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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17988

FusionGeneSummary for IVD_IVD

check button Fusion gene summary
Fusion gene informationFusion gene name: IVD_IVD
Fusion gene ID: 17988
HgeneTgene
Gene symbol

IVD

IVD

Gene ID

3712

3712

Gene nameisovaleryl-CoA dehydrogenaseisovaleryl-CoA dehydrogenase
SynonymsACAD2ACAD2
Cytomap

15q15.1

15q15.1

Type of geneprotein-codingprotein-coding
Descriptionisovaleryl-CoA dehydrogenase, mitochondrialisovaleryl Coenzyme A dehydrogenaseisovaleryl-CoA dehydrogenase, mitochondrialisovaleryl Coenzyme A dehydrogenase
Modification date2018052320180523
UniProtAcc

P26440

P26440

Ensembl transtripts involved in fusion geneENST00000249760, ENST00000490194, 
ENST00000487418, ENST00000479013, 
ENST00000249760, ENST00000490194, 
ENST00000487418, ENST00000479013, 
Fusion gene scores* DoF score4 X 5 X 2=403 X 3 X 3=27
# samples 64
** MAII scorelog2(6/40*10)=0.584962500721156
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/27*10)=0.567040592723894
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: IVD [Title/Abstract] AND IVD [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIVD

GO:0033539

fatty acid beta-oxidation using acyl-CoA dehydrogenase

3597357

TgeneIVD

GO:0033539

fatty acid beta-oxidation using acyl-CoA dehydrogenase

3597357


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA232469IVDchr15

40703459

-IVDchr15

40702909

+
ChiTaRS3.1BC037304IVDchr1

84545407

+IVDchr15

40711638

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000249760ENST00000249760IVDchr15

40703459

-IVDchr15

40702909

+
intron-3UTRENST00000249760ENST00000490194IVDchr15

40703459

-IVDchr15

40702909

+
intron-3UTRENST00000249760ENST00000487418IVDchr15

40703459

-IVDchr15

40702909

+
intron-3UTRENST00000249760ENST00000479013IVDchr15

40703459

-IVDchr15

40702909

+
intron-3CDSENST00000490194ENST00000249760IVDchr15

40703459

-IVDchr15

40702909

+
intron-3UTRENST00000490194ENST00000490194IVDchr15

40703459

-IVDchr15

40702909

+
intron-3UTRENST00000490194ENST00000487418IVDchr15

40703459

-IVDchr15

40702909

+
intron-3UTRENST00000490194ENST00000479013IVDchr15

40703459

-IVDchr15

40702909

+
intron-3CDSENST00000487418ENST00000249760IVDchr15

40703459

-IVDchr15

40702909

+
intron-3UTRENST00000487418ENST00000490194IVDchr15

40703459

-IVDchr15

40702909

+
intron-3UTRENST00000487418ENST00000487418IVDchr15

40703459

-IVDchr15

40702909

+
intron-3UTRENST00000487418ENST00000479013IVDchr15

40703459

-IVDchr15

40702909

+
intron-3CDSENST00000479013ENST00000249760IVDchr15

40703459

-IVDchr15

40702909

+
intron-3UTRENST00000479013ENST00000490194IVDchr15

40703459

-IVDchr15

40702909

+
intron-3UTRENST00000479013ENST00000487418IVDchr15

40703459

-IVDchr15

40702909

+
intron-3UTRENST00000479013ENST00000479013IVDchr15

40703459

-IVDchr15

40702909

+
intron-3UTRENST00000249760ENST00000249760IVDchr1

84545407

+IVDchr15

40711638

+
intron-intronENST00000249760ENST00000490194IVDchr1

84545407

+IVDchr15

40711638

+
intron-intronENST00000249760ENST00000487418IVDchr1

84545407

+IVDchr15

40711638

+
intron-3UTRENST00000249760ENST00000479013IVDchr1

84545407

+IVDchr15

40711638

+
intron-3UTRENST00000490194ENST00000249760IVDchr1

84545407

+IVDchr15

40711638

+
intron-intronENST00000490194ENST00000490194IVDchr1

84545407

+IVDchr15

40711638

+
intron-intronENST00000490194ENST00000487418IVDchr1

84545407

+IVDchr15

40711638

+
intron-3UTRENST00000490194ENST00000479013IVDchr1

84545407

+IVDchr15

40711638

+
intron-3UTRENST00000487418ENST00000249760IVDchr1

84545407

+IVDchr15

40711638

+
intron-intronENST00000487418ENST00000490194IVDchr1

84545407

+IVDchr15

40711638

+
intron-intronENST00000487418ENST00000487418IVDchr1

84545407

+IVDchr15

40711638

+
intron-3UTRENST00000487418ENST00000479013IVDchr1

84545407

+IVDchr15

40711638

+
intron-3UTRENST00000479013ENST00000249760IVDchr1

84545407

+IVDchr15

40711638

+
intron-intronENST00000479013ENST00000490194IVDchr1

84545407

+IVDchr15

40711638

+
intron-intronENST00000479013ENST00000487418IVDchr1

84545407

+IVDchr15

40711638

+
intron-3UTRENST00000479013ENST00000479013IVDchr1

84545407

+IVDchr15

40711638

+

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FusionProtFeatures for IVD_IVD


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IVD

P26440

IVD

P26440


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for IVD_IVD


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for IVD_IVD


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for IVD_IVD


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for IVD_IVD


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIVDC0268575Isovaleryl-CoA dehydrogenase deficiency5CTD_human;ORPHANET;UNIPROT
HgeneIVDC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneIVDC0268575Isovaleryl-CoA dehydrogenase deficiency5CTD_human;ORPHANET;UNIPROT
TgeneIVDC0023893Liver Cirrhosis, Experimental1CTD_human