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Fusion gene ID: 18005 |
FusionGeneSummary for JAK1_ATF3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: JAK1_ATF3 | Fusion gene ID: 18005 | Hgene | Tgene | Gene symbol | JAK1 | ATF3 | Gene ID | 3716 | 467 |
| Gene name | Janus kinase 1 | activating transcription factor 3 | |
| Synonyms | JAK1A|JAK1B|JTK3 | - | |
| Cytomap | 1p31.3 | 1q32.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tyrosine-protein kinase JAK1 | cyclic AMP-dependent transcription factor ATF-3cAMP-dependent transcription factor ATF-3 | |
| Modification date | 20180527 | 20180523 | |
| UniProtAcc | P23458 | P18847 | |
| Ensembl transtripts involved in fusion gene | ENST00000342505, ENST00000465376, | ENST00000366987, ENST00000341491, ENST00000366985, ENST00000492118, ENST00000336937, ENST00000366983, | |
| Fusion gene scores | * DoF score | 6 X 4 X 5=120 | 4 X 4 X 2=32 |
| # samples | 6 | 4 | |
| ** MAII score | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: JAK1 [Title/Abstract] AND ATF3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | JAK1 | GO:0038110 | interleukin-2-mediated signaling pathway | 11909529 |
| Hgene | JAK1 | GO:0046677 | response to antibiotic | 16280321 |
| Tgene | ATF3 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 8622660 |
| Tgene | ATF3 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 16300731 |
| Tgene | ATF3 | GO:1990440 | positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress | 24939851 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BE719597 | JAK1 | chr1 | 65339137 | - | ATF3 | chr1 | 212791479 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000342505 | ENST00000366987 | JAK1 | chr1 | 65339137 | - | ATF3 | chr1 | 212791479 | + |
| intron-3CDS | ENST00000342505 | ENST00000341491 | JAK1 | chr1 | 65339137 | - | ATF3 | chr1 | 212791479 | + |
| intron-3CDS | ENST00000342505 | ENST00000366985 | JAK1 | chr1 | 65339137 | - | ATF3 | chr1 | 212791479 | + |
| intron-intron | ENST00000342505 | ENST00000492118 | JAK1 | chr1 | 65339137 | - | ATF3 | chr1 | 212791479 | + |
| intron-intron | ENST00000342505 | ENST00000336937 | JAK1 | chr1 | 65339137 | - | ATF3 | chr1 | 212791479 | + |
| intron-intron | ENST00000342505 | ENST00000366983 | JAK1 | chr1 | 65339137 | - | ATF3 | chr1 | 212791479 | + |
| intron-3CDS | ENST00000465376 | ENST00000366987 | JAK1 | chr1 | 65339137 | - | ATF3 | chr1 | 212791479 | + |
| intron-3CDS | ENST00000465376 | ENST00000341491 | JAK1 | chr1 | 65339137 | - | ATF3 | chr1 | 212791479 | + |
| intron-3CDS | ENST00000465376 | ENST00000366985 | JAK1 | chr1 | 65339137 | - | ATF3 | chr1 | 212791479 | + |
| intron-intron | ENST00000465376 | ENST00000492118 | JAK1 | chr1 | 65339137 | - | ATF3 | chr1 | 212791479 | + |
| intron-intron | ENST00000465376 | ENST00000336937 | JAK1 | chr1 | 65339137 | - | ATF3 | chr1 | 212791479 | + |
| intron-intron | ENST00000465376 | ENST00000366983 | JAK1 | chr1 | 65339137 | - | ATF3 | chr1 | 212791479 | + |
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FusionProtFeatures for JAK1_ATF3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| JAK1 | ATF3 |
| Tyrosine kinase of the non-receptor type, involved inthe IFN-alpha/beta/gamma signal pathway (PubMed:7615558). Kinasepartner for the interleukin (IL)-2 receptor (PubMed:11909529).{ECO:0000269|PubMed:11909529, ECO:0000269|PubMed:7615558}. | This protein binds the cAMP response element (CRE)(consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in manyviral and cellular promoters. Represses transcription frompromoters with ATF sites. It may repress transcription bystabilizing the binding of inhibitory cofactors at the promoter.Isoform 2 activates transcription presumably by sequesteringinhibitory cofactors away from the promoters. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for JAK1_ATF3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for JAK1_ATF3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for JAK1_ATF3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | JAK1 | P23458 | DB08877 | Ruxolitinib | Tyrosine-protein kinase JAK1 | small molecule | approved |
| Hgene | JAK1 | P23458 | DB08895 | Tofacitinib | Tyrosine-protein kinase JAK1 | small molecule | approved|investigational |
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RelatedDiseases for JAK1_ATF3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | ATF3 | C0027765 | nervous system disorder | 2 | CTD_human |
| Tgene | ATF3 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
| Tgene | ATF3 | C0011570 | Mental Depression | 1 | PSYGENET |
| Tgene | ATF3 | C0011581 | Depressive disorder | 1 | PSYGENET |
| Tgene | ATF3 | C0011853 | Diabetes Mellitus, Experimental | 1 | CTD_human |
| Tgene | ATF3 | C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | CTD_human |
| Tgene | ATF3 | C0021400 | Influenza | 1 | CTD_human |
| Tgene | ATF3 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | ATF3 | C0023903 | Liver neoplasms | 1 | CTD_human |
| Tgene | ATF3 | C0031117 | Peripheral Neuropathy | 1 | CTD_human |
| Tgene | ATF3 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
| Tgene | ATF3 | C0740392 | Infarction, Middle Cerebral Artery | 1 | CTD_human |
| Tgene | ATF3 | C0848558 | Hypospadias | 1 | CTD_human |
| Tgene | ATF3 | C0878544 | Cardiomyopathies | 1 | CTD_human |
| Tgene | ATF3 | C0919267 | ovarian neoplasm | 1 | CTD_human |
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