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Fusion gene ID: 17934 |
FusionGeneSummary for ITPKA_NUSAP1 |
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Fusion gene information | Fusion gene name: ITPKA_NUSAP1 | Fusion gene ID: 17934 | Hgene | Tgene | Gene symbol | ITPKA | NUSAP1 | Gene ID | 3706 | 51203 |
Gene name | inositol-trisphosphate 3-kinase A | nucleolar and spindle associated protein 1 | |
Synonyms | IP3-3KA|IP3KA | ANKT|BM037|LNP|NUSAP|PRO0310p1|Q0310|SAPL | |
Cytomap | 15q15.1 | 15q15.1 | |
Type of gene | protein-coding | protein-coding | |
Description | inositol-trisphosphate 3-kinase AIP3 3-kinase AIP3K Ainositol 1,4,5-trisphosphate 3-kinase AinsP 3-kinase A | nucleolar and spindle-associated protein 1nucleolar protein ANKT | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | P23677 | Q9BXS6 | |
Ensembl transtripts involved in fusion gene | ENST00000260386, | ENST00000558123, ENST00000260359, ENST00000450318, ENST00000450592, ENST00000559596, ENST00000414849, ENST00000560747, ENST00000560177, | |
Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 3 X 3 X 2=18 |
# samples | 3 | 3 | |
** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ITPKA [Title/Abstract] AND NUSAP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | NUSAP1 | GO:0000070 | mitotic sister chromatid segregation | 12963707 |
Tgene | NUSAP1 | GO:0000281 | mitotic cytokinesis | 12963707 |
Tgene | NUSAP1 | GO:0007076 | mitotic chromosome condensation | 12963707 |
Tgene | NUSAP1 | GO:0040001 | establishment of mitotic spindle localization | 12963707 |
Tgene | NUSAP1 | GO:0045840 | positive regulation of mitotic nuclear division | 12963707 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | ACC | TCGA-OR-A5J9-01A | ITPKA | chr15 | 41786614 | + | NUSAP1 | chr15 | 41634584 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000260386 | ENST00000558123 | ITPKA | chr15 | 41786614 | + | NUSAP1 | chr15 | 41634584 | + |
5CDS-3UTR | ENST00000260386 | ENST00000260359 | ITPKA | chr15 | 41786614 | + | NUSAP1 | chr15 | 41634584 | + |
5CDS-3UTR | ENST00000260386 | ENST00000450318 | ITPKA | chr15 | 41786614 | + | NUSAP1 | chr15 | 41634584 | + |
5CDS-intron | ENST00000260386 | ENST00000450592 | ITPKA | chr15 | 41786614 | + | NUSAP1 | chr15 | 41634584 | + |
5CDS-intron | ENST00000260386 | ENST00000559596 | ITPKA | chr15 | 41786614 | + | NUSAP1 | chr15 | 41634584 | + |
5CDS-intron | ENST00000260386 | ENST00000414849 | ITPKA | chr15 | 41786614 | + | NUSAP1 | chr15 | 41634584 | + |
5CDS-intron | ENST00000260386 | ENST00000560747 | ITPKA | chr15 | 41786614 | + | NUSAP1 | chr15 | 41634584 | + |
5CDS-intron | ENST00000260386 | ENST00000560177 | ITPKA | chr15 | 41786614 | + | NUSAP1 | chr15 | 41634584 | + |
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FusionProtFeatures for ITPKA_NUSAP1 |
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Hgene | Tgene |
ITPKA | NUSAP1 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ITPKA_NUSAP1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ITPKA_NUSAP1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ITPKA | ITSN2, DBN1 | NUSAP1 | KHDRBS2, ELAVL1, APP, SLC9A3R2, HPDL, CCNF, AP2B1, PLOD2, PPP1R12A, PRDX3, PTPN12, UGP2, USP15, UBE4B, CEP70, KPNB1, IPO7, GAPDHS, RANBP2, CST6, NUP153, S100P, C5orf30, GSTA2, RCC1, CHAF1A, HIST1H2BG, HIST1H3A, TMPO, U2AF2, CDC14B, B2M, HP1BP3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ITPKA_NUSAP1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ITPKA_NUSAP1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |