FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 1808

FusionGeneSummary for ANKRD17_SQRDL

check button Fusion gene summary
Fusion gene informationFusion gene name: ANKRD17_SQRDL
Fusion gene ID: 1808
HgeneTgene
Gene symbol

ANKRD17

SQRDL

Gene ID

26057

Gene nameankyrin repeat domain 17
SynonymsGTAR|MASK2|NY-BR-16
Cytomap

4q13.3

Type of geneprotein-coding
Descriptionankyrin repeat domain-containing protein 17gene trap ankyrin repeat proteinserologically defined breast cancer antigen NY-BR-16
Modification date20180523
UniProtAcc

O75179

Ensembl transtripts involved in fusion geneENST00000358602, ENST00000509867, 
ENST00000330838, ENST00000514252, 
ENST00000568606, ENST00000260324, 
Fusion gene scores* DoF score8 X 13 X 4=4164 X 3 X 4=48
# samples 174
** MAII scorelog2(17/416*10)=-1.29104878200339
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANKRD17 [Title/Abstract] AND SQRDL [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneANKRD17

GO:0042742

defense response to bacterium

23711367

HgeneANKRD17

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

22328336

HgeneANKRD17

GO:0045087

innate immune response

23711367

HgeneANKRD17

GO:1900245

positive regulation of MDA-5 signaling pathway

22328336

HgeneANKRD17

GO:1900246

positive regulation of RIG-I signaling pathway

22328336


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-78-7539-01AANKRD17chr4

74123993

-SQRDLchr15

45951105

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000358602ENST00000568606ANKRD17chr4

74123993

-SQRDLchr15

45951105

+
5CDS-5UTRENST00000358602ENST00000260324ANKRD17chr4

74123993

-SQRDLchr15

45951105

+
intron-5UTRENST00000509867ENST00000568606ANKRD17chr4

74123993

-SQRDLchr15

45951105

+
intron-5UTRENST00000509867ENST00000260324ANKRD17chr4

74123993

-SQRDLchr15

45951105

+
5CDS-5UTRENST00000330838ENST00000568606ANKRD17chr4

74123993

-SQRDLchr15

45951105

+
5CDS-5UTRENST00000330838ENST00000260324ANKRD17chr4

74123993

-SQRDLchr15

45951105

+
intron-5UTRENST00000514252ENST00000568606ANKRD17chr4

74123993

-SQRDLchr15

45951105

+
intron-5UTRENST00000514252ENST00000260324ANKRD17chr4

74123993

-SQRDLchr15

45951105

+

Top

FusionProtFeatures for ANKRD17_SQRDL


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANKRD17

O75179

SQRDL

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ANKRD17_SQRDL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ANKRD17_SQRDL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ANKRD17BAP1, APC, ITSN2, SIRT7, KIAA0368, ITGA4, ADH6, MDM2, AURKB, CDKN1A, HOXC4, MAGEA1, ZC3H3, FOSL2, SFRP4, LHX9, RBM23, MSH6, NTRK1, FGFR1OP, CAPN1, RPL10, CREB1, FOS, AKAP17A, FGF3, FGF8, STX11, TRIM41, TCEANC2, TGIF2LY, ZNF263, IRF9, CDX1, SIX2, ZNF414, TRMT2A, HOXD4SQRDLMYC, SMAD2, SMAD3, NONO, MOV10, SLC25A3, SAMM50, ATF2, IQCB1, NOS2, CFTR, MYO1C, TUBG1, XRCC3, MATR3, ZWINT, NCSTN, HAUS2, FAM46A, SKI, COQ9, SLC45A2, FAM60A, CDK15


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ANKRD17_SQRDL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ANKRD17_SQRDL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource