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Fusion gene ID: 17989 |
FusionGeneSummary for IVD_MALAT1 |
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Fusion gene information | Fusion gene name: IVD_MALAT1 | Fusion gene ID: 17989 | Hgene | Tgene | Gene symbol | IVD | MALAT1 | Gene ID | 3712 | 378938 |
Gene name | isovaleryl-CoA dehydrogenase | metastasis associated lung adenocarcinoma transcript 1 | |
Synonyms | ACAD2 | HCN|LINC00047|NCRNA00047|NEAT2|PRO2853 | |
Cytomap | 15q15.1 | 11q13.1 | |
Type of gene | protein-coding | ncRNA | |
Description | isovaleryl-CoA dehydrogenase, mitochondrialisovaleryl Coenzyme A dehydrogenase | hepcarcinlong intergenic non-protein coding RNA 47metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)nuclear enriched abundant transcript 2nuclear paraspeckle assembly transcript 2 (non-protein coding) | |
Modification date | 20180523 | 20180527 | |
UniProtAcc | P26440 | ||
Ensembl transtripts involved in fusion gene | ENST00000249760, ENST00000490194, ENST00000487418, ENST00000479013, | ENST00000534336, | |
Fusion gene scores | * DoF score | 4 X 5 X 2=40 | 71 X 110 X 1=7810 |
# samples | 6 | 126 | |
** MAII score | log2(6/40*10)=0.584962500721156 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(126/7810*10)=-2.63189881464206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: IVD [Title/Abstract] AND MALAT1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | IVD | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase | 3597357 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AI928420 | IVD | chr15 | 40713130 | - | MALAT1 | chr11 | 65268007 | - | ||
ChiTaRS3.1 | AA618569 | IVD | chr15 | 40713130 | - | MALAT1 | chr11 | 65268007 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3UTR | ENST00000249760 | ENST00000534336 | IVD | chr15 | 40713130 | - | MALAT1 | chr11 | 65268007 | - |
intron-3UTR | ENST00000490194 | ENST00000534336 | IVD | chr15 | 40713130 | - | MALAT1 | chr11 | 65268007 | - |
intron-3UTR | ENST00000487418 | ENST00000534336 | IVD | chr15 | 40713130 | - | MALAT1 | chr11 | 65268007 | - |
3UTR-3UTR | ENST00000479013 | ENST00000534336 | IVD | chr15 | 40713130 | - | MALAT1 | chr11 | 65268007 | - |
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FusionProtFeatures for IVD_MALAT1 |
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Hgene | Tgene |
IVD | MALAT1 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for IVD_MALAT1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for IVD_MALAT1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for IVD_MALAT1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for IVD_MALAT1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | IVD | C0268575 | Isovaleryl-CoA dehydrogenase deficiency | 5 | CTD_human;ORPHANET;UNIPROT |
Hgene | IVD | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | MALAT1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | MALAT1 | C0023903 | Liver neoplasms | 1 | CTD_human |
Tgene | MALAT1 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Tgene | MALAT1 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Tgene | MALAT1 | C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |
Tgene | MALAT1 | C0236663 | Alcohol withdrawal syndrome | 1 | PSYGENET |
Tgene | MALAT1 | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |