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Fusion gene ID: 18024 |
FusionGeneSummary for JARID2_BMP6 |
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Fusion gene information | Fusion gene name: JARID2_BMP6 | Fusion gene ID: 18024 | Hgene | Tgene | Gene symbol | JARID2 | BMP6 | Gene ID | 3720 | 654 |
Gene name | jumonji and AT-rich interaction domain containing 2 | bone morphogenetic protein 6 | |
Synonyms | JMJ | VGR|VGR1 | |
Cytomap | 6p22.3 | 6p24.3 | |
Type of gene | protein-coding | protein-coding | |
Description | protein Jumonjijumonji homologjumonji, AT rich interactive domain 2jumonji-like proteinjumonji/ARID domain-containing protein 2 | bone morphogenetic protein 6VG-1-RVG-1-related proteinvegetal related growth factor (TGFB-related) | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q92833 | P22004 | |
Ensembl transtripts involved in fusion gene | ENST00000341776, ENST00000397311, ENST00000541660, ENST00000474854, | ENST00000283147, | |
Fusion gene scores | * DoF score | 16 X 6 X 10=960 | 3 X 3 X 2=18 |
# samples | 15 | 3 | |
** MAII score | log2(15/960*10)=-2.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: JARID2 [Title/Abstract] AND BMP6 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | BMP6 | GO:0003323 | type B pancreatic cell development | 11865031 |
Tgene | BMP6 | GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation | 17244894|19366699 |
Tgene | BMP6 | GO:0030501 | positive regulation of bone mineralization | 18436533 |
Tgene | BMP6 | GO:0030509 | BMP signaling pathway | 18436533 |
Tgene | BMP6 | GO:0032349 | positive regulation of aldosterone biosynthetic process | 16527843 |
Tgene | BMP6 | GO:0045669 | positive regulation of osteoblast differentiation | 18436533 |
Tgene | BMP6 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 16527843 |
Tgene | BMP6 | GO:0050679 | positive regulation of epithelial cell proliferation | 11865031 |
Tgene | BMP6 | GO:0060395 | SMAD protein signal transduction | 17244894 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-E2-A9RU-01A | JARID2 | chr6 | 15410596 | + | BMP6 | chr6 | 7879307 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000341776 | ENST00000283147 | JARID2 | chr6 | 15410596 | + | BMP6 | chr6 | 7879307 | + |
5UTR-3CDS | ENST00000397311 | ENST00000283147 | JARID2 | chr6 | 15410596 | + | BMP6 | chr6 | 7879307 | + |
Frame-shift | ENST00000541660 | ENST00000283147 | JARID2 | chr6 | 15410596 | + | BMP6 | chr6 | 7879307 | + |
intron-3CDS | ENST00000474854 | ENST00000283147 | JARID2 | chr6 | 15410596 | + | BMP6 | chr6 | 7879307 | + |
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FusionProtFeatures for JARID2_BMP6 |
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Hgene | Tgene |
JARID2 | BMP6 |
Regulator of histone methyltransferase complexes thatplays an essential role in embryonic development, including heartand liver development, neural tube fusion process andhematopoiesis. Acts by modulating histone methyltransferaseactivity and promoting the recruitment of histonemethyltransferase complexes to their target genes. Binds DNA andmediates the recruitment of the PRC2 complex to target genes inembryonic stem cells. Does not have histone demethylase activitybut regulates activity of various histone methyltransferasecomplexes. In embryonic stem cells, it associates with the PRC2complex and inhibits trimethylation of 'Lys-27' of histone H3(H3K27me3) by the PRC2 complex, thereby playing a key role indifferentiation of embryonic stem cells and normal development. Incardiac cells, it is required to repress expression of cyclin-D1(CCND1) by activating methylation of 'Lys-9' of histone H3(H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histonemethyltransferases. Also acts as a transcriptional repressor ofANF via its interaction with GATA4 and NKX2-5. Participates in thenegative regulation of cell proliferation signaling.{ECO:0000269|PubMed:20075857}. | Induces cartilage and bone formation. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for JARID2_BMP6 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for JARID2_BMP6 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
JARID2 | EHMT2, EHMT1, EZH2, SUZ12, MTF2, GATA4, SETDB1, ELAVL1, NKX2-5, ALB, EZH1, EED, AEBP2, RBBP4, RBBP7, HDAC2, SLAIN2, NANOG, POU5F1, DDB2 | BMP6 | ACVR2A, ACVR2B, BMPR2, BMPR1A, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for JARID2_BMP6 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for JARID2_BMP6 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | JARID2 | C0036341 | Schizophrenia | 2 | PSYGENET |
Hgene | JARID2 | C1510586 | Autism Spectrum Disorders | 1 | CTD_human |
Tgene | BMP6 | C0018995 | Hemochromatosis | 2 | CTD_human |
Tgene | BMP6 | C0003873 | Rheumatoid Arthritis | 1 | CTD_human |
Tgene | BMP6 | C0023493 | Adult T-Cell Lymphoma/Leukemia | 1 | CTD_human |
Tgene | BMP6 | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
Tgene | BMP6 | C0162820 | Dermatitis, Allergic Contact | 1 | CTD_human |