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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18076

FusionGeneSummary for JMJD7-PLA2G4B_SPARC

check button Fusion gene summary
Fusion gene informationFusion gene name: JMJD7-PLA2G4B_SPARC
Fusion gene ID: 18076
HgeneTgene
Gene symbol

JMJD7-PLA2G4B

SPARC

Gene ID

8681

6678

Gene nameJMJD7-PLA2G4B readthroughsecreted protein acidic and cysteine rich
SynonymsHsT16992|cPLA2-betaBM-40|OI17|ON
Cytomap

15q15.1

5q33.1

Type of geneprotein-codingprotein-coding
DescriptionJMJD7-PLA2G4B proteinjumonji domain containing 7-phospholipase A2, group IVB (cytosolic) read-throughSPARCbasement-membrane protein 40secreted protein, acidic, cysteine-rich (osteonectin)
Modification date2018051920180523
UniProtAcc

P09486

Ensembl transtripts involved in fusion geneENST00000382448, ENST00000342159, 
ENST00000476036, 
ENST00000231061, 
ENST00000537849, 
Fusion gene scores* DoF score1 X 1 X 1=110 X 14 X 2=280
# samples 114
** MAII scorelog2(1/1*10)=3.32192809488736log2(14/280*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: JMJD7-PLA2G4B [Title/Abstract] AND SPARC [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSPARC

GO:0001937

negative regulation of endothelial cell proliferation

12867428

TgeneSPARC

GO:0010595

positive regulation of endothelial cell migration

12867428

TgeneSPARC

GO:0016525

negative regulation of angiogenesis

12867428

TgeneSPARC

GO:0022604

regulation of cell morphogenesis

15389586


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW469613JMJD7-PLA2G4Bchr15

42140206

-SPARCchr5

151055693

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000382448ENST00000231061JMJD7-PLA2G4Bchr15

42140206

-SPARCchr5

151055693

+
3UTR-intronENST00000382448ENST00000537849JMJD7-PLA2G4Bchr15

42140206

-SPARCchr5

151055693

+
intron-intronENST00000342159ENST00000231061JMJD7-PLA2G4Bchr15

42140206

-SPARCchr5

151055693

+
intron-intronENST00000342159ENST00000537849JMJD7-PLA2G4Bchr15

42140206

-SPARCchr5

151055693

+
intron-intronENST00000476036ENST00000231061JMJD7-PLA2G4Bchr15

42140206

-SPARCchr5

151055693

+
intron-intronENST00000476036ENST00000537849JMJD7-PLA2G4Bchr15

42140206

-SPARCchr5

151055693

+

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FusionProtFeatures for JMJD7-PLA2G4B_SPARC


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
JMJD7-PLA2G4B

SPARC

P09486

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Appears to regulate cell growth through interactionswith the extracellular matrix and cytokines. Binds calcium andcopper, several types of collagen, albumin, thrombospondin, PDGFand cell membranes. There are two calcium binding sites; an acidicdomain that binds 5 to 8 Ca(2+) with a low affinity and an EF-handloop that binds a Ca(2+) ion with a high affinity.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for JMJD7-PLA2G4B_SPARC


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for JMJD7-PLA2G4B_SPARC


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for JMJD7-PLA2G4B_SPARC


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneSPARCP09486DB11093Calcium CitrateSPARCsmall moleculeapproved
TgeneSPARCP09486DB11348Calcium PhosphateSPARCsmall moleculeapproved

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RelatedDiseases for JMJD7-PLA2G4B_SPARC


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSPARCC0023893Liver Cirrhosis, Experimental2CTD_human
TgeneSPARCC0009375Colonic Neoplasms1CTD_human
TgeneSPARCC0009404Colorectal Neoplasms1CTD_human
TgeneSPARCC0019158Hepatitis1CTD_human
TgeneSPARCC0020429Hyperalgesia1CTD_human
TgeneSPARCC0022658Kidney Diseases1CTD_human
TgeneSPARCC0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneSPARCC0023890Liver Cirrhosis1CTD_human
TgeneSPARCC0024031Low Back Pain1CTD_human
TgeneSPARCC0026764Multiple Myeloma1CTD_human
TgeneSPARCC0027540Necrosis1CTD_human
TgeneSPARCC0027659Neoplasms, Experimental1CTD_human
TgeneSPARCC0029434Osteogenesis Imperfecta1CTD_human
TgeneSPARCC0041948Uremia1CTD_human
TgeneSPARCC0043094Weight Gain1CTD_human
TgeneSPARCC0151744Myocardial Ischemia1CTD_human
TgeneSPARCC0158266Intervertebral Disc Degeneration1CTD_human
TgeneSPARCC0206686Adrenocortical carcinoma1CTD_human
TgeneSPARCC0919267ovarian neoplasm1CTD_human
TgeneSPARCC4225301OSTEOGENESIS IMPERFECTA, TYPE XVII1UNIPROT