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Fusion gene ID: 17873 |
FusionGeneSummary for ITGB4_PLSCR1 |
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Fusion gene information | Fusion gene name: ITGB4_PLSCR1 | Fusion gene ID: 17873 | Hgene | Tgene | Gene symbol | ITGB4 | PLSCR1 | Gene ID | 3691 | 5359 |
Gene name | integrin subunit beta 4 | phospholipid scramblase 1 | |
Synonyms | CD104|GP150 | MMTRA1B | |
Cytomap | 17q25.1 | 3q24 | |
Type of gene | protein-coding | protein-coding | |
Description | integrin beta-4CD104 antigen | phospholipid scramblase 1PL scramblase 1ca(2+)-dependent phospholipid scramblase 1erythrocyte phospholipid scramblase | |
Modification date | 20180527 | 20180523 | |
UniProtAcc | P16144 | O15162 | |
Ensembl transtripts involved in fusion gene | ENST00000579662, ENST00000339591, ENST00000200181, ENST00000450894, ENST00000449880, ENST00000584558, | ENST00000342435, ENST00000448205, ENST00000487389, ENST00000448787, ENST00000484560, | |
Fusion gene scores | * DoF score | 15 X 12 X 8=1440 | 5 X 5 X 1=25 |
# samples | 16 | 5 | |
** MAII score | log2(16/1440*10)=-3.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/25*10)=1 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ITGB4 [Title/Abstract] AND PLSCR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ITGB4 | GO:0009611 | response to wounding | 19403692 |
Hgene | ITGB4 | GO:0031581 | hemidesmosome assembly | 12482924 |
Tgene | PLSCR1 | GO:0006915 | apoptotic process | 10770950 |
Tgene | PLSCR1 | GO:0017121 | phospholipid scrambling | 9218461|10770950|18629440 |
Tgene | PLSCR1 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 16091359 |
Tgene | PLSCR1 | GO:2000373 | positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity | 17567603 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW369496 | ITGB4 | chr17 | 73748632 | + | PLSCR1 | chr3 | 146239375 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000579662 | ENST00000342435 | ITGB4 | chr17 | 73748632 | + | PLSCR1 | chr3 | 146239375 | + |
5CDS-intron | ENST00000579662 | ENST00000448205 | ITGB4 | chr17 | 73748632 | + | PLSCR1 | chr3 | 146239375 | + |
5CDS-intron | ENST00000579662 | ENST00000487389 | ITGB4 | chr17 | 73748632 | + | PLSCR1 | chr3 | 146239375 | + |
5CDS-intron | ENST00000579662 | ENST00000448787 | ITGB4 | chr17 | 73748632 | + | PLSCR1 | chr3 | 146239375 | + |
5CDS-intron | ENST00000579662 | ENST00000484560 | ITGB4 | chr17 | 73748632 | + | PLSCR1 | chr3 | 146239375 | + |
Frame-shift | ENST00000339591 | ENST00000342435 | ITGB4 | chr17 | 73748632 | + | PLSCR1 | chr3 | 146239375 | + |
5CDS-intron | ENST00000339591 | ENST00000448205 | ITGB4 | chr17 | 73748632 | + | PLSCR1 | chr3 | 146239375 | + |
5CDS-intron | ENST00000339591 | ENST00000487389 | ITGB4 | chr17 | 73748632 | + | PLSCR1 | chr3 | 146239375 | + |
5CDS-intron | ENST00000339591 | ENST00000448787 | ITGB4 | chr17 | 73748632 | + | PLSCR1 | chr3 | 146239375 | + |
5CDS-intron | ENST00000339591 | ENST00000484560 | ITGB4 | chr17 | 73748632 | + | PLSCR1 | chr3 | 146239375 | + |
Frame-shift | ENST00000200181 | ENST00000342435 | ITGB4 | chr17 | 73748632 | + | PLSCR1 | chr3 | 146239375 | + |
5CDS-intron | ENST00000200181 | ENST00000448205 | ITGB4 | chr17 | 73748632 | + | PLSCR1 | chr3 | 146239375 | + |
5CDS-intron | ENST00000200181 | ENST00000487389 | ITGB4 | chr17 | 73748632 | + | PLSCR1 | chr3 | 146239375 | + |
5CDS-intron | ENST00000200181 | ENST00000448787 | ITGB4 | chr17 | 73748632 | + | PLSCR1 | chr3 | 146239375 | + |
5CDS-intron | ENST00000200181 | ENST00000484560 | ITGB4 | chr17 | 73748632 | + | PLSCR1 | chr3 | 146239375 | + |
Frame-shift | ENST00000450894 | ENST00000342435 | ITGB4 | chr17 | 73748632 | + | PLSCR1 | chr3 | 146239375 | + |
5CDS-intron | ENST00000450894 | ENST00000448205 | ITGB4 | chr17 | 73748632 | + | PLSCR1 | chr3 | 146239375 | + |
5CDS-intron | ENST00000450894 | ENST00000487389 | ITGB4 | chr17 | 73748632 | + | PLSCR1 | chr3 | 146239375 | + |
5CDS-intron | ENST00000450894 | ENST00000448787 | ITGB4 | chr17 | 73748632 | + | PLSCR1 | chr3 | 146239375 | + |
5CDS-intron | ENST00000450894 | ENST00000484560 | ITGB4 | chr17 | 73748632 | + | PLSCR1 | chr3 | 146239375 | + |
Frame-shift | ENST00000449880 | ENST00000342435 | ITGB4 | chr17 | 73748632 | + | PLSCR1 | chr3 | 146239375 | + |
5CDS-intron | ENST00000449880 | ENST00000448205 | ITGB4 | chr17 | 73748632 | + | PLSCR1 | chr3 | 146239375 | + |
5CDS-intron | ENST00000449880 | ENST00000487389 | ITGB4 | chr17 | 73748632 | + | PLSCR1 | chr3 | 146239375 | + |
5CDS-intron | ENST00000449880 | ENST00000448787 | ITGB4 | chr17 | 73748632 | + | PLSCR1 | chr3 | 146239375 | + |
5CDS-intron | ENST00000449880 | ENST00000484560 | ITGB4 | chr17 | 73748632 | + | PLSCR1 | chr3 | 146239375 | + |
intron-3CDS | ENST00000584558 | ENST00000342435 | ITGB4 | chr17 | 73748632 | + | PLSCR1 | chr3 | 146239375 | + |
intron-intron | ENST00000584558 | ENST00000448205 | ITGB4 | chr17 | 73748632 | + | PLSCR1 | chr3 | 146239375 | + |
intron-intron | ENST00000584558 | ENST00000487389 | ITGB4 | chr17 | 73748632 | + | PLSCR1 | chr3 | 146239375 | + |
intron-intron | ENST00000584558 | ENST00000448787 | ITGB4 | chr17 | 73748632 | + | PLSCR1 | chr3 | 146239375 | + |
intron-intron | ENST00000584558 | ENST00000484560 | ITGB4 | chr17 | 73748632 | + | PLSCR1 | chr3 | 146239375 | + |
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FusionProtFeatures for ITGB4_PLSCR1 |
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Hgene | Tgene |
ITGB4 | PLSCR1 |
May mediate accelerated ATP-independent bidirectionaltransbilayer migration of phospholipids upon binding calcium ionsthat results in a loss of phospholipid asymmetry in the plasmamembrane. May play a central role in the initiation of fibrin clotformation, in the activation of mast cells and in the recognitionof apoptotic and injured cells by the reticuloendothelial system. May play a role in the antiviral response of interferon(IFN) by amplifying and enhancing the IFN response throughincreased expression of select subset of potent antiviral genes.May contribute to cytokine-regulated cell proliferation anddifferentiation. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ITGB4_PLSCR1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ITGB4_PLSCR1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ITGB4_PLSCR1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ITGB4_PLSCR1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ITGB4 | C1856934 | Epidermolysis bullosa with pyloric atresia | 9 | CTD_human;ORPHANET;UNIPROT |
Hgene | ITGB4 | C0266159 | Pyloric Atresia | 2 | CTD_human |
Hgene | ITGB4 | C0000786 | Spontaneous abortion | 1 | CTD_human |
Hgene | ITGB4 | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
Hgene | ITGB4 | C0013575 | Ectodermal Dysplasia | 1 | CTD_human |
Hgene | ITGB4 | C0014527 | Epidermolysis Bullosa | 1 | CTD_human |
Hgene | ITGB4 | C0017639 | Gliosis | 1 | CTD_human |
Hgene | ITGB4 | C0036095 | Salivary Gland Neoplasms | 1 | CTD_human |
Hgene | ITGB4 | C0079301 | Junctional Epidermolysis Bullosa | 1 | CTD_human |
Hgene | ITGB4 | C0268374 | Adult junctional epidermolysis bullosa (disorder) | 1 | CTD_human;ORPHANET;UNIPROT |
Tgene | PLSCR1 | C0021400 | Influenza | 1 | CTD_human |
Tgene | PLSCR1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |