FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 17798

FusionGeneSummary for ITFG1_TRIM60

check button Fusion gene summary
Fusion gene informationFusion gene name: ITFG1_TRIM60
Fusion gene ID: 17798
HgeneTgene
Gene symbol

ITFG1

TRIM60

Gene ID

81533

166655

Gene nameintegrin alpha FG-GAP repeat containing 1tripartite motif containing 60
Synonyms2310047C21Rik|CDA08|LNKN-1|TIPRNF129|RNF33
Cytomap

16q12.1

4q32.3

Type of geneprotein-codingprotein-coding
DescriptionT-cell immunomodulatory proteinLINKINintegrin-alpha FG-GAP repeat-containing protein 1tripartite motif-containing protein 60ring finger protein 129ring finger protein 33
Modification date2018051920180329
UniProtAcc

Q8TB96

Q495X7

Ensembl transtripts involved in fusion geneENST00000568047, ENST00000320640, 
ENST00000544001, 
ENST00000512596, 
ENST00000341062, ENST00000508504, 
Fusion gene scores* DoF score2 X 2 X 2=81 X 1 X 1=1
# samples 21
** MAII scorelog2(2/8*10)=1.32192809488736log2(1/1*10)=3.32192809488736
Context

PubMed: ITFG1 [Title/Abstract] AND TRIM60 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI867902ITFG1chr16

47252077

+TRIM60chr4

165962478

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000568047ENST00000512596ITFG1chr16

47252077

+TRIM60chr4

165962478

-
intron-3CDSENST00000568047ENST00000341062ITFG1chr16

47252077

+TRIM60chr4

165962478

-
intron-3CDSENST00000568047ENST00000508504ITFG1chr16

47252077

+TRIM60chr4

165962478

-
intron-3CDSENST00000320640ENST00000512596ITFG1chr16

47252077

+TRIM60chr4

165962478

-
intron-3CDSENST00000320640ENST00000341062ITFG1chr16

47252077

+TRIM60chr4

165962478

-
intron-3CDSENST00000320640ENST00000508504ITFG1chr16

47252077

+TRIM60chr4

165962478

-
intron-3CDSENST00000544001ENST00000512596ITFG1chr16

47252077

+TRIM60chr4

165962478

-
intron-3CDSENST00000544001ENST00000341062ITFG1chr16

47252077

+TRIM60chr4

165962478

-
intron-3CDSENST00000544001ENST00000508504ITFG1chr16

47252077

+TRIM60chr4

165962478

-

Top

FusionProtFeatures for ITFG1_TRIM60


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ITFG1

Q8TB96

TRIM60

Q495X7

Modulator of T-cell function. Has a protective effect ingraft versus host disease model (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for ITFG1_TRIM60


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for ITFG1_TRIM60


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for ITFG1_TRIM60


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for ITFG1_TRIM60


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource