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Fusion gene ID: 17823 |
FusionGeneSummary for ITGA3_ZDHHC2 |
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Fusion gene information | Fusion gene name: ITGA3_ZDHHC2 | Fusion gene ID: 17823 | Hgene | Tgene | Gene symbol | ITGA3 | ZDHHC2 | Gene ID | 3675 | 51201 |
Gene name | integrin subunit alpha 3 | zinc finger DHHC-type containing 2 | |
Synonyms | CD49C|FRP-2|GAP-B3|GAPB3|ILNEB|MSK18|VCA-2|VL3A|VLA3a | DHHC2|ZNF372 | |
Cytomap | 17q21.33 | 8p22 | |
Type of gene | protein-coding | protein-coding | |
Description | integrin alpha-3CD49 antigen-like family member Calpha 3 subunit of VLA-3 receptorantigen CD49Cantigen identified by monoclonal antibody J143galactoprotein B3integrin alpha 3integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)testi | palmitoyltransferase ZDHHC2DHHC-2reamrecreduced expression associated with metastasis proteinreduced expression in cancer proteintestis tissue sperm-binding protein Li 56ezinc finger DHHC domain-containing protein 2zinc finger protein 372zinc fin | |
Modification date | 20180522 | 20180523 | |
UniProtAcc | P26006 | Q9UIJ5 | |
Ensembl transtripts involved in fusion gene | ENST00000544892, ENST00000320031, ENST00000007722, | ENST00000262096, | |
Fusion gene scores | * DoF score | 7 X 7 X 5=245 | 5 X 5 X 4=100 |
# samples | 7 | 5 | |
** MAII score | log2(7/245*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ITGA3 [Title/Abstract] AND ZDHHC2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ITGA3 | GO:1903078 | positive regulation of protein localization to plasma membrane | 10455171 |
Tgene | ZDHHC2 | GO:0018345 | protein palmitoylation | 23034182 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CA422988 | ITGA3 | chr17 | 48167773 | - | ZDHHC2 | chr8 | 17056957 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000544892 | ENST00000262096 | ITGA3 | chr17 | 48167773 | - | ZDHHC2 | chr8 | 17056957 | - |
3UTR-intron | ENST00000320031 | ENST00000262096 | ITGA3 | chr17 | 48167773 | - | ZDHHC2 | chr8 | 17056957 | - |
intron-intron | ENST00000007722 | ENST00000262096 | ITGA3 | chr17 | 48167773 | - | ZDHHC2 | chr8 | 17056957 | - |
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FusionProtFeatures for ITGA3_ZDHHC2 |
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Hgene | Tgene |
ITGA3 | ZDHHC2 |
Integrin alpha-3/beta-1 is a receptor for fibronectin,laminin, collagen, epiligrin, thrombospondin and CSPG4. Integrinalpha-3/beta-1 provides a docking site for FAP (seprase) atinvadopodia plasma membranes in a collagen-dependent manner andhence may participate in the adhesion, formation of invadopodiaand matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 ofendothelial cells migration. {ECO:0000269|PubMed:10455171,ECO:0000269|PubMed:15181153}. | Palmitoyltransferase specific for GAP43 and DLG4/PSD95.{ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ITGA3_ZDHHC2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ITGA3_ZDHHC2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ITGA3_ZDHHC2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ITGA3_ZDHHC2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ITGA3 | C3553636 | INTERSTITIAL LUNG DISEASE, NEPHROTIC SYNDROME, AND EPIDERMOLYSIS BULLOSA, CONGENITAL | 2 | ORPHANET;UNIPROT |
Tgene | ZDHHC2 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | ZDHHC2 | C0023903 | Liver neoplasms | 1 | CTD_human |
Tgene | ZDHHC2 | C0043094 | Weight Gain | 1 | CTD_human |