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Fusion gene ID: 18040 |
FusionGeneSummary for JAZF1_CDCA7L |
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Fusion gene information | Fusion gene name: JAZF1_CDCA7L | Fusion gene ID: 18040 | Hgene | Tgene | Gene symbol | JAZF1 | CDCA7L | Gene ID | 221895 | 55536 |
Gene name | JAZF zinc finger 1 | cell division cycle associated 7 like | |
Synonyms | TIP27|ZNF802 | JPO2|R1|RAM2 | |
Cytomap | 7p15.2-p15.1 | 7p15.3 | |
Type of gene | protein-coding | protein-coding | |
Description | juxtaposed with another zinc finger protein 1TAK1-interacting protein 27juxtaposed with another zinc finger gene 1zinc finger protein 802 | cell division cycle-associated 7-like proteintranscription factor RAM2 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q86VZ6 | Q96GN5 | |
Ensembl transtripts involved in fusion gene | ENST00000283928, ENST00000466516, | ENST00000356195, ENST00000406877, ENST00000373934, ENST00000465490, | |
Fusion gene scores | * DoF score | 13 X 7 X 7=637 | 1 X 1 X 1=1 |
# samples | 13 | 1 | |
** MAII score | log2(13/637*10)=-2.29278174922785 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: JAZF1 [Title/Abstract] AND CDCA7L [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | JAZF1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 15302918 |
Tgene | CDCA7L | GO:0008284 | positive regulation of cell proliferation | 15994933 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA303712 | JAZF1 | chr7 | 28220082 | - | CDCA7L | chr7 | 21956513 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000283928 | ENST00000356195 | JAZF1 | chr7 | 28220082 | - | CDCA7L | chr7 | 21956513 | - |
5CDS-5UTR | ENST00000283928 | ENST00000406877 | JAZF1 | chr7 | 28220082 | - | CDCA7L | chr7 | 21956513 | - |
5CDS-5UTR | ENST00000283928 | ENST00000373934 | JAZF1 | chr7 | 28220082 | - | CDCA7L | chr7 | 21956513 | - |
5CDS-5UTR | ENST00000283928 | ENST00000465490 | JAZF1 | chr7 | 28220082 | - | CDCA7L | chr7 | 21956513 | - |
intron-5UTR | ENST00000466516 | ENST00000356195 | JAZF1 | chr7 | 28220082 | - | CDCA7L | chr7 | 21956513 | - |
intron-5UTR | ENST00000466516 | ENST00000406877 | JAZF1 | chr7 | 28220082 | - | CDCA7L | chr7 | 21956513 | - |
intron-5UTR | ENST00000466516 | ENST00000373934 | JAZF1 | chr7 | 28220082 | - | CDCA7L | chr7 | 21956513 | - |
intron-5UTR | ENST00000466516 | ENST00000465490 | JAZF1 | chr7 | 28220082 | - | CDCA7L | chr7 | 21956513 | - |
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FusionProtFeatures for JAZF1_CDCA7L |
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Hgene | Tgene |
JAZF1 | CDCA7L |
Acts as a transcriptional corepressor of orphan nuclearreceptor NR2C2 (PubMed:15302918). Inhibits expression of thegluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity(By similarity). Also involved in transcriptional activation ofNAMPT by promoting expression of PPARA and PPARD (By similarity).Plays a role in lipid metabolism by suppressing lipogenesis,increasing lipolysis and decreasing lipid accumulation in adiposetissue (By similarity). Plays a role in glucose homeostasis byimproving glucose metabolism and insulin sensitivity (Bysimilarity). {ECO:0000250|UniProtKB:Q80ZQ5,ECO:0000269|PubMed:15302918}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for JAZF1_CDCA7L |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for JAZF1_CDCA7L |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
JAZF1 | NR2C2, PPARG, RXRA, YEATS4, TRRAP, MEAF6, RUVBL1, MYCL, HIST1H2BA, MORF4L2 | CDCA7L | MYC, ELAVL1, VDR, SUV39H1, ANKRD11, BYSL, DAXX, LMO1, MDFI, MFAP1, NOP2, TADA2A, UBL4A, STX11, EIF4A3, PPP1R16B, PRPF31, ABT1, TFPT, CDCA7L, ZNF821, CTNNBL1, UTP3, ZNF250, PRDM14, CARD9, CCDC33, CEP70, TRAF3IP3, ING5, SSX2IP, DEDD2, FAM9B, BEND7, MORN3, TRIM42, KRTAP10-7, ZGPAT, EZH2, TM9SF4, MLH1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for JAZF1_CDCA7L |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for JAZF1_CDCA7L |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | JAZF1 | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human |
Hgene | JAZF1 | C0014170 | Endometrial Neoplasms | 1 | CTD_human |
Hgene | JAZF1 | C0024141 | Lupus Erythematosus, Systemic | 1 | CTD_human |
Hgene | JAZF1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |