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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 18059

FusionGeneSummary for JHDM1D_BRAF

check button Fusion gene summary
Fusion gene informationFusion gene name: JHDM1D_BRAF
Fusion gene ID: 18059
HgeneTgene
Gene symbol

JHDM1D

BRAF

Gene ID

80853

673

Gene namelysine demethylase 7AB-Raf proto-oncogene, serine/threonine kinase
SynonymsJHDM1DB-RAF1|B-raf|BRAF1|NS7|RAFB1
Cytomap

7q34

7q34

Type of geneprotein-codingprotein-coding
Descriptionlysine-specific demethylase 7Ahistone lysine demethylase JHDM1DjmjC domain-containing histone demethylation protein 1Djumonji C domain containing histone demethylase 1 homolog Dlysine (K)-specific demethylase 7Alysine-specific demethylase 7serine/threonine-protein kinase B-raf94 kDa B-raf proteinB-Raf proto-oncogene serine/threonine-protein kinase (p94)B-Raf serine/threonine-proteinmurine sarcoma viral (v-raf) oncogene homolog B1proto-oncogene B-Rafv-raf murine sarcoma viral oncogene
Modification date2018033120180527
UniProtAcc

P15056

Ensembl transtripts involved in fusion geneENST00000397560, ENST00000006967, 
ENST00000288602, 
Fusion gene scores* DoF score3 X 3 X 2=1824 X 11 X 10=2640
# samples 335
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(35/2640*10)=-2.91511110241349
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: JHDM1D [Title/Abstract] AND BRAF [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Kinase involved fusion gene, inframe and retained kinase domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneJHDM1D

GO:0033169

histone H3-K9 demethylation

20023638|20194436|20622853

HgeneJHDM1D

GO:0035574

histone H4-K20 demethylation

20622853

HgeneJHDM1D

GO:0070544

histone H3-K36 demethylation

20622853

HgeneJHDM1D

GO:0071557

histone H3-K27 demethylation

20023638|20194436|20622853

TgeneBRAF

GO:0006468

protein phosphorylation

17563371

TgeneBRAF

GO:0010828

positive regulation of glucose transmembrane transport

23010278

TgeneBRAF

GO:0033138

positive regulation of peptidyl-serine phosphorylation

19667065

TgeneBRAF

GO:0043066

negative regulation of apoptotic process

19667065

TgeneBRAF

GO:0070374

positive regulation of ERK1 and ERK2 cascade

22065586

TgeneBRAF

GO:0071277

cellular response to calcium ion

18567582

TgeneBRAF

GO:0090150

establishment of protein localization to membrane

23010278


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-CH-5737-01AJHDM1Dchr7

139810895

-BRAFchr7

140481493

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000397560ENST00000288602JHDM1Dchr7

139810895

-BRAFchr7

140481493

-
In-frameENST00000006967ENST00000288602JHDM1Dchr7

139810895

-BRAFchr7

140481493

-

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FusionProtFeatures for JHDM1D_BRAF


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
JHDM1D

BRAF

P15056

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneBRAFchr7:139810895chr7:140481493ENST00000288602-918457_717438767DomainProtein kinase
TgeneBRAFchr7:139810895chr7:140481493ENST00000288602-918463_471438767Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneBRAFchr7:139810895chr7:140481493ENST00000288602-918122_129438767Compositional biasNote=Poly-Ser
TgeneBRAFchr7:139810895chr7:140481493ENST00000288602-918428_432438767Compositional biasNote=Poly-Ser
TgeneBRAFchr7:139810895chr7:140481493ENST00000288602-9186_11438767Compositional biasNote=Poly-Gly
TgeneBRAFchr7:139810895chr7:140481493ENST00000288602-918155_227438767DomainRBD
TgeneBRAFchr7:139810895chr7:140481493ENST00000288602-918234_280438767Zinc fingerPhorbol-ester/DAG-type


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FusionGeneSequence for JHDM1D_BRAF


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_JHDM1D_ENST00000397560_chr7_139810895_-_BRAF_ENST00000288602_chr7_140481493_-_805aa
MAGAAAAVAAGAAAGAAAAAVSVAAPGRASAPPPPPPVYCVCRQPYDVNRFMIECDICKDWFHGSCVGVEEHHAVDIDLYHCPNCAVLHG
SSLMKKRRNWHRHDYTEIDDGSKPVQAGTRTFIKELRSRVFPSADEIIIKMHGSQLTQRYLEKHGFDVPIMVPKLDDLGLRLPSPTFSVM
DVERYVGGDKVIDVIDVARQADSKMTLHNYVKYFMNPNRPKVLNVISLEFSDTKMSELVEVPDIAKKLSWVENYWPDDSVFPKPFVQKYC
LMGVQDSYTDFHIDFGGTSVWYHVLWGEKIFYLIKPTDENLARYESWSSSVTQSEVFFGDKVDKCYKCVVKQGHTLFVPTGWIHAVLTSQ
DCMAFGGNFLHNLNIGMQLRCYEMEKRLKTPDLFKFPFFEAICWFVAKNLLETLKELREDGFQPQTYLVQGVKALHTALKLWMKKELVSE
HAFEIPDNVRPGHLIKELSKVIRAIEKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEV
GVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKI
GDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVR

>In-frame_JHDM1D_ENST00000006967_chr7_139810895_-_BRAF_ENST00000288602_chr7_140481493_-_805aa
MAGAAAAVAAGAAAGAAAAAVSVAAPGRASAPPPPPPVYCVCRQPYDVNRFMIECDICKDWFHGSCVGVEEHHAVDIDLYHCPNCAVLHG
SSLMKKRRNWHRHDYTEIDDGSKPVQAGTRTFIKELRSRVFPSADEIIIKMHGSQLTQRYLEKHGFDVPIMVPKLDDLGLRLPSPTFSVM
DVERYVGGDKVIDVIDVARQADSKMTLHNYVKYFMNPNRPKVLNVISLEFSDTKMSELVEVPDIAKKLSWVENYWPDDSVFPKPFVQKYC
LMGVQDSYTDFHIDFGGTSVWYHVLWGEKIFYLIKPTDENLARYESWSSSVTQSEVFFGDKVDKCYKCVVKQGHTLFVPTGWIHAVLTSQ
DCMAFGGNFLHNLNIGMQLRCYEMEKRLKTPDLFKFPFFEAICWFVAKNLLETLKELREDGFQPQTYLVQGVKALHTALKLWMKKELVSE
HAFEIPDNVRPGHLIKELSKVIRAIEKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEV
GVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKI
GDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVR


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_JHDM1D_ENST00000397560_chr7_139810895_-_BRAF_ENST00000288602_chr7_140481493_-_2415nt
ATGGCCGGAGCGGCGGCGGCGGTGGCCGCGGGAGCAGCAGCTGGAGCCGCCGCGGCAGCCGTGTCGGTGGCGGCTCCCGGCCGGGCCTCG
GCGCCTCCGCCGCCCCCGCCCGTGTACTGTGTGTGCCGGCAGCCGTACGACGTGAACCGCTTCATGATCGAGTGCGATATCTGCAAGGAC
TGGTTCCACGGCAGCTGTGTTGGAGTAGAAGAACATCATGCTGTTGACATTGACCTGTATCACTGTCCCAACTGTGCAGTTTTACATGGT
TCCTCCTTGATGAAAAAAAGGAGGAACTGGCACAGACATGACTACACAGAAATTGATGATGGTTCCAAACCAGTGCAAGCTGGAACTAGA
ACTTTCATTAAGGAATTACGCTCTCGAGTCTTCCCAAGTGCCGATGAAATAATTATAAAGATGCATGGCAGCCAGCTGACACAAAGATAT
CTGGAGAAACATGGATTTGATGTCCCTATTATGGTCCCAAAATTAGATGATCTAGGACTCAGGCTCCCTTCACCTACATTTTCTGTGATG
GATGTGGAACGTTATGTAGGTGGTGACAAAGTGATAGATGTCATTGATGTGGCGAGGCAGGCAGACAGCAAAATGACACTTCACAATTAT
GTTAAATACTTCATGAATCCTAACAGACCAAAAGTGTTAAATGTGATCAGCCTTGAATTTTCAGATACAAAGATGTCTGAATTGGTGGAG
GTCCCTGATATAGCCAAAAAACTTTCCTGGGTGGAAAATTATTGGCCAGATGATTCAGTCTTTCCCAAGCCATTTGTTCAGAAATATTGC
TTAATGGGAGTTCAAGACAGCTATACAGATTTCCACATTGACTTCGGTGGAACTTCAGTCTGGTACCATGTCCTCTGGGGTGAGAAGATT
TTTTATTTAATAAAGCCAACAGATGAAAATTTGGCACGTTATGAATCTTGGAGTTCATCTGTGACCCAGAGTGAGGTGTTCTTTGGAGAT
AAGGTGGATAAATGCTACAAATGTGTGGTAAAGCAGGGACATACCTTATTTGTTCCTACAGGGTGGATCCATGCTGTGCTCACTTCTCAG
GACTGTATGGCTTTTGGGGGGAACTTCCTGCACAACCTTAACATTGGCATGCAGCTCAGGTGTTATGAGATGGAGAAAAGGCTAAAAACA
CCAGATCTTTTCAAATTCCCTTTCTTTGAAGCCATATGTTGGTTTGTAGCCAAAAACTTGCTGGAAACCCTGAAAGAACTGAGAGAAGAT
GGTTTCCAGCCTCAAACTTACCTAGTACAGGGAGTGAAAGCACTGCATACTGCTTTAAAATTATGGATGAAAAAAGAACTTGTATCTGAA
CATGCCTTTGAAATTCCAGACAATGTTAGACCTGGACACCTTATTAAAGAACTTTCTAAAGTAATTCGAGCAATAGAGAAAACACTTGGT
AGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGATCATTTGGAACAGTCTAC
AAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAAGCCTTCAAAAATGAAGTA
GGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCTATTGTTACCCAGTGGTGT
GAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATTGCACGACAGACTGCACAG
GGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAAGACCTCACAGTAAAAATA
GGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCCATTTTGTGGATGGCACCA
GAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTGTATGAATTGATGACTGGA
CAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCAGATCTCAGTAAGGTACGG
AGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCCCAAATTCTCGCC
TCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTCCAAACAGAGGAT

>In-frame_JHDM1D_ENST00000006967_chr7_139810895_-_BRAF_ENST00000288602_chr7_140481493_-_2415nt
ATGGCCGGAGCGGCGGCGGCGGTGGCCGCGGGAGCAGCAGCTGGAGCCGCCGCGGCAGCCGTGTCGGTGGCGGCTCCCGGCCGGGCCTCG
GCGCCTCCGCCGCCCCCGCCCGTGTACTGTGTGTGCCGGCAGCCGTACGACGTGAACCGCTTCATGATCGAGTGCGATATCTGCAAGGAC
TGGTTCCACGGCAGCTGTGTTGGAGTAGAAGAACATCATGCTGTTGACATTGACCTGTATCACTGTCCCAACTGTGCAGTTTTACATGGT
TCCTCCTTGATGAAAAAAAGGAGGAACTGGCACAGACATGACTACACAGAAATTGATGATGGTTCCAAACCAGTGCAAGCTGGAACTAGA
ACTTTCATTAAGGAATTACGCTCTCGAGTCTTCCCAAGTGCCGATGAAATAATTATAAAGATGCATGGCAGCCAGCTGACACAAAGATAT
CTGGAGAAACATGGATTTGATGTCCCTATTATGGTCCCAAAATTAGATGATCTAGGACTCAGGCTCCCTTCACCTACATTTTCTGTGATG
GATGTGGAACGTTATGTAGGTGGTGACAAAGTGATAGATGTCATTGATGTGGCGAGGCAGGCAGACAGCAAAATGACACTTCACAATTAT
GTTAAATACTTCATGAATCCTAACAGACCAAAAGTGTTAAATGTGATCAGCCTTGAATTTTCAGATACAAAGATGTCTGAATTGGTGGAG
GTCCCTGATATAGCCAAAAAACTTTCCTGGGTGGAAAATTATTGGCCAGATGATTCAGTCTTTCCCAAGCCATTTGTTCAGAAATATTGC
TTAATGGGAGTTCAAGACAGCTATACAGATTTCCACATTGACTTCGGTGGAACTTCAGTCTGGTACCATGTCCTCTGGGGTGAGAAGATT
TTTTATTTAATAAAGCCAACAGATGAAAATTTGGCACGTTATGAATCTTGGAGTTCATCTGTGACCCAGAGTGAGGTGTTCTTTGGAGAT
AAGGTGGATAAATGCTACAAATGTGTGGTAAAGCAGGGACATACCTTATTTGTTCCTACAGGGTGGATCCATGCTGTGCTCACTTCTCAG
GACTGTATGGCTTTTGGGGGGAACTTCCTGCACAACCTTAACATTGGCATGCAGCTCAGGTGTTATGAGATGGAGAAAAGGCTAAAAACA
CCAGATCTTTTCAAATTCCCTTTCTTTGAAGCCATATGTTGGTTTGTAGCCAAAAACTTGCTGGAAACCCTGAAAGAACTGAGAGAAGAT
GGTTTCCAGCCTCAAACTTACCTAGTACAGGGAGTGAAAGCACTGCATACTGCTTTAAAATTATGGATGAAAAAAGAACTTGTATCTGAA
CATGCCTTTGAAATTCCAGACAATGTTAGACCTGGACACCTTATTAAAGAACTTTCTAAAGTAATTCGAGCAATAGAGAAAACACTTGGT
AGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGATCATTTGGAACAGTCTAC
AAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAAGCCTTCAAAAATGAAGTA
GGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCTATTGTTACCCAGTGGTGT
GAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATTGCACGACAGACTGCACAG
GGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAAGACCTCACAGTAAAAATA
GGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCCATTTTGTGGATGGCACCA
GAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTGTATGAATTGATGACTGGA
CAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCAGATCTCAGTAAGGTACGG
AGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCCCAAATTCTCGCC
TCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTCCAAACAGAGGAT


* Fusion transcript sequences (Full-length transcript).
>In-frame_JHDM1D_ENST00000397560_chr7_139810895_-_BRAF_ENST00000288602_chr7_140481493_-_2631nt
GCCGCCGCGGCTGCTGCAGGAGGCGGCGCTGGCTGGCGGCTGCGCTCGCTCCAGTCGGCGAGCGGAGTAGCGAGCGAGCGTGTGTGTGTT
TTTTAAAGATGGCCGGAGCGGCGGCGGCGGTGGCCGCGGGAGCAGCAGCTGGAGCCGCCGCGGCAGCCGTGTCGGTGGCGGCTCCCGGCC
GGGCCTCGGCGCCTCCGCCGCCCCCGCCCGTGTACTGTGTGTGCCGGCAGCCGTACGACGTGAACCGCTTCATGATCGAGTGCGATATCT
GCAAGGACTGGTTCCACGGCAGCTGTGTTGGAGTAGAAGAACATCATGCTGTTGACATTGACCTGTATCACTGTCCCAACTGTGCAGTTT
TACATGGTTCCTCCTTGATGAAAAAAAGGAGGAACTGGCACAGACATGACTACACAGAAATTGATGATGGTTCCAAACCAGTGCAAGCTG
GAACTAGAACTTTCATTAAGGAATTACGCTCTCGAGTCTTCCCAAGTGCCGATGAAATAATTATAAAGATGCATGGCAGCCAGCTGACAC
AAAGATATCTGGAGAAACATGGATTTGATGTCCCTATTATGGTCCCAAAATTAGATGATCTAGGACTCAGGCTCCCTTCACCTACATTTT
CTGTGATGGATGTGGAACGTTATGTAGGTGGTGACAAAGTGATAGATGTCATTGATGTGGCGAGGCAGGCAGACAGCAAAATGACACTTC
ACAATTATGTTAAATACTTCATGAATCCTAACAGACCAAAAGTGTTAAATGTGATCAGCCTTGAATTTTCAGATACAAAGATGTCTGAAT
TGGTGGAGGTCCCTGATATAGCCAAAAAACTTTCCTGGGTGGAAAATTATTGGCCAGATGATTCAGTCTTTCCCAAGCCATTTGTTCAGA
AATATTGCTTAATGGGAGTTCAAGACAGCTATACAGATTTCCACATTGACTTCGGTGGAACTTCAGTCTGGTACCATGTCCTCTGGGGTG
AGAAGATTTTTTATTTAATAAAGCCAACAGATGAAAATTTGGCACGTTATGAATCTTGGAGTTCATCTGTGACCCAGAGTGAGGTGTTCT
TTGGAGATAAGGTGGATAAATGCTACAAATGTGTGGTAAAGCAGGGACATACCTTATTTGTTCCTACAGGGTGGATCCATGCTGTGCTCA
CTTCTCAGGACTGTATGGCTTTTGGGGGGAACTTCCTGCACAACCTTAACATTGGCATGCAGCTCAGGTGTTATGAGATGGAGAAAAGGC
TAAAAACACCAGATCTTTTCAAATTCCCTTTCTTTGAAGCCATATGTTGGTTTGTAGCCAAAAACTTGCTGGAAACCCTGAAAGAACTGA
GAGAAGATGGTTTCCAGCCTCAAACTTACCTAGTACAGGGAGTGAAAGCACTGCATACTGCTTTAAAATTATGGATGAAAAAAGAACTTG
TATCTGAACATGCCTTTGAAATTCCAGACAATGTTAGACCTGGACACCTTATTAAAGAACTTTCTAAAGTAATTCGAGCAATAGAGAAAA
CACTTGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGATCATTTGGAA
CAGTCTACAAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAAGCCTTCAAAA
ATGAAGTAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCTATTGTTACCC
AGTGGTGTGAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATTGCACGACAGA
CTGCACAGGGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAAGACCTCACAG
TAAAAATAGGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCCATTTTGTGGA
TGGCACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTGTATGAATTGA
TGACTGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCAGATCTCAGTA
AGGTACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCCCAAA
TTCTCGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTCCAAA
CAGAGGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGATATGGTGCGTTTCCTGTCCACTGAAACAAAT
GAGTGAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACATATGTTTGCTTATATGTTAAATTGAATAAAATACTCTCTTTT

>In-frame_JHDM1D_ENST00000006967_chr7_139810895_-_BRAF_ENST00000288602_chr7_140481493_-_2537nt
AAAGATGGCCGGAGCGGCGGCGGCGGTGGCCGCGGGAGCAGCAGCTGGAGCCGCCGCGGCAGCCGTGTCGGTGGCGGCTCCCGGCCGGGC
CTCGGCGCCTCCGCCGCCCCCGCCCGTGTACTGTGTGTGCCGGCAGCCGTACGACGTGAACCGCTTCATGATCGAGTGCGATATCTGCAA
GGACTGGTTCCACGGCAGCTGTGTTGGAGTAGAAGAACATCATGCTGTTGACATTGACCTGTATCACTGTCCCAACTGTGCAGTTTTACA
TGGTTCCTCCTTGATGAAAAAAAGGAGGAACTGGCACAGACATGACTACACAGAAATTGATGATGGTTCCAAACCAGTGCAAGCTGGAAC
TAGAACTTTCATTAAGGAATTACGCTCTCGAGTCTTCCCAAGTGCCGATGAAATAATTATAAAGATGCATGGCAGCCAGCTGACACAAAG
ATATCTGGAGAAACATGGATTTGATGTCCCTATTATGGTCCCAAAATTAGATGATCTAGGACTCAGGCTCCCTTCACCTACATTTTCTGT
GATGGATGTGGAACGTTATGTAGGTGGTGACAAAGTGATAGATGTCATTGATGTGGCGAGGCAGGCAGACAGCAAAATGACACTTCACAA
TTATGTTAAATACTTCATGAATCCTAACAGACCAAAAGTGTTAAATGTGATCAGCCTTGAATTTTCAGATACAAAGATGTCTGAATTGGT
GGAGGTCCCTGATATAGCCAAAAAACTTTCCTGGGTGGAAAATTATTGGCCAGATGATTCAGTCTTTCCCAAGCCATTTGTTCAGAAATA
TTGCTTAATGGGAGTTCAAGACAGCTATACAGATTTCCACATTGACTTCGGTGGAACTTCAGTCTGGTACCATGTCCTCTGGGGTGAGAA
GATTTTTTATTTAATAAAGCCAACAGATGAAAATTTGGCACGTTATGAATCTTGGAGTTCATCTGTGACCCAGAGTGAGGTGTTCTTTGG
AGATAAGGTGGATAAATGCTACAAATGTGTGGTAAAGCAGGGACATACCTTATTTGTTCCTACAGGGTGGATCCATGCTGTGCTCACTTC
TCAGGACTGTATGGCTTTTGGGGGGAACTTCCTGCACAACCTTAACATTGGCATGCAGCTCAGGTGTTATGAGATGGAGAAAAGGCTAAA
AACACCAGATCTTTTCAAATTCCCTTTCTTTGAAGCCATATGTTGGTTTGTAGCCAAAAACTTGCTGGAAACCCTGAAAGAACTGAGAGA
AGATGGTTTCCAGCCTCAAACTTACCTAGTACAGGGAGTGAAAGCACTGCATACTGCTTTAAAATTATGGATGAAAAAAGAACTTGTATC
TGAACATGCCTTTGAAATTCCAGACAATGTTAGACCTGGACACCTTATTAAAGAACTTTCTAAAGTAATTCGAGCAATAGAGAAAACACT
TGGTAGACGGGACTCGAGTGATGATTGGGAGATTCCTGATGGGCAGATTACAGTGGGACAAAGAATTGGATCTGGATCATTTGGAACAGT
CTACAAGGGAAAGTGGCATGGTGATGTGGCAGTGAAAATGTTGAATGTGACAGCACCTACACCTCAGCAGTTACAAGCCTTCAAAAATGA
AGTAGGAGTACTCAGGAAAACACGACATGTGAATATCCTACTCTTCATGGGCTATTCCACAAAGCCACAACTGGCTATTGTTACCCAGTG
GTGTGAGGGCTCCAGCTTGTATCACCATCTCCATATCATTGAGACCAAATTTGAGATGATCAAACTTATAGATATTGCACGACAGACTGC
ACAGGGCATGGATTACTTACACGCCAAGTCAATCATCCACAGAGACCTCAAGAGTAATAATATATTTCTTCATGAAGACCTCACAGTAAA
AATAGGTGATTTTGGTCTAGCTACAGTGAAATCTCGATGGAGTGGGTCCCATCAGTTTGAACAGTTGTCTGGATCCATTTTGTGGATGGC
ACCAGAAGTCATCAGAATGCAAGATAAAAATCCATACAGCTTTCAGTCAGATGTATATGCATTTGGAATTGTTCTGTATGAATTGATGAC
TGGACAGTTACCTTATTCAAACATCAACAACAGGGACCAGATAATTTTTATGGTGGGACGAGGATACCTGTCTCCAGATCTCAGTAAGGT
ACGGAGTAACTGTCCAAAAGCCATGAAGAGATTAATGGCAGAGTGCCTCAAAAAGAAAAGAGATGAGAGACCACTCTTTCCCCAAATTCT
CGCCTCTATTGAGCTGCTGGCCCGCTCATTGCCAAAAATTCACCGCAGTGCATCAGAACCCTCCTTGAATCGGGCTGGTTTCCAAACAGA
GGATTTTAGTCTATATGCTTGTGCTTCTCCAAAAACACCCATCCAGGCAGGGGGATATGGTGCGTTTCCTGTCCACTGAAACAAATGAGT
GAGAGAGTTCAGGAGAGTAGCAACAAAAGGAAAATAAATGAACATATGTTTGCTTATATGTTAAATTGAATAAAATACTCTCTTTTTTTT


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FusionGenePPI for JHDM1D_BRAF


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
JHDM1DBRAFYWHAB, YWHAG, YWHAQ, YWHAZ, SFN, HRAS, AKT1, MAPK3, RAP1GAP, RAF1, MRAS, RAP1A, PAK2, TERF1, CCDC88A, NEDD4L, MAP2K1, RNF149, KSR1, BRAP, PRKCE, RPS6KB2, HSP90AA1, BRAF, YWHAE, HSPA5, MAP2K2, HSPA1A, HSPA8, YWHAH, HSPA9, ARAF, CDC37, HSP90AB1, PHKB, LIMK1, IQGAP1, MAPK1, BAD, LIPF, MUS81, FBXW7, FGFR2, BRCA2, VHL, FNTA, HDAC2, PIK3CA, EGFR, PTEN, FNIP1, FNIP2, RAB3GAP1, KRAS, KIAA0141, FKBPL, ARMCX3, KCNC4, RPTOR, CYLD, NRAS


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for JHDM1D_BRAF


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneBRAFP15056DB08881VemurafenibSerine/threonine-protein kinase B-rafsmall moleculeapproved
TgeneBRAFP15056DB08896RegorafenibSerine/threonine-protein kinase B-rafsmall moleculeapproved
TgeneBRAFP15056DB00398SorafenibSerine/threonine-protein kinase B-rafsmall moleculeapproved|investigational
TgeneBRAFP15056DB08912DabrafenibSerine/threonine-protein kinase B-rafsmall moleculeapproved|investigational

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RelatedDiseases for JHDM1D_BRAF


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneBRAFC0025202melanoma21CTD_human
TgeneBRAFC1527249Colorectal Cancer8UNIPROT
TgeneBRAFC1275081Cardio-facio-cutaneous syndrome6CTD_human;ORPHANET;UNIPROT
TgeneBRAFC0009404Colorectal Neoplasms4CTD_human
TgeneBRAFC0040136Thyroid Neoplasm4CTD_human
TgeneBRAFC0024305Lymphoma, Non-Hodgkin3UNIPROT
TgeneBRAFC0684249Carcinoma of lung3UNIPROT
TgeneBRAFC3150970NOONAN SYNDROME 73CTD_human;UNIPROT
TgeneBRAFC0152013Adenocarcinoma of lung (disorder)2CTD_human
TgeneBRAFC0002448Ameloblastoma1CTD_human
TgeneBRAFC0004114Astrocytoma1CTD_human
TgeneBRAFC0010276Craniopharyngioma1CTD_human;ORPHANET
TgeneBRAFC0017638Glioma1CTD_human
TgeneBRAFC0022665Kidney Neoplasm1CTD_human
TgeneBRAFC0023903Liver neoplasms1CTD_human
TgeneBRAFC0024694Mandibular Neoplasms1CTD_human
TgeneBRAFC0028326Noonan Syndrome1CTD_human;ORPHANET
TgeneBRAFC0033578Prostatic Neoplasms1CTD_human
TgeneBRAFC0036920Sezary Syndrome1CTD_human
TgeneBRAFC0079773Lymphoma, T-Cell, Cutaneous1CTD_human
TgeneBRAFC0206686Adrenocortical carcinoma1CTD_human
TgeneBRAFC0206754Neuroendocrine Tumors1CTD_human
TgeneBRAFC0238463Papillary thyroid carcinoma1CTD_human;ORPHANET
TgeneBRAFC0587248Costello syndrome (disorder)1CTD_human
TgeneBRAFC0596263Carcinogenesis1CTD_human
TgeneBRAFC0920269Microsatellite Instability1CTD_human
TgeneBRAFC2239176Liver carcinoma1CTD_human