FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 17802

FusionGeneSummary for ITFG3_LUC7L

check button Fusion gene summary
Fusion gene informationFusion gene name: ITFG3_LUC7L
Fusion gene ID: 17802
HgeneTgene
Gene symbol

ITFG3

LUC7L

Gene ID

83986

55692

Gene namefamily with sequence similarity 234 member ALUC7 like
SynonymsC16orf9|ITFG3|gs19LUC7B1|Luc7|SR+89|hLuc7B1
Cytomap

16p13.3

16p13.3

Type of geneprotein-codingprotein-coding
Descriptionprotein FAM234Aintegrin alpha FG-GAP repeat containing 3protein ITFG3putative RNA-binding protein Luc7-like 1putative SR protein LUC7B1sarcoplasmic reticulum protein LUC7B1
Modification date2018052320180523
UniProtAcc

Q9NQ29

Ensembl transtripts involved in fusion geneENST00000399932, ENST00000301679, 
ENST00000442458, ENST00000301678, 
ENST00000450082, ENST00000600536, 
ENST00000293872, ENST00000337351, 
ENST00000397783, ENST00000397780, 
ENST00000494366, 
Fusion gene scores* DoF score2 X 2 X 2=811 X 10 X 6=660
# samples 212
** MAII scorelog2(2/8*10)=1.32192809488736log2(12/660*10)=-2.4594316186373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ITFG3 [Title/Abstract] AND LUC7L [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVHNSCTCGA-CV-6940-01AITFG3chr16

299653

+LUC7Lchr16

258187

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000399932ENST00000293872ITFG3chr16

299653

+LUC7Lchr16

258187

-
5UTR-3CDSENST00000399932ENST00000337351ITFG3chr16

299653

+LUC7Lchr16

258187

-
5UTR-3CDSENST00000399932ENST00000397783ITFG3chr16

299653

+LUC7Lchr16

258187

-
5UTR-3CDSENST00000399932ENST00000397780ITFG3chr16

299653

+LUC7Lchr16

258187

-
5UTR-intronENST00000399932ENST00000494366ITFG3chr16

299653

+LUC7Lchr16

258187

-
5UTR-3CDSENST00000301679ENST00000293872ITFG3chr16

299653

+LUC7Lchr16

258187

-
5UTR-3CDSENST00000301679ENST00000337351ITFG3chr16

299653

+LUC7Lchr16

258187

-
5UTR-3CDSENST00000301679ENST00000397783ITFG3chr16

299653

+LUC7Lchr16

258187

-
5UTR-3CDSENST00000301679ENST00000397780ITFG3chr16

299653

+LUC7Lchr16

258187

-
5UTR-intronENST00000301679ENST00000494366ITFG3chr16

299653

+LUC7Lchr16

258187

-
5UTR-3CDSENST00000442458ENST00000293872ITFG3chr16

299653

+LUC7Lchr16

258187

-
5UTR-3CDSENST00000442458ENST00000337351ITFG3chr16

299653

+LUC7Lchr16

258187

-
5UTR-3CDSENST00000442458ENST00000397783ITFG3chr16

299653

+LUC7Lchr16

258187

-
5UTR-3CDSENST00000442458ENST00000397780ITFG3chr16

299653

+LUC7Lchr16

258187

-
5UTR-intronENST00000442458ENST00000494366ITFG3chr16

299653

+LUC7Lchr16

258187

-
5UTR-3CDSENST00000301678ENST00000293872ITFG3chr16

299653

+LUC7Lchr16

258187

-
5UTR-3CDSENST00000301678ENST00000337351ITFG3chr16

299653

+LUC7Lchr16

258187

-
5UTR-3CDSENST00000301678ENST00000397783ITFG3chr16

299653

+LUC7Lchr16

258187

-
5UTR-3CDSENST00000301678ENST00000397780ITFG3chr16

299653

+LUC7Lchr16

258187

-
5UTR-intronENST00000301678ENST00000494366ITFG3chr16

299653

+LUC7Lchr16

258187

-
5UTR-3CDSENST00000450082ENST00000293872ITFG3chr16

299653

+LUC7Lchr16

258187

-
5UTR-3CDSENST00000450082ENST00000337351ITFG3chr16

299653

+LUC7Lchr16

258187

-
5UTR-3CDSENST00000450082ENST00000397783ITFG3chr16

299653

+LUC7Lchr16

258187

-
5UTR-3CDSENST00000450082ENST00000397780ITFG3chr16

299653

+LUC7Lchr16

258187

-
5UTR-intronENST00000450082ENST00000494366ITFG3chr16

299653

+LUC7Lchr16

258187

-
5UTR-3CDSENST00000600536ENST00000293872ITFG3chr16

299653

+LUC7Lchr16

258187

-
5UTR-3CDSENST00000600536ENST00000337351ITFG3chr16

299653

+LUC7Lchr16

258187

-
5UTR-3CDSENST00000600536ENST00000397783ITFG3chr16

299653

+LUC7Lchr16

258187

-
5UTR-3CDSENST00000600536ENST00000397780ITFG3chr16

299653

+LUC7Lchr16

258187

-
5UTR-intronENST00000600536ENST00000494366ITFG3chr16

299653

+LUC7Lchr16

258187

-

Top

FusionProtFeatures for ITFG3_LUC7L


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ITFG3

LUC7L

Q9NQ29

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. May bind to RNA via its Arg/Ser-rich domain.{ECO:0000269|PubMed:11170747}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ITFG3_LUC7L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ITFG3_LUC7L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ITFG3MME, FBXO6, STX12, TMEM17, XKRX, SCGB1D1LUC7LRNPS1, NFKBIL1, FAM173A, USP50, TADA2A, CALM1, JMJD6, TCERG1, GADD45G, BARD1, CHERP, CTNNBL1, LUC7L, FBXO25, PRDX1, SRPK2, SRPK1, CLK2, SRPK3, PRMT5, CCDC8, SUZ12, EAF1, TRA2A, ZRANB2, LUC7L2, RBM27, RBM26, ZFP91, MRPL46, EIF2B1, ZC3H18, NKAP, BCLAF1, THRAP3, RECQL4, PRPF4B, C1QBP, SRRM2, FXR1, PTCD3, ZNF638, RBM23, GPATCH8, MRPS27, U2AF2, NRD1, UBE2O, LSM14B, SRRM1, CMAS, PPIG, PNN, VANGL1, ZCCHC8, LBR, DDX50, MRPS5, RBBP6, CSNK2A2, RBM25, MRPS9, SRRT, LARP1, CLK3, PRPF40A, CSNK2A1, PSME3, LUC7L3, TNPO3, RNMTL1, RBM7, SRSF11, MRPS22, MEPCE, CASC3, ACIN1, SCAF4, PHF10, RNASEH1, NKTR, CLASRP, SETD2, FTL, PRPF38B, MRS2, CPSF7, KBTBD6, VANGL2, MKRN1, YY1AP1, CHCHD2P9, SRSF10, SRSF8, PRRC2A, IBA57, HNRNPR, SF3B3, SNRNP70, SNRPD1, SNRPD2, SNRPD3, SYNCRIP, NTRK1, XPO1, NLRP3, SNW1, CDC5L, NANOG, RC3H1, CHCHD10, MRPL52, SRSF1, NCBP1, MRPL35, ZC3H14, INO80B, DLST, PDHA1, FOXA1, G3BP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ITFG3_LUC7L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ITFG3_LUC7L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource