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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 1792

FusionGeneSummary for ANKRD12_PTPRM

check button Fusion gene summary
Fusion gene informationFusion gene name: ANKRD12_PTPRM
Fusion gene ID: 1792
HgeneTgene
Gene symbol

ANKRD12

PTPRM

Gene ID

23253

5797

Gene nameankyrin repeat domain 12protein tyrosine phosphatase, receptor type M
SynonymsANCO-2|ANCO1|GAC-1|Nbla00144PTPRL1|R-PTP-MU|RPTPM|RPTPU|hR-PTPu
Cytomap

18p11.22

18p11.23

Type of geneprotein-codingprotein-coding
Descriptionankyrin repeat domain-containing protein 12ankyrin repeat-containing cofactor 2receptor-type tyrosine-protein phosphatase muprotein tyrosine phosphatase muprotein tyrosine phosphatase, receptor type, mu polypeptide
Modification date2018051920180522
UniProtAcc

Q6UB98

P28827

Ensembl transtripts involved in fusion geneENST00000383440, ENST00000262126, 
ENST00000540578, ENST00000400020, 
ENST00000580170, ENST00000332175, 
ENST00000400060, ENST00000400053, 
ENST00000444013, ENST00000578571, 
Fusion gene scores* DoF score10 X 9 X 8=7206 X 8 X 4=192
# samples 128
** MAII scorelog2(12/720*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/192*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ANKRD12 [Title/Abstract] AND PTPRM [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePTPRM

GO:0006470

protein dephosphorylation

8393854|10809770

TgenePTPRM

GO:0007156

homophilic cell adhesion via plasma membrane adhesion molecules

8393854

TgenePTPRM

GO:0007165

signal transduction

15080886

TgenePTPRM

GO:0031175

neuron projection development

16380380

TgenePTPRM

GO:0031290

retinal ganglion cell axon guidance

15080886

TgenePTPRM

GO:0042493

response to drug

18566238


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-05-4395-01AANKRD12chr18

9136963

+PTPRMchr18

8394474

+
TCGALDLUADTCGA-05-4395-01AANKRD12chr18

9137871

+PTPRMchr18

8394474

+
TCGALDOVTCGA-24-1557-01AANKRD12chr18

9136963

+PTPRMchr18

8296366

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000383440ENST00000580170ANKRD12chr18

9136963

+PTPRMchr18

8394474

+
5UTR-3CDSENST00000383440ENST00000332175ANKRD12chr18

9136963

+PTPRMchr18

8394474

+
5UTR-3CDSENST00000383440ENST00000400060ANKRD12chr18

9136963

+PTPRMchr18

8394474

+
5UTR-3CDSENST00000383440ENST00000400053ANKRD12chr18

9136963

+PTPRMchr18

8394474

+
5UTR-3CDSENST00000383440ENST00000444013ANKRD12chr18

9136963

+PTPRMchr18

8394474

+
5UTR-intronENST00000383440ENST00000578571ANKRD12chr18

9136963

+PTPRMchr18

8394474

+
5UTR-3CDSENST00000262126ENST00000580170ANKRD12chr18

9136963

+PTPRMchr18

8394474

+
5UTR-3CDSENST00000262126ENST00000332175ANKRD12chr18

9136963

+PTPRMchr18

8394474

+
5UTR-3CDSENST00000262126ENST00000400060ANKRD12chr18

9136963

+PTPRMchr18

8394474

+
5UTR-3CDSENST00000262126ENST00000400053ANKRD12chr18

9136963

+PTPRMchr18

8394474

+
5UTR-3CDSENST00000262126ENST00000444013ANKRD12chr18

9136963

+PTPRMchr18

8394474

+
5UTR-intronENST00000262126ENST00000578571ANKRD12chr18

9136963

+PTPRMchr18

8394474

+
3UTR-3CDSENST00000540578ENST00000580170ANKRD12chr18

9136963

+PTPRMchr18

8394474

+
3UTR-3CDSENST00000540578ENST00000332175ANKRD12chr18

9136963

+PTPRMchr18

8394474

+
3UTR-3CDSENST00000540578ENST00000400060ANKRD12chr18

9136963

+PTPRMchr18

8394474

+
3UTR-3CDSENST00000540578ENST00000400053ANKRD12chr18

9136963

+PTPRMchr18

8394474

+
3UTR-3CDSENST00000540578ENST00000444013ANKRD12chr18

9136963

+PTPRMchr18

8394474

+
3UTR-intronENST00000540578ENST00000578571ANKRD12chr18

9136963

+PTPRMchr18

8394474

+
intron-3CDSENST00000400020ENST00000580170ANKRD12chr18

9136963

+PTPRMchr18

8394474

+
intron-3CDSENST00000400020ENST00000332175ANKRD12chr18

9136963

+PTPRMchr18

8394474

+
intron-3CDSENST00000400020ENST00000400060ANKRD12chr18

9136963

+PTPRMchr18

8394474

+
intron-3CDSENST00000400020ENST00000400053ANKRD12chr18

9136963

+PTPRMchr18

8394474

+
intron-3CDSENST00000400020ENST00000444013ANKRD12chr18

9136963

+PTPRMchr18

8394474

+
intron-intronENST00000400020ENST00000578571ANKRD12chr18

9136963

+PTPRMchr18

8394474

+
intron-3CDSENST00000383440ENST00000580170ANKRD12chr18

9137871

+PTPRMchr18

8394474

+
intron-3CDSENST00000383440ENST00000332175ANKRD12chr18

9137871

+PTPRMchr18

8394474

+
intron-3CDSENST00000383440ENST00000400060ANKRD12chr18

9137871

+PTPRMchr18

8394474

+
intron-3CDSENST00000383440ENST00000400053ANKRD12chr18

9137871

+PTPRMchr18

8394474

+
intron-3CDSENST00000383440ENST00000444013ANKRD12chr18

9137871

+PTPRMchr18

8394474

+
intron-intronENST00000383440ENST00000578571ANKRD12chr18

9137871

+PTPRMchr18

8394474

+
intron-3CDSENST00000262126ENST00000580170ANKRD12chr18

9137871

+PTPRMchr18

8394474

+
intron-3CDSENST00000262126ENST00000332175ANKRD12chr18

9137871

+PTPRMchr18

8394474

+
intron-3CDSENST00000262126ENST00000400060ANKRD12chr18

9137871

+PTPRMchr18

8394474

+
intron-3CDSENST00000262126ENST00000400053ANKRD12chr18

9137871

+PTPRMchr18

8394474

+
intron-3CDSENST00000262126ENST00000444013ANKRD12chr18

9137871

+PTPRMchr18

8394474

+
intron-intronENST00000262126ENST00000578571ANKRD12chr18

9137871

+PTPRMchr18

8394474

+
intron-3CDSENST00000540578ENST00000580170ANKRD12chr18

9137871

+PTPRMchr18

8394474

+
intron-3CDSENST00000540578ENST00000332175ANKRD12chr18

9137871

+PTPRMchr18

8394474

+
intron-3CDSENST00000540578ENST00000400060ANKRD12chr18

9137871

+PTPRMchr18

8394474

+
intron-3CDSENST00000540578ENST00000400053ANKRD12chr18

9137871

+PTPRMchr18

8394474

+
intron-3CDSENST00000540578ENST00000444013ANKRD12chr18

9137871

+PTPRMchr18

8394474

+
intron-intronENST00000540578ENST00000578571ANKRD12chr18

9137871

+PTPRMchr18

8394474

+
5UTR-3CDSENST00000400020ENST00000580170ANKRD12chr18

9137871

+PTPRMchr18

8394474

+
5UTR-3CDSENST00000400020ENST00000332175ANKRD12chr18

9137871

+PTPRMchr18

8394474

+
5UTR-3CDSENST00000400020ENST00000400060ANKRD12chr18

9137871

+PTPRMchr18

8394474

+
5UTR-3CDSENST00000400020ENST00000400053ANKRD12chr18

9137871

+PTPRMchr18

8394474

+
5UTR-3CDSENST00000400020ENST00000444013ANKRD12chr18

9137871

+PTPRMchr18

8394474

+
5UTR-intronENST00000400020ENST00000578571ANKRD12chr18

9137871

+PTPRMchr18

8394474

+
5UTR-3CDSENST00000383440ENST00000580170ANKRD12chr18

9136963

+PTPRMchr18

8296366

+
5UTR-3CDSENST00000383440ENST00000332175ANKRD12chr18

9136963

+PTPRMchr18

8296366

+
5UTR-3CDSENST00000383440ENST00000400060ANKRD12chr18

9136963

+PTPRMchr18

8296366

+
5UTR-3CDSENST00000383440ENST00000400053ANKRD12chr18

9136963

+PTPRMchr18

8296366

+
5UTR-3CDSENST00000383440ENST00000444013ANKRD12chr18

9136963

+PTPRMchr18

8296366

+
5UTR-intronENST00000383440ENST00000578571ANKRD12chr18

9136963

+PTPRMchr18

8296366

+
5UTR-3CDSENST00000262126ENST00000580170ANKRD12chr18

9136963

+PTPRMchr18

8296366

+
5UTR-3CDSENST00000262126ENST00000332175ANKRD12chr18

9136963

+PTPRMchr18

8296366

+
5UTR-3CDSENST00000262126ENST00000400060ANKRD12chr18

9136963

+PTPRMchr18

8296366

+
5UTR-3CDSENST00000262126ENST00000400053ANKRD12chr18

9136963

+PTPRMchr18

8296366

+
5UTR-3CDSENST00000262126ENST00000444013ANKRD12chr18

9136963

+PTPRMchr18

8296366

+
5UTR-intronENST00000262126ENST00000578571ANKRD12chr18

9136963

+PTPRMchr18

8296366

+
3UTR-3CDSENST00000540578ENST00000580170ANKRD12chr18

9136963

+PTPRMchr18

8296366

+
3UTR-3CDSENST00000540578ENST00000332175ANKRD12chr18

9136963

+PTPRMchr18

8296366

+
3UTR-3CDSENST00000540578ENST00000400060ANKRD12chr18

9136963

+PTPRMchr18

8296366

+
3UTR-3CDSENST00000540578ENST00000400053ANKRD12chr18

9136963

+PTPRMchr18

8296366

+
3UTR-3CDSENST00000540578ENST00000444013ANKRD12chr18

9136963

+PTPRMchr18

8296366

+
3UTR-intronENST00000540578ENST00000578571ANKRD12chr18

9136963

+PTPRMchr18

8296366

+
intron-3CDSENST00000400020ENST00000580170ANKRD12chr18

9136963

+PTPRMchr18

8296366

+
intron-3CDSENST00000400020ENST00000332175ANKRD12chr18

9136963

+PTPRMchr18

8296366

+
intron-3CDSENST00000400020ENST00000400060ANKRD12chr18

9136963

+PTPRMchr18

8296366

+
intron-3CDSENST00000400020ENST00000400053ANKRD12chr18

9136963

+PTPRMchr18

8296366

+
intron-3CDSENST00000400020ENST00000444013ANKRD12chr18

9136963

+PTPRMchr18

8296366

+
intron-intronENST00000400020ENST00000578571ANKRD12chr18

9136963

+PTPRMchr18

8296366

+

Top

FusionProtFeatures for ANKRD12_PTPRM


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANKRD12

Q6UB98

PTPRM

P28827

May recruit HDACs to the p160 coactivators/nuclearreceptor complex to inhibit ligand-dependent transactivation. Involved in cell-cell adhesion through homophilicinteractions. May play a key role in signal transduction andgrowth control. {ECO:0000269|PubMed:16456543}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ANKRD12_PTPRM


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ANKRD12_PTPRM


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ANKRD12TADA3, HDAC3, COPS5, CDK4, CDK6, SGPL1, GLIPR2, PHYHIP, FYN, YES1, ULBP2, SLIT2, HIF1AN, GNB4, MTNR1APTPRMGNB2L1, CTNND1, DTNBP1, LMTK2, EHD4, CDC42BPA, NHSL1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ANKRD12_PTPRM


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ANKRD12_PTPRM


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource