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Fusion gene ID: 18059 |
FusionGeneSummary for JHDM1D_BRAF |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: JHDM1D_BRAF | Fusion gene ID: 18059 | Hgene | Tgene | Gene symbol | JHDM1D | BRAF | Gene ID | 80853 | 673 |
| Gene name | lysine demethylase 7A | B-Raf proto-oncogene, serine/threonine kinase | |
| Synonyms | JHDM1D | B-RAF1|B-raf|BRAF1|NS7|RAFB1 | |
| Cytomap | 7q34 | 7q34 | |
| Type of gene | protein-coding | protein-coding | |
| Description | lysine-specific demethylase 7Ahistone lysine demethylase JHDM1DjmjC domain-containing histone demethylation protein 1Djumonji C domain containing histone demethylase 1 homolog Dlysine (K)-specific demethylase 7Alysine-specific demethylase 7 | serine/threonine-protein kinase B-raf94 kDa B-raf proteinB-Raf proto-oncogene serine/threonine-protein kinase (p94)B-Raf serine/threonine-proteinmurine sarcoma viral (v-raf) oncogene homolog B1proto-oncogene B-Rafv-raf murine sarcoma viral oncogene | |
| Modification date | 20180331 | 20180527 | |
| UniProtAcc | P15056 | ||
| Ensembl transtripts involved in fusion gene | ENST00000397560, ENST00000006967, | ENST00000288602, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 24 X 11 X 10=2640 |
| # samples | 3 | 35 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(35/2640*10)=-2.91511110241349 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: JHDM1D [Title/Abstract] AND BRAF [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | JHDM1D | GO:0033169 | histone H3-K9 demethylation | 20023638|20194436|20622853 |
| Hgene | JHDM1D | GO:0035574 | histone H4-K20 demethylation | 20622853 |
| Hgene | JHDM1D | GO:0070544 | histone H3-K36 demethylation | 20622853 |
| Hgene | JHDM1D | GO:0071557 | histone H3-K27 demethylation | 20023638|20194436|20622853 |
| Tgene | BRAF | GO:0006468 | protein phosphorylation | 17563371 |
| Tgene | BRAF | GO:0010828 | positive regulation of glucose transmembrane transport | 23010278 |
| Tgene | BRAF | GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 19667065 |
| Tgene | BRAF | GO:0043066 | negative regulation of apoptotic process | 19667065 |
| Tgene | BRAF | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 22065586 |
| Tgene | BRAF | GO:0071277 | cellular response to calcium ion | 18567582 |
| Tgene | BRAF | GO:0090150 | establishment of protein localization to membrane | 23010278 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-CH-5737-01A | JHDM1D | chr7 | 139810895 | - | BRAF | chr7 | 140481493 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000397560 | ENST00000288602 | JHDM1D | chr7 | 139810895 | - | BRAF | chr7 | 140481493 | - |
| In-frame | ENST00000006967 | ENST00000288602 | JHDM1D | chr7 | 139810895 | - | BRAF | chr7 | 140481493 | - |
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FusionProtFeatures for JHDM1D_BRAF |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| JHDM1D | BRAF |
| Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >BRAF | chr7:139810895 | chr7:140481493 | ENST00000288602 | - | 9 | 18 | 457_717 | 438 | 767 | Domain | Protein kinase |
| Tgene | >BRAF | chr7:139810895 | chr7:140481493 | ENST00000288602 | - | 9 | 18 | 463_471 | 438 | 767 | Nucleotide binding | ATP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | BRAF | chr7:139810895 | chr7:140481493 | ENST00000288602 | - | 9 | 18 | 122_129 | 438 | 767 | Compositional bias | Note=Poly-Ser |
| Tgene | BRAF | chr7:139810895 | chr7:140481493 | ENST00000288602 | - | 9 | 18 | 428_432 | 438 | 767 | Compositional bias | Note=Poly-Ser |
| Tgene | BRAF | chr7:139810895 | chr7:140481493 | ENST00000288602 | - | 9 | 18 | 6_11 | 438 | 767 | Compositional bias | Note=Poly-Gly |
| Tgene | BRAF | chr7:139810895 | chr7:140481493 | ENST00000288602 | - | 9 | 18 | 155_227 | 438 | 767 | Domain | RBD |
| Tgene | BRAF | chr7:139810895 | chr7:140481493 | ENST00000288602 | - | 9 | 18 | 234_280 | 438 | 767 | Zinc finger | Phorbol-ester/DAG-type |
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FusionGeneSequence for JHDM1D_BRAF |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_JHDM1D_ENST00000397560_chr7_139810895_-_BRAF_ENST00000288602_chr7_140481493_-_805aa MAGAAAAVAAGAAAGAAAAAVSVAAPGRASAPPPPPPVYCVCRQPYDVNRFMIECDICKDWFHGSCVGVEEHHAVDIDLYHCPNCAVLHG SSLMKKRRNWHRHDYTEIDDGSKPVQAGTRTFIKELRSRVFPSADEIIIKMHGSQLTQRYLEKHGFDVPIMVPKLDDLGLRLPSPTFSVM DVERYVGGDKVIDVIDVARQADSKMTLHNYVKYFMNPNRPKVLNVISLEFSDTKMSELVEVPDIAKKLSWVENYWPDDSVFPKPFVQKYC LMGVQDSYTDFHIDFGGTSVWYHVLWGEKIFYLIKPTDENLARYESWSSSVTQSEVFFGDKVDKCYKCVVKQGHTLFVPTGWIHAVLTSQ DCMAFGGNFLHNLNIGMQLRCYEMEKRLKTPDLFKFPFFEAICWFVAKNLLETLKELREDGFQPQTYLVQGVKALHTALKLWMKKELVSE HAFEIPDNVRPGHLIKELSKVIRAIEKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEV GVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKI GDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVR >In-frame_JHDM1D_ENST00000006967_chr7_139810895_-_BRAF_ENST00000288602_chr7_140481493_-_805aa MAGAAAAVAAGAAAGAAAAAVSVAAPGRASAPPPPPPVYCVCRQPYDVNRFMIECDICKDWFHGSCVGVEEHHAVDIDLYHCPNCAVLHG SSLMKKRRNWHRHDYTEIDDGSKPVQAGTRTFIKELRSRVFPSADEIIIKMHGSQLTQRYLEKHGFDVPIMVPKLDDLGLRLPSPTFSVM DVERYVGGDKVIDVIDVARQADSKMTLHNYVKYFMNPNRPKVLNVISLEFSDTKMSELVEVPDIAKKLSWVENYWPDDSVFPKPFVQKYC LMGVQDSYTDFHIDFGGTSVWYHVLWGEKIFYLIKPTDENLARYESWSSSVTQSEVFFGDKVDKCYKCVVKQGHTLFVPTGWIHAVLTSQ DCMAFGGNFLHNLNIGMQLRCYEMEKRLKTPDLFKFPFFEAICWFVAKNLLETLKELREDGFQPQTYLVQGVKALHTALKLWMKKELVSE HAFEIPDNVRPGHLIKELSKVIRAIEKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEV GVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKI GDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVR |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_JHDM1D_ENST00000397560_chr7_139810895_-_BRAF_ENST00000288602_chr7_140481493_-_2415nt ATGGCCGGAGCGGCGGCGGCGGTGGCCGCGGGAGCAGCAGCTGGAGCCGCCGCGGCAGCCGTGTCGGTGGCGGCTCCCGGCCGGGCCTCG GCGCCTCCGCCGCCCCCGCCCGTGTACTGTGTGTGCCGGCAGCCGTACGACGTGAACCGCTTCATGATCGAGTGCGATATCTGCAAGGAC TGGTTCCACGGCAGCTGTGTTGGAGTAGAAGAACATCATGCTGTTGACATTGACCTGTATCACTGTCCCAACTGTGCAGTTTTACATGGT TCCTCCTTGATGAAAAAAAGGAGGAACTGGCACAGACATGACTACACAGAAATTGATGATGGTTCCAAACCAGTGCAAGCTGGAACTAGA ACTTTCATTAAGGAATTACGCTCTCGAGTCTTCCCAAGTGCCGATGAAATAATTATAAAGATGCATGGCAGCCAGCTGACACAAAGATAT CTGGAGAAACATGGATTTGATGTCCCTATTATGGTCCCAAAATTAGATGATCTAGGACTCAGGCTCCCTTCACCTACATTTTCTGTGATG GATGTGGAACGTTATGTAGGTGGTGACAAAGTGATAGATGTCATTGATGTGGCGAGGCAGGCAGACAGCAAAATGACACTTCACAATTAT GTTAAATACTTCATGAATCCTAACAGACCAAAAGTGTTAAATGTGATCAGCCTTGAATTTTCAGATACAAAGATGTCTGAATTGGTGGAG GTCCCTGATATAGCCAAAAAACTTTCCTGGGTGGAAAATTATTGGCCAGATGATTCAGTCTTTCCCAAGCCATTTGTTCAGAAATATTGC TTAATGGGAGTTCAAGACAGCTATACAGATTTCCACATTGACTTCGGTGGAACTTCAGTCTGGTACCATGTCCTCTGGGGTGAGAAGATT TTTTATTTAATAAAGCCAACAGATGAAAATTTGGCACGTTATGAATCTTGGAGTTCATCTGTGACCCAGAGTGAGGTGTTCTTTGGAGAT AAGGTGGATAAATGCTACAAATGTGTGGTAAAGCAGGGACATACCTTATTTGTTCCTACAGGGTGGATCCATGCTGTGCTCACTTCTCAG GACTGTATGGCTTTTGGGGGGAACTTCCTGCACAACCTTAACATTGGCATGCAGCTCAGGTGTTATGAGATGGAGAAAAGGCTAAAAACA CCAGATCTTTTCAAATTCCCTTTCTTTGAAGCCATATGTTGGTTTGTAGCCAAAAACTTGCTGGAAACCCTGAAAGAACTGAGAGAAGAT GGTTTCCAGCCTCAAACTTACCTAGTACAGGGAGTGAAAGCACTGCATACTGCTTTAAAATTATGGATGAAAAAAGAACTTGTATCTGAA CATGCCTTTGAAATTCCAGACAATGTTAGACCTGGACACCTTATTAAAGAACTTTCTAAAGTAATTCGAGCAATAGAGAAAACACTTGGT AGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGATCATTTGGAACAGTCTAC AAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAAGCCTTCAAAAATGAAGTA GGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCTATTGTTACCCAGTGGTGT GAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATTGCACGACAGACTGCACAG GGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAAGACCTCACAGTAAAAATA GGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCCATTTTGTGGATGGCACCA GAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTGTATGAATTGATGACTGGA CAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCAGATCTCAGTAAGGTACGG AGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCCCAAATTCTCGCC TCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTCCAAACAGAGGAT >In-frame_JHDM1D_ENST00000006967_chr7_139810895_-_BRAF_ENST00000288602_chr7_140481493_-_2415nt ATGGCCGGAGCGGCGGCGGCGGTGGCCGCGGGAGCAGCAGCTGGAGCCGCCGCGGCAGCCGTGTCGGTGGCGGCTCCCGGCCGGGCCTCG GCGCCTCCGCCGCCCCCGCCCGTGTACTGTGTGTGCCGGCAGCCGTACGACGTGAACCGCTTCATGATCGAGTGCGATATCTGCAAGGAC TGGTTCCACGGCAGCTGTGTTGGAGTAGAAGAACATCATGCTGTTGACATTGACCTGTATCACTGTCCCAACTGTGCAGTTTTACATGGT TCCTCCTTGATGAAAAAAAGGAGGAACTGGCACAGACATGACTACACAGAAATTGATGATGGTTCCAAACCAGTGCAAGCTGGAACTAGA ACTTTCATTAAGGAATTACGCTCTCGAGTCTTCCCAAGTGCCGATGAAATAATTATAAAGATGCATGGCAGCCAGCTGACACAAAGATAT CTGGAGAAACATGGATTTGATGTCCCTATTATGGTCCCAAAATTAGATGATCTAGGACTCAGGCTCCCTTCACCTACATTTTCTGTGATG GATGTGGAACGTTATGTAGGTGGTGACAAAGTGATAGATGTCATTGATGTGGCGAGGCAGGCAGACAGCAAAATGACACTTCACAATTAT GTTAAATACTTCATGAATCCTAACAGACCAAAAGTGTTAAATGTGATCAGCCTTGAATTTTCAGATACAAAGATGTCTGAATTGGTGGAG GTCCCTGATATAGCCAAAAAACTTTCCTGGGTGGAAAATTATTGGCCAGATGATTCAGTCTTTCCCAAGCCATTTGTTCAGAAATATTGC TTAATGGGAGTTCAAGACAGCTATACAGATTTCCACATTGACTTCGGTGGAACTTCAGTCTGGTACCATGTCCTCTGGGGTGAGAAGATT TTTTATTTAATAAAGCCAACAGATGAAAATTTGGCACGTTATGAATCTTGGAGTTCATCTGTGACCCAGAGTGAGGTGTTCTTTGGAGAT AAGGTGGATAAATGCTACAAATGTGTGGTAAAGCAGGGACATACCTTATTTGTTCCTACAGGGTGGATCCATGCTGTGCTCACTTCTCAG GACTGTATGGCTTTTGGGGGGAACTTCCTGCACAACCTTAACATTGGCATGCAGCTCAGGTGTTATGAGATGGAGAAAAGGCTAAAAACA CCAGATCTTTTCAAATTCCCTTTCTTTGAAGCCATATGTTGGTTTGTAGCCAAAAACTTGCTGGAAACCCTGAAAGAACTGAGAGAAGAT GGTTTCCAGCCTCAAACTTACCTAGTACAGGGAGTGAAAGCACTGCATACTGCTTTAAAATTATGGATGAAAAAAGAACTTGTATCTGAA CATGCCTTTGAAATTCCAGACAATGTTAGACCTGGACACCTTATTAAAGAACTTTCTAAAGTAATTCGAGCAATAGAGAAAACACTTGGT AGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGATCATTTGGAACAGTCTAC AAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAAGCCTTCAAAAATGAAGTA GGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCTATTGTTACCCAGTGGTGT GAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATTGCACGACAGACTGCACAG GGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAAGACCTCACAGTAAAAATA GGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCCATTTTGTGGATGGCACCA GAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTGTATGAATTGATGACTGGA CAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCAGATCTCAGTAAGGTACGG AGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCCCAAATTCTCGCC TCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTCCAAACAGAGGAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_JHDM1D_ENST00000397560_chr7_139810895_-_BRAF_ENST00000288602_chr7_140481493_-_2631nt GCCGCCGCGGCTGCTGCAGGAGGCGGCGCTGGCTGGCGGCTGCGCTCGCTCCAGTCGGCGAGCGGAGTAGCGAGCGAGCGTGTGTGTGTT TTTTAAAGATGGCCGGAGCGGCGGCGGCGGTGGCCGCGGGAGCAGCAGCTGGAGCCGCCGCGGCAGCCGTGTCGGTGGCGGCTCCCGGCC GGGCCTCGGCGCCTCCGCCGCCCCCGCCCGTGTACTGTGTGTGCCGGCAGCCGTACGACGTGAACCGCTTCATGATCGAGTGCGATATCT GCAAGGACTGGTTCCACGGCAGCTGTGTTGGAGTAGAAGAACATCATGCTGTTGACATTGACCTGTATCACTGTCCCAACTGTGCAGTTT TACATGGTTCCTCCTTGATGAAAAAAAGGAGGAACTGGCACAGACATGACTACACAGAAATTGATGATGGTTCCAAACCAGTGCAAGCTG GAACTAGAACTTTCATTAAGGAATTACGCTCTCGAGTCTTCCCAAGTGCCGATGAAATAATTATAAAGATGCATGGCAGCCAGCTGACAC AAAGATATCTGGAGAAACATGGATTTGATGTCCCTATTATGGTCCCAAAATTAGATGATCTAGGACTCAGGCTCCCTTCACCTACATTTT CTGTGATGGATGTGGAACGTTATGTAGGTGGTGACAAAGTGATAGATGTCATTGATGTGGCGAGGCAGGCAGACAGCAAAATGACACTTC ACAATTATGTTAAATACTTCATGAATCCTAACAGACCAAAAGTGTTAAATGTGATCAGCCTTGAATTTTCAGATACAAAGATGTCTGAAT TGGTGGAGGTCCCTGATATAGCCAAAAAACTTTCCTGGGTGGAAAATTATTGGCCAGATGATTCAGTCTTTCCCAAGCCATTTGTTCAGA AATATTGCTTAATGGGAGTTCAAGACAGCTATACAGATTTCCACATTGACTTCGGTGGAACTTCAGTCTGGTACCATGTCCTCTGGGGTG AGAAGATTTTTTATTTAATAAAGCCAACAGATGAAAATTTGGCACGTTATGAATCTTGGAGTTCATCTGTGACCCAGAGTGAGGTGTTCT TTGGAGATAAGGTGGATAAATGCTACAAATGTGTGGTAAAGCAGGGACATACCTTATTTGTTCCTACAGGGTGGATCCATGCTGTGCTCA CTTCTCAGGACTGTATGGCTTTTGGGGGGAACTTCCTGCACAACCTTAACATTGGCATGCAGCTCAGGTGTTATGAGATGGAGAAAAGGC TAAAAACACCAGATCTTTTCAAATTCCCTTTCTTTGAAGCCATATGTTGGTTTGTAGCCAAAAACTTGCTGGAAACCCTGAAAGAACTGA GAGAAGATGGTTTCCAGCCTCAAACTTACCTAGTACAGGGAGTGAAAGCACTGCATACTGCTTTAAAATTATGGATGAAAAAAGAACTTG TATCTGAACATGCCTTTGAAATTCCAGACAATGTTAGACCTGGACACCTTATTAAAGAACTTTCTAAAGTAATTCGAGCAATAGAGAAAA CACTTGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGATCATTTGGAA CAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAAGCCTTCAAAA ATGAAGTAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCTATTGTTACCC AGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATTGCACGACAGA CTGCACAGGGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAAGACCTCACAG TAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCCATTTTGTGGA TGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTGTATGAATTGA TGACTGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCAGATCTCAGTA AGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCCCAAA TTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTCCAAA CAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGATATGGTGCGTTTCCTGTCCACTGAAACAAAT GAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACATATGTTTGCTTATATGTTAAATTGAATAAAATACTCTCTTTT >In-frame_JHDM1D_ENST00000006967_chr7_139810895_-_BRAF_ENST00000288602_chr7_140481493_-_2537nt AAAGATGGCCGGAGCGGCGGCGGCGGTGGCCGCGGGAGCAGCAGCTGGAGCCGCCGCGGCAGCCGTGTCGGTGGCGGCTCCCGGCCGGGC CTCGGCGCCTCCGCCGCCCCCGCCCGTGTACTGTGTGTGCCGGCAGCCGTACGACGTGAACCGCTTCATGATCGAGTGCGATATCTGCAA GGACTGGTTCCACGGCAGCTGTGTTGGAGTAGAAGAACATCATGCTGTTGACATTGACCTGTATCACTGTCCCAACTGTGCAGTTTTACA TGGTTCCTCCTTGATGAAAAAAAGGAGGAACTGGCACAGACATGACTACACAGAAATTGATGATGGTTCCAAACCAGTGCAAGCTGGAAC TAGAACTTTCATTAAGGAATTACGCTCTCGAGTCTTCCCAAGTGCCGATGAAATAATTATAAAGATGCATGGCAGCCAGCTGACACAAAG ATATCTGGAGAAACATGGATTTGATGTCCCTATTATGGTCCCAAAATTAGATGATCTAGGACTCAGGCTCCCTTCACCTACATTTTCTGT GATGGATGTGGAACGTTATGTAGGTGGTGACAAAGTGATAGATGTCATTGATGTGGCGAGGCAGGCAGACAGCAAAATGACACTTCACAA TTATGTTAAATACTTCATGAATCCTAACAGACCAAAAGTGTTAAATGTGATCAGCCTTGAATTTTCAGATACAAAGATGTCTGAATTGGT GGAGGTCCCTGATATAGCCAAAAAACTTTCCTGGGTGGAAAATTATTGGCCAGATGATTCAGTCTTTCCCAAGCCATTTGTTCAGAAATA TTGCTTAATGGGAGTTCAAGACAGCTATACAGATTTCCACATTGACTTCGGTGGAACTTCAGTCTGGTACCATGTCCTCTGGGGTGAGAA GATTTTTTATTTAATAAAGCCAACAGATGAAAATTTGGCACGTTATGAATCTTGGAGTTCATCTGTGACCCAGAGTGAGGTGTTCTTTGG AGATAAGGTGGATAAATGCTACAAATGTGTGGTAAAGCAGGGACATACCTTATTTGTTCCTACAGGGTGGATCCATGCTGTGCTCACTTC TCAGGACTGTATGGCTTTTGGGGGGAACTTCCTGCACAACCTTAACATTGGCATGCAGCTCAGGTGTTATGAGATGGAGAAAAGGCTAAA AACACCAGATCTTTTCAAATTCCCTTTCTTTGAAGCCATATGTTGGTTTGTAGCCAAAAACTTGCTGGAAACCCTGAAAGAACTGAGAGA AGATGGTTTCCAGCCTCAAACTTACCTAGTACAGGGAGTGAAAGCACTGCATACTGCTTTAAAATTATGGATGAAAAAAGAACTTGTATC TGAACATGCCTTTGAAATTCCAGACAATGTTAGACCTGGACACCTTATTAAAGAACTTTCTAAAGTAATTCGAGCAATAGAGAAAACACT TGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGATCATTTGGAACAGT CTACAAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAAGCCTTCAAAAATGA AGTAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCTATTGTTACCCAGTG GTGTGAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATTGCACGACAGACTGC ACAGGGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAAGACCTCACAGTAAA AATAGGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCCATTTTGTGGATGGC ACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTGTATGAATTGATGAC TGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCAGATCTCAGTAAGGT ACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCCCAAATTCT CGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTCCAAACAGA GGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGATATGGTGCGTTTCCTGTCCACTGAAACAAATGAGT GAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACATATGTTTGCTTATATGTTAAATTGAATAAAATACTCTCTTTTTTTT |
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FusionGenePPI for JHDM1D_BRAF |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| JHDM1D | BRAF | YWHAB, YWHAG, YWHAQ, YWHAZ, SFN, HRAS, AKT1, MAPK3, RAP1GAP, RAF1, MRAS, RAP1A, PAK2, TERF1, CCDC88A, NEDD4L, MAP2K1, RNF149, KSR1, BRAP, PRKCE, RPS6KB2, HSP90AA1, BRAF, YWHAE, HSPA5, MAP2K2, HSPA1A, HSPA8, YWHAH, HSPA9, ARAF, CDC37, HSP90AB1, PHKB, LIMK1, IQGAP1, MAPK1, BAD, LIPF, MUS81, FBXW7, FGFR2, BRCA2, VHL, FNTA, HDAC2, PIK3CA, EGFR, PTEN, FNIP1, FNIP2, RAB3GAP1, KRAS, KIAA0141, FKBPL, ARMCX3, KCNC4, RPTOR, CYLD, NRAS |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for JHDM1D_BRAF |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Tgene | BRAF | P15056 | DB08881 | Vemurafenib | Serine/threonine-protein kinase B-raf | small molecule | approved |
| Tgene | BRAF | P15056 | DB08896 | Regorafenib | Serine/threonine-protein kinase B-raf | small molecule | approved |
| Tgene | BRAF | P15056 | DB00398 | Sorafenib | Serine/threonine-protein kinase B-raf | small molecule | approved|investigational |
| Tgene | BRAF | P15056 | DB08912 | Dabrafenib | Serine/threonine-protein kinase B-raf | small molecule | approved|investigational |
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RelatedDiseases for JHDM1D_BRAF |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | BRAF | C0025202 | melanoma | 21 | CTD_human |
| Tgene | BRAF | C1527249 | Colorectal Cancer | 8 | UNIPROT |
| Tgene | BRAF | C1275081 | Cardio-facio-cutaneous syndrome | 6 | CTD_human;ORPHANET;UNIPROT |
| Tgene | BRAF | C0009404 | Colorectal Neoplasms | 4 | CTD_human |
| Tgene | BRAF | C0040136 | Thyroid Neoplasm | 4 | CTD_human |
| Tgene | BRAF | C0024305 | Lymphoma, Non-Hodgkin | 3 | UNIPROT |
| Tgene | BRAF | C0684249 | Carcinoma of lung | 3 | UNIPROT |
| Tgene | BRAF | C3150970 | NOONAN SYNDROME 7 | 3 | CTD_human;UNIPROT |
| Tgene | BRAF | C0152013 | Adenocarcinoma of lung (disorder) | 2 | CTD_human |
| Tgene | BRAF | C0002448 | Ameloblastoma | 1 | CTD_human |
| Tgene | BRAF | C0004114 | Astrocytoma | 1 | CTD_human |
| Tgene | BRAF | C0010276 | Craniopharyngioma | 1 | CTD_human;ORPHANET |
| Tgene | BRAF | C0017638 | Glioma | 1 | CTD_human |
| Tgene | BRAF | C0022665 | Kidney Neoplasm | 1 | CTD_human |
| Tgene | BRAF | C0023903 | Liver neoplasms | 1 | CTD_human |
| Tgene | BRAF | C0024694 | Mandibular Neoplasms | 1 | CTD_human |
| Tgene | BRAF | C0028326 | Noonan Syndrome | 1 | CTD_human;ORPHANET |
| Tgene | BRAF | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | BRAF | C0036920 | Sezary Syndrome | 1 | CTD_human |
| Tgene | BRAF | C0079773 | Lymphoma, T-Cell, Cutaneous | 1 | CTD_human |
| Tgene | BRAF | C0206686 | Adrenocortical carcinoma | 1 | CTD_human |
| Tgene | BRAF | C0206754 | Neuroendocrine Tumors | 1 | CTD_human |
| Tgene | BRAF | C0238463 | Papillary thyroid carcinoma | 1 | CTD_human;ORPHANET |
| Tgene | BRAF | C0587248 | Costello syndrome (disorder) | 1 | CTD_human |
| Tgene | BRAF | C0596263 | Carcinogenesis | 1 | CTD_human |
| Tgene | BRAF | C0920269 | Microsatellite Instability | 1 | CTD_human |
| Tgene | BRAF | C2239176 | Liver carcinoma | 1 | CTD_human |
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