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Fusion gene ID: 18099 |
FusionGeneSummary for JUN_MPV17 |
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Fusion gene information | Fusion gene name: JUN_MPV17 | Fusion gene ID: 18099 | Hgene | Tgene | Gene symbol | JUN | MPV17 | Gene ID | 3725 | 4358 |
Gene name | Jun proto-oncogene, AP-1 transcription factor subunit | MPV17, mitochondrial inner membrane protein | |
Synonyms | AP-1|AP1|c-Jun|p39 | MTDPS6|SYM1 | |
Cytomap | 1p32.1 | 2p23.3 | |
Type of gene | protein-coding | protein-coding | |
Description | transcription factor AP-1Jun activation domain binding proteinactivator protein 1enhancer-binding protein AP1jun oncogeneproto-oncogene c-Junv-jun avian sarcoma virus 17 oncogene homologv-jun sarcoma virus 17 oncogene homolog | protein Mpv17MpV17 mitochondrial inner membrane proteinMpv17, human homolog of glomerulosclerosis and nephrotic syndrome | |
Modification date | 20180527 | 20180525 | |
UniProtAcc | P05412 | P39210 | |
Ensembl transtripts involved in fusion gene | ENST00000371222, | ENST00000233545, ENST00000402310, ENST00000380044, ENST00000357186, ENST00000402722, ENST00000405983, ENST00000405076, ENST00000403262, ENST00000399052, | |
Fusion gene scores | * DoF score | 4 X 4 X 1=16 | 2 X 2 X 1=4 |
# samples | 8 | 2 | |
** MAII score | log2(8/16*10)=2.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: JUN [Title/Abstract] AND MPV17 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | JUN | GO:0007179 | transforming growth factor beta receptor signaling pathway | 9732876 |
Hgene | JUN | GO:0007265 | Ras protein signal transduction | 24623306 |
Hgene | JUN | GO:0043392 | negative regulation of DNA binding | 14645924 |
Hgene | JUN | GO:0043922 | negative regulation by host of viral transcription | 2833704 |
Hgene | JUN | GO:0043923 | positive regulation by host of viral transcription | 2833704 |
Hgene | JUN | GO:0045892 | negative regulation of transcription, DNA-templated | 2833704 |
Hgene | JUN | GO:0045893 | positive regulation of transcription, DNA-templated | 2833704|9732876 |
Hgene | JUN | GO:0045944 | positive regulation of transcription by RNA polymerase II | 2833704|10508860|12490281 |
Hgene | JUN | GO:0060395 | SMAD protein signal transduction | 9732876 |
Hgene | JUN | GO:2000144 | positive regulation of DNA-templated transcription, initiation | 23027619 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CR981234 | JUN | chr1 | 59248665 | - | MPV17 | chr2 | 27532533 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000371222 | ENST00000233545 | JUN | chr1 | 59248665 | - | MPV17 | chr2 | 27532533 | - |
intron-3UTR | ENST00000371222 | ENST00000402310 | JUN | chr1 | 59248665 | - | MPV17 | chr2 | 27532533 | - |
intron-3UTR | ENST00000371222 | ENST00000380044 | JUN | chr1 | 59248665 | - | MPV17 | chr2 | 27532533 | - |
intron-3UTR | ENST00000371222 | ENST00000357186 | JUN | chr1 | 59248665 | - | MPV17 | chr2 | 27532533 | - |
intron-3UTR | ENST00000371222 | ENST00000402722 | JUN | chr1 | 59248665 | - | MPV17 | chr2 | 27532533 | - |
intron-3UTR | ENST00000371222 | ENST00000405983 | JUN | chr1 | 59248665 | - | MPV17 | chr2 | 27532533 | - |
intron-intron | ENST00000371222 | ENST00000405076 | JUN | chr1 | 59248665 | - | MPV17 | chr2 | 27532533 | - |
intron-intron | ENST00000371222 | ENST00000403262 | JUN | chr1 | 59248665 | - | MPV17 | chr2 | 27532533 | - |
intron-intron | ENST00000371222 | ENST00000399052 | JUN | chr1 | 59248665 | - | MPV17 | chr2 | 27532533 | - |
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FusionProtFeatures for JUN_MPV17 |
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Hgene | Tgene |
JUN | MPV17 |
Transcription factor that recognizes and binds to theenhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity ofNR5A1 when phosphorylated by HIPK3 leading to increasedsteroidogenic gene expression upon cAMP signaling pathwaystimulation. Involved in activated KRAS-mediated transcriptionalactivation of USP28 in colorectal cancer (CRC) cells(PubMed:24623306). Binds to the USP28 promoter in colorectalcancer (CRC) cells (PubMed:24623306).{ECO:0000269|PubMed:10995748, ECO:0000269|PubMed:17210646,ECO:0000269|PubMed:24623306}. | Involved in mitochondria homeostasis. May be involved inthe metabolism of reactive oxygen species and control of oxidativephosphorylation and mitochondrial DNA (mtDNA) maintenance. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for JUN_MPV17 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for JUN_MPV17 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for JUN_MPV17 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | JUN | P05412 | DB00570 | Vinblastine | Transcription factor AP-1 | small molecule | approved |
Hgene | JUN | P05412 | DB01029 | Irbesartan | Transcription factor AP-1 | small molecule | approved|investigational |
Hgene | JUN | P05412 | DB01169 | Arsenic trioxide | Transcription factor AP-1 | small molecule | approved|investigational |
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RelatedDiseases for JUN_MPV17 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | JUN | C0009375 | Colonic Neoplasms | 2 | CTD_human |
Hgene | JUN | C0023903 | Liver neoplasms | 2 | CTD_human |
Hgene | JUN | C0036341 | Schizophrenia | 2 | PSYGENET |
Hgene | JUN | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
Hgene | JUN | C0007786 | Brain Ischemia | 1 | CTD_human |
Hgene | JUN | C0018843 | Heat Stroke | 1 | CTD_human |
Hgene | JUN | C0018923 | Hemangiosarcoma | 1 | CTD_human |
Hgene | JUN | C0020538 | Hypertensive disease | 1 | CTD_human |
Hgene | JUN | C0021846 | Intestinal Polyps | 1 | CTD_human |
Hgene | JUN | C0024121 | Lung Neoplasms | 1 | CTD_human |
Hgene | JUN | C0029463 | Osteosarcoma | 1 | CTD_human |
Hgene | JUN | C0031117 | Peripheral Neuropathy | 1 | CTD_human |
Hgene | JUN | C0035126 | Reperfusion Injury | 1 | CTD_human |
Hgene | JUN | C0038220 | Status Epilepticus | 1 | CTD_human |
Hgene | JUN | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Hgene | JUN | C0546127 | Mercury Poisoning, Nervous System | 1 | CTD_human |
Hgene | JUN | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Hgene | JUN | C2239176 | Liver carcinoma | 1 | CTD_human |
Hgene | JUN | C3495559 | Juvenile arthritis | 1 | CTD_human |
Tgene | MPV17 | C1850406 | NAVAJO NEUROHEPATOPATHY | 3 | CTD_human;ORPHANET;UNIPROT |
Tgene | MPV17 | C0009197 | Cochlear Diseases | 1 | CTD_human |
Tgene | MPV17 | C0017668 | Focal glomerulosclerosis | 1 | CTD_human |
Tgene | MPV17 | C0033687 | Proteinuria | 1 | CTD_human |
Tgene | MPV17 | C0549567 | Pigmentation Disorders | 1 | CTD_human |
Tgene | MPV17 | C0751651 | Mitochondrial Diseases | 1 | CTD_human |