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Fusion gene ID: 17968 |
FusionGeneSummary for ITPRIP_FAM171B |
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Fusion gene information | Fusion gene name: ITPRIP_FAM171B | Fusion gene ID: 17968 | Hgene | Tgene | Gene symbol | ITPRIP | FAM171B | Gene ID | 85450 | 165215 |
Gene name | inositol 1,4,5-trisphosphate receptor interacting protein | family with sequence similarity 171 member B | |
Synonyms | DANGER|KIAA1754|bA127L20|bA127L20.2 | KIAA1946 | |
Cytomap | 10q25.1 | 2q32.1 | |
Type of gene | protein-coding | protein-coding | |
Description | inositol 1,4,5-trisphosphate receptor-interacting proteininositol 1,4,5-triphosphate receptor-interacting protein | protein FAM171B | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q8IWB1 | Q6P995 | |
Ensembl transtripts involved in fusion gene | ENST00000337478, ENST00000278071, ENST00000358187, | ENST00000304698, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 3 X 4 X 3=36 |
# samples | 2 | 5 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(5/36*10)=0.473931188332412 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ITPRIP [Title/Abstract] AND FAM171B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE812272 | ITPRIP | chr10 | 106072123 | + | FAM171B | chr2 | 187585476 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000337478 | ENST00000304698 | ITPRIP | chr10 | 106072123 | + | FAM171B | chr2 | 187585476 | - |
intron-intron | ENST00000278071 | ENST00000304698 | ITPRIP | chr10 | 106072123 | + | FAM171B | chr2 | 187585476 | - |
intron-intron | ENST00000358187 | ENST00000304698 | ITPRIP | chr10 | 106072123 | + | FAM171B | chr2 | 187585476 | - |
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FusionProtFeatures for ITPRIP_FAM171B |
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Hgene | Tgene |
ITPRIP | FAM171B |
Enhances Ca(2+)-mediated inhibition of inositol 1,4,5-triphosphate receptor (ITPR) Ca(2+) release.{ECO:0000269|PubMed:16990268}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ITPRIP_FAM171B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ITPRIP_FAM171B |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ITPRIP_FAM171B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ITPRIP_FAM171B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |