![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 17967 |
FusionGeneSummary for ITPRIPL2_GGCX |
![]() |
Fusion gene information | Fusion gene name: ITPRIPL2_GGCX | Fusion gene ID: 17967 | Hgene | Tgene | Gene symbol | ITPRIPL2 | GGCX | Gene ID | 162073 | 2677 |
Gene name | ITPRIP like 2 | gamma-glutamyl carboxylase | |
Synonyms | - | VKCFD1 | |
Cytomap | 16p12.3 | 2p11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | inositol 1,4,5-trisphosphate receptor-interacting protein-like 2inositol 1,4,5-triphosphate receptor-interacting protein-like 2inositol 1,4,5-trisphosphate receptor interacting protein like 2 | vitamin K-dependent gamma-carboxylasepeptidyl-glutamate 4-carboxylase | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q3MIP1 | P38435 | |
Ensembl transtripts involved in fusion gene | ENST00000381440, | ENST00000233838, ENST00000430215, ENST00000473665, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 5 X 5 X 4=100 |
# samples | 3 | 5 | |
** MAII score | log2(3/4*10)=2.90689059560852 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ITPRIPL2 [Title/Abstract] AND GGCX [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | L17128 | ITPRIPL2 | chr16 | 19130736 | + | GGCX | chr2 | 85788583 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-5UTR | ENST00000381440 | ENST00000233838 | ITPRIPL2 | chr16 | 19130736 | + | GGCX | chr2 | 85788583 | - |
3UTR-5UTR | ENST00000381440 | ENST00000430215 | ITPRIPL2 | chr16 | 19130736 | + | GGCX | chr2 | 85788583 | - |
3UTR-intron | ENST00000381440 | ENST00000473665 | ITPRIPL2 | chr16 | 19130736 | + | GGCX | chr2 | 85788583 | - |
Top |
FusionProtFeatures for ITPRIPL2_GGCX |
![]() |
Hgene | Tgene |
ITPRIPL2 | GGCX |
Mediates the vitamin K-dependent carboxylation ofglutamate residues to calcium-binding gamma-carboxyglutamate (Gla)residues with the concomitant conversion of the reducedhydroquinone form of vitamin K to vitamin K epoxide.{ECO:0000269|PubMed:17073445}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for ITPRIPL2_GGCX |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for ITPRIPL2_GGCX |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for ITPRIPL2_GGCX |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | GGCX | P38435 | DB00036 | Coagulation factor VIIa Recombinant Human | Vitamin K-dependent gamma-carboxylase | biotech | approved |
Tgene | GGCX | P38435 | DB00100 | Coagulation Factor IX (Recombinant) | Vitamin K-dependent gamma-carboxylase | biotech | approved|investigational |
Tgene | GGCX | P38435 | DB01022 | Phylloquinone | Vitamin K-dependent gamma-carboxylase | small molecule | approved|investigational |
Tgene | GGCX | P38435 | DB00055 | Drotrecogin alfa | Vitamin K-dependent gamma-carboxylase | biotech | approved|investigational|withdrawn |
Tgene | GGCX | P38435 | DB00142 | Glutamic Acid | Vitamin K-dependent gamma-carboxylase | small molecule | approved|nutraceutical |
Tgene | GGCX | P38435 | DB00170 | Menadione | Vitamin K-dependent gamma-carboxylase | small molecule | approved|nutraceutical |
Top |
RelatedDiseases for ITPRIPL2_GGCX |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | GGCX | C1848534 | VITAMIN K-DEPENDENT CLOTTING FACTORS, COMBINED DEFICIENCY OF, 1 | 4 | CTD_human;ORPHANET;UNIPROT |
Tgene | GGCX | C0005779 | Blood Coagulation Disorders | 1 | CTD_human |
Tgene | GGCX | C1835813 | Pseudoxanthoma Elasticum-Like Disorder with Multiple Coagulation Factor Deficiency | 1 | CTD_human;ORPHANET;UNIPROT |