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Fusion gene ID: 18076 |
FusionGeneSummary for JMJD7-PLA2G4B_SPARC |
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Fusion gene information | Fusion gene name: JMJD7-PLA2G4B_SPARC | Fusion gene ID: 18076 | Hgene | Tgene | Gene symbol | JMJD7-PLA2G4B | SPARC | Gene ID | 8681 | 6678 |
Gene name | JMJD7-PLA2G4B readthrough | secreted protein acidic and cysteine rich | |
Synonyms | HsT16992|cPLA2-beta | BM-40|OI17|ON | |
Cytomap | 15q15.1 | 5q33.1 | |
Type of gene | protein-coding | protein-coding | |
Description | JMJD7-PLA2G4B proteinjumonji domain containing 7-phospholipase A2, group IVB (cytosolic) read-through | SPARCbasement-membrane protein 40secreted protein, acidic, cysteine-rich (osteonectin) | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | P09486 | ||
Ensembl transtripts involved in fusion gene | ENST00000382448, ENST00000342159, ENST00000476036, | ENST00000231061, ENST00000537849, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 10 X 14 X 2=280 |
# samples | 1 | 14 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(14/280*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: JMJD7-PLA2G4B [Title/Abstract] AND SPARC [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | SPARC | GO:0001937 | negative regulation of endothelial cell proliferation | 12867428 |
Tgene | SPARC | GO:0010595 | positive regulation of endothelial cell migration | 12867428 |
Tgene | SPARC | GO:0016525 | negative regulation of angiogenesis | 12867428 |
Tgene | SPARC | GO:0022604 | regulation of cell morphogenesis | 15389586 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW469613 | JMJD7-PLA2G4B | chr15 | 42140206 | - | SPARC | chr5 | 151055693 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-intron | ENST00000382448 | ENST00000231061 | JMJD7-PLA2G4B | chr15 | 42140206 | - | SPARC | chr5 | 151055693 | + |
3UTR-intron | ENST00000382448 | ENST00000537849 | JMJD7-PLA2G4B | chr15 | 42140206 | - | SPARC | chr5 | 151055693 | + |
intron-intron | ENST00000342159 | ENST00000231061 | JMJD7-PLA2G4B | chr15 | 42140206 | - | SPARC | chr5 | 151055693 | + |
intron-intron | ENST00000342159 | ENST00000537849 | JMJD7-PLA2G4B | chr15 | 42140206 | - | SPARC | chr5 | 151055693 | + |
intron-intron | ENST00000476036 | ENST00000231061 | JMJD7-PLA2G4B | chr15 | 42140206 | - | SPARC | chr5 | 151055693 | + |
intron-intron | ENST00000476036 | ENST00000537849 | JMJD7-PLA2G4B | chr15 | 42140206 | - | SPARC | chr5 | 151055693 | + |
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FusionProtFeatures for JMJD7-PLA2G4B_SPARC |
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Hgene | Tgene |
JMJD7-PLA2G4B | SPARC |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. | Appears to regulate cell growth through interactionswith the extracellular matrix and cytokines. Binds calcium andcopper, several types of collagen, albumin, thrombospondin, PDGFand cell membranes. There are two calcium binding sites; an acidicdomain that binds 5 to 8 Ca(2+) with a low affinity and an EF-handloop that binds a Ca(2+) ion with a high affinity. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for JMJD7-PLA2G4B_SPARC |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for JMJD7-PLA2G4B_SPARC |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for JMJD7-PLA2G4B_SPARC |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | SPARC | P09486 | DB11093 | Calcium Citrate | SPARC | small molecule | approved |
Tgene | SPARC | P09486 | DB11348 | Calcium Phosphate | SPARC | small molecule | approved |
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RelatedDiseases for JMJD7-PLA2G4B_SPARC |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | SPARC | C0023893 | Liver Cirrhosis, Experimental | 2 | CTD_human |
Tgene | SPARC | C0009375 | Colonic Neoplasms | 1 | CTD_human |
Tgene | SPARC | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
Tgene | SPARC | C0019158 | Hepatitis | 1 | CTD_human |
Tgene | SPARC | C0020429 | Hyperalgesia | 1 | CTD_human |
Tgene | SPARC | C0022658 | Kidney Diseases | 1 | CTD_human |
Tgene | SPARC | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
Tgene | SPARC | C0023890 | Liver Cirrhosis | 1 | CTD_human |
Tgene | SPARC | C0024031 | Low Back Pain | 1 | CTD_human |
Tgene | SPARC | C0026764 | Multiple Myeloma | 1 | CTD_human |
Tgene | SPARC | C0027540 | Necrosis | 1 | CTD_human |
Tgene | SPARC | C0027659 | Neoplasms, Experimental | 1 | CTD_human |
Tgene | SPARC | C0029434 | Osteogenesis Imperfecta | 1 | CTD_human |
Tgene | SPARC | C0041948 | Uremia | 1 | CTD_human |
Tgene | SPARC | C0043094 | Weight Gain | 1 | CTD_human |
Tgene | SPARC | C0151744 | Myocardial Ischemia | 1 | CTD_human |
Tgene | SPARC | C0158266 | Intervertebral Disc Degeneration | 1 | CTD_human |
Tgene | SPARC | C0206686 | Adrenocortical carcinoma | 1 | CTD_human |
Tgene | SPARC | C0919267 | ovarian neoplasm | 1 | CTD_human |
Tgene | SPARC | C4225301 | OSTEOGENESIS IMPERFECTA, TYPE XVII | 1 | UNIPROT |