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Fusion gene ID: 17886 |
FusionGeneSummary for ITGB5_PPP6R3 |
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Fusion gene information | Fusion gene name: ITGB5_PPP6R3 | Fusion gene ID: 17886 | Hgene | Tgene | Gene symbol | ITGB5 | PPP6R3 | Gene ID | 3693 | 55291 |
Gene name | integrin subunit beta 5 | protein phosphatase 6 regulatory subunit 3 | |
Synonyms | - | C11orf23|PP6R3|SAP190|SAPL|SAPLa|SAPS3 | |
Cytomap | 3q21.2 | 11q13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | integrin beta-5testis secretory sperm-binding protein Li 217p | serine/threonine-protein phosphatase 6 regulatory subunit 3SAPS domain family, member 3sporulation-induced transcript 4-associated protein SAPL | |
Modification date | 20180523 | 20180520 | |
UniProtAcc | P18084 | Q5H9R7 | |
Ensembl transtripts involved in fusion gene | ENST00000296181, ENST00000461306, | ENST00000393799, ENST00000530427, ENST00000393800, ENST00000534534, ENST00000524845, ENST00000265637, ENST00000524904, ENST00000393801, ENST00000265636, ENST00000529710, ENST00000527403, | |
Fusion gene scores | * DoF score | 8 X 8 X 6=384 | 15 X 15 X 6=1350 |
# samples | 9 | 19 | |
** MAII score | log2(9/384*10)=-2.09310940439148 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(19/1350*10)=-2.82888808360725 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ITGB5 [Title/Abstract] AND PPP6R3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | PPP6R3 | GO:0043666 | regulation of phosphoprotein phosphatase activity | 16716191 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BQ331562 | ITGB5 | chr3 | 124567184 | + | PPP6R3 | chr11 | 68274778 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000296181 | ENST00000393799 | ITGB5 | chr3 | 124567184 | + | PPP6R3 | chr11 | 68274778 | + |
intron-intron | ENST00000296181 | ENST00000530427 | ITGB5 | chr3 | 124567184 | + | PPP6R3 | chr11 | 68274778 | + |
intron-intron | ENST00000296181 | ENST00000393800 | ITGB5 | chr3 | 124567184 | + | PPP6R3 | chr11 | 68274778 | + |
intron-intron | ENST00000296181 | ENST00000534534 | ITGB5 | chr3 | 124567184 | + | PPP6R3 | chr11 | 68274778 | + |
intron-intron | ENST00000296181 | ENST00000524845 | ITGB5 | chr3 | 124567184 | + | PPP6R3 | chr11 | 68274778 | + |
intron-intron | ENST00000296181 | ENST00000265637 | ITGB5 | chr3 | 124567184 | + | PPP6R3 | chr11 | 68274778 | + |
intron-intron | ENST00000296181 | ENST00000524904 | ITGB5 | chr3 | 124567184 | + | PPP6R3 | chr11 | 68274778 | + |
intron-intron | ENST00000296181 | ENST00000393801 | ITGB5 | chr3 | 124567184 | + | PPP6R3 | chr11 | 68274778 | + |
intron-intron | ENST00000296181 | ENST00000265636 | ITGB5 | chr3 | 124567184 | + | PPP6R3 | chr11 | 68274778 | + |
intron-intron | ENST00000296181 | ENST00000529710 | ITGB5 | chr3 | 124567184 | + | PPP6R3 | chr11 | 68274778 | + |
intron-intron | ENST00000296181 | ENST00000527403 | ITGB5 | chr3 | 124567184 | + | PPP6R3 | chr11 | 68274778 | + |
intron-intron | ENST00000461306 | ENST00000393799 | ITGB5 | chr3 | 124567184 | + | PPP6R3 | chr11 | 68274778 | + |
intron-intron | ENST00000461306 | ENST00000530427 | ITGB5 | chr3 | 124567184 | + | PPP6R3 | chr11 | 68274778 | + |
intron-intron | ENST00000461306 | ENST00000393800 | ITGB5 | chr3 | 124567184 | + | PPP6R3 | chr11 | 68274778 | + |
intron-intron | ENST00000461306 | ENST00000534534 | ITGB5 | chr3 | 124567184 | + | PPP6R3 | chr11 | 68274778 | + |
intron-intron | ENST00000461306 | ENST00000524845 | ITGB5 | chr3 | 124567184 | + | PPP6R3 | chr11 | 68274778 | + |
intron-intron | ENST00000461306 | ENST00000265637 | ITGB5 | chr3 | 124567184 | + | PPP6R3 | chr11 | 68274778 | + |
intron-intron | ENST00000461306 | ENST00000524904 | ITGB5 | chr3 | 124567184 | + | PPP6R3 | chr11 | 68274778 | + |
intron-intron | ENST00000461306 | ENST00000393801 | ITGB5 | chr3 | 124567184 | + | PPP6R3 | chr11 | 68274778 | + |
intron-intron | ENST00000461306 | ENST00000265636 | ITGB5 | chr3 | 124567184 | + | PPP6R3 | chr11 | 68274778 | + |
intron-intron | ENST00000461306 | ENST00000529710 | ITGB5 | chr3 | 124567184 | + | PPP6R3 | chr11 | 68274778 | + |
intron-intron | ENST00000461306 | ENST00000527403 | ITGB5 | chr3 | 124567184 | + | PPP6R3 | chr11 | 68274778 | + |
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FusionProtFeatures for ITGB5_PPP6R3 |
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Hgene | Tgene |
ITGB5 | PPP6R3 |
Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor forfibronectin. It recognizes the sequence R-G-D in its ligand. (Microbial infection) Integrin ITGAV:ITGB5 acts as areceptor for adenovirus type C. {ECO:0000269|PubMed:20615244}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ITGB5_PPP6R3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ITGB5_PPP6R3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ITGB5_PPP6R3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ITGB5_PPP6R3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ITGB5 | C0040128 | Thyroid Diseases | 1 | CTD_human |
Hgene | ITGB5 | C3495559 | Juvenile arthritis | 1 | CTD_human |