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Fusion gene ID: 1802 |
FusionGeneSummary for ANKRD17_AK2 |
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Fusion gene information | Fusion gene name: ANKRD17_AK2 | Fusion gene ID: 1802 | Hgene | Tgene | Gene symbol | ANKRD17 | AK2 | Gene ID | 26057 | 204 |
Gene name | ankyrin repeat domain 17 | adenylate kinase 2 | |
Synonyms | GTAR|MASK2|NY-BR-16 | ADK2 | |
Cytomap | 4q13.3 | 1p35.1 | |
Type of gene | protein-coding | protein-coding | |
Description | ankyrin repeat domain-containing protein 17gene trap ankyrin repeat proteinserologically defined breast cancer antigen NY-BR-16 | adenylate kinase 2, mitochondrialATP-AMP transphosphorylase 2ATP:AMP phosphotransferaseadenylate kinase isoenzyme 2, mitochondrialadenylate monophosphate kinasetestis secretory sperm-binding protein Li 220n | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | O75179 | P54819 | |
Ensembl transtripts involved in fusion gene | ENST00000358602, ENST00000509867, ENST00000330838, ENST00000514252, | ENST00000373449, ENST00000548033, ENST00000491241, ENST00000467905, ENST00000480134, ENST00000354858, ENST00000487289, | |
Fusion gene scores | * DoF score | 8 X 13 X 4=416 | 1 X 1 X 1=1 |
# samples | 17 | 1 | |
** MAII score | log2(17/416*10)=-1.29104878200339 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: ANKRD17 [Title/Abstract] AND AK2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ANKRD17 | GO:0042742 | defense response to bacterium | 23711367 |
Hgene | ANKRD17 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 22328336 |
Hgene | ANKRD17 | GO:0045087 | innate immune response | 23711367 |
Hgene | ANKRD17 | GO:1900245 | positive regulation of MDA-5 signaling pathway | 22328336 |
Hgene | ANKRD17 | GO:1900246 | positive regulation of RIG-I signaling pathway | 22328336 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | OV | TCGA-29-1691-01A | ANKRD17 | chr4 | 74123991 | - | AK2 | chr1 | 33480193 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000358602 | ENST00000373449 | ANKRD17 | chr4 | 74123991 | - | AK2 | chr1 | 33480193 | - |
Frame-shift | ENST00000358602 | ENST00000548033 | ANKRD17 | chr4 | 74123991 | - | AK2 | chr1 | 33480193 | - |
5CDS-intron | ENST00000358602 | ENST00000491241 | ANKRD17 | chr4 | 74123991 | - | AK2 | chr1 | 33480193 | - |
5CDS-intron | ENST00000358602 | ENST00000467905 | ANKRD17 | chr4 | 74123991 | - | AK2 | chr1 | 33480193 | - |
5CDS-intron | ENST00000358602 | ENST00000480134 | ANKRD17 | chr4 | 74123991 | - | AK2 | chr1 | 33480193 | - |
5CDS-intron | ENST00000358602 | ENST00000354858 | ANKRD17 | chr4 | 74123991 | - | AK2 | chr1 | 33480193 | - |
5CDS-intron | ENST00000358602 | ENST00000487289 | ANKRD17 | chr4 | 74123991 | - | AK2 | chr1 | 33480193 | - |
intron-3CDS | ENST00000509867 | ENST00000373449 | ANKRD17 | chr4 | 74123991 | - | AK2 | chr1 | 33480193 | - |
intron-3CDS | ENST00000509867 | ENST00000548033 | ANKRD17 | chr4 | 74123991 | - | AK2 | chr1 | 33480193 | - |
intron-intron | ENST00000509867 | ENST00000491241 | ANKRD17 | chr4 | 74123991 | - | AK2 | chr1 | 33480193 | - |
intron-intron | ENST00000509867 | ENST00000467905 | ANKRD17 | chr4 | 74123991 | - | AK2 | chr1 | 33480193 | - |
intron-intron | ENST00000509867 | ENST00000480134 | ANKRD17 | chr4 | 74123991 | - | AK2 | chr1 | 33480193 | - |
intron-intron | ENST00000509867 | ENST00000354858 | ANKRD17 | chr4 | 74123991 | - | AK2 | chr1 | 33480193 | - |
intron-intron | ENST00000509867 | ENST00000487289 | ANKRD17 | chr4 | 74123991 | - | AK2 | chr1 | 33480193 | - |
Frame-shift | ENST00000330838 | ENST00000373449 | ANKRD17 | chr4 | 74123991 | - | AK2 | chr1 | 33480193 | - |
Frame-shift | ENST00000330838 | ENST00000548033 | ANKRD17 | chr4 | 74123991 | - | AK2 | chr1 | 33480193 | - |
5CDS-intron | ENST00000330838 | ENST00000491241 | ANKRD17 | chr4 | 74123991 | - | AK2 | chr1 | 33480193 | - |
5CDS-intron | ENST00000330838 | ENST00000467905 | ANKRD17 | chr4 | 74123991 | - | AK2 | chr1 | 33480193 | - |
5CDS-intron | ENST00000330838 | ENST00000480134 | ANKRD17 | chr4 | 74123991 | - | AK2 | chr1 | 33480193 | - |
5CDS-intron | ENST00000330838 | ENST00000354858 | ANKRD17 | chr4 | 74123991 | - | AK2 | chr1 | 33480193 | - |
5CDS-intron | ENST00000330838 | ENST00000487289 | ANKRD17 | chr4 | 74123991 | - | AK2 | chr1 | 33480193 | - |
intron-3CDS | ENST00000514252 | ENST00000373449 | ANKRD17 | chr4 | 74123991 | - | AK2 | chr1 | 33480193 | - |
intron-3CDS | ENST00000514252 | ENST00000548033 | ANKRD17 | chr4 | 74123991 | - | AK2 | chr1 | 33480193 | - |
intron-intron | ENST00000514252 | ENST00000491241 | ANKRD17 | chr4 | 74123991 | - | AK2 | chr1 | 33480193 | - |
intron-intron | ENST00000514252 | ENST00000467905 | ANKRD17 | chr4 | 74123991 | - | AK2 | chr1 | 33480193 | - |
intron-intron | ENST00000514252 | ENST00000480134 | ANKRD17 | chr4 | 74123991 | - | AK2 | chr1 | 33480193 | - |
intron-intron | ENST00000514252 | ENST00000354858 | ANKRD17 | chr4 | 74123991 | - | AK2 | chr1 | 33480193 | - |
intron-intron | ENST00000514252 | ENST00000487289 | ANKRD17 | chr4 | 74123991 | - | AK2 | chr1 | 33480193 | - |
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FusionProtFeatures for ANKRD17_AK2 |
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Hgene | Tgene |
ANKRD17 | AK2 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ANKRD17_AK2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ANKRD17_AK2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ANKRD17 | BAP1, APC, ITSN2, SIRT7, KIAA0368, ITGA4, ADH6, MDM2, AURKB, CDKN1A, HOXC4, MAGEA1, ZC3H3, FOSL2, SFRP4, LHX9, RBM23, MSH6, NTRK1, FGFR1OP, CAPN1, RPL10, CREB1, FOS, AKAP17A, FGF3, FGF8, STX11, TRIM41, TCEANC2, TGIF2LY, ZNF263, IRF9, CDX1, SIX2, ZNF414, TRMT2A, HOXD4 | AK2 | MEPCE, CUL3, SHBG, DSP, SAFB, MRPL12, RAVER1, TELO2, DLD, TUFM, IDH1, BAG3, ABCC6, ABCC5, HUWE1, ABCE1, ACAA2, AFG3L2, CRIP1, SOD1, DUT, FSCN1, GNB2L1, MRPS7, NME1-NME2, NME2, SIGMAR1, TKT, TRAP1, NTRK1, CEP290, MAPT, HDAC6, BCOR, U2AF2, SBF2, AIFM1, PDHA1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ANKRD17_AK2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ANKRD17_AK2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | AK2 | C0085110 | Severe Combined Immunodeficiency | 2 | CTD_human;HPO |
Tgene | AK2 | C0011053 | Deafness | 1 | CTD_human;HPO |
Tgene | AK2 | C0272167 | Reticular dysgenesis | 1 | CTD_human;ORPHANET;UNIPROT |