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Fusion gene ID: 17816 |
FusionGeneSummary for ITGA2_RNF180 |
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Fusion gene information | Fusion gene name: ITGA2_RNF180 | Fusion gene ID: 17816 | Hgene | Tgene | Gene symbol | ITGA2 | RNF180 | Gene ID | 3673 | 285671 |
Gene name | integrin subunit alpha 2 | ring finger protein 180 | |
Synonyms | BR|CD49B|GPIa|HPA-5|VLA-2|VLAA2 | RINES | |
Cytomap | 5q11.2 | 5q12.3 | |
Type of gene | protein-coding | protein-coding | |
Description | integrin alpha-2CD49 antigen-like family member Balpha 2 subunit of VLA-2 receptorcollagen receptorhuman platelet alloantigen system 5integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)platelet antigen Brplatelet glycoprotein GPIaplatelet | E3 ubiquitin-protein ligase RNF180RING-type E3 ubiquitin transferase RNF180 | |
Modification date | 20180527 | 20180523 | |
UniProtAcc | P17301 | Q86T96 | |
Ensembl transtripts involved in fusion gene | ENST00000296585, | ENST00000389100, ENST00000296615, ENST00000381081, | |
Fusion gene scores | * DoF score | 8 X 5 X 5=200 | 5 X 4 X 4=80 |
# samples | 8 | 5 | |
** MAII score | log2(8/200*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: ITGA2 [Title/Abstract] AND RNF180 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | KIRP | TCGA-B9-A5W9-01A | ITGA2 | chr5 | 52285362 | + | RNF180 | chr5 | 63621013 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000296585 | ENST00000389100 | ITGA2 | chr5 | 52285362 | + | RNF180 | chr5 | 63621013 | + |
5CDS-intron | ENST00000296585 | ENST00000296615 | ITGA2 | chr5 | 52285362 | + | RNF180 | chr5 | 63621013 | + |
5CDS-intron | ENST00000296585 | ENST00000381081 | ITGA2 | chr5 | 52285362 | + | RNF180 | chr5 | 63621013 | + |
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FusionProtFeatures for ITGA2_RNF180 |
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Hgene | Tgene |
ITGA2 | RNF180 |
Integrin alpha-2/beta-1 is a receptor for laminin,collagen, collagen C-propeptides, fibronectin and E-cadherin. Itrecognizes the proline-hydroxylated sequence G-F-P-G-E-R incollagen. It is responsible for adhesion of platelets and othercells to collagens, modulation of collagen and collagenase geneexpression, force generation and organization of newly synthesizedextracellular matrix. (Microbial infection) Integrin ITGA2:ITGB1 acts as areceptor for Human rotavirus A. {ECO:0000269|PubMed:12941907}. (Microbial infection) Integrin ITGA2:ITGB1 acts as areceptor for Human echoviruses 1 and 8.{ECO:0000269|PubMed:8411387}. | E3 ubiquitin-protein ligase which promotespolyubiquitination and degradation by the proteasome pathway ofZIC2. {ECO:0000250|UniProtKB:Q3U827}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ITGA2_RNF180 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ITGA2_RNF180 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ITGA2 | COL1A1, CD46, AUP1, MMP1, LAMA1, RABIF, PSMD4, SHARPIN, ITGB1, ERGIC1, PDIA3, ALB, ATF2, LGALS3, LGALS8, BTNL8, ZACN, RSRP1, TSC22D2, MGAT4C, TMED6, SCGB1D1, SERPINA12 | RNF180 | ZIC2, LYN |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ITGA2_RNF180 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ITGA2_RNF180 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ITGA2 | C0014175 | Endometriosis | 1 | CTD_human |
Hgene | ITGA2 | C0017639 | Gliosis | 1 | CTD_human |
Hgene | ITGA2 | C0020429 | Hyperalgesia | 1 | CTD_human |
Hgene | ITGA2 | C0035328 | Retinal Vein Occlusion | 1 | CTD_human |