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Fusion gene ID: 17798 |
FusionGeneSummary for ITFG1_TRIM60 |
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Fusion gene information | Fusion gene name: ITFG1_TRIM60 | Fusion gene ID: 17798 | Hgene | Tgene | Gene symbol | ITFG1 | TRIM60 | Gene ID | 81533 | 166655 |
Gene name | integrin alpha FG-GAP repeat containing 1 | tripartite motif containing 60 | |
Synonyms | 2310047C21Rik|CDA08|LNKN-1|TIP | RNF129|RNF33 | |
Cytomap | 16q12.1 | 4q32.3 | |
Type of gene | protein-coding | protein-coding | |
Description | T-cell immunomodulatory proteinLINKINintegrin-alpha FG-GAP repeat-containing protein 1 | tripartite motif-containing protein 60ring finger protein 129ring finger protein 33 | |
Modification date | 20180519 | 20180329 | |
UniProtAcc | Q8TB96 | Q495X7 | |
Ensembl transtripts involved in fusion gene | ENST00000568047, ENST00000320640, ENST00000544001, | ENST00000512596, ENST00000341062, ENST00000508504, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 1 X 1 X 1=1 |
# samples | 2 | 1 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: ITFG1 [Title/Abstract] AND TRIM60 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AI867902 | ITFG1 | chr16 | 47252077 | + | TRIM60 | chr4 | 165962478 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000568047 | ENST00000512596 | ITFG1 | chr16 | 47252077 | + | TRIM60 | chr4 | 165962478 | - |
intron-3CDS | ENST00000568047 | ENST00000341062 | ITFG1 | chr16 | 47252077 | + | TRIM60 | chr4 | 165962478 | - |
intron-3CDS | ENST00000568047 | ENST00000508504 | ITFG1 | chr16 | 47252077 | + | TRIM60 | chr4 | 165962478 | - |
intron-3CDS | ENST00000320640 | ENST00000512596 | ITFG1 | chr16 | 47252077 | + | TRIM60 | chr4 | 165962478 | - |
intron-3CDS | ENST00000320640 | ENST00000341062 | ITFG1 | chr16 | 47252077 | + | TRIM60 | chr4 | 165962478 | - |
intron-3CDS | ENST00000320640 | ENST00000508504 | ITFG1 | chr16 | 47252077 | + | TRIM60 | chr4 | 165962478 | - |
intron-3CDS | ENST00000544001 | ENST00000512596 | ITFG1 | chr16 | 47252077 | + | TRIM60 | chr4 | 165962478 | - |
intron-3CDS | ENST00000544001 | ENST00000341062 | ITFG1 | chr16 | 47252077 | + | TRIM60 | chr4 | 165962478 | - |
intron-3CDS | ENST00000544001 | ENST00000508504 | ITFG1 | chr16 | 47252077 | + | TRIM60 | chr4 | 165962478 | - |
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FusionProtFeatures for ITFG1_TRIM60 |
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Hgene | Tgene |
ITFG1 | TRIM60 |
Modulator of T-cell function. Has a protective effect ingraft versus host disease model (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ITFG1_TRIM60 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ITFG1_TRIM60 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ITFG1_TRIM60 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ITFG1_TRIM60 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |