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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18097

FusionGeneSummary for JUN_GMPR2

check button Fusion gene summary
Fusion gene informationFusion gene name: JUN_GMPR2
Fusion gene ID: 18097
HgeneTgene
Gene symbol

JUN

GMPR2

Gene ID

3725

51292

Gene nameJun proto-oncogene, AP-1 transcription factor subunitguanosine monophosphate reductase 2
SynonymsAP-1|AP1|c-Jun|p39GMPR 2
Cytomap

1p32.1

14q12

Type of geneprotein-codingprotein-coding
Descriptiontranscription factor AP-1Jun activation domain binding proteinactivator protein 1enhancer-binding protein AP1jun oncogeneproto-oncogene c-Junv-jun avian sarcoma virus 17 oncogene homologv-jun sarcoma virus 17 oncogene homologGMP reductase 2guanosine 5'-monophosphate oxidoreductase 2guanosine monophosphate reductase isolog
Modification date2018052720180523
UniProtAcc

P05412

Q9P2T1

Ensembl transtripts involved in fusion geneENST00000371222, ENST00000355299, 
ENST00000559836, ENST00000559910, 
ENST00000399440, ENST00000420554, 
ENST00000348719, ENST00000557854, 
ENST00000559104, ENST00000456667, 
ENST00000560517, 
Fusion gene scores* DoF score4 X 4 X 1=161 X 1 X 1=1
# samples 81
** MAII scorelog2(8/16*10)=2.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(1/1*10)=3.32192809488736
Context

PubMed: JUN [Title/Abstract] AND GMPR2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneJUN

GO:0007179

transforming growth factor beta receptor signaling pathway

9732876

HgeneJUN

GO:0007265

Ras protein signal transduction

24623306

HgeneJUN

GO:0043392

negative regulation of DNA binding

14645924

HgeneJUN

GO:0043922

negative regulation by host of viral transcription

2833704

HgeneJUN

GO:0043923

positive regulation by host of viral transcription

2833704

HgeneJUN

GO:0045892

negative regulation of transcription, DNA-templated

2833704

HgeneJUN

GO:0045893

positive regulation of transcription, DNA-templated

2833704|9732876

HgeneJUN

GO:0045944

positive regulation of transcription by RNA polymerase II

2833704|10508860|12490281

HgeneJUN

GO:0060395

SMAD protein signal transduction

9732876

HgeneJUN

GO:2000144

positive regulation of DNA-templated transcription, initiation

23027619

TgeneGMPR2

GO:0046037

GMP metabolic process

22037469


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF916399JUNchr1

59247923

-GMPR2chr14

24708184

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000371222ENST00000355299JUNchr1

59247923

-GMPR2chr14

24708184

+
intron-3UTRENST00000371222ENST00000559836JUNchr1

59247923

-GMPR2chr14

24708184

+
intron-3UTRENST00000371222ENST00000559910JUNchr1

59247923

-GMPR2chr14

24708184

+
intron-3UTRENST00000371222ENST00000399440JUNchr1

59247923

-GMPR2chr14

24708184

+
intron-3UTRENST00000371222ENST00000420554JUNchr1

59247923

-GMPR2chr14

24708184

+
intron-3UTRENST00000371222ENST00000348719JUNchr1

59247923

-GMPR2chr14

24708184

+
intron-3UTRENST00000371222ENST00000557854JUNchr1

59247923

-GMPR2chr14

24708184

+
intron-3UTRENST00000371222ENST00000559104JUNchr1

59247923

-GMPR2chr14

24708184

+
intron-3UTRENST00000371222ENST00000456667JUNchr1

59247923

-GMPR2chr14

24708184

+
intron-intronENST00000371222ENST00000560517JUNchr1

59247923

-GMPR2chr14

24708184

+

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FusionProtFeatures for JUN_GMPR2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
JUN

P05412

GMPR2

Q9P2T1

Transcription factor that recognizes and binds to theenhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity ofNR5A1 when phosphorylated by HIPK3 leading to increasedsteroidogenic gene expression upon cAMP signaling pathwaystimulation. Involved in activated KRAS-mediated transcriptionalactivation of USP28 in colorectal cancer (CRC) cells(PubMed:24623306). Binds to the USP28 promoter in colorectalcancer (CRC) cells (PubMed:24623306).{ECO:0000269|PubMed:10995748, ECO:0000269|PubMed:17210646,ECO:0000269|PubMed:24623306}. Catalyzes the irreversible NADPH-dependent deaminationof GMP to IMP. It functions in the conversion of nucleobase,nucleoside and nucleotide derivatives of G to A nucleotides, andin maintaining the intracellular balance of A and G nucleotides(PubMed:12009299, PubMed:12669231, PubMed:16359702,PubMed:22037469). Plays a role in modulating cellulardifferentiation (PubMed:12669231). {ECO:0000255|HAMAP-Rule:MF_03195, ECO:0000269|PubMed:12009299,ECO:0000269|PubMed:12669231, ECO:0000269|PubMed:16359702,ECO:0000269|PubMed:22037469}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for JUN_GMPR2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for JUN_GMPR2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for JUN_GMPR2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneJUNP05412DB00570VinblastineTranscription factor AP-1small moleculeapproved
HgeneJUNP05412DB01029IrbesartanTranscription factor AP-1small moleculeapproved|investigational
HgeneJUNP05412DB01169Arsenic trioxideTranscription factor AP-1small moleculeapproved|investigational

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RelatedDiseases for JUN_GMPR2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneJUNC0009375Colonic Neoplasms2CTD_human
HgeneJUNC0023903Liver neoplasms2CTD_human
HgeneJUNC0036341Schizophrenia2PSYGENET
HgeneJUNC0007621Neoplastic Cell Transformation1CTD_human
HgeneJUNC0007786Brain Ischemia1CTD_human
HgeneJUNC0018843Heat Stroke1CTD_human
HgeneJUNC0018923Hemangiosarcoma1CTD_human
HgeneJUNC0020538Hypertensive disease1CTD_human
HgeneJUNC0021846Intestinal Polyps1CTD_human
HgeneJUNC0024121Lung Neoplasms1CTD_human
HgeneJUNC0029463Osteosarcoma1CTD_human
HgeneJUNC0031117Peripheral Neuropathy1CTD_human
HgeneJUNC0035126Reperfusion Injury1CTD_human
HgeneJUNC0038220Status Epilepticus1CTD_human
HgeneJUNC0038356Stomach Neoplasms1CTD_human
HgeneJUNC0546127Mercury Poisoning, Nervous System1CTD_human
HgeneJUNC1458155Mammary Neoplasms1CTD_human
HgeneJUNC2239176Liver carcinoma1CTD_human
HgeneJUNC3495559Juvenile arthritis1CTD_human
TgeneGMPR2C0001418Adenocarcinoma1CTD_human
TgeneGMPR2C0038356Stomach Neoplasms1CTD_human