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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17992

FusionGeneSummary for IVNS1ABP_IVNS1ABP

check button Fusion gene summary
Fusion gene informationFusion gene name: IVNS1ABP_IVNS1ABP
Fusion gene ID: 17992
HgeneTgene
Gene symbol

IVNS1ABP

IVNS1ABP

Gene ID

10625

10625

Gene nameinfluenza virus NS1A binding proteininfluenza virus NS1A binding protein
SynonymsARA3|FLARA3|HSPC068|KLHL39|ND1|NS-1|NS1-BP|NS1BPARA3|FLARA3|HSPC068|KLHL39|ND1|NS-1|NS1-BP|NS1BP
Cytomap

1q25.3

1q25.3

Type of geneprotein-codingprotein-coding
Descriptioninfluenza virus NS1A-binding proteinNCX downstream gene 1NS1-binding proteinaryl hydrocarbon receptor-associated 3aryl hydrocarbon receptor-associated protein 3kelch-like family member 39influenza virus NS1A-binding proteinNCX downstream gene 1NS1-binding proteinaryl hydrocarbon receptor-associated 3aryl hydrocarbon receptor-associated protein 3kelch-like family member 39
Modification date2018052220180522
UniProtAcc

Q9Y6Y0

Q9Y6Y0

Ensembl transtripts involved in fusion geneENST00000367498, ENST00000459929, 
ENST00000392007, ENST00000367497, 
ENST00000367498, ENST00000459929, 
ENST00000392007, ENST00000367497, 
Fusion gene scores* DoF score4 X 5 X 1=203 X 4 X 2=24
# samples 54
** MAII scorelog2(5/20*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: IVNS1ABP [Title/Abstract] AND IVNS1ABP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI750915IVNS1ABPchr1

185266972

-IVNS1ABPchr1

185267154

+
ChiTaRS3.1BU619849IVNS1ABPchr1

185266962

+IVNS1ABPchr1

185280304

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000367498ENST00000367498IVNS1ABPchr1

185266972

-IVNS1ABPchr1

185267154

+
intron-5UTRENST00000367498ENST00000459929IVNS1ABPchr1

185266972

-IVNS1ABPchr1

185267154

+
intron-3UTRENST00000367498ENST00000392007IVNS1ABPchr1

185266972

-IVNS1ABPchr1

185267154

+
intron-intronENST00000367498ENST00000367497IVNS1ABPchr1

185266972

-IVNS1ABPchr1

185267154

+
intron-3UTRENST00000459929ENST00000367498IVNS1ABPchr1

185266972

-IVNS1ABPchr1

185267154

+
intron-5UTRENST00000459929ENST00000459929IVNS1ABPchr1

185266972

-IVNS1ABPchr1

185267154

+
intron-3UTRENST00000459929ENST00000392007IVNS1ABPchr1

185266972

-IVNS1ABPchr1

185267154

+
intron-intronENST00000459929ENST00000367497IVNS1ABPchr1

185266972

-IVNS1ABPchr1

185267154

+
intron-3UTRENST00000392007ENST00000367498IVNS1ABPchr1

185266972

-IVNS1ABPchr1

185267154

+
intron-5UTRENST00000392007ENST00000459929IVNS1ABPchr1

185266972

-IVNS1ABPchr1

185267154

+
intron-3UTRENST00000392007ENST00000392007IVNS1ABPchr1

185266972

-IVNS1ABPchr1

185267154

+
intron-intronENST00000392007ENST00000367497IVNS1ABPchr1

185266972

-IVNS1ABPchr1

185267154

+
intron-3UTRENST00000367497ENST00000367498IVNS1ABPchr1

185266972

-IVNS1ABPchr1

185267154

+
intron-5UTRENST00000367497ENST00000459929IVNS1ABPchr1

185266972

-IVNS1ABPchr1

185267154

+
intron-3UTRENST00000367497ENST00000392007IVNS1ABPchr1

185266972

-IVNS1ABPchr1

185267154

+
intron-intronENST00000367497ENST00000367497IVNS1ABPchr1

185266972

-IVNS1ABPchr1

185267154

+
intron-5UTRENST00000367498ENST00000367498IVNS1ABPchr1

185266962

+IVNS1ABPchr1

185280304

-
intron-5UTRENST00000367498ENST00000459929IVNS1ABPchr1

185266962

+IVNS1ABPchr1

185280304

-
intron-5UTRENST00000367498ENST00000392007IVNS1ABPchr1

185266962

+IVNS1ABPchr1

185280304

-
intron-intronENST00000367498ENST00000367497IVNS1ABPchr1

185266962

+IVNS1ABPchr1

185280304

-
intron-5UTRENST00000459929ENST00000367498IVNS1ABPchr1

185266962

+IVNS1ABPchr1

185280304

-
intron-5UTRENST00000459929ENST00000459929IVNS1ABPchr1

185266962

+IVNS1ABPchr1

185280304

-
intron-5UTRENST00000459929ENST00000392007IVNS1ABPchr1

185266962

+IVNS1ABPchr1

185280304

-
intron-intronENST00000459929ENST00000367497IVNS1ABPchr1

185266962

+IVNS1ABPchr1

185280304

-
intron-5UTRENST00000392007ENST00000367498IVNS1ABPchr1

185266962

+IVNS1ABPchr1

185280304

-
intron-5UTRENST00000392007ENST00000459929IVNS1ABPchr1

185266962

+IVNS1ABPchr1

185280304

-
intron-5UTRENST00000392007ENST00000392007IVNS1ABPchr1

185266962

+IVNS1ABPchr1

185280304

-
intron-intronENST00000392007ENST00000367497IVNS1ABPchr1

185266962

+IVNS1ABPchr1

185280304

-
intron-5UTRENST00000367497ENST00000367498IVNS1ABPchr1

185266962

+IVNS1ABPchr1

185280304

-
intron-5UTRENST00000367497ENST00000459929IVNS1ABPchr1

185266962

+IVNS1ABPchr1

185280304

-
intron-5UTRENST00000367497ENST00000392007IVNS1ABPchr1

185266962

+IVNS1ABPchr1

185280304

-
intron-intronENST00000367497ENST00000367497IVNS1ABPchr1

185266962

+IVNS1ABPchr1

185280304

-

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FusionProtFeatures for IVNS1ABP_IVNS1ABP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IVNS1ABP

Q9Y6Y0

IVNS1ABP

Q9Y6Y0


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for IVNS1ABP_IVNS1ABP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for IVNS1ABP_IVNS1ABP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for IVNS1ABP_IVNS1ABP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for IVNS1ABP_IVNS1ABP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIVNS1ABPC0033578Prostatic Neoplasms1CTD_human
TgeneIVNS1ABPC0033578Prostatic Neoplasms1CTD_human