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Fusion gene ID: 18019 |
FusionGeneSummary for JAM3_ACAD8 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: JAM3_ACAD8 | Fusion gene ID: 18019 | Hgene | Tgene | Gene symbol | JAM3 | ACAD8 | Gene ID | 83700 | 27034 |
| Gene name | junctional adhesion molecule 3 | acyl-CoA dehydrogenase family member 8 | |
| Synonyms | JAM-2|JAM-3|JAM-C|JAMC | ACAD-8|ARC42 | |
| Cytomap | 11q25 | 11q25 | |
| Type of gene | protein-coding | protein-coding | |
| Description | junctional adhesion molecule C | isobutyryl-CoA dehydrogenase, mitochondrialactivator-recruited cofactor 42 kDa componentacyl-Coenzyme A dehydrogenase family, member 8 | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q9BX67 | Q9UKU7 | |
| Ensembl transtripts involved in fusion gene | ENST00000529443, ENST00000299106, ENST00000441717, ENST00000524969, | ENST00000281182, ENST00000537423, ENST00000543332, ENST00000374752, ENST00000524547, | |
| Fusion gene scores | * DoF score | 4 X 4 X 3=48 | 1 X 1 X 1=1 |
| # samples | 4 | 1 | |
| ** MAII score | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: JAM3 [Title/Abstract] AND ACAD8 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | JAM3 | GO:0001525 | angiogenesis | 20592283 |
| Hgene | JAM3 | GO:0090022 | regulation of neutrophil chemotaxis | 15194813 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-HB-A3YV-01A | JAM3 | chr11 | 133939054 | + | ACAD8 | chr11 | 134126442 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000529443 | ENST00000281182 | JAM3 | chr11 | 133939054 | + | ACAD8 | chr11 | 134126442 | + |
| 5CDS-intron | ENST00000529443 | ENST00000537423 | JAM3 | chr11 | 133939054 | + | ACAD8 | chr11 | 134126442 | + |
| 5CDS-5UTR | ENST00000529443 | ENST00000543332 | JAM3 | chr11 | 133939054 | + | ACAD8 | chr11 | 134126442 | + |
| 5CDS-intron | ENST00000529443 | ENST00000374752 | JAM3 | chr11 | 133939054 | + | ACAD8 | chr11 | 134126442 | + |
| 5CDS-intron | ENST00000529443 | ENST00000524547 | JAM3 | chr11 | 133939054 | + | ACAD8 | chr11 | 134126442 | + |
| In-frame | ENST00000299106 | ENST00000281182 | JAM3 | chr11 | 133939054 | + | ACAD8 | chr11 | 134126442 | + |
| 5CDS-intron | ENST00000299106 | ENST00000537423 | JAM3 | chr11 | 133939054 | + | ACAD8 | chr11 | 134126442 | + |
| 5CDS-5UTR | ENST00000299106 | ENST00000543332 | JAM3 | chr11 | 133939054 | + | ACAD8 | chr11 | 134126442 | + |
| 5CDS-intron | ENST00000299106 | ENST00000374752 | JAM3 | chr11 | 133939054 | + | ACAD8 | chr11 | 134126442 | + |
| 5CDS-intron | ENST00000299106 | ENST00000524547 | JAM3 | chr11 | 133939054 | + | ACAD8 | chr11 | 134126442 | + |
| In-frame | ENST00000441717 | ENST00000281182 | JAM3 | chr11 | 133939054 | + | ACAD8 | chr11 | 134126442 | + |
| 5CDS-intron | ENST00000441717 | ENST00000537423 | JAM3 | chr11 | 133939054 | + | ACAD8 | chr11 | 134126442 | + |
| 5CDS-5UTR | ENST00000441717 | ENST00000543332 | JAM3 | chr11 | 133939054 | + | ACAD8 | chr11 | 134126442 | + |
| 5CDS-intron | ENST00000441717 | ENST00000374752 | JAM3 | chr11 | 133939054 | + | ACAD8 | chr11 | 134126442 | + |
| 5CDS-intron | ENST00000441717 | ENST00000524547 | JAM3 | chr11 | 133939054 | + | ACAD8 | chr11 | 134126442 | + |
| intron-3CDS | ENST00000524969 | ENST00000281182 | JAM3 | chr11 | 133939054 | + | ACAD8 | chr11 | 134126442 | + |
| intron-intron | ENST00000524969 | ENST00000537423 | JAM3 | chr11 | 133939054 | + | ACAD8 | chr11 | 134126442 | + |
| intron-5UTR | ENST00000524969 | ENST00000543332 | JAM3 | chr11 | 133939054 | + | ACAD8 | chr11 | 134126442 | + |
| intron-intron | ENST00000524969 | ENST00000374752 | JAM3 | chr11 | 133939054 | + | ACAD8 | chr11 | 134126442 | + |
| intron-intron | ENST00000524969 | ENST00000524547 | JAM3 | chr11 | 133939054 | + | ACAD8 | chr11 | 134126442 | + |
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FusionProtFeatures for JAM3_ACAD8 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| JAM3 | ACAD8 |
| Participates in cell-cell adhesion. It is a counter-receptor for ITGAM, mediating leukocyte-platelet interactions andis involved in the regulation of transepithelial migration ofpolymorphonuclear neutrophils (PMN). The soluble form is amediator of angiogenesis. {ECO:0000269|PubMed:12208882,ECO:0000269|PubMed:15194813, ECO:0000269|PubMed:20592283}. | Has very high activity toward isobutyryl-CoA. Is anisobutyryl-CoA dehydrogenase that functions in valine catabolism.Plays a role in transcriptional coactivation within the ARCcomplex. {ECO:0000269|PubMed:12359132}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >ACAD8 | chr11:133939054 | chr11:134126442 | ENST00000281182 | + | 0 | 11 | 158_167 | 36 | 416 | Nucleotide binding | FAD |
| Tgene | >ACAD8 | chr11:133939054 | chr11:134126442 | ENST00000281182 | + | 0 | 11 | 191_193 | 36 | 416 | Nucleotide binding | FAD |
| Tgene | >ACAD8 | chr11:133939054 | chr11:134126442 | ENST00000281182 | + | 0 | 11 | 312_313 | 36 | 416 | Nucleotide binding | FAD%3B shared with dimeric partner |
| Tgene | >ACAD8 | chr11:133939054 | chr11:134126442 | ENST00000281182 | + | 0 | 11 | 371_375 | 36 | 416 | Nucleotide binding | FAD%3B shared with dimeric partner |
| Tgene | >ACAD8 | chr11:133939054 | chr11:134126442 | ENST00000281182 | + | 0 | 11 | 400_402 | 36 | 416 | Nucleotide binding | FAD |
| Tgene | >ACAD8 | chr11:133939054 | chr11:134126442 | ENST00000281182 | + | 0 | 11 | 274_277 | 36 | 416 | Region | Note=Substrate binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >JAM3 | chr11:133939054 | chr11:134126442 | ENST00000299106 | + | 1 | 9 | 139_236 | 25 | 311 | Domain | Note=Ig-like C2-type |
| Hgene | >JAM3 | chr11:133939054 | chr11:134126442 | ENST00000299106 | + | 1 | 9 | 35_127 | 25 | 311 | Domain | Note=Ig-like V-type |
| Hgene | >JAM3 | chr11:133939054 | chr11:134126442 | ENST00000441717 | + | 1 | 8 | 139_236 | 25 | 260 | Domain | Note=Ig-like C2-type |
| Hgene | >JAM3 | chr11:133939054 | chr11:134126442 | ENST00000441717 | + | 1 | 8 | 35_127 | 25 | 260 | Domain | Note=Ig-like V-type |
| Hgene | >JAM3 | chr11:133939054 | chr11:134126442 | ENST00000529443 | + | 1 | 9 | 139_236 | 70 | 356 | Domain | Note=Ig-like C2-type |
| Hgene | >JAM3 | chr11:133939054 | chr11:134126442 | ENST00000529443 | + | 1 | 9 | 35_127 | 70 | 356 | Domain | Note=Ig-like V-type |
| Hgene | >JAM3 | chr11:133939054 | chr11:134126442 | ENST00000299106 | + | 1 | 9 | 263_310 | 25 | 311 | Topological domain | Cytoplasmic |
| Hgene | >JAM3 | chr11:133939054 | chr11:134126442 | ENST00000299106 | + | 1 | 9 | 32_241 | 25 | 311 | Topological domain | Extracellular |
| Hgene | >JAM3 | chr11:133939054 | chr11:134126442 | ENST00000441717 | + | 1 | 8 | 263_310 | 25 | 260 | Topological domain | Cytoplasmic |
| Hgene | >JAM3 | chr11:133939054 | chr11:134126442 | ENST00000441717 | + | 1 | 8 | 32_241 | 25 | 260 | Topological domain | Extracellular |
| Hgene | >JAM3 | chr11:133939054 | chr11:134126442 | ENST00000529443 | + | 1 | 9 | 263_310 | 70 | 356 | Topological domain | Cytoplasmic |
| Hgene | >JAM3 | chr11:133939054 | chr11:134126442 | ENST00000529443 | + | 1 | 9 | 32_241 | 70 | 356 | Topological domain | Extracellular |
| Hgene | >JAM3 | chr11:133939054 | chr11:134126442 | ENST00000299106 | + | 1 | 9 | 242_262 | 25 | 311 | Transmembrane | Helical |
| Hgene | >JAM3 | chr11:133939054 | chr11:134126442 | ENST00000441717 | + | 1 | 8 | 242_262 | 25 | 260 | Transmembrane | Helical |
| Hgene | >JAM3 | chr11:133939054 | chr11:134126442 | ENST00000529443 | + | 1 | 9 | 242_262 | 70 | 356 | Transmembrane | Helical |
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FusionGeneSequence for JAM3_ACAD8 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_JAM3_ENST00000529443_chr11_133939054_+_ACAD8_ENST00000281182_chr11_134126442_+_450aa MVPARLGPAVAMVTGAGRRVLAGWAHARGDYKPRRAAAGPSATLDMALRRPPRLRLCARLPDFFLLLLFRASMGLNEEQKEFQKVAFDFA AREMAPNMAEWDQKELFPVDVMRKAAQLGFGGVYIQTDVGGSGLSRLDTSVIFEALATGCTSTTAYISIHNMCAWMIDSFGNEEQRHKFC PPLCTMEKFASYCLTEPGSGSDAASLLTSAKKQGDHYILNGSKAFISGAGESDIYVVMCRTGGPGPKGISCIVVEKGTPGLSFGKKEKKV GWNSQPTRAVIFEDCAVPVANRIGSEGQGFLIAVRGLNGGRINIASCSLGAAHASVILTRDHLNVRKQFGEPLASNQYLQFTLADMATRL VAARLMVRNAAVALQEERKDAVALCSMAKLFATDECFAICNQALQMHGGYGYLKDYAVQQYVRDSRVHQILEGSNEVMRILISRSLLQEX >In-frame_JAM3_ENST00000299106_chr11_133939054_+_ACAD8_ENST00000281182_chr11_134126442_+_405aa MALRRPPRLRLCARLPDFFLLLLFRASMGLNEEQKEFQKVAFDFAAREMAPNMAEWDQKELFPVDVMRKAAQLGFGGVYIQTDVGGSGLS RLDTSVIFEALATGCTSTTAYISIHNMCAWMIDSFGNEEQRHKFCPPLCTMEKFASYCLTEPGSGSDAASLLTSAKKQGDHYILNGSKAF ISGAGESDIYVVMCRTGGPGPKGISCIVVEKGTPGLSFGKKEKKVGWNSQPTRAVIFEDCAVPVANRIGSEGQGFLIAVRGLNGGRINIA SCSLGAAHASVILTRDHLNVRKQFGEPLASNQYLQFTLADMATRLVAARLMVRNAAVALQEERKDAVALCSMAKLFATDECFAICNQALQ >In-frame_JAM3_ENST00000441717_chr11_133939054_+_ACAD8_ENST00000281182_chr11_134126442_+_405aa MALRRPPRLRLCARLPDFFLLLLFRASMGLNEEQKEFQKVAFDFAAREMAPNMAEWDQKELFPVDVMRKAAQLGFGGVYIQTDVGGSGLS RLDTSVIFEALATGCTSTTAYISIHNMCAWMIDSFGNEEQRHKFCPPLCTMEKFASYCLTEPGSGSDAASLLTSAKKQGDHYILNGSKAF ISGAGESDIYVVMCRTGGPGPKGISCIVVEKGTPGLSFGKKEKKVGWNSQPTRAVIFEDCAVPVANRIGSEGQGFLIAVRGLNGGRINIA SCSLGAAHASVILTRDHLNVRKQFGEPLASNQYLQFTLADMATRLVAARLMVRNAAVALQEERKDAVALCSMAKLFATDECFAICNQALQ |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_JAM3_ENST00000529443_chr11_133939054_+_ACAD8_ENST00000281182_chr11_134126442_+_1350nt ATGGTGCCGGCTCGGCTGGGCCCGGCGGTCGCCATGGTAACTGGGGCGGGTCGCAGGGTCCTGGCAGGCTGGGCGCATGCGCGCGGGGAC TACAAGCCGCGCCGCGCTGCCGCTGGCCCCTCAGCAACCCTCGACATGGCGCTGAGGCGGCCACCGCGACTCCGGCTCTGCGCTCGGCTG CCTGACTTCTTCCTGCTGCTGCTTTTCAGGGCTTCCATGGGACTTAATGAAGAGCAGAAAGAATTTCAAAAAGTGGCCTTTGACTTTGCT GCCCGAGAGATGGCTCCAAATATGGCAGAGTGGGACCAGAAGGAGCTGTTCCCAGTGGATGTGATGCGGAAGGCAGCCCAGCTAGGCTTC GGAGGGGTCTACATACAAACAGATGTGGGCGGGTCTGGGCTGTCACGTCTTGATACCTCTGTCATTTTTGAAGCCTTGGCTACAGGCTGC ACCAGCACCACAGCCTATATAAGCATCCACAACATGTGTGCCTGGATGATTGATAGCTTCGGAAATGAGGAACAGAGGCACAAATTTTGC CCACCGCTCTGTACCATGGAGAAGTTTGCTTCCTACTGCCTCACTGAACCAGGAAGTGGGAGTGATGCTGCCTCTCTTCTGACCTCCGCT AAGAAACAGGGAGATCATTACATCCTCAATGGCTCCAAGGCCTTCATCAGTGGTGCTGGTGAGTCAGACATCTATGTGGTCATGTGCCGA ACAGGAGGACCAGGCCCCAAGGGCATCTCATGCATAGTTGTTGAGAAGGGGACCCCTGGCCTCAGCTTTGGCAAGAAGGAGAAAAAGGTG GGGTGGAACTCCCAGCCAACACGAGCTGTGATCTTCGAAGACTGTGCTGTCCCTGTGGCCAACAGAATTGGGAGCGAGGGGCAGGGCTTC CTCATTGCCGTGAGAGGACTGAACGGAGGGAGGATCAATATTGCTTCCTGCTCCCTGGGGGCTGCCCACGCCTCTGTCATCCTCACCCGA GACCACCTCAATGTCCGGAAGCAGTTTGGAGAGCCTCTGGCCAGTAACCAGTACTTGCAATTCACACTGGCTGATATGGCAACAAGGCTG GTGGCCGCGCGGCTGATGGTCCGCAATGCAGCAGTGGCTCTGCAGGAGGAGAGGAAGGATGCAGTGGCCTTGTGCTCCATGGCCAAGCTC TTTGCTACAGATGAATGCTTTGCCATCTGCAACCAGGCCTTGCAGATGCACGGGGGCTACGGCTACCTGAAGGATTACGCTGTTCAGCAG TACGTGCGGGACTCCAGGGTCCACCAGATTCTAGAAGGTAGCAATGAAGTGATGAGGATACTGATCTCTAGAAGCCTGCTTCAGGAGTAG >In-frame_JAM3_ENST00000299106_chr11_133939054_+_ACAD8_ENST00000281182_chr11_134126442_+_1215nt ATGGCGCTGAGGCGGCCACCGCGACTCCGGCTCTGCGCTCGGCTGCCTGACTTCTTCCTGCTGCTGCTTTTCAGGGCTTCCATGGGACTT AATGAAGAGCAGAAAGAATTTCAAAAAGTGGCCTTTGACTTTGCTGCCCGAGAGATGGCTCCAAATATGGCAGAGTGGGACCAGAAGGAG CTGTTCCCAGTGGATGTGATGCGGAAGGCAGCCCAGCTAGGCTTCGGAGGGGTCTACATACAAACAGATGTGGGCGGGTCTGGGCTGTCA CGTCTTGATACCTCTGTCATTTTTGAAGCCTTGGCTACAGGCTGCACCAGCACCACAGCCTATATAAGCATCCACAACATGTGTGCCTGG ATGATTGATAGCTTCGGAAATGAGGAACAGAGGCACAAATTTTGCCCACCGCTCTGTACCATGGAGAAGTTTGCTTCCTACTGCCTCACT GAACCAGGAAGTGGGAGTGATGCTGCCTCTCTTCTGACCTCCGCTAAGAAACAGGGAGATCATTACATCCTCAATGGCTCCAAGGCCTTC ATCAGTGGTGCTGGTGAGTCAGACATCTATGTGGTCATGTGCCGAACAGGAGGACCAGGCCCCAAGGGCATCTCATGCATAGTTGTTGAG AAGGGGACCCCTGGCCTCAGCTTTGGCAAGAAGGAGAAAAAGGTGGGGTGGAACTCCCAGCCAACACGAGCTGTGATCTTCGAAGACTGT GCTGTCCCTGTGGCCAACAGAATTGGGAGCGAGGGGCAGGGCTTCCTCATTGCCGTGAGAGGACTGAACGGAGGGAGGATCAATATTGCT TCCTGCTCCCTGGGGGCTGCCCACGCCTCTGTCATCCTCACCCGAGACCACCTCAATGTCCGGAAGCAGTTTGGAGAGCCTCTGGCCAGT AACCAGTACTTGCAATTCACACTGGCTGATATGGCAACAAGGCTGGTGGCCGCGCGGCTGATGGTCCGCAATGCAGCAGTGGCTCTGCAG GAGGAGAGGAAGGATGCAGTGGCCTTGTGCTCCATGGCCAAGCTCTTTGCTACAGATGAATGCTTTGCCATCTGCAACCAGGCCTTGCAG ATGCACGGGGGCTACGGCTACCTGAAGGATTACGCTGTTCAGCAGTACGTGCGGGACTCCAGGGTCCACCAGATTCTAGAAGGTAGCAAT >In-frame_JAM3_ENST00000441717_chr11_133939054_+_ACAD8_ENST00000281182_chr11_134126442_+_1215nt ATGGCGCTGAGGCGGCCACCGCGACTCCGGCTCTGCGCTCGGCTGCCTGACTTCTTCCTGCTGCTGCTTTTCAGGGCTTCCATGGGACTT AATGAAGAGCAGAAAGAATTTCAAAAAGTGGCCTTTGACTTTGCTGCCCGAGAGATGGCTCCAAATATGGCAGAGTGGGACCAGAAGGAG CTGTTCCCAGTGGATGTGATGCGGAAGGCAGCCCAGCTAGGCTTCGGAGGGGTCTACATACAAACAGATGTGGGCGGGTCTGGGCTGTCA CGTCTTGATACCTCTGTCATTTTTGAAGCCTTGGCTACAGGCTGCACCAGCACCACAGCCTATATAAGCATCCACAACATGTGTGCCTGG ATGATTGATAGCTTCGGAAATGAGGAACAGAGGCACAAATTTTGCCCACCGCTCTGTACCATGGAGAAGTTTGCTTCCTACTGCCTCACT GAACCAGGAAGTGGGAGTGATGCTGCCTCTCTTCTGACCTCCGCTAAGAAACAGGGAGATCATTACATCCTCAATGGCTCCAAGGCCTTC ATCAGTGGTGCTGGTGAGTCAGACATCTATGTGGTCATGTGCCGAACAGGAGGACCAGGCCCCAAGGGCATCTCATGCATAGTTGTTGAG AAGGGGACCCCTGGCCTCAGCTTTGGCAAGAAGGAGAAAAAGGTGGGGTGGAACTCCCAGCCAACACGAGCTGTGATCTTCGAAGACTGT GCTGTCCCTGTGGCCAACAGAATTGGGAGCGAGGGGCAGGGCTTCCTCATTGCCGTGAGAGGACTGAACGGAGGGAGGATCAATATTGCT TCCTGCTCCCTGGGGGCTGCCCACGCCTCTGTCATCCTCACCCGAGACCACCTCAATGTCCGGAAGCAGTTTGGAGAGCCTCTGGCCAGT AACCAGTACTTGCAATTCACACTGGCTGATATGGCAACAAGGCTGGTGGCCGCGCGGCTGATGGTCCGCAATGCAGCAGTGGCTCTGCAG GAGGAGAGGAAGGATGCAGTGGCCTTGTGCTCCATGGCCAAGCTCTTTGCTACAGATGAATGCTTTGCCATCTGCAACCAGGCCTTGCAG ATGCACGGGGGCTACGGCTACCTGAAGGATTACGCTGTTCAGCAGTACGTGCGGGACTCCAGGGTCCACCAGATTCTAGAAGGTAGCAAT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_JAM3_ENST00000529443_chr11_133939054_+_ACAD8_ENST00000281182_chr11_134126442_+_2269nt TAGACCTCAGCTTCCTCTGTCACCATGGTGCCGGCTCGGCTGGGCCCGGCGGTCGCCATGGTAACTGGGGCGGGTCGCAGGGTCCTGGCA GGCTGGGCGCATGCGCGCGGGGACTACAAGCCGCGCCGCGCTGCCGCTGGCCCCTCAGCAACCCTCGACATGGCGCTGAGGCGGCCACCG CGACTCCGGCTCTGCGCTCGGCTGCCTGACTTCTTCCTGCTGCTGCTTTTCAGGGCTTCCATGGGACTTAATGAAGAGCAGAAAGAATTT CAAAAAGTGGCCTTTGACTTTGCTGCCCGAGAGATGGCTCCAAATATGGCAGAGTGGGACCAGAAGGAGCTGTTCCCAGTGGATGTGATG CGGAAGGCAGCCCAGCTAGGCTTCGGAGGGGTCTACATACAAACAGATGTGGGCGGGTCTGGGCTGTCACGTCTTGATACCTCTGTCATT TTTGAAGCCTTGGCTACAGGCTGCACCAGCACCACAGCCTATATAAGCATCCACAACATGTGTGCCTGGATGATTGATAGCTTCGGAAAT GAGGAACAGAGGCACAAATTTTGCCCACCGCTCTGTACCATGGAGAAGTTTGCTTCCTACTGCCTCACTGAACCAGGAAGTGGGAGTGAT GCTGCCTCTCTTCTGACCTCCGCTAAGAAACAGGGAGATCATTACATCCTCAATGGCTCCAAGGCCTTCATCAGTGGTGCTGGTGAGTCA GACATCTATGTGGTCATGTGCCGAACAGGAGGACCAGGCCCCAAGGGCATCTCATGCATAGTTGTTGAGAAGGGGACCCCTGGCCTCAGC TTTGGCAAGAAGGAGAAAAAGGTGGGGTGGAACTCCCAGCCAACACGAGCTGTGATCTTCGAAGACTGTGCTGTCCCTGTGGCCAACAGA ATTGGGAGCGAGGGGCAGGGCTTCCTCATTGCCGTGAGAGGACTGAACGGAGGGAGGATCAATATTGCTTCCTGCTCCCTGGGGGCTGCC CACGCCTCTGTCATCCTCACCCGAGACCACCTCAATGTCCGGAAGCAGTTTGGAGAGCCTCTGGCCAGTAACCAGTACTTGCAATTCACA CTGGCTGATATGGCAACAAGGCTGGTGGCCGCGCGGCTGATGGTCCGCAATGCAGCAGTGGCTCTGCAGGAGGAGAGGAAGGATGCAGTG GCCTTGTGCTCCATGGCCAAGCTCTTTGCTACAGATGAATGCTTTGCCATCTGCAACCAGGCCTTGCAGATGCACGGGGGCTACGGCTAC CTGAAGGATTACGCTGTTCAGCAGTACGTGCGGGACTCCAGGGTCCACCAGATTCTAGAAGGTAGCAATGAAGTGATGAGGATACTGATC TCTAGAAGCCTGCTTCAGGAGTAGAACCCACACTTGTTCTGGCCTGGTGTTCAGTGCGACTGCAGTCAGTGTTGAGTGGTGCCATGTGGG CCGCTCTATTCCAAAGGAATCATGGATTAGACCCAAGGGCTGAGCTCCTCTAGGGCAGGACCTGCACCCTGTGTGTTGGCACCAGCATCG GGTCTTGGACTGGGGCAGAATCCCCAGTGGAACCGGAAGAGCTGGACTGATGAGAAACATCAGAAGAACACATACTACCTTGTTTTCCTA ATGCCAGAAGGGTGACCAGTGAAGATTCACCGTCAAACCATGAAAGTCCTTTCTTGGATCCACTTTATCTTGATTAGTCTGCATTTTACT AGTTCACTGGATCCCTCCTCTAGGGGCCTGGGGACTTTCACTGATGCTCTTCCTGATTCTAGAGCAAAGGTGTGGGAAGGGGAAATGGAG GAATGCCCTCCTGTCTGTGTCGTTCTCTGTGCCACAGCTACAGATGCAGAAGGTTTCTCTGGATAGCACACCTCTGAATGTAAATCATGA TAAAATGGATATTTGGAAACTTACTCCTAAGCTGTGATTTAGGGTGTATTTCTACTTCTGGACTGCCTCAATATCAAGGGCTGAGACTTT TGAATTTTGAATATTCGTTGGGTTTCATGTTAAGAAGCCTGTGGTCTAGGAGTGCTATTCAGTGTTTCTTTTCCTGATAAACACTTTGAA TATTTTTTTTGTGTTTTTGTTTCCTTTTCTGAAGCTGTTCCTCCTTTTAAATATTTTTAATCACATTGATAAAATCTATCCTTCACCACC TCTGGTTCTACTATAGTTGATTTTTATTTTAAATGTTTAATTGTATTTGATTAAACACTTAACTGGATTTTGGAATAATAAAACTCTCGT >In-frame_JAM3_ENST00000299106_chr11_133939054_+_ACAD8_ENST00000281182_chr11_134126442_+_2269nt TAGACCTCAGCTTCCTCTGTCACCATGGTGCCGGCTCGGCTGGGCCCGGCGGTCGCCATGGTAACTGGGGCGGGTCGCAGGGTCCTGGCA GGCTGGGCGCATGCGCGCGGGGACTACAAGCCGCGCCGCGCTGCCGCTGGCCCCTCAGCAACCCTCGACATGGCGCTGAGGCGGCCACCG CGACTCCGGCTCTGCGCTCGGCTGCCTGACTTCTTCCTGCTGCTGCTTTTCAGGGCTTCCATGGGACTTAATGAAGAGCAGAAAGAATTT CAAAAAGTGGCCTTTGACTTTGCTGCCCGAGAGATGGCTCCAAATATGGCAGAGTGGGACCAGAAGGAGCTGTTCCCAGTGGATGTGATG CGGAAGGCAGCCCAGCTAGGCTTCGGAGGGGTCTACATACAAACAGATGTGGGCGGGTCTGGGCTGTCACGTCTTGATACCTCTGTCATT TTTGAAGCCTTGGCTACAGGCTGCACCAGCACCACAGCCTATATAAGCATCCACAACATGTGTGCCTGGATGATTGATAGCTTCGGAAAT GAGGAACAGAGGCACAAATTTTGCCCACCGCTCTGTACCATGGAGAAGTTTGCTTCCTACTGCCTCACTGAACCAGGAAGTGGGAGTGAT GCTGCCTCTCTTCTGACCTCCGCTAAGAAACAGGGAGATCATTACATCCTCAATGGCTCCAAGGCCTTCATCAGTGGTGCTGGTGAGTCA GACATCTATGTGGTCATGTGCCGAACAGGAGGACCAGGCCCCAAGGGCATCTCATGCATAGTTGTTGAGAAGGGGACCCCTGGCCTCAGC TTTGGCAAGAAGGAGAAAAAGGTGGGGTGGAACTCCCAGCCAACACGAGCTGTGATCTTCGAAGACTGTGCTGTCCCTGTGGCCAACAGA ATTGGGAGCGAGGGGCAGGGCTTCCTCATTGCCGTGAGAGGACTGAACGGAGGGAGGATCAATATTGCTTCCTGCTCCCTGGGGGCTGCC CACGCCTCTGTCATCCTCACCCGAGACCACCTCAATGTCCGGAAGCAGTTTGGAGAGCCTCTGGCCAGTAACCAGTACTTGCAATTCACA CTGGCTGATATGGCAACAAGGCTGGTGGCCGCGCGGCTGATGGTCCGCAATGCAGCAGTGGCTCTGCAGGAGGAGAGGAAGGATGCAGTG GCCTTGTGCTCCATGGCCAAGCTCTTTGCTACAGATGAATGCTTTGCCATCTGCAACCAGGCCTTGCAGATGCACGGGGGCTACGGCTAC CTGAAGGATTACGCTGTTCAGCAGTACGTGCGGGACTCCAGGGTCCACCAGATTCTAGAAGGTAGCAATGAAGTGATGAGGATACTGATC TCTAGAAGCCTGCTTCAGGAGTAGAACCCACACTTGTTCTGGCCTGGTGTTCAGTGCGACTGCAGTCAGTGTTGAGTGGTGCCATGTGGG CCGCTCTATTCCAAAGGAATCATGGATTAGACCCAAGGGCTGAGCTCCTCTAGGGCAGGACCTGCACCCTGTGTGTTGGCACCAGCATCG GGTCTTGGACTGGGGCAGAATCCCCAGTGGAACCGGAAGAGCTGGACTGATGAGAAACATCAGAAGAACACATACTACCTTGTTTTCCTA ATGCCAGAAGGGTGACCAGTGAAGATTCACCGTCAAACCATGAAAGTCCTTTCTTGGATCCACTTTATCTTGATTAGTCTGCATTTTACT AGTTCACTGGATCCCTCCTCTAGGGGCCTGGGGACTTTCACTGATGCTCTTCCTGATTCTAGAGCAAAGGTGTGGGAAGGGGAAATGGAG GAATGCCCTCCTGTCTGTGTCGTTCTCTGTGCCACAGCTACAGATGCAGAAGGTTTCTCTGGATAGCACACCTCTGAATGTAAATCATGA TAAAATGGATATTTGGAAACTTACTCCTAAGCTGTGATTTAGGGTGTATTTCTACTTCTGGACTGCCTCAATATCAAGGGCTGAGACTTT TGAATTTTGAATATTCGTTGGGTTTCATGTTAAGAAGCCTGTGGTCTAGGAGTGCTATTCAGTGTTTCTTTTCCTGATAAACACTTTGAA TATTTTTTTTGTGTTTTTGTTTCCTTTTCTGAAGCTGTTCCTCCTTTTAAATATTTTTAATCACATTGATAAAATCTATCCTTCACCACC TCTGGTTCTACTATAGTTGATTTTTATTTTAAATGTTTAATTGTATTTGATTAAACACTTAACTGGATTTTGGAATAATAAAACTCTCGT >In-frame_JAM3_ENST00000441717_chr11_133939054_+_ACAD8_ENST00000281182_chr11_134126442_+_2123nt AGCAACCCTCGACATGGCGCTGAGGCGGCCACCGCGACTCCGGCTCTGCGCTCGGCTGCCTGACTTCTTCCTGCTGCTGCTTTTCAGGGC TTCCATGGGACTTAATGAAGAGCAGAAAGAATTTCAAAAAGTGGCCTTTGACTTTGCTGCCCGAGAGATGGCTCCAAATATGGCAGAGTG GGACCAGAAGGAGCTGTTCCCAGTGGATGTGATGCGGAAGGCAGCCCAGCTAGGCTTCGGAGGGGTCTACATACAAACAGATGTGGGCGG GTCTGGGCTGTCACGTCTTGATACCTCTGTCATTTTTGAAGCCTTGGCTACAGGCTGCACCAGCACCACAGCCTATATAAGCATCCACAA CATGTGTGCCTGGATGATTGATAGCTTCGGAAATGAGGAACAGAGGCACAAATTTTGCCCACCGCTCTGTACCATGGAGAAGTTTGCTTC CTACTGCCTCACTGAACCAGGAAGTGGGAGTGATGCTGCCTCTCTTCTGACCTCCGCTAAGAAACAGGGAGATCATTACATCCTCAATGG CTCCAAGGCCTTCATCAGTGGTGCTGGTGAGTCAGACATCTATGTGGTCATGTGCCGAACAGGAGGACCAGGCCCCAAGGGCATCTCATG CATAGTTGTTGAGAAGGGGACCCCTGGCCTCAGCTTTGGCAAGAAGGAGAAAAAGGTGGGGTGGAACTCCCAGCCAACACGAGCTGTGAT CTTCGAAGACTGTGCTGTCCCTGTGGCCAACAGAATTGGGAGCGAGGGGCAGGGCTTCCTCATTGCCGTGAGAGGACTGAACGGAGGGAG GATCAATATTGCTTCCTGCTCCCTGGGGGCTGCCCACGCCTCTGTCATCCTCACCCGAGACCACCTCAATGTCCGGAAGCAGTTTGGAGA GCCTCTGGCCAGTAACCAGTACTTGCAATTCACACTGGCTGATATGGCAACAAGGCTGGTGGCCGCGCGGCTGATGGTCCGCAATGCAGC AGTGGCTCTGCAGGAGGAGAGGAAGGATGCAGTGGCCTTGTGCTCCATGGCCAAGCTCTTTGCTACAGATGAATGCTTTGCCATCTGCAA CCAGGCCTTGCAGATGCACGGGGGCTACGGCTACCTGAAGGATTACGCTGTTCAGCAGTACGTGCGGGACTCCAGGGTCCACCAGATTCT AGAAGGTAGCAATGAAGTGATGAGGATACTGATCTCTAGAAGCCTGCTTCAGGAGTAGAACCCACACTTGTTCTGGCCTGGTGTTCAGTG CGACTGCAGTCAGTGTTGAGTGGTGCCATGTGGGCCGCTCTATTCCAAAGGAATCATGGATTAGACCCAAGGGCTGAGCTCCTCTAGGGC AGGACCTGCACCCTGTGTGTTGGCACCAGCATCGGGTCTTGGACTGGGGCAGAATCCCCAGTGGAACCGGAAGAGCTGGACTGATGAGAA ACATCAGAAGAACACATACTACCTTGTTTTCCTAATGCCAGAAGGGTGACCAGTGAAGATTCACCGTCAAACCATGAAAGTCCTTTCTTG GATCCACTTTATCTTGATTAGTCTGCATTTTACTAGTTCACTGGATCCCTCCTCTAGGGGCCTGGGGACTTTCACTGATGCTCTTCCTGA TTCTAGAGCAAAGGTGTGGGAAGGGGAAATGGAGGAATGCCCTCCTGTCTGTGTCGTTCTCTGTGCCACAGCTACAGATGCAGAAGGTTT CTCTGGATAGCACACCTCTGAATGTAAATCATGATAAAATGGATATTTGGAAACTTACTCCTAAGCTGTGATTTAGGGTGTATTTCTACT TCTGGACTGCCTCAATATCAAGGGCTGAGACTTTTGAATTTTGAATATTCGTTGGGTTTCATGTTAAGAAGCCTGTGGTCTAGGAGTGCT ATTCAGTGTTTCTTTTCCTGATAAACACTTTGAATATTTTTTTTGTGTTTTTGTTTCCTTTTCTGAAGCTGTTCCTCCTTTTAAATATTT TTAATCACATTGATAAAATCTATCCTTCACCACCTCTGGTTCTACTATAGTTGATTTTTATTTTAAATGTTTAATTGTATTTGATTAAAC |
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FusionGenePPI for JAM3_ACAD8 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| JAM3 | PARD3, TJP1, ITGAM, JAM2, JAM3, RHOU | ACAD8 | PPP1CC, TRUB2, SRGAP3, CYP2C18, VSTM2A, ACADSB, DLG3, CKAP5, IPO8, LDHD, RHOU, ABHD11, MTMR14, VPS37D, DUSP14, FAM161B, FCGR1A, POLM, PTPN14, PTPN21, PTPN22, TENC1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for JAM3_ACAD8 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for JAM3_ACAD8 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | JAM3 | C3151000 | HEMORRHAGIC DESTRUCTION OF THE BRAIN, SUBEPENDYMAL CALCIFICATION, AND CATARACTS | 1 | CTD_human;ORPHANET;UNIPROT |
| Tgene | ACAD8 | C1969809 | Isobutyryl-CoA dehydrogenase deficiency | 2 | CTD_human;ORPHANET;UNIPROT |
| Tgene | ACAD8 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
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