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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17991

FusionGeneSummary for IVNS1ABP_GRSF1

check button Fusion gene summary
Fusion gene informationFusion gene name: IVNS1ABP_GRSF1
Fusion gene ID: 17991
HgeneTgene
Gene symbol

IVNS1ABP

GRSF1

Gene ID

10625

2926

Gene nameinfluenza virus NS1A binding proteinG-rich RNA sequence binding factor 1
SynonymsARA3|FLARA3|HSPC068|KLHL39|ND1|NS-1|NS1-BP|NS1BP-
Cytomap

1q25.3

4q13.3

Type of geneprotein-codingprotein-coding
Descriptioninfluenza virus NS1A-binding proteinNCX downstream gene 1NS1-binding proteinaryl hydrocarbon receptor-associated 3aryl hydrocarbon receptor-associated protein 3kelch-like family member 39G-rich sequence factor 1GRSF-1
Modification date2018052220180519
UniProtAcc

Q9Y6Y0

Q12849

Ensembl transtripts involved in fusion geneENST00000367498, ENST00000459929, 
ENST00000392007, ENST00000367497, 
ENST00000254799, ENST00000439371, 
ENST00000502323, ENST00000545193, 
ENST00000508091, 
Fusion gene scores* DoF score4 X 5 X 1=205 X 4 X 2=40
# samples 55
** MAII scorelog2(5/20*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: IVNS1ABP [Title/Abstract] AND GRSF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE173356IVNS1ABPchr1

185266657

-GRSF1chr4

71685543

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000367498ENST00000254799IVNS1ABPchr1

185266657

-GRSF1chr4

71685543

+
intron-3UTRENST00000367498ENST00000439371IVNS1ABPchr1

185266657

-GRSF1chr4

71685543

+
intron-intronENST00000367498ENST00000502323IVNS1ABPchr1

185266657

-GRSF1chr4

71685543

+
intron-intronENST00000367498ENST00000545193IVNS1ABPchr1

185266657

-GRSF1chr4

71685543

+
intron-intronENST00000367498ENST00000508091IVNS1ABPchr1

185266657

-GRSF1chr4

71685543

+
intron-3UTRENST00000459929ENST00000254799IVNS1ABPchr1

185266657

-GRSF1chr4

71685543

+
intron-3UTRENST00000459929ENST00000439371IVNS1ABPchr1

185266657

-GRSF1chr4

71685543

+
intron-intronENST00000459929ENST00000502323IVNS1ABPchr1

185266657

-GRSF1chr4

71685543

+
intron-intronENST00000459929ENST00000545193IVNS1ABPchr1

185266657

-GRSF1chr4

71685543

+
intron-intronENST00000459929ENST00000508091IVNS1ABPchr1

185266657

-GRSF1chr4

71685543

+
intron-3UTRENST00000392007ENST00000254799IVNS1ABPchr1

185266657

-GRSF1chr4

71685543

+
intron-3UTRENST00000392007ENST00000439371IVNS1ABPchr1

185266657

-GRSF1chr4

71685543

+
intron-intronENST00000392007ENST00000502323IVNS1ABPchr1

185266657

-GRSF1chr4

71685543

+
intron-intronENST00000392007ENST00000545193IVNS1ABPchr1

185266657

-GRSF1chr4

71685543

+
intron-intronENST00000392007ENST00000508091IVNS1ABPchr1

185266657

-GRSF1chr4

71685543

+
intron-3UTRENST00000367497ENST00000254799IVNS1ABPchr1

185266657

-GRSF1chr4

71685543

+
intron-3UTRENST00000367497ENST00000439371IVNS1ABPchr1

185266657

-GRSF1chr4

71685543

+
intron-intronENST00000367497ENST00000502323IVNS1ABPchr1

185266657

-GRSF1chr4

71685543

+
intron-intronENST00000367497ENST00000545193IVNS1ABPchr1

185266657

-GRSF1chr4

71685543

+
intron-intronENST00000367497ENST00000508091IVNS1ABPchr1

185266657

-GRSF1chr4

71685543

+

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FusionProtFeatures for IVNS1ABP_GRSF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IVNS1ABP

Q9Y6Y0

GRSF1

Q12849

Regulator of post-transcriptional mitochondrial geneexpression, required for assembly of the mitochondrial ribosomeand for recruitment of mRNA and lncRNA. Binds RNAs containing the14 base G-rich element. Preferentially binds RNAs transcribed fromthree contiguous genes on the light strand of mtDNA, the ND6 mRNA,and the long non-coding RNAs for MT-CYB and MT-ND5, each of whichcontains multiple consensus binding sequences.{ECO:0000269|PubMed:23473033, ECO:0000269|PubMed:23473034}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for IVNS1ABP_GRSF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for IVNS1ABP_GRSF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for IVNS1ABP_GRSF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for IVNS1ABP_GRSF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIVNS1ABPC0033578Prostatic Neoplasms1CTD_human