![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 1808 |
FusionGeneSummary for ANKRD17_SQRDL |
![]() |
Fusion gene information | Fusion gene name: ANKRD17_SQRDL | Fusion gene ID: 1808 | Hgene | Tgene | Gene symbol | ANKRD17 | SQRDL | Gene ID | 26057 |
Gene name | ankyrin repeat domain 17 | ||
Synonyms | GTAR|MASK2|NY-BR-16 | ||
Cytomap | 4q13.3 | ||
Type of gene | protein-coding | ||
Description | ankyrin repeat domain-containing protein 17gene trap ankyrin repeat proteinserologically defined breast cancer antigen NY-BR-16 | ||
Modification date | 20180523 | ||
UniProtAcc | O75179 | ||
Ensembl transtripts involved in fusion gene | ENST00000358602, ENST00000509867, ENST00000330838, ENST00000514252, | ENST00000568606, ENST00000260324, | |
Fusion gene scores | * DoF score | 8 X 13 X 4=416 | 4 X 3 X 4=48 |
# samples | 17 | 4 | |
** MAII score | log2(17/416*10)=-1.29104878200339 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ANKRD17 [Title/Abstract] AND SQRDL [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ANKRD17 | GO:0042742 | defense response to bacterium | 23711367 |
Hgene | ANKRD17 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 22328336 |
Hgene | ANKRD17 | GO:0045087 | innate immune response | 23711367 |
Hgene | ANKRD17 | GO:1900245 | positive regulation of MDA-5 signaling pathway | 22328336 |
Hgene | ANKRD17 | GO:1900246 | positive regulation of RIG-I signaling pathway | 22328336 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUAD | TCGA-78-7539-01A | ANKRD17 | chr4 | 74123993 | - | SQRDL | chr15 | 45951105 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000358602 | ENST00000568606 | ANKRD17 | chr4 | 74123993 | - | SQRDL | chr15 | 45951105 | + |
5CDS-5UTR | ENST00000358602 | ENST00000260324 | ANKRD17 | chr4 | 74123993 | - | SQRDL | chr15 | 45951105 | + |
intron-5UTR | ENST00000509867 | ENST00000568606 | ANKRD17 | chr4 | 74123993 | - | SQRDL | chr15 | 45951105 | + |
intron-5UTR | ENST00000509867 | ENST00000260324 | ANKRD17 | chr4 | 74123993 | - | SQRDL | chr15 | 45951105 | + |
5CDS-5UTR | ENST00000330838 | ENST00000568606 | ANKRD17 | chr4 | 74123993 | - | SQRDL | chr15 | 45951105 | + |
5CDS-5UTR | ENST00000330838 | ENST00000260324 | ANKRD17 | chr4 | 74123993 | - | SQRDL | chr15 | 45951105 | + |
intron-5UTR | ENST00000514252 | ENST00000568606 | ANKRD17 | chr4 | 74123993 | - | SQRDL | chr15 | 45951105 | + |
intron-5UTR | ENST00000514252 | ENST00000260324 | ANKRD17 | chr4 | 74123993 | - | SQRDL | chr15 | 45951105 | + |
Top |
FusionProtFeatures for ANKRD17_SQRDL |
![]() |
Hgene | Tgene |
ANKRD17 | SQRDL |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for ANKRD17_SQRDL |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for ANKRD17_SQRDL |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ANKRD17 | BAP1, APC, ITSN2, SIRT7, KIAA0368, ITGA4, ADH6, MDM2, AURKB, CDKN1A, HOXC4, MAGEA1, ZC3H3, FOSL2, SFRP4, LHX9, RBM23, MSH6, NTRK1, FGFR1OP, CAPN1, RPL10, CREB1, FOS, AKAP17A, FGF3, FGF8, STX11, TRIM41, TCEANC2, TGIF2LY, ZNF263, IRF9, CDX1, SIX2, ZNF414, TRMT2A, HOXD4 | SQRDL | MYC, SMAD2, SMAD3, NONO, MOV10, SLC25A3, SAMM50, ATF2, IQCB1, NOS2, CFTR, MYO1C, TUBG1, XRCC3, MATR3, ZWINT, NCSTN, HAUS2, FAM46A, SKI, COQ9, SLC45A2, FAM60A, CDK15 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for ANKRD17_SQRDL |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for ANKRD17_SQRDL |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |