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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 18068

FusionGeneSummary for JMJD1C_INO80

check button Fusion gene summary
Fusion gene informationFusion gene name: JMJD1C_INO80
Fusion gene ID: 18068
HgeneTgene
Gene symbol

JMJD1C

INO80

Gene ID

221037

54617

Gene namejumonji domain containing 1CINO80 complex subunit
SynonymsKDM3C|TRIP-8|TRIP8INO80A|INOC1|hINO80
Cytomap

10q21.3

15q15.1

Type of geneprotein-codingprotein-coding
Descriptionprobable JmjC domain-containing histone demethylation protein 2CTR-interacting protein 8thyroid hormone receptor interactor 8thyroid receptor-interacting protein 8DNA helicase INO80INO80 complex subunit AINO80 homologhomolog of yeast INO80putative DNA helicase INO80 complex homolog 1
Modification date2018052320180523
UniProtAcc

Q15652

Q9ULG1

Ensembl transtripts involved in fusion geneENST00000399262, ENST00000402544, 
ENST00000399251, ENST00000542921, 
ENST00000489372, 		ENST00000361937, 
ENST00000401393, ENST00000561244, 
Fusion gene scores* DoF score13 X 8 X 6=6246 X 6 X 3=108
# samples 137
** MAII scorelog2(13/624*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/108*10)=-0.625604485218502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: JMJD1C [Title/Abstract] AND INO80 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF370837JMJD1Cchr10

65079531

+INO80chr15

41319205

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000399262ENST00000361937JMJD1Cchr10

65079531

+INO80chr15

41319205

-
intron-intronENST00000399262ENST00000401393JMJD1Cchr10

65079531

+INO80chr15

41319205

-
intron-intronENST00000399262ENST00000561244JMJD1Cchr10

65079531

+INO80chr15

41319205

-
intron-intronENST00000402544ENST00000361937JMJD1Cchr10

65079531

+INO80chr15

41319205

-
intron-intronENST00000402544ENST00000401393JMJD1Cchr10

65079531

+INO80chr15

41319205

-
intron-intronENST00000402544ENST00000561244JMJD1Cchr10

65079531

+INO80chr15

41319205

-
intron-intronENST00000399251ENST00000361937JMJD1Cchr10

65079531

+INO80chr15

41319205

-
intron-intronENST00000399251ENST00000401393JMJD1Cchr10

65079531

+INO80chr15

41319205

-
intron-intronENST00000399251ENST00000561244JMJD1Cchr10

65079531

+INO80chr15

41319205

-
intron-intronENST00000542921ENST00000361937JMJD1Cchr10

65079531

+INO80chr15

41319205

-
intron-intronENST00000542921ENST00000401393JMJD1Cchr10

65079531

+INO80chr15

41319205

-
intron-intronENST00000542921ENST00000561244JMJD1Cchr10

65079531

+INO80chr15

41319205

-
intron-intronENST00000489372ENST00000361937JMJD1Cchr10

65079531

+INO80chr15

41319205

-
intron-intronENST00000489372ENST00000401393JMJD1Cchr10

65079531

+INO80chr15

41319205

-
intron-intronENST00000489372ENST00000561244JMJD1Cchr10

65079531

+INO80chr15

41319205

-

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FusionProtFeatures for JMJD1C_INO80


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
JMJD1C

Q15652

INO80

Q9ULG1

ATPase component of the chromatin remodeling INO80complex which is involved in transcriptional regulation, DNAreplication and DNA repair (PubMed:16230350, PubMed:16298340,PubMed:17721549, PubMed:20855601, PubMed:20237820). Binds DNA(PubMed:16298340, PubMed:21303910). As part of the INO80 complex,remodels chromatin by shifting nucleosomes (PubMed:16230350,PubMed:21303910). Regulates transcription upon recruitment by YY1to YY1-activated genes, where it acts as an essential coactivator(PubMed:17721549). Involved in UV-damage excision DNA repair(PubMed:20855601). The contribution to DNA double-strand breakrepair appears to be largely indirect through transcriptionalregulation (PubMed:20687897). Involved in DNA replication(PubMed:20237820). Required for microtubule assembly duringmitosis thereby regulating chromosome segregation cycle(PubMed:20237820). {ECO:0000269|PubMed:16230350,ECO:0000269|PubMed:16298340, ECO:0000269|PubMed:17721549,ECO:0000269|PubMed:20237820, ECO:0000269|PubMed:20687897,ECO:0000269|PubMed:20855601, ECO:0000269|PubMed:21303910}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for JMJD1C_INO80


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for JMJD1C_INO80


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for JMJD1C_INO80


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for JMJD1C_INO80


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneJMJD1CC0004352Autistic Disorder1CTD_human
HgeneJMJD1CC0010606Adenoid Cystic Carcinoma1CTD_human
HgeneJMJD1CC3495559Juvenile arthritis1CTD_human