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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1802

FusionGeneSummary for ANKRD17_AK2

check button Fusion gene summary
Fusion gene informationFusion gene name: ANKRD17_AK2
Fusion gene ID: 1802
HgeneTgene
Gene symbol

ANKRD17

AK2

Gene ID

26057

204

Gene nameankyrin repeat domain 17adenylate kinase 2
SynonymsGTAR|MASK2|NY-BR-16ADK2
Cytomap

4q13.3

1p35.1

Type of geneprotein-codingprotein-coding
Descriptionankyrin repeat domain-containing protein 17gene trap ankyrin repeat proteinserologically defined breast cancer antigen NY-BR-16adenylate kinase 2, mitochondrialATP-AMP transphosphorylase 2ATP:AMP phosphotransferaseadenylate kinase isoenzyme 2, mitochondrialadenylate monophosphate kinasetestis secretory sperm-binding protein Li 220n
Modification date2018052320180519
UniProtAcc

O75179

P54819

Ensembl transtripts involved in fusion geneENST00000358602, ENST00000509867, 
ENST00000330838, ENST00000514252, 
ENST00000373449, ENST00000548033, 
ENST00000491241, ENST00000467905, 
ENST00000480134, ENST00000354858, 
ENST00000487289, 
Fusion gene scores* DoF score8 X 13 X 4=4161 X 1 X 1=1
# samples 171
** MAII scorelog2(17/416*10)=-1.29104878200339
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: ANKRD17 [Title/Abstract] AND AK2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneANKRD17

GO:0042742

defense response to bacterium

23711367

HgeneANKRD17

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

22328336

HgeneANKRD17

GO:0045087

innate immune response

23711367

HgeneANKRD17

GO:1900245

positive regulation of MDA-5 signaling pathway

22328336

HgeneANKRD17

GO:1900246

positive regulation of RIG-I signaling pathway

22328336


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDOVTCGA-29-1691-01AANKRD17chr4

74123991

-AK2chr1

33480193

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000358602ENST00000373449ANKRD17chr4

74123991

-AK2chr1

33480193

-
Frame-shiftENST00000358602ENST00000548033ANKRD17chr4

74123991

-AK2chr1

33480193

-
5CDS-intronENST00000358602ENST00000491241ANKRD17chr4

74123991

-AK2chr1

33480193

-
5CDS-intronENST00000358602ENST00000467905ANKRD17chr4

74123991

-AK2chr1

33480193

-
5CDS-intronENST00000358602ENST00000480134ANKRD17chr4

74123991

-AK2chr1

33480193

-
5CDS-intronENST00000358602ENST00000354858ANKRD17chr4

74123991

-AK2chr1

33480193

-
5CDS-intronENST00000358602ENST00000487289ANKRD17chr4

74123991

-AK2chr1

33480193

-
intron-3CDSENST00000509867ENST00000373449ANKRD17chr4

74123991

-AK2chr1

33480193

-
intron-3CDSENST00000509867ENST00000548033ANKRD17chr4

74123991

-AK2chr1

33480193

-
intron-intronENST00000509867ENST00000491241ANKRD17chr4

74123991

-AK2chr1

33480193

-
intron-intronENST00000509867ENST00000467905ANKRD17chr4

74123991

-AK2chr1

33480193

-
intron-intronENST00000509867ENST00000480134ANKRD17chr4

74123991

-AK2chr1

33480193

-
intron-intronENST00000509867ENST00000354858ANKRD17chr4

74123991

-AK2chr1

33480193

-
intron-intronENST00000509867ENST00000487289ANKRD17chr4

74123991

-AK2chr1

33480193

-
Frame-shiftENST00000330838ENST00000373449ANKRD17chr4

74123991

-AK2chr1

33480193

-
Frame-shiftENST00000330838ENST00000548033ANKRD17chr4

74123991

-AK2chr1

33480193

-
5CDS-intronENST00000330838ENST00000491241ANKRD17chr4

74123991

-AK2chr1

33480193

-
5CDS-intronENST00000330838ENST00000467905ANKRD17chr4

74123991

-AK2chr1

33480193

-
5CDS-intronENST00000330838ENST00000480134ANKRD17chr4

74123991

-AK2chr1

33480193

-
5CDS-intronENST00000330838ENST00000354858ANKRD17chr4

74123991

-AK2chr1

33480193

-
5CDS-intronENST00000330838ENST00000487289ANKRD17chr4

74123991

-AK2chr1

33480193

-
intron-3CDSENST00000514252ENST00000373449ANKRD17chr4

74123991

-AK2chr1

33480193

-
intron-3CDSENST00000514252ENST00000548033ANKRD17chr4

74123991

-AK2chr1

33480193

-
intron-intronENST00000514252ENST00000491241ANKRD17chr4

74123991

-AK2chr1

33480193

-
intron-intronENST00000514252ENST00000467905ANKRD17chr4

74123991

-AK2chr1

33480193

-
intron-intronENST00000514252ENST00000480134ANKRD17chr4

74123991

-AK2chr1

33480193

-
intron-intronENST00000514252ENST00000354858ANKRD17chr4

74123991

-AK2chr1

33480193

-
intron-intronENST00000514252ENST00000487289ANKRD17chr4

74123991

-AK2chr1

33480193

-

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FusionProtFeatures for ANKRD17_AK2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANKRD17

O75179

AK2

P54819


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ANKRD17_AK2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ANKRD17_AK2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ANKRD17BAP1, APC, ITSN2, SIRT7, KIAA0368, ITGA4, ADH6, MDM2, AURKB, CDKN1A, HOXC4, MAGEA1, ZC3H3, FOSL2, SFRP4, LHX9, RBM23, MSH6, NTRK1, FGFR1OP, CAPN1, RPL10, CREB1, FOS, AKAP17A, FGF3, FGF8, STX11, TRIM41, TCEANC2, TGIF2LY, ZNF263, IRF9, CDX1, SIX2, ZNF414, TRMT2A, HOXD4AK2MEPCE, CUL3, SHBG, DSP, SAFB, MRPL12, RAVER1, TELO2, DLD, TUFM, IDH1, BAG3, ABCC6, ABCC5, HUWE1, ABCE1, ACAA2, AFG3L2, CRIP1, SOD1, DUT, FSCN1, GNB2L1, MRPS7, NME1-NME2, NME2, SIGMAR1, TKT, TRAP1, NTRK1, CEP290, MAPT, HDAC6, BCOR, U2AF2, SBF2, AIFM1, PDHA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ANKRD17_AK2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ANKRD17_AK2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneAK2C0085110Severe Combined Immunodeficiency2CTD_human;HPO
TgeneAK2C0011053Deafness1CTD_human;HPO
TgeneAK2C0272167Reticular dysgenesis1CTD_human;ORPHANET;UNIPROT