930-101895_1715322005DomainH15
HgeneKAT6Achr8:41812814chr8:39694731ENST00000406337-101895_1715322005DomainH15
HgeneKAT6Achr8:41812814chr8:39694731ENST00000265713-9171_1445322005RegionNote=Required for activation of RUNX1-1
HgeneKAT6Achr8:41812814chr8:39694731ENST00000265713-91752_1665322005RegionNote=Required for nuclear localization
HgeneKAT6Achr8:41812814chr8:39694731ENST00000396930-10181_1445322005RegionNote=Required for activation of RUNX1-1
HgeneKAT6Achr8:41812814chr8:39694731ENST00000396930-101852_1665322005RegionNote=Required for nuclear localization
HgeneKAT6Achr8:41812814chr8:39694731ENST00000406337-10181_1445322005RegionNote=Required for activation of RUNX1-1
HgeneKAT6Achr8:41812814chr8:39694731ENST00000406337-101852_1665322005RegionNote=Required for nuclear localization
HgeneKAT6Achr8:41812814chr8:39694731ENST00000265713-917206_2655322005Zinc fingerPHD-type 1
HgeneKAT6Achr8:41812814chr8:39694731ENST00000265713-917259_3135322005Zinc fingerPHD-type 2
HgeneKAT6Achr8:41812814chr8:39694731ENST00000396930-1018206_2655322005Zinc fingerPHD-type 1
HgeneKAT6Achr8:41812814chr8:39694731ENST00000396930-1018259_3135322005Zinc fingerPHD-type 2
HgeneKAT6Achr8:41812814chr8:39694731ENST00000406337-1018206_2655322005Zinc fingerPHD-type 1
HgeneKAT6Achr8:41812814chr8:39694731ENST00000406337-1018259_3135322005Zinc fingerPHD-type 2
TgeneADAM2chr8:41812814chr8:39694731ENST00000265708-021477_60618788Compositional biasNote=Cys-rich
TgeneADAM2chr8:41812814chr8:39694731ENST00000347580-020477_60618796Compositional biasNote=Cys-rich
TgeneADAM2chr8:41812814chr8:39694731ENST00000265708-021178_37518788DomainPeptidase M12B
TgeneADAM2chr8:41812814chr8:39694731ENST00000265708-021384_47318788DomainDisintegrin
TgeneADAM2chr8:41812814chr8:39694731ENST00000265708-021612_64518788DomainNote=EGF-like
TgeneADAM2chr8:41812814chr8:39694731ENST00000347580-020178_37518796DomainPeptidase M12B
TgeneADAM2chr8:41812814chr8:39694731ENST00000347580-020384_47318796DomainDisintegrin
TgeneADAM2chr8:41812814chr8:39694731ENST00000347580-020612_64518796DomainNote=EGF-like
TgeneADAM2chr8:41812814chr8:39694731ENST00000265708-021175_68618788Topological domainExtracellular
TgeneADAM2chr8:41812814chr8:39694731ENST00000265708-021708_73518788Topological domainCytoplasmic
TgeneADAM2chr8:41812814chr8:39694731ENST00000347580-020175_68618796Topological domainExtracellular
TgeneADAM2chr8:41812814chr8:39694731ENST00000347580-020708_73518796Topological domainCytoplasmic
TgeneADAM2chr8:41812814chr8:39694731ENST00000265708-021687_70718788TransmembraneHelical
TgeneADAM2chr8:41812814chr8:39694731ENST00000347580-020687_70718796TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKAT6Achr8:41812814chr8:39694731ENST00000265713-9171019_10265322005Compositional biasNote=Poly-Arg
HgeneKAT6Achr8:41812814chr8:39694731ENST00000265713-9171069_10785322005Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41812814chr8:39694731ENST00000265713-9171147_11505322005Compositional biasNote=Poly-Lys
HgeneKAT6Achr8:41812814chr8:39694731ENST00000265713-9171221_12425322005Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41812814chr8:39694731ENST00000265713-9171267_13025322005Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41812814chr8:39694731ENST00000265713-9171411_14145322005Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41812814chr8:39694731ENST00000265713-9171593_15975322005Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41812814chr8:39694731ENST00000265713-9171643_17045322005Compositional biasNote=Gln/Pro-rich
HgeneKAT6Achr8:41812814chr8:39694731ENST00000265713-9171897_19775322005Compositional biasNote=Met-rich
HgeneKAT6Achr8:41812814chr8:39694731ENST00000265713-917788_8015322005Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41812814chr8:39694731ENST00000265713-917989_9955322005Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41812814chr8:39694731ENST00000396930-10181019_10265322005Compositional biasNote=Poly-Arg
HgeneKAT6Achr8:41812814chr8:39694731ENST00000396930-10181069_10785322005Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41812814chr8:39694731ENST00000396930-10181147_11505322005Compositional biasNote=Poly-Lys
HgeneKAT6Achr8:41812814chr8:39694731ENST00000396930-10181221_12425322005Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41812814chr8:39694731ENST00000396930-10181267_13025322005Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41812814chr8:39694731ENST00000396930-10181411_14145322005Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41812814chr8:39694731ENST00000396930-10181593_15975322005Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41812814chr8:39694731ENST00000396930-10181643_17045322005Compositional biasNote=Gln/Pro-rich
HgeneKAT6Achr8:41812814chr8:39694731ENST00000396930-10181897_19775322005Compositional biasNote=Met-rich
HgeneKAT6Achr8:41812814chr8:39694731ENST00000396930-1018788_8015322005Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41812814chr8:39694731ENST00000396930-1018989_9955322005Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41812814chr8:39694731ENST00000406337-10181019_10265322005Compositional biasNote=Poly-Arg
HgeneKAT6Achr8:41812814chr8:39694731ENST00000406337-10181069_10785322005Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41812814chr8:39694731ENST00000406337-10181147_11505322005Compositional biasNote=Poly-Lys
HgeneKAT6Achr8:41812814chr8:39694731ENST00000406337-10181221_12425322005Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41812814chr8:39694731ENST00000406337-10181267_13025322005Compositional biasNote=Glu-rich
HgeneKAT6Achr8:41812814chr8:39694731ENST00000406337-10181411_14145322005Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41812814chr8:39694731ENST00000406337-10181593_15975322005Compositional biasNote=Poly-Ser
HgeneKAT6Achr8:41812814chr8:39694731ENST00000406337-10181643_17045322005Compositional biasNote=Gln/Pro-rich
HgeneKAT6Achr8:41812814chr8:39694731ENST00000406337-10181897_19775322005Compositional biasNote=Met-rich
HgeneKAT6Achr8:41812814chr8:39694731ENST00000406337-1018788_8015322005Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41812814chr8:39694731ENST00000406337-1018989_9955322005Compositional biasNote=Poly-Glu
HgeneKAT6Achr8:41812814chr8:39694731ENST00000265713-917504_7785322005DomainMYST-type HAT
HgeneKAT6Achr8:41812814chr8:39694731ENST00000396930-1018504_7785322005DomainMYST-type HAT
HgeneKAT6Achr8:41812814chr8:39694731ENST00000406337-1018504_7785322005DomainMYST-type HAT
HgeneKAT6Achr8:41812814chr8:39694731ENST00000265713-9171913_19485322005RegionNote=Required for activation of RUNX1-2
HgeneKAT6Achr8:41812814chr8:39694731ENST00000265713-917488_7785322005RegionNote=Catalytic
HgeneKAT6Achr8:41812814chr8:39694731ENST00000265713-917645_6495322005RegionAcetyl-CoA binding
HgeneKAT6Achr8:41812814chr8:39694731ENST00000265713-917654_6605322005RegionAcetyl-CoA binding
HgeneKAT6Achr8:41812814chr8:39694731ENST00000396930-10181913_19485322005RegionNote=Required for activation of RUNX1-2
HgeneKAT6Achr8:41812814chr8:39694731ENST00000396930-1018488_7785322005RegionNote=Catalytic
HgeneKAT6Achr8:41812814chr8:39694731ENST00000396930-1018645_6495322005RegionAcetyl-CoA binding
HgeneKAT6Achr8:41812814chr8:39694731ENST00000396930-1018654_6605322005RegionAcetyl-CoA binding
HgeneKAT6Achr8:41812814chr8:39694731ENST00000406337-10181913_19485322005RegionNote=Required for activation of RUNX1-2
HgeneKAT6Achr8:41812814chr8:39694731ENST00000406337-1018488_7785322005RegionNote=Catalytic
HgeneKAT6Achr8:41812814chr8:39694731ENST00000406337-1018645_6495322005RegionAcetyl-CoA binding
HgeneKAT6Achr8:41812814chr8:39694731ENST00000406337-1018654_6605322005RegionAcetyl-CoA binding
HgeneKAT6Achr8:41812814chr8:39694731ENST00000265713-917537_5625322005Zinc fingerC2HC MYST-type
HgeneKAT6Achr8:41812814chr8:39694731ENST00000396930-1018537_5625322005Zinc fingerC2HC MYST-type
HgeneKAT6Achr8:41812814chr8:39694731ENST00000406337-1018537_5625322005Zinc fingerC2HC MYST-type


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FusionGeneSequence for KAT6A_ADAM2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_KAT6A_ENST00000406337_chr8_41812814_-_ADAM2_ENST00000347580_chr8_39694731_-_532aa
MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGK
LDNKQNVDWNKLIKRAVEGLAESGGSTLKSIERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKE
SCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKKPEELISCADCGNSGHPSCLKFSPELTVRVKALRWQCIECKTCSSCRD
QGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKLLQKKAAQIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGP
GRGRKRKITLSSQSASSSSEEGYLERIDGLDFCRDSNVSLKFNKKTKGLIDGLTKFFTPSPDGRKARGEVVDYSEQYRIRKRGNRKSSTS

>In-frame_KAT6A_ENST00000406337_chr8_41812814_-_ADAM2_ENST00000379853_chr8_39694731_-_532aa
MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGK
LDNKQNVDWNKLIKRAVEGLAESGGSTLKSIERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKE
SCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKKPEELISCADCGNSGHPSCLKFSPELTVRVKALRWQCIECKTCSSCRD
QGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKLLQKKAAQIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGP
GRGRKRKITLSSQSASSSSEEGYLERIDGLDFCRDSNVSLKFNKKTKGLIDGLTKFFTPSPDGRKARGEVVDYSEQYRIRKRGNRKSSTS

>In-frame_KAT6A_ENST00000406337_chr8_41812814_-_ADAM2_ENST00000265708_chr8_39694731_-_532aa
MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGK
LDNKQNVDWNKLIKRAVEGLAESGGSTLKSIERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKE
SCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKKPEELISCADCGNSGHPSCLKFSPELTVRVKALRWQCIECKTCSSCRD
QGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKLLQKKAAQIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGP
GRGRKRKITLSSQSASSSSEEGYLERIDGLDFCRDSNVSLKFNKKTKGLIDGLTKFFTPSPDGRKARGEVVDYSEQYRIRKRGNRKSSTS

>In-frame_KAT6A_ENST00000406337_chr8_41812814_-_ADAM2_ENST00000521880_chr8_39694731_-_532aa
MVKLANPLYTEWILEAIKKVKKQKQRPSEERICNAVSSSHGLDRKTVLEQLELSVKDGTILKVSNKGLNSYKDPDNPGRIALPKPRNHGK
LDNKQNVDWNKLIKRAVEGLAESGGSTLKSIERFLKGQKDVSALFGGSAASGFHQQLRLAIKRAIGHGRLLKDGPLYRLNTKATNVDGKE
SCESLSCLPPVSLLPHEKDKPVAEPIPICSFCLGTKEQNREKKPEELISCADCGNSGHPSCLKFSPELTVRVKALRWQCIECKTCSSCRD
QGKNADNMLFCDSCDRGFHMECCDPPLTRMPKGMWICQICRPRKKGRKLLQKKAAQIKRRYTNPIGRPKNRLKKQNTVSKGPFSKVRTGP
GRGRKRKITLSSQSASSSSEEGYLERIDGLDFCRDSNVSLKFNKKTKGLIDGLTKFFTPSPDGRKARGEVVDYSEQYRIRKRGNRKSSTS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_KAT6A_ENST00000406337_chr8_41812814_-_ADAM2_ENST00000347580_chr8_39694731_-_1598nt
ATGGTAAAACTCGCAAACCCGCTTTATACTGAGTGGATTTTGGAGGCCATCAAAAAAGTGAAAAAGCAGAAACAGCGTCCTTCAGAAGAA
AGGATATGCAATGCTGTGTCTTCATCCCATGGCTTGGATCGTAAAACTGTTTTAGAACAATTGGAGTTGAGTGTTAAAGATGGAACAATT
TTAAAAGTCTCAAATAAAGGACTCAATTCCTATAAAGATCCTGATAATCCTGGGCGAATAGCACTTCCTAAGCCTCGGAACCATGGAAAA
TTGGATAATAAACAAAATGTGGATTGGAATAAACTGATAAAGCGGGCAGTTGAGGGCTTGGCAGAGTCTGGTGGCTCAACTTTGAAAAGC
ATTGAACGTTTTTTGAAAGGTCAGAAGGATGTGTCTGCATTATTCGGAGGCAGTGCTGCCTCTGGCTTTCACCAGCAGTTACGATTGGCT
ATCAAACGTGCCATTGGCCACGGCAGACTCCTTAAAGATGGACCTCTTTATCGGCTCAACACTAAAGCAACCAACGTGGATGGGAAAGAG
AGTTGTGAGTCTCTTTCCTGTTTACCTCCAGTGTCCCTTCTTCCACATGAAAAGGATAAGCCGGTTGCTGAACCAATCCCCATCTGTAGT
TTCTGTCTTGGTACAAAAGAACAAAACCGAGAAAAGAAGCCAGAGGAACTCATCTCCTGTGCCGACTGTGGCAACAGTGGCCATCCATCC
TGTTTAAAGTTTTCCCCTGAACTAACGGTTCGAGTGAAGGCCTTACGGTGGCAGTGCATCGAGTGTAAAACATGCAGCTCCTGTCGAGAT
CAAGGCAAAAATGCGGATAACATGCTCTTTTGTGATTCATGTGACCGAGGTTTTCACATGGAGTGTTGTGATCCGCCACTCACCCGTATG
CCAAAAGGCATGTGGATATGTCAAATATGTCGACCTAGGAAAAAAGGACGAAAACTTCTACAAAAGAAGGCAGCACAGATAAAACGGCGC
TATACTAATCCAATAGGACGTCCAAAAAACAGGTTAAAGAAACAAAACACGGTATCAAAAGGTCCCTTCAGCAAAGTTCGAACTGGCCCT
GGAAGGGGTAGGAAACGAAAAATCACTCTTTCCAGCCAATCAGCATCATCATCATCAGAAGAAGGATATTTAGAGCGGATAGATGGCTTG
GACTTCTGCAGAGATAGCAATGTCTCCTTGAAGTTCAACAAGAAAACCAAAGGGCTCATTGATGGCCTTACCAAATTTTTTACCCCTTCC
CCTGATGGGCGGAAAGCTCGGGGGGAAGTGGTGGACTACTCTGAGCAATATCGAATCAGAAAGAGGGGCAACAGGAAATCAAGCACTTCA
GATTGGCCCACAGACAATCAGGATGGCTGGGATGGCAAACAAGAAAATGAGGAGCGACTTTTTGGGAGCCAGGAAATCATGACTGAGAAA
GATATGGAATTATTTCGTGATATCCAAGAACAAGCACTGCAGAAAGTTGGAGTGACTGGTCCCCCTGATCCACAAGTCCGCTGTCCCTCT

>In-frame_KAT6A_ENST00000406337_chr8_41812814_-_ADAM2_ENST00000379853_chr8_39694731_-_1598nt
ATGGTAAAACTCGCAAACCCGCTTTATACTGAGTGGATTTTGGAGGCCATCAAAAAAGTGAAAAAGCAGAAACAGCGTCCTTCAGAAGAA
AGGATATGCAATGCTGTGTCTTCATCCCATGGCTTGGATCGTAAAACTGTTTTAGAACAATTGGAGTTGAGTGTTAAAGATGGAACAATT
TTAAAAGTCTCAAATAAAGGACTCAATTCCTATAAAGATCCTGATAATCCTGGGCGAATAGCACTTCCTAAGCCTCGGAACCATGGAAAA
TTGGATAATAAACAAAATGTGGATTGGAATAAACTGATAAAGCGGGCAGTTGAGGGCTTGGCAGAGTCTGGTGGCTCAACTTTGAAAAGC
ATTGAACGTTTTTTGAAAGGTCAGAAGGATGTGTCTGCATTATTCGGAGGCAGTGCTGCCTCTGGCTTTCACCAGCAGTTACGATTGGCT
ATCAAACGTGCCATTGGCCACGGCAGACTCCTTAAAGATGGACCTCTTTATCGGCTCAACACTAAAGCAACCAACGTGGATGGGAAAGAG
AGTTGTGAGTCTCTTTCCTGTTTACCTCCAGTGTCCCTTCTTCCACATGAAAAGGATAAGCCGGTTGCTGAACCAATCCCCATCTGTAGT
TTCTGTCTTGGTACAAAAGAACAAAACCGAGAAAAGAAGCCAGAGGAACTCATCTCCTGTGCCGACTGTGGCAACAGTGGCCATCCATCC
TGTTTAAAGTTTTCCCCTGAACTAACGGTTCGAGTGAAGGCCTTACGGTGGCAGTGCATCGAGTGTAAAACATGCAGCTCCTGTCGAGAT
CAAGGCAAAAATGCGGATAACATGCTCTTTTGTGATTCATGTGACCGAGGTTTTCACATGGAGTGTTGTGATCCGCCACTCACCCGTATG
CCAAAAGGCATGTGGATATGTCAAATATGTCGACCTAGGAAAAAAGGACGAAAACTTCTACAAAAGAAGGCAGCACAGATAAAACGGCGC
TATACTAATCCAATAGGACGTCCAAAAAACAGGTTAAAGAAACAAAACACGGTATCAAAAGGTCCCTTCAGCAAAGTTCGAACTGGCCCT
GGAAGGGGTAGGAAACGAAAAATCACTCTTTCCAGCCAATCAGCATCATCATCATCAGAAGAAGGATATTTAGAGCGGATAGATGGCTTG
GACTTCTGCAGAGATAGCAATGTCTCCTTGAAGTTCAACAAGAAAACCAAAGGGCTCATTGATGGCCTTACCAAATTTTTTACCCCTTCC
CCTGATGGGCGGAAAGCTCGGGGGGAAGTGGTGGACTACTCTGAGCAATATCGAATCAGAAAGAGGGGCAACAGGAAATCAAGCACTTCA
GATTGGCCCACAGACAATCAGGATGGCTGGGATGGCAAACAAGAAAATGAGGAGCGACTTTTTGGGAGCCAGGAAATCATGACTGAGAAA
GATATGGAATTATTTCGTGATATCCAAGAACAAGCACTGCAGAAAGTTGGAGTGACTGGTCCCCCTGATCCACAAGTCCGCTGTCCCTCT

>In-frame_KAT6A_ENST00000406337_chr8_41812814_-_ADAM2_ENST00000265708_chr8_39694731_-_1598nt
ATGGTAAAACTCGCAAACCCGCTTTATACTGAGTGGATTTTGGAGGCCATCAAAAAAGTGAAAAAGCAGAAACAGCGTCCTTCAGAAGAA
AGGATATGCAATGCTGTGTCTTCATCCCATGGCTTGGATCGTAAAACTGTTTTAGAACAATTGGAGTTGAGTGTTAAAGATGGAACAATT
TTAAAAGTCTCAAATAAAGGACTCAATTCCTATAAAGATCCTGATAATCCTGGGCGAATAGCACTTCCTAAGCCTCGGAACCATGGAAAA
TTGGATAATAAACAAAATGTGGATTGGAATAAACTGATAAAGCGGGCAGTTGAGGGCTTGGCAGAGTCTGGTGGCTCAACTTTGAAAAGC
ATTGAACGTTTTTTGAAAGGTCAGAAGGATGTGTCTGCATTATTCGGAGGCAGTGCTGCCTCTGGCTTTCACCAGCAGTTACGATTGGCT
ATCAAACGTGCCATTGGCCACGGCAGACTCCTTAAAGATGGACCTCTTTATCGGCTCAACACTAAAGCAACCAACGTGGATGGGAAAGAG
AGTTGTGAGTCTCTTTCCTGTTTACCTCCAGTGTCCCTTCTTCCACATGAAAAGGATAAGCCGGTTGCTGAACCAATCCCCATCTGTAGT
TTCTGTCTTGGTACAAAAGAACAAAACCGAGAAAAGAAGCCAGAGGAACTCATCTCCTGTGCCGACTGTGGCAACAGTGGCCATCCATCC
TGTTTAAAGTTTTCCCCTGAACTAACGGTTCGAGTGAAGGCCTTACGGTGGCAGTGCATCGAGTGTAAAACATGCAGCTCCTGTCGAGAT
CAAGGCAAAAATGCGGATAACATGCTCTTTTGTGATTCATGTGACCGAGGTTTTCACATGGAGTGTTGTGATCCGCCACTCACCCGTATG
CCAAAAGGCATGTGGATATGTCAAATATGTCGACCTAGGAAAAAAGGACGAAAACTTCTACAAAAGAAGGCAGCACAGATAAAACGGCGC
TATACTAATCCAATAGGACGTCCAAAAAACAGGTTAAAGAAACAAAACACGGTATCAAAAGGTCCCTTCAGCAAAGTTCGAACTGGCCCT
GGAAGGGGTAGGAAACGAAAAATCACTCTTTCCAGCCAATCAGCATCATCATCATCAGAAGAAGGATATTTAGAGCGGATAGATGGCTTG
GACTTCTGCAGAGATAGCAATGTCTCCTTGAAGTTCAACAAGAAAACCAAAGGGCTCATTGATGGCCTTACCAAATTTTTTACCCCTTCC
CCTGATGGGCGGAAAGCTCGGGGGGAAGTGGTGGACTACTCTGAGCAATATCGAATCAGAAAGAGGGGCAACAGGAAATCAAGCACTTCA
GATTGGCCCACAGACAATCAGGATGGCTGGGATGGCAAACAAGAAAATGAGGAGCGACTTTTTGGGAGCCAGGAAATCATGACTGAGAAA
GATATGGAATTATTTCGTGATATCCAAGAACAAGCACTGCAGAAAGTTGGAGTGACTGGTCCCCCTGATCCACAAGTCCGCTGTCCCTCT

>In-frame_KAT6A_ENST00000406337_chr8_41812814_-_ADAM2_ENST00000521880_chr8_39694731_-_1598nt
ATGGTAAAACTCGCAAACCCGCTTTATACTGAGTGGATTTTGGAGGCCATCAAAAAAGTGAAAAAGCAGAAACAGCGTCCTTCAGAAGAA
AGGATATGCAATGCTGTGTCTTCATCCCATGGCTTGGATCGTAAAACTGTTTTAGAACAATTGGAGTTGAGTGTTAAAGATGGAACAATT
TTAAAAGTCTCAAATAAAGGACTCAATTCCTATAAAGATCCTGATAATCCTGGGCGAATAGCACTTCCTAAGCCTCGGAACCATGGAAAA
TTGGATAATAAACAAAATGTGGATTGGAATAAACTGATAAAGCGGGCAGTTGAGGGCTTGGCAGAGTCTGGTGGCTCAACTTTGAAAAGC
ATTGAACGTTTTTTGAAAGGTCAGAAGGATGTGTCTGCATTATTCGGAGGCAGTGCTGCCTCTGGCTTTCACCAGCAGTTACGATTGGCT
ATCAAACGTGCCATTGGCCACGGCAGACTCCTTAAAGATGGACCTCTTTATCGGCTCAACACTAAAGCAACCAACGTGGATGGGAAAGAG
AGTTGTGAGTCTCTTTCCTGTTTACCTCCAGTGTCCCTTCTTCCACATGAAAAGGATAAGCCGGTTGCTGAACCAATCCCCATCTGTAGT
TTCTGTCTTGGTACAAAAGAACAAAACCGAGAAAAGAAGCCAGAGGAACTCATCTCCTGTGCCGACTGTGGCAACAGTGGCCATCCATCC
TGTTTAAAGTTTTCCCCTGAACTAACGGTTCGAGTGAAGGCCTTACGGTGGCAGTGCATCGAGTGTAAAACATGCAGCTCCTGTCGAGAT
CAAGGCAAAAATGCGGATAACATGCTCTTTTGTGATTCATGTGACCGAGGTTTTCACATGGAGTGTTGTGATCCGCCACTCACCCGTATG
CCAAAAGGCATGTGGATATGTCAAATATGTCGACCTAGGAAAAAAGGACGAAAACTTCTACAAAAGAAGGCAGCACAGATAAAACGGCGC
TATACTAATCCAATAGGACGTCCAAAAAACAGGTTAAAGAAACAAAACACGGTATCAAAAGGTCCCTTCAGCAAAGTTCGAACTGGCCCT
GGAAGGGGTAGGAAACGAAAAATCACTCTTTCCAGCCAATCAGCATCATCATCATCAGAAGAAGGATATTTAGAGCGGATAGATGGCTTG
GACTTCTGCAGAGATAGCAATGTCTCCTTGAAGTTCAACAAGAAAACCAAAGGGCTCATTGATGGCCTTACCAAATTTTTTACCCCTTCC
CCTGATGGGCGGAAAGCTCGGGGGGAAGTGGTGGACTACTCTGAGCAATATCGAATCAGAAAGAGGGGCAACAGGAAATCAAGCACTTCA
GATTGGCCCACAGACAATCAGGATGGCTGGGATGGCAAACAAGAAAATGAGGAGCGACTTTTTGGGAGCCAGGAAATCATGACTGAGAAA
GATATGGAATTATTTCGTGATATCCAAGAACAAGCACTGCAGAAAGTTGGAGTGACTGGTCCCCCTGATCCACAAGTCCGCTGTCCCTCT


* Fusion transcript sequences (Full-length transcript).
>In-frame_KAT6A_ENST00000406337_chr8_41812814_-_ADAM2_ENST00000347580_chr8_39694731_-_4554nt
ACTGTCTCCAAGATGGCGGCCGTGTCAGTTTGGGGCATCTCCGCGGTCCGGCCCGGGGCCCCGGGATCTCGGCTGTCCTTCCTCCCGGAT
TCTTTCTACTAATCCAGATACTTGTTGAAGTGCTGACTAGTTTCTTGGGGAAAGATGTCAAGGAAGAGTTGAAATTCCTAGACTGGCATA
AGATGCACATTTTTCTGCTCTGGAGCCGGGAATGAAATATTCTTGAGTTCTTACAACTTTATGACGAGACCCATGTGTGGTGCTATTGAG
AAATTCATTGGGAAGTTGGAAGACATTTCAATCAACAGGTTGTTTTGGTTTCTATAGTACAATTGGGGTGGCATTCTGTTTTGTGAAAGG
AGGAAGGACTTAGGCCAGAAAACTCATATGCTATGGTTAACTGGTTCCCAGCCTCCGAGAATCTTGTTTTCCATGGTGTAAAACTTACTC
AGCATCAGGATAAGGGATAACGACTCTATGGATATACAGAATCCTTCACCATGGTAAAACTCGCAAACCCGCTTTATACTGAGTGGATTT
TGGAGGCCATCAAAAAAGTGAAAAAGCAGAAACAGCGTCCTTCAGAAGAAAGGATATGCAATGCTGTGTCTTCATCCCATGGCTTGGATC
GTAAAACTGTTTTAGAACAATTGGAGTTGAGTGTTAAAGATGGAACAATTTTAAAAGTCTCAAATAAAGGACTCAATTCCTATAAAGATC
CTGATAATCCTGGGCGAATAGCACTTCCTAAGCCTCGGAACCATGGAAAATTGGATAATAAACAAAATGTGGATTGGAATAAACTGATAA
AGCGGGCAGTTGAGGGCTTGGCAGAGTCTGGTGGCTCAACTTTGAAAAGCATTGAACGTTTTTTGAAAGGTCAGAAGGATGTGTCTGCAT
TATTCGGAGGCAGTGCTGCCTCTGGCTTTCACCAGCAGTTACGATTGGCTATCAAACGTGCCATTGGCCACGGCAGACTCCTTAAAGATG
GACCTCTTTATCGGCTCAACACTAAAGCAACCAACGTGGATGGGAAAGAGAGTTGTGAGTCTCTTTCCTGTTTACCTCCAGTGTCCCTTC
TTCCACATGAAAAGGATAAGCCGGTTGCTGAACCAATCCCCATCTGTAGTTTCTGTCTTGGTACAAAAGAACAAAACCGAGAAAAGAAGC
CAGAGGAACTCATCTCCTGTGCCGACTGTGGCAACAGTGGCCATCCATCCTGTTTAAAGTTTTCCCCTGAACTAACGGTTCGAGTGAAGG
CCTTACGGTGGCAGTGCATCGAGTGTAAAACATGCAGCTCCTGTCGAGATCAAGGCAAAAATGCGGATAACATGCTCTTTTGTGATTCAT
GTGACCGAGGTTTTCACATGGAGTGTTGTGATCCGCCACTCACCCGTATGCCAAAAGGCATGTGGATATGTCAAATATGTCGACCTAGGA
AAAAAGGACGAAAACTTCTACAAAAGAAGGCAGCACAGATAAAACGGCGCTATACTAATCCAATAGGACGTCCAAAAAACAGGTTAAAGA
AACAAAACACGGTATCAAAAGGTCCCTTCAGCAAAGTTCGAACTGGCCCTGGAAGGGGTAGGAAACGAAAAATCACTCTTTCCAGCCAAT
CAGCATCATCATCATCAGAAGAAGGATATTTAGAGCGGATAGATGGCTTGGACTTCTGCAGAGATAGCAATGTCTCCTTGAAGTTCAACA
AGAAAACCAAAGGGCTCATTGATGGCCTTACCAAATTTTTTACCCCTTCCCCTGATGGGCGGAAAGCTCGGGGGGAAGTGGTGGACTACT
CTGAGCAATATCGAATCAGAAAGAGGGGCAACAGGAAATCAAGCACTTCAGATTGGCCCACAGACAATCAGGATGGCTGGGATGGCAAAC
AAGAAAATGAGGAGCGACTTTTTGGGAGCCAGGAAATCATGACTGAGAAAGATATGGAATTATTTCGTGATATCCAAGAACAAGCACTGC
AGAAAGTTGGAGTGACTGGTCCCCCTGATCCACAAGTCCGCTGTCCCTCTGTCATTGAGTTTGGGAAGTATGAAATTCACACCTGGTACT
CCTCCCCATATCCTCAAGAATACTCAAGATTTTGATAGTTTACCTGTGCAAATTACAGTTCCGGAGAAAATACGGTCAATAATAAAGGAA
GGAATTGAATCGCAGGCATCCTACAAAATTGTAATTGAAGGGAAACCATATACTGTGAATTTAATGCAAAAAAACTTTTTACCCCATAAT
TTTAGAGTTTACAGTTATAGTGGCACAGGAATTATGAAACCACTTGACCAAGATTTTCAGAATTTCTGCCACTACCAAGGGTATATTGAA
GGTTATCCAAAATCTGTGGTGATGGTTAGCACATGTACTGGACTCAGGGGCGTACTACAGTTTGAAAATGTTAGTTATGGAATAGAACCC
CTGGAGTCTTCAGTTGGCTTTGAACATGTAATTTACCAAGTAAAACATAAGAAAGCAGATGTTTCCTTATATAATGAGAAGGATATTGAA
TCAAGAGATCTGTCCTTTAAATTACAAAGCGTAGAGTATAATCATATGGGGTCTGATACAACTGTTGTCGCTCAAAAAGTTTTCCAGTTG
ATTGGATTGACGAATGCTATTTTTGTTTCATTTAATATTACAATTATTCTGTCTTCATTGGAGCTTTGGATAGATGAAAATAAAATTGCA
ACCACTGGAGAAGCTAATGAGTTATTACACACATTTTTAAGATGGAAAACATCTTATCTTGTTTTACGTCCTCATGATGTGGCATTTTTA
CTTGTTTACAGAGAAAAGTCAAATTATGTTGGTGCAACCTTTCAAGGGAAGATGTGTGATGCAAACTATGCAGGAGGTGTTGTTCTGCAC
CCCAGAACCATAAGTCTGGAATCACTTGCAGTTATTTTAGCTCAATTATTGAGCCTTAGTATGGGGATCACTTATGATGACATTAACAAA
TGCCAGTGCTCAGGAGCTGTCTGCATTATGAATCCAGAAGCAATTCATTTCAGTGGTGTGAAGATCTTTAGTAACTGCAGCTTCGAAGAC
TTTGCACATTTTATTTCAAAGCAGAAGTCCCAGTGTCTTCACAATCAGCCTCGCTTAGATCCTTTTTTCAAACAGCAAGCAGTGTGTGGT
AATGCAAAGCTGGAAGCAGGAGAGGAGTGTGACTGTGGGACTGAACAGGATTGTGCCCTTATTGGAGAAACATGCTGTGATATTGCCACA
TGTAGATTTAAAGCCGGTTCAAACTGTGCTGAAGGACCATGCTGCGAAAACTGTCTATTTATGTCAAAAGAAAGAATGTGTAGGCCTTCC
TTTGAAGAATGCGACCTCCCTGAATATTGCAATGGATCATCTGCATCATGCCCAGAAAACCACTATGTTCAGACTGGGCATCCGTGTGGA
CTGAATCAATGGATCTGTATAGATGGAGTTTGTATGAGTGGGGATAAACAATGTACAGACACATTTGGCAAAGAAGTAGAGTTTGGCCCT
TCAGAATGTTATTCTCACCTTAATTCAAAGACTGATGTATCTGGAAACTGTGGTATAAGTGATTCAGGATACACACAGTGTGAAGCTGAC
AATCTGCAGTGCGGAAAATTAATATGTAAATATGTAGGTAAATTTTTATTACAAATTCCAAGAGCCACTATTATTTATGCCAACATAAGT
GGACATCTCTGCATTGCTGTGGAATTTGCCAGTGATCATGCAGACAGCCAAAAGATGTGGATAAAAGATGGAACTTCTTGTGGTTCAAAT
AAGGTTTGCAGGAATCAAAGATGTGTGAGTTCTTCATACTTGGGTTATGATTGTACTACTGACAAATGCAATGATAGAGGTGTATGCAAT
AACAAAAAGCACTGTCACTGTAGTGCTTCATATTTACCTCCAGATTGCTCAGTTCAATCAGATCTATGGCCTGGTGGGAGTATTGACAGT
GGCAATTTTCCACCTGTAGCTATACCAGCCAGACTCCCTGAAAGGCGCTACATTGAGAACATTTACCATTCCAAACCAATGAGATGGCCA
TTTTTCTTATTCATTCCTTTCTTTATTATTTTCTGTGTACTGATTGCTATAATGGTGAAAGTTAATTTCCAAAGGAAAAAATGGAGAACT
GAGGACTATTCAAGCGATGAGCAACCTGAAAGTGAGAGTGAACCTAAAGGGTAGTCTGGACAACAGAGATGCCATGATATCACTTCTTCT
AGAGTAATTATCTGTGATGGATGGACACAAAAAAATGGAAAGAAAAGAATGTACATTACCTGGTTTCCTGGGATTCAAACCTGCATATTG
TGATTTTAATTTGACCAGAAAATATGATATATATGTATAATTTCACAGATAATTTACTTATTTAAAAATGCATGATAATGAGTTTTACAT
TACAAATTTCTGTTTTTTTAAAGTTATCTTACGCTATTTCTGTTGGTTAGTAGACACTAATTCTGTCAGTAGGGGCATGGTATAAGGAAA

>In-frame_KAT6A_ENST00000406337_chr8_41812814_-_ADAM2_ENST00000379853_chr8_39694731_-_4143nt
ACTGTCTCCAAGATGGCGGCCGTGTCAGTTTGGGGCATCTCCGCGGTCCGGCCCGGGGCCCCGGGATCTCGGCTGTCCTTCCTCCCGGAT
TCTTTCTACTAATCCAGATACTTGTTGAAGTGCTGACTAGTTTCTTGGGGAAAGATGTCAAGGAAGAGTTGAAATTCCTAGACTGGCATA
AGATGCACATTTTTCTGCTCTGGAGCCGGGAATGAAATATTCTTGAGTTCTTACAACTTTATGACGAGACCCATGTGTGGTGCTATTGAG
AAATTCATTGGGAAGTTGGAAGACATTTCAATCAACAGGTTGTTTTGGTTTCTATAGTACAATTGGGGTGGCATTCTGTTTTGTGAAAGG
AGGAAGGACTTAGGCCAGAAAACTCATATGCTATGGTTAACTGGTTCCCAGCCTCCGAGAATCTTGTTTTCCATGGTGTAAAACTTACTC
AGCATCAGGATAAGGGATAACGACTCTATGGATATACAGAATCCTTCACCATGGTAAAACTCGCAAACCCGCTTTATACTGAGTGGATTT
TGGAGGCCATCAAAAAAGTGAAAAAGCAGAAACAGCGTCCTTCAGAAGAAAGGATATGCAATGCTGTGTCTTCATCCCATGGCTTGGATC
GTAAAACTGTTTTAGAACAATTGGAGTTGAGTGTTAAAGATGGAACAATTTTAAAAGTCTCAAATAAAGGACTCAATTCCTATAAAGATC
CTGATAATCCTGGGCGAATAGCACTTCCTAAGCCTCGGAACCATGGAAAATTGGATAATAAACAAAATGTGGATTGGAATAAACTGATAA
AGCGGGCAGTTGAGGGCTTGGCAGAGTCTGGTGGCTCAACTTTGAAAAGCATTGAACGTTTTTTGAAAGGTCAGAAGGATGTGTCTGCAT
TATTCGGAGGCAGTGCTGCCTCTGGCTTTCACCAGCAGTTACGATTGGCTATCAAACGTGCCATTGGCCACGGCAGACTCCTTAAAGATG
GACCTCTTTATCGGCTCAACACTAAAGCAACCAACGTGGATGGGAAAGAGAGTTGTGAGTCTCTTTCCTGTTTACCTCCAGTGTCCCTTC
TTCCACATGAAAAGGATAAGCCGGTTGCTGAACCAATCCCCATCTGTAGTTTCTGTCTTGGTACAAAAGAACAAAACCGAGAAAAGAAGC
CAGAGGAACTCATCTCCTGTGCCGACTGTGGCAACAGTGGCCATCCATCCTGTTTAAAGTTTTCCCCTGAACTAACGGTTCGAGTGAAGG
CCTTACGGTGGCAGTGCATCGAGTGTAAAACATGCAGCTCCTGTCGAGATCAAGGCAAAAATGCGGATAACATGCTCTTTTGTGATTCAT
GTGACCGAGGTTTTCACATGGAGTGTTGTGATCCGCCACTCACCCGTATGCCAAAAGGCATGTGGATATGTCAAATATGTCGACCTAGGA
AAAAAGGACGAAAACTTCTACAAAAGAAGGCAGCACAGATAAAACGGCGCTATACTAATCCAATAGGACGTCCAAAAAACAGGTTAAAGA
AACAAAACACGGTATCAAAAGGTCCCTTCAGCAAAGTTCGAACTGGCCCTGGAAGGGGTAGGAAACGAAAAATCACTCTTTCCAGCCAAT
CAGCATCATCATCATCAGAAGAAGGATATTTAGAGCGGATAGATGGCTTGGACTTCTGCAGAGATAGCAATGTCTCCTTGAAGTTCAACA
AGAAAACCAAAGGGCTCATTGATGGCCTTACCAAATTTTTTACCCCTTCCCCTGATGGGCGGAAAGCTCGGGGGGAAGTGGTGGACTACT
CTGAGCAATATCGAATCAGAAAGAGGGGCAACAGGAAATCAAGCACTTCAGATTGGCCCACAGACAATCAGGATGGCTGGGATGGCAAAC
AAGAAAATGAGGAGCGACTTTTTGGGAGCCAGGAAATCATGACTGAGAAAGATATGGAATTATTTCGTGATATCCAAGAACAAGCACTGC
AGAAAGTTGGAGTGACTGGTCCCCCTGATCCACAAGTCCGCTGTCCCTCTGTCATTGAGTTTGGGAAGTATGAAATTCACACCTGGTACT
CCTCCCCATATCCTCAAGAATACTCAAGATTTTGATAGTTTACCTGTGCAAATTACAGTTCCGGAGAAAATACGGTCAATAATAAAGGAA
GGAATTGAATCGCAGGCATCCTACAAAATTGTAATTGAAGGGAAACCATATACTGTGAATTTAATGCAAAAAAACTTTTTACCCCATAAT
TTTAGAGTTTACAGTTATAGTGGCACAGGAATTATGAAACCACTTGACCAAGATTTTCAGAATTTCTGCCACTACCAAGGGTATATTGAA
GGTTATCCAAAATCTGTGGTGATGGTTAGCACATGTACTGGACTCAGGGGCGTACTACAGTTTGAAAATGTTAGTTATGGAATAGAACCC
CTGGAGTCTTCAGTTGGCTTTGAACATGTAATTTACCAAGTAAAACATAAGAAAGCAGATGTTTCCTTATATAATGAGAAGGATATTGAA
TCAAGAGATCTGTCCTTTAAATTACAAAGCGTAGAGCACCCCAGAACCATAAGTCTGGAATCACTTGCAGTTATTTTAGCTCAATTATTG
AGCCTTAGTATGGGGATCACTTATGATGACATTAACAAATGCCAGTGCTCAGGAGCTGTCTGCATTATGAATCCAGAAGCAATTCATTTC
AGTGGTGTGAAGATCTTTAGTAACTGCAGCTTCGAAGACTTTGCACATTTTATTTCAAAGCAGAAGTCCCAGTGTCTTCACAATCAGCCT
CGCTTAGATCCTTTTTTCAAACAGCAAGCAGTGTGTGGTAATGCAAAGCTGGAAGCAGGAGAGGAGTGTGACTGTGGGACTGAACAGGAT
TGTGCCCTTATTGGAGAAACATGCTGTGATATTGCCACATGTAGATTTAAAGCCGGTTCAAACTGTGCTGAAGGACCATGCTGCGAAAAC
TGTCTATTTATGTCAAAAGAAAGAATGTGTAGGCCTTCCTTTGAAGAATGCGACCTCCCTGAATATTGCAATGGATCATCTGCATCATGC
CCAGAAAACCACTATGTTCAGACTGGGCATCCGTGTGGACTGAATCAATGGATCTGTATAGATGGAGTTTGTATGAGTGGGGATAAACAA
TGTACAGACACATTTGGCAAAGAAGTAGAGTTTGGCCCTTCAGAATGTTATTCTCACCTTAATTCAAAGACTGATGTATCTGGAAACTGT
GGTATAAGTGATTCAGGATACACACAGTGTGAAGCTGATGGACATCTCTGCATTGCTGTGGAATTTGCCAGTGATCATGCAGACAGCCAA
AAGATGTGGATAAAAGATGGAACTTCTTGTGGTTCAAATAAGGTTTGCAGGAATCAAAGATGTGTGAGTTCTTCATACTTGGGTTATGAT
TGTACTACTGACAAATGCAATGATAGAGGTGTATGCAATAACAAAAAGCACTGTCACTGTAGTGCTTCATATTTACCTCCAGATTGCTCA
GTTCAATCAGATCTATGGCCTGGTGGGAGTATTGACAGTGGCAATTTTCCACCTGTAGCTATACCAGCCAGACTCCCTGAAAGGCGCTAC
ATTGAGAACATTTACCATTCCAAACCAATGAGATGGCCATTTTTCTTATTCATTCCTTTCTTTATTATTTTCTGTGTACTGATTGCTATA
ATGGTGAAAGTTAATTTCCAAAGGAAAAAATGGAGAACTGAGGACTATTCAAGCGATGAGCAACCTGAAAGTGAGAGTGAACCTAAAGGG
TAGTCTGGACAACAGAGATGCCATGATATCACTTCTTCTAGAGTAATTATCTGTGATGGATGGACACAAAAAAATGGAAAGAAAAGAATG
TACATTACCTGGTTTCCTGGGATTCAAACCTGCATATTGTGATTTTAATTTGACCAGAAAATATGATATATATGTATAATTTCACAGATA
ATTTACTTATTTAAAAATGCATGATAATGAGTTTTACATTACAAATTTCTGTTTTTTTAAAGTTATCTTACGCTATTTCTGTTGGTTAGT
AGACACTAATTCTGTCAGTAGGGGCATGGTATAAGGAAATATCATAATGTAATGAGGTGGTACTATGATTAAAAGCCACTGTTACATTTC

>In-frame_KAT6A_ENST00000406337_chr8_41812814_-_ADAM2_ENST00000265708_chr8_39694731_-_4611nt
ACTGTCTCCAAGATGGCGGCCGTGTCAGTTTGGGGCATCTCCGCGGTCCGGCCCGGGGCCCCGGGATCTCGGCTGTCCTTCCTCCCGGAT
TCTTTCTACTAATCCAGATACTTGTTGAAGTGCTGACTAGTTTCTTGGGGAAAGATGTCAAGGAAGAGTTGAAATTCCTAGACTGGCATA
AGATGCACATTTTTCTGCTCTGGAGCCGGGAATGAAATATTCTTGAGTTCTTACAACTTTATGACGAGACCCATGTGTGGTGCTATTGAG
AAATTCATTGGGAAGTTGGAAGACATTTCAATCAACAGGTTGTTTTGGTTTCTATAGTACAATTGGGGTGGCATTCTGTTTTGTGAAAGG
AGGAAGGACTTAGGCCAGAAAACTCATATGCTATGGTTAACTGGTTCCCAGCCTCCGAGAATCTTGTTTTCCATGGTGTAAAACTTACTC
AGCATCAGGATAAGGGATAACGACTCTATGGATATACAGAATCCTTCACCATGGTAAAACTCGCAAACCCGCTTTATACTGAGTGGATTT
TGGAGGCCATCAAAAAAGTGAAAAAGCAGAAACAGCGTCCTTCAGAAGAAAGGATATGCAATGCTGTGTCTTCATCCCATGGCTTGGATC
GTAAAACTGTTTTAGAACAATTGGAGTTGAGTGTTAAAGATGGAACAATTTTAAAAGTCTCAAATAAAGGACTCAATTCCTATAAAGATC
CTGATAATCCTGGGCGAATAGCACTTCCTAAGCCTCGGAACCATGGAAAATTGGATAATAAACAAAATGTGGATTGGAATAAACTGATAA
AGCGGGCAGTTGAGGGCTTGGCAGAGTCTGGTGGCTCAACTTTGAAAAGCATTGAACGTTTTTTGAAAGGTCAGAAGGATGTGTCTGCAT
TATTCGGAGGCAGTGCTGCCTCTGGCTTTCACCAGCAGTTACGATTGGCTATCAAACGTGCCATTGGCCACGGCAGACTCCTTAAAGATG
GACCTCTTTATCGGCTCAACACTAAAGCAACCAACGTGGATGGGAAAGAGAGTTGTGAGTCTCTTTCCTGTTTACCTCCAGTGTCCCTTC
TTCCACATGAAAAGGATAAGCCGGTTGCTGAACCAATCCCCATCTGTAGTTTCTGTCTTGGTACAAAAGAACAAAACCGAGAAAAGAAGC
CAGAGGAACTCATCTCCTGTGCCGACTGTGGCAACAGTGGCCATCCATCCTGTTTAAAGTTTTCCCCTGAACTAACGGTTCGAGTGAAGG
CCTTACGGTGGCAGTGCATCGAGTGTAAAACATGCAGCTCCTGTCGAGATCAAGGCAAAAATGCGGATAACATGCTCTTTTGTGATTCAT
GTGACCGAGGTTTTCACATGGAGTGTTGTGATCCGCCACTCACCCGTATGCCAAAAGGCATGTGGATATGTCAAATATGTCGACCTAGGA
AAAAAGGACGAAAACTTCTACAAAAGAAGGCAGCACAGATAAAACGGCGCTATACTAATCCAATAGGACGTCCAAAAAACAGGTTAAAGA
AACAAAACACGGTATCAAAAGGTCCCTTCAGCAAAGTTCGAACTGGCCCTGGAAGGGGTAGGAAACGAAAAATCACTCTTTCCAGCCAAT
CAGCATCATCATCATCAGAAGAAGGATATTTAGAGCGGATAGATGGCTTGGACTTCTGCAGAGATAGCAATGTCTCCTTGAAGTTCAACA
AGAAAACCAAAGGGCTCATTGATGGCCTTACCAAATTTTTTACCCCTTCCCCTGATGGGCGGAAAGCTCGGGGGGAAGTGGTGGACTACT
CTGAGCAATATCGAATCAGAAAGAGGGGCAACAGGAAATCAAGCACTTCAGATTGGCCCACAGACAATCAGGATGGCTGGGATGGCAAAC
AAGAAAATGAGGAGCGACTTTTTGGGAGCCAGGAAATCATGACTGAGAAAGATATGGAATTATTTCGTGATATCCAAGAACAAGCACTGC
AGAAAGTTGGAGTGACTGGTCCCCCTGATCCACAAGTCCGCTGTCCCTCTGTCATTGAGTTTGGGAAGTATGAAATTCACACCTGGTACT
CCTCCCCATATCCTCAAGAATACTCAAGATTTTGATAGTTTACCTGTGCAAATTACAGTTCCGGAGAAAATACGGTCAATAATAAAGGAA
GGAATTGAATCGCAGGCATCCTACAAAATTGTAATTGAAGGGAAACCATATACTGTGAATTTAATGCAAAAAAACTTTTTACCCCATAAT
TTTAGAGTTTACAGTTATAGTGGCACAGGAATTATGAAACCACTTGACCAAGATTTTCAGAATTTCTGCCACTACCAAGGGTATATTGAA
GGTTATCCAAAATCTGTGGTGATGGTTAGCACATGTACTGGACTCAGGGGCGTACTACAGTTTGAAAATGTTAGTTATGGAATAGAACCC
CTGGAGTCTTCAGTTGGCTTTGAACATGTAATTTACCAAGTAAAACATAAGAAAGCAGATGTTTCCTTATATAATGAGAAGGATATTGAA
TCAAGAGATCTGTCCTTTAAATTACAAAGCGTAGAGCCACAGCAAGATTTTGCAAAGTATATAGAAATGCATGTTATAGTTGAAAAACAA
TTGTATAATCATATGGGGTCTGATACAACTGTTGTCGCTCAAAAAGTTTTCCAGTTGATTGGATTGACGAATGCTATTTTTGTTTCATTT
AATATTACAATTATTCTGTCTTCATTGGAGCTTTGGATAGATGAAAATAAAATTGCAACCACTGGAGAAGCTAATGAGTTATTACACACA
TTTTTAAGATGGAAAACATCTTATCTTGTTTTACGTCCTCATGATGTGGCATTTTTACTTGTTTACAGAGAAAAGTCAAATTATGTTGGT
GCAACCTTTCAAGGGAAGATGTGTGATGCAAACTATGCAGGAGGTGTTGTTCTGCACCCCAGAACCATAAGTCTGGAATCACTTGCAGTT
ATTTTAGCTCAATTATTGAGCCTTAGTATGGGGATCACTTATGATGACATTAACAAATGCCAGTGCTCAGGAGCTGTCTGCATTATGAAT
CCAGAAGCAATTCATTTCAGTGGTGTGAAGATCTTTAGTAACTGCAGCTTCGAAGACTTTGCACATTTTATTTCAAAGCAGAAGTCCCAG
TGTCTTCACAATCAGCCTCGCTTAGATCCTTTTTTCAAACAGCAAGCAGTGTGTGGTAATGCAAAGCTGGAAGCAGGAGAGGAGTGTGAC
TGTGGGACTGAACAGGATTGTGCCCTTATTGGAGAAACATGCTGTGATATTGCCACATGTAGATTTAAAGCCGGTTCAAACTGTGCTGAA
GGACCATGCTGCGAAAACTGTCTATTTATGTCAAAAGAAAGAATGTGTAGGCCTTCCTTTGAAGAATGCGACCTCCCTGAATATTGCAAT
GGATCATCTGCATCATGCCCAGAAAACCACTATGTTCAGACTGGGCATCCGTGTGGACTGAATCAATGGATCTGTATAGATGGAGTTTGT
ATGAGTGGGGATAAACAATGTACAGACACATTTGGCAAAGAAGTAGAGTTTGGCCCTTCAGAATGTTATTCTCACCTTAATTCAAAGACT
GATGTATCTGGAAACTGTGGTATAAGTGATTCAGGATACACACAGTGTGAAGCTGACAATCTGCAGTGCGGAAAATTAATATGTAAATAT
GTAGGTAAATTTTTATTACAAATTCCAAGAGCCACTATTATTTATGCCAACATAAGTGGACATCTCTGCATTGCTGTGGAATTTGCCAGT
GATCATGCAGACAGCCAAAAGATGTGGATAAAAGATGGAACTTCTTGTGGTTCAAATAAGGTTTGCAGGAATCAAAGATGTGTGAGTTCT
TCATACTTGGGTTATGATTGTACTACTGACAAATGCAATGATAGAGGTGTATGCAATAACAAAAAGCACTGTCACTGTAGTGCTTCATAT
TTACCTCCAGATTGCTCAGTTCAATCAGATCTATGGCCTGGTGGGAGTATTGACAGTGGCAATTTTCCACCTGTAGCTATACCAGCCAGA
CTCCCTGAAAGGCGCTACATTGAGAACATTTACCATTCCAAACCAATGAGATGGCCATTTTTCTTATTCATTCCTTTCTTTATTATTTTC
TGTGTACTGATTGCTATAATGGTGAAAGTTAATTTCCAAAGGAAAAAATGGAGAACTGAGGACTATTCAAGCGATGAGCAACCTGAAAGT
GAGAGTGAACCTAAAGGGTAGTCTGGACAACAGAGATGCCATGATATCACTTCTTCTAGAGTAATTATCTGTGATGGATGGACACAAAAA
AATGGAAAGAAAAGAATGTACATTACCTGGTTTCCTGGGATTCAAACCTGCATATTGTGATTTTAATTTGACCAGAAAATATGATATATA
TGTATAATTTCACAGATAATTTACTTATTTAAAAATGCATGATAATGAGTTTTACATTACAAATTTCTGTTTTTTTAAAGTTATCTTACG
CTATTTCTGTTGGTTAGTAGACACTAATTCTGTCAGTAGGGGCATGGTATAAGGAAATATCATAATGTAATGAGGTGGTACTATGATTAA

>In-frame_KAT6A_ENST00000406337_chr8_41812814_-_ADAM2_ENST00000521880_chr8_39694731_-_4126nt
ACTGTCTCCAAGATGGCGGCCGTGTCAGTTTGGGGCATCTCCGCGGTCCGGCCCGGGGCCCCGGGATCTCGGCTGTCCTTCCTCCCGGAT
TCTTTCTACTAATCCAGATACTTGTTGAAGTGCTGACTAGTTTCTTGGGGAAAGATGTCAAGGAAGAGTTGAAATTCCTAGACTGGCATA
AGATGCACATTTTTCTGCTCTGGAGCCGGGAATGAAATATTCTTGAGTTCTTACAACTTTATGACGAGACCCATGTGTGGTGCTATTGAG
AAATTCATTGGGAAGTTGGAAGACATTTCAATCAACAGGTTGTTTTGGTTTCTATAGTACAATTGGGGTGGCATTCTGTTTTGTGAAAGG
AGGAAGGACTTAGGCCAGAAAACTCATATGCTATGGTTAACTGGTTCCCAGCCTCCGAGAATCTTGTTTTCCATGGTGTAAAACTTACTC
AGCATCAGGATAAGGGATAACGACTCTATGGATATACAGAATCCTTCACCATGGTAAAACTCGCAAACCCGCTTTATACTGAGTGGATTT
TGGAGGCCATCAAAAAAGTGAAAAAGCAGAAACAGCGTCCTTCAGAAGAAAGGATATGCAATGCTGTGTCTTCATCCCATGGCTTGGATC
GTAAAACTGTTTTAGAACAATTGGAGTTGAGTGTTAAAGATGGAACAATTTTAAAAGTCTCAAATAAAGGACTCAATTCCTATAAAGATC
CTGATAATCCTGGGCGAATAGCACTTCCTAAGCCTCGGAACCATGGAAAATTGGATAATAAACAAAATGTGGATTGGAATAAACTGATAA
AGCGGGCAGTTGAGGGCTTGGCAGAGTCTGGTGGCTCAACTTTGAAAAGCATTGAACGTTTTTTGAAAGGTCAGAAGGATGTGTCTGCAT
TATTCGGAGGCAGTGCTGCCTCTGGCTTTCACCAGCAGTTACGATTGGCTATCAAACGTGCCATTGGCCACGGCAGACTCCTTAAAGATG
GACCTCTTTATCGGCTCAACACTAAAGCAACCAACGTGGATGGGAAAGAGAGTTGTGAGTCTCTTTCCTGTTTACCTCCAGTGTCCCTTC
TTCCACATGAAAAGGATAAGCCGGTTGCTGAACCAATCCCCATCTGTAGTTTCTGTCTTGGTACAAAAGAACAAAACCGAGAAAAGAAGC
CAGAGGAACTCATCTCCTGTGCCGACTGTGGCAACAGTGGCCATCCATCCTGTTTAAAGTTTTCCCCTGAACTAACGGTTCGAGTGAAGG
CCTTACGGTGGCAGTGCATCGAGTGTAAAACATGCAGCTCCTGTCGAGATCAAGGCAAAAATGCGGATAACATGCTCTTTTGTGATTCAT
GTGACCGAGGTTTTCACATGGAGTGTTGTGATCCGCCACTCACCCGTATGCCAAAAGGCATGTGGATATGTCAAATATGTCGACCTAGGA
AAAAAGGACGAAAACTTCTACAAAAGAAGGCAGCACAGATAAAACGGCGCTATACTAATCCAATAGGACGTCCAAAAAACAGGTTAAAGA
AACAAAACACGGTATCAAAAGGTCCCTTCAGCAAAGTTCGAACTGGCCCTGGAAGGGGTAGGAAACGAAAAATCACTCTTTCCAGCCAAT
CAGCATCATCATCATCAGAAGAAGGATATTTAGAGCGGATAGATGGCTTGGACTTCTGCAGAGATAGCAATGTCTCCTTGAAGTTCAACA
AGAAAACCAAAGGGCTCATTGATGGCCTTACCAAATTTTTTACCCCTTCCCCTGATGGGCGGAAAGCTCGGGGGGAAGTGGTGGACTACT
CTGAGCAATATCGAATCAGAAAGAGGGGCAACAGGAAATCAAGCACTTCAGATTGGCCCACAGACAATCAGGATGGCTGGGATGGCAAAC
AAGAAAATGAGGAGCGACTTTTTGGGAGCCAGGAAATCATGACTGAGAAAGATATGGAATTATTTCGTGATATCCAAGAACAAGCACTGC
AGAAAGTTGGAGTGACTGGTCCCCCTGATCCACAAGTCCGCTGTCCCTCTGTCATTGAGTTTGGGAAGTATGAAATTCACACCTGGTACT
CCTCCCCATATCCTCAAGAATACTCAAGATTTTGATAGTTTACCTGTGCAAATTACAGTTCCGGAGAAAATACGGTCAATAATAAAGGAA
GGAATTGAATCGCAGGCATCCTACAAAATTGTAATTGAAGGGAAACCATATACTGTGAATTTAATGCAAAAAAACTTTTTACCCCATAAT
TTTAGAGTTTACAGTTATAGTGGCACAGGAATTATGAAACCACTTGACCAAGATTTTCAGAATTTCTGCCACTACCAAGGGTATATTGAA
GGTTATCCAAAATCTGTGGTGATGGTTAGCACATGTACTGGACTCAGGGGCGTACTACAGTTTGAAAATGTTAGTTATGGAATAGAACCC
CTGGAGTCTTCAGTTGGCTTTGAACATGTAATTTACCAAGTAAAACATAAGAAAGCAGATGTTTCCTTATATAATGAGAAGGATATTGAA
TCAAGAGATCTGTCCTTTAAATTACAAAGCGTAGAGCCACAGCAAGATTTTGCAAAGTATATAGAAATGCATGTTATAGTTGAAAAACAA
TTGTATAATCATATGGGGTCTGATACAACTGTTGTCGCTCAAAAAGTTTTCCAGTTGATTGGATTGACGAATGCTATTTTTGTTTCATTT
AATATTACAATTATTCTGTCTTCATTGGAGCTTTGGATAGATGAAAATAAAATTGCAACCACTGGAGAAGCTAATGAGTTATTACACACA
TTTTTAAGATGGAAAACATCTTATCTTGTTTTACGTCCTCATGATGTGGCATTTTTACTTGTTTACAGAGAAAAGTCAAATTATGTTGGT
GCAACCTTTCAAGGGAAGATGTGTGATGCAAACTATGCAGGAGGTGTTGTTCTGCACCCCAGAACCATAAGTCTGGAATCACTTGCAGTT
ATTTTAGCTCAATTATTGAGCCTTAGTATGGGGATCACTTATGATGACATTAACAAATGCCAGTGCTCAGGAGCTGTCTGCATTATGAAT
CCAGAAGCAATTCATTTCAGTGGTGTGAAGATCTTTAGTAACTGCAGCTTCGAAGACTTTGCACATTTTATTTCAAAGCAGAAGTCCCAG
TGTCTTCACAATCAGCCTCGCTTAGATCCTTTTTTCAAACAGCAAGCAGTGTGTGGTAATGCAAAGCTGGAAGCAGGAGAGGAGTGTGAC
TGTGGGACTGAACAGGATTGTGCCCTTATTGGAGAAACATGCTGTGATATTGCCACATGTAGATTTAAAGCCGGTTCAAACTGTGCTGAA
GGACCATGCTGCGAAAACTGTCTATTTATGTCAAAAGAAAGAATGTGTAGGCCTTCCTTTGAAGAATGCGACCTCCCTGAATATTGCAAT
GGATCATCTGCATCATGCCCAGAAAACCACTATGTTCAGACTGGGCATCCGTGTGGACTGAATCAATGGATCTGTATAGATGGAGTTTGT
ATGAGTGGGGATAAACAATGTACAGACACATTTGGCAAAGAAGTAGAGTTTGGCCCTTCAGAATGTTATTCTCACCTTAATTCAAAGACT
GATGTATCTGGAAACTGTGGTATAAGTGATTCAGGATACACACAGTGTGAAGTTTGCAGGAATCAAAGATGTGTGAGTTCTTCATACTTG
GGTTATGATTGTACTACTGACAAATGCAATGATAGAGGTGTATGCAATAACAAAAAGCACTGTCACTGTAGTGCTTCATATTTACCTCCA
GATTGCTCAGTTCAATCAGATCTATGGCCTGGTGGGAGTATTGACAGTGGCAATTTTCCACCTGTAGCTATACCAGCCAGACTCCCTGAA
AGGCGCTACATTGAGAACATTTACCATTCCAAACCAATGAGATGGCCATTTTTCTTATTCATTCCTTTCTTTATTATTTTCTGTGTACTG
ATTGCTATAATGGTGAAAGTTAATTTCCAAAGGAAAAAATGGAGAACTGAGGACTATTCAAGCGATGAGCAACCTGAAAGTGAGAGTGAA


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FusionGenePPI for KAT6A_ADAM2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
KAT6AING5, UBE2U, MAFK, BRPF1, HSPA4, TP53, EP300, MEAF6, HIST1H3A, HIST1H4A, RUNX1, CREBBP, ESR1, KMT2A, WDR5, HIST2H3C, ELAVL1, ATN1, ATXN1, RERE, H3F3C, HIST1H4I, HIST3H3, PML, SYMPK, AKT1, HIST4H4, CCNB1, CRK, RPL10, RNPS1, L1TD1, PHF14, TNRC6B, PNPLA8, RSF1, HEMGNADAM2CLGN, CRYAB, DNM1, ASPHD2, C6orf120, ADAMTS2, LRRC3, TTN, LCLAT1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneKAT6Achr8:41812814chr8:39694731ENST00000265713-917144_6645322005PML
HgeneKAT6Achr8:41812814chr8:39694731ENST00000265713-9171517_17415322005PML
HgeneKAT6Achr8:41812814chr8:39694731ENST00000396930-1018144_6645322005PML
HgeneKAT6Achr8:41812814chr8:39694731ENST00000396930-10181517_17415322005PML
HgeneKAT6Achr8:41812814chr8:39694731ENST00000406337-1018144_6645322005PML
HgeneKAT6Achr8:41812814chr8:39694731ENST00000406337-10181517_17415322005PML
HgeneKAT6Achr8:41812814chr8:39694731ENST00000265713-917312_6645322005RUNX1-1
HgeneKAT6Achr8:41812814chr8:39694731ENST00000396930-1018312_6645322005RUNX1-1
HgeneKAT6Achr8:41812814chr8:39694731ENST00000406337-1018312_6645322005RUNX1-1
HgeneKAT6Achr8:41812814chr8:39694731ENST00000265713-9171517_16425322005RUNX1-2
HgeneKAT6Achr8:41812814chr8:39694731ENST00000396930-10181517_16425322005RUNX1-2
HgeneKAT6Achr8:41812814chr8:39694731ENST00000406337-10181517_16425322005RUNX1-2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for KAT6A_ADAM2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for KAT6A_ADAM2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneKAT6AC0010606Adenoid Cystic Carcinoma1CTD_human
HgeneKAT6AC0025149Medulloblastoma1CTD_human