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Fusion gene ID: 17747 |
FusionGeneSummary for IRX1_ADAMTS16 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: IRX1_ADAMTS16 | Fusion gene ID: 17747 | Hgene | Tgene | Gene symbol | IRX1 | ADAMTS16 | Gene ID | 79192 | 170690 |
| Gene name | iroquois homeobox 1 | ADAM metallopeptidase with thrombospondin type 1 motif 16 | |
| Synonyms | IRX-5|IRXA1 | ADAMTS16s | |
| Cytomap | 5p15.33 | 5p15.32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | iroquois-class homeodomain protein IRX-1homeodomain protein IRXA1iroquois homeobox protein 1 | A disintegrin and metalloproteinase with thrombospondin motifs 16ADAM-TS 16ADAM-TS16ADAMTS-16a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 16 | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | P78414 | Q8TE57 | |
| Ensembl transtripts involved in fusion gene | ENST00000302006, | ENST00000274181, ENST00000511368, ENST00000513709, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 4 X 5 X 3=60 |
| # samples | 1 | 4 | |
| ** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/60*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: IRX1 [Title/Abstract] AND ADAMTS16 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | IRX1 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 20440264 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-BF-AAP6-01A | IRX1 | chr5 | 3596495 | + | ADAMTS16 | chr5 | 5182157 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000302006 | ENST00000274181 | IRX1 | chr5 | 3596495 | + | ADAMTS16 | chr5 | 5182157 | + |
| In-frame | ENST00000302006 | ENST00000511368 | IRX1 | chr5 | 3596495 | + | ADAMTS16 | chr5 | 5182157 | + |
| 5CDS-intron | ENST00000302006 | ENST00000513709 | IRX1 | chr5 | 3596495 | + | ADAMTS16 | chr5 | 5182157 | + |
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FusionProtFeatures for IRX1_ADAMTS16 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| IRX1 | ADAMTS16 |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >ADAMTS16 | chr5:3596495 | chr5:5182157 | ENST00000274181 | + | 2 | 23 | 642_746 | 167 | 1225 | Compositional bias | Note=Cys-rich |
| Tgene | >ADAMTS16 | chr5:3596495 | chr5:5182157 | ENST00000274181 | + | 2 | 23 | 1051_1115 | 167 | 1225 | Domain | TSP type-1 5 |
| Tgene | >ADAMTS16 | chr5:3596495 | chr5:5182157 | ENST00000274181 | + | 2 | 23 | 1127_1181 | 167 | 1225 | Domain | TSP type-1 6 |
| Tgene | >ADAMTS16 | chr5:3596495 | chr5:5182157 | ENST00000274181 | + | 2 | 23 | 1186_1223 | 167 | 1225 | Domain | PLAC |
| Tgene | >ADAMTS16 | chr5:3596495 | chr5:5182157 | ENST00000274181 | + | 2 | 23 | 290_495 | 167 | 1225 | Domain | Peptidase M12B |
| Tgene | >ADAMTS16 | chr5:3596495 | chr5:5182157 | ENST00000274181 | + | 2 | 23 | 496_585 | 167 | 1225 | Domain | Note=Disintegrin |
| Tgene | >ADAMTS16 | chr5:3596495 | chr5:5182157 | ENST00000274181 | + | 2 | 23 | 586_641 | 167 | 1225 | Domain | TSP type-1 1 |
| Tgene | >ADAMTS16 | chr5:3596495 | chr5:5182157 | ENST00000274181 | + | 2 | 23 | 874_922 | 167 | 1225 | Domain | TSP type-1 2 |
| Tgene | >ADAMTS16 | chr5:3596495 | chr5:5182157 | ENST00000274181 | + | 2 | 23 | 927_987 | 167 | 1225 | Domain | TSP type-1 3 |
| Tgene | >ADAMTS16 | chr5:3596495 | chr5:5182157 | ENST00000274181 | + | 2 | 23 | 988_1048 | 167 | 1225 | Domain | TSP type-1 4 |
| Tgene | >ADAMTS16 | chr5:3596495 | chr5:5182157 | ENST00000274181 | + | 2 | 23 | 247_254 | 167 | 1225 | Motif | Cysteine switch |
| Tgene | >ADAMTS16 | chr5:3596495 | chr5:5182157 | ENST00000274181 | + | 2 | 23 | 747_873 | 167 | 1225 | Region | Note=Spacer |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >IRX1 | chr5:3596495 | chr5:5182157 | ENST00000302006 | + | 1 | 4 | 334_337 | 92 | 481 | Compositional bias | Note=Poly-Pro |
| Hgene | >IRX1 | chr5:3596495 | chr5:5182157 | ENST00000302006 | + | 1 | 4 | 407_415 | 92 | 481 | Compositional bias | Note=Poly-Pro |
| Hgene | >IRX1 | chr5:3596495 | chr5:5182157 | ENST00000302006 | + | 1 | 4 | 125_188 | 92 | 481 | DNA binding | Homeobox%3B TALE-type |
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FusionGeneSequence for IRX1_ADAMTS16 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_IRX1_ENST00000302006_chr5_3596495_+_ADAMTS16_ENST00000274181_chr5_5182157_+_1150aa MSFPQLGYPQYLSAAGPGAYGGERPGVLAAAAAAAAAASSGRPGAAELGGGAGAAAVTSVLGMYAAAGPYAGAPNYSAFLPYAADLSLFS QMSGMIRTEEADYFLRPLPSHLSWKLGRAAQGSSPSHVLYKRSTEPHAPGASEVLVTSRTWELAHQPLHSSDLRLGLPQKQHFCGRRKKY MPQPPKEDLFILPDEYKSCLRHKRSLLRSHRNEELNVETLVVVDKKMMQNHGHENITTYVLTILNMVSALFKDGTIGGNINIAIVGLILL EDEQPGLVISHHADHTLSSFCQWQSGLMGKDGTRHDHAILLTGLDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHES GHNFGMIHDGEGNMCKKSEGNIMSPTLAGRNGVFSWSPCSRQYLHKFLSTAQAICLADQPKPVKEYKYPEKLPGELYDANTQCKWQFGEK AKLCMLDFKKDICKALWCHRIGRKCETKFMPAAEGTICGHDMWCRGGQCVKYGDEGPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTN PKPSHGGKFCEGSTRTLKLCNSQKCPRDSVDFRAAQCAEHNSRRFRGRHYKWKPYTQVEDQDLCKLYCIAEGFDFFFSLSNKVKDGTPCS EDSRNVCIDGICERVGCDNVLGSDAVEDVCGVCNGNNSACTIHRGLYTKHHHTNQYYHMVTIPSGARSIRIYEMNVSTSYISVRNALRRY YLNGHWTVDWPGRYKFSGTTFDYRRSYNEPENLIATGPTNETLIVELLFQGRNPGVAWEYSMPRLGTEKQPPAQPSYTWAIVRSECSVSC GGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVPCKVSACPPSWSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQPAP SSRQACNSQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLVSAWSQCSV TCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLA >In-frame_IRX1_ENST00000302006_chr5_3596495_+_ADAMTS16_ENST00000511368_chr5_5182157_+_496aa MSFPQLGYPQYLSAAGPGAYGGERPGVLAAAAAAAAAASSGRPGAAELGGGAGAAAVTSVLGMYAAAGPYAGAPNYSAFLPYAADLSLFS QMSGMIRTEEADYFLRPLPSHLSWKLGRAAQGSSPSHVLYKRSTEPHAPGASEVLVTSRTWELAHQPLHSSDLRLGLPQKQHFCGRRKKY MPQPPKEDLFILPDEYKSCLRHKRSLLRSHRNEELNVETLVVVDKKMMQNHGHENITTYVLTILNMVSALFKDGTIGGNINIAIVGLILL EDEQPGLVISHHADHTLSSFCQWQSGLMGKDGTRHDHAILLTGLDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHES GHNFGMIHDGEGNMCKKSEGNIMSPTLAGRNGVFSWSPCSRQYLHKFLSTAQAICLADQPKPVKEYKYPEKLPGELYDANTQCKWQFGEK |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_IRX1_ENST00000302006_chr5_3596495_+_ADAMTS16_ENST00000274181_chr5_5182157_+_3450nt ATGTCCTTCCCGCAGCTGGGCTACCCGCAGTACCTGAGCGCCGCGGGGCCGGGCGCCTACGGCGGCGAGCGCCCGGGGGTGCTGGCCGCG GCCGCTGCGGCGGCTGCCGCCGCCTCGTCGGGCCGACCGGGGGCCGCGGAGCTGGGCGGCGGGGCAGGCGCGGCTGCAGTCACCTCGGTG CTGGGCATGTACGCGGCGGCGGGGCCGTACGCGGGCGCGCCCAACTACAGCGCCTTCCTGCCCTACGCCGCGGATCTCAGCCTCTTCTCG CAGATGTCAGGCATGATACGAACAGAAGAGGCAGATTACTTCCTAAGGCCACTTCCTTCACACCTCTCATGGAAACTCGGCAGAGCTGCC CAAGGCAGCTCGCCATCCCACGTACTGTACAAGAGATCCACAGAGCCCCATGCTCCTGGGGCCAGTGAGGTCCTGGTGACCTCAAGGACA TGGGAGCTGGCACATCAACCCCTGCACAGCAGCGACCTTCGCCTGGGACTGCCACAAAAGCAGCATTTCTGTGGAAGACGCAAGAAATAC ATGCCCCAGCCTCCCAAGGAAGACCTCTTCATCTTGCCAGATGAGTATAAGTCTTGCTTACGGCATAAGCGCTCTCTTCTGAGGTCCCAT AGAAATGAAGAACTGAACGTGGAGACCTTGGTGGTGGTCGACAAAAAGATGATGCAAAACCATGGCCATGAAAATATCACCACCTACGTG CTCACGATACTCAACATGGTATCTGCTTTATTCAAAGATGGAACAATAGGAGGAAACATCAACATTGCAATTGTAGGTCTGATTCTTCTA GAAGATGAACAGCCAGGACTGGTGATAAGTCACCACGCAGACCACACCTTAAGTAGCTTCTGCCAGTGGCAGTCTGGATTGATGGGGAAA GATGGGACTCGTCATGACCACGCCATCTTACTGACTGGTCTGGATATATGTTCCTGGAAGAATGAGCCCTGTGACACTTTGGGATTTGCA CCCATAAGTGGAATGTGTAGTAAATATCGCAGCTGCACGATTAATGAAGATACAGGTCTTGGACTGGCCTTCACCATTGCCCATGAGTCT GGACACAACTTTGGCATGATTCATGATGGAGAAGGGAACATGTGCAAAAAGTCCGAGGGCAACATCATGTCCCCTACATTGGCAGGACGC AATGGAGTCTTCTCCTGGTCACCCTGCAGCCGCCAGTATCTACACAAATTTCTAAGCACCGCTCAAGCTATCTGCCTTGCTGATCAGCCA AAGCCTGTGAAGGAATACAAGTATCCTGAGAAATTGCCAGGAGAATTATATGATGCAAACACACAGTGCAAGTGGCAGTTCGGAGAGAAA GCCAAGCTCTGCATGCTGGACTTTAAAAAGGACATCTGTAAAGCCCTGTGGTGCCATCGTATTGGAAGGAAATGTGAGACTAAATTTATG CCAGCAGCAGAAGGCACAATTTGTGGGCATGACATGTGGTGCCGGGGAGGACAGTGTGTGAAATATGGTGATGAAGGCCCCAAGCCCACC CATGGCCACTGGTCGGACTGGTCTTCTTGGTCCCCATGCTCCAGGACCTGCGGAGGGGGAGTATCTCATAGGAGTCGCCTCTGCACCAAC CCCAAGCCATCGCATGGAGGGAAGTTCTGTGAGGGCTCCACTCGCACTCTGAAGCTCTGCAACAGTCAGAAATGTCCCCGGGACAGTGTT GACTTCCGTGCTGCTCAGTGTGCCGAGCACAACAGCAGACGATTCAGAGGGCGGCACTACAAGTGGAAGCCTTACACTCAAGTAGAAGAT CAGGACTTATGCAAACTCTACTGTATCGCAGAAGGATTTGATTTCTTCTTTTCTTTGTCAAATAAAGTCAAAGATGGGACTCCATGCTCG GAGGATAGCCGTAATGTTTGTATAGATGGGATATGTGAGAGAGTTGGATGTGACAATGTCCTTGGATCTGATGCTGTTGAAGACGTCTGT GGGGTGTGTAACGGGAATAACTCAGCCTGCACGATTCACAGGGGTCTCTACACCAAGCACCACCACACCAACCAGTATTATCACATGGTC ACCATTCCTTCTGGAGCCCGGAGTATCCGCATCTATGAAATGAACGTCTCTACCTCCTACATTTCTGTGCGCAATGCCCTCAGAAGGTAC TACCTGAATGGGCACTGGACCGTGGACTGGCCCGGCCGGTACAAATTTTCGGGCACTACTTTCGACTACAGACGGTCCTATAATGAGCCC GAGAACTTAATCGCTACTGGACCAACCAACGAGACACTGATTGTGGAGCTGCTGTTTCAGGGAAGGAACCCGGGTGTTGCCTGGGAATAC TCCATGCCTCGCTTGGGGACCGAGAAGCAGCCCCCTGCCCAGCCCAGCTACACTTGGGCCATCGTGCGCTCTGAGTGCTCCGTGTCCTGC GGAGGGGGACAGATGACCGTGAGAGAGGGCTGCTACAGAGACCTGAAGTTTCAAGTAAATATGTCCTTCTGCAATCCCAAGACACGACCT GTCACGGGGCTGGTGCCTTGCAAAGTATCTGCCTGTCCTCCCAGCTGGTCCGTGGGGAACTGGAGTGCCTGCAGTCGGACGTGTGGCGGG GGTGCCCAGAGCCGCCCCGTGCAGTGCACACGGCGGGTGCACTATGACTCGGAGCCAGTCCCGGCCAGCCTGTGCCCTCAGCCTGCTCCC TCCAGCAGGCAGGCCTGCAACTCTCAGAGCTGCCCACCTGCATGGAGCGCCGGGCCCTGGGCAGAGTGCTCACACACCTGTGGGAAGGGG TGGAGGAAGCGGGCAGTGGCCTGTAAGAGCACCAACCCCTCGGCCAGAGCGCAGCTGCTGCCCGACGCTGTCTGCACCTCCGAGCCCAAG CCCAGGATGCATGAAGCCTGTCTGCTTCAGCGCTGCCACAAGCCCAAGAAGCTGCAGTGGCTGGTGTCCGCCTGGTCCCAGTGCTCTGTG ACATGTGAAAGAGGAACACAGAAAAGATTCTTAAAATGTGCTGAAAAGTATGTTTCTGGAAAGTATCGAGAGCTGGCCTCAAAGAAGTGC TCACATTTGCCGAAGCCCAGCCTGGAGCTGGAACGTGCCTGCGCCCCGCTTCCATGCCCCAGGCACCCCCCATTTGCTGCTGCGGGACCC TCGAGGGGCAGCTGGTTTGCCTCACCCTGGTCTCAGTGCACGGCCAGCTGTGGGGGAGGCGTTCAGACGAGGTCCGTGCAGTGCCTGGCT GGGGGCCGGCCGGCCTCAGGCTGCCTCCTGCACCAGAAGCCTTCGGCCTCCCTGGCCTGCAACACTCACTTCTGCCCCATTGCAGAGAAG AAAGATGCCTTCTGCAAAGACTACTTCCACTGGTGCTACCTGGTACCCCAGCACGGGATGTGCAGCCACAAGTTCTACGGCAAGCAGTGC >In-frame_IRX1_ENST00000302006_chr5_3596495_+_ADAMTS16_ENST00000511368_chr5_5182157_+_1488nt ATGTCCTTCCCGCAGCTGGGCTACCCGCAGTACCTGAGCGCCGCGGGGCCGGGCGCCTACGGCGGCGAGCGCCCGGGGGTGCTGGCCGCG GCCGCTGCGGCGGCTGCCGCCGCCTCGTCGGGCCGACCGGGGGCCGCGGAGCTGGGCGGCGGGGCAGGCGCGGCTGCAGTCACCTCGGTG CTGGGCATGTACGCGGCGGCGGGGCCGTACGCGGGCGCGCCCAACTACAGCGCCTTCCTGCCCTACGCCGCGGATCTCAGCCTCTTCTCG CAGATGTCAGGCATGATACGAACAGAAGAGGCAGATTACTTCCTAAGGCCACTTCCTTCACACCTCTCATGGAAACTCGGCAGAGCTGCC CAAGGCAGCTCGCCATCCCACGTACTGTACAAGAGATCCACAGAGCCCCATGCTCCTGGGGCCAGTGAGGTCCTGGTGACCTCAAGGACA TGGGAGCTGGCACATCAACCCCTGCACAGCAGCGACCTTCGCCTGGGACTGCCACAAAAGCAGCATTTCTGTGGAAGACGCAAGAAATAC ATGCCCCAGCCTCCCAAGGAAGACCTCTTCATCTTGCCAGATGAGTATAAGTCTTGCTTACGGCATAAGCGCTCTCTTCTGAGGTCCCAT AGAAATGAAGAACTGAACGTGGAGACCTTGGTGGTGGTCGACAAAAAGATGATGCAAAACCATGGCCATGAAAATATCACCACCTACGTG CTCACGATACTCAACATGGTATCTGCTTTATTCAAAGATGGAACAATAGGAGGAAACATCAACATTGCAATTGTAGGTCTGATTCTTCTA GAAGATGAACAGCCAGGACTGGTGATAAGTCACCACGCAGACCACACCTTAAGTAGCTTCTGCCAGTGGCAGTCTGGATTGATGGGGAAA GATGGGACTCGTCATGACCACGCCATCTTACTGACTGGTCTGGATATATGTTCCTGGAAGAATGAGCCCTGTGACACTTTGGGATTTGCA CCCATAAGTGGAATGTGTAGTAAATATCGCAGCTGCACGATTAATGAAGATACAGGTCTTGGACTGGCCTTCACCATTGCCCATGAGTCT GGACACAACTTTGGCATGATTCATGATGGAGAAGGGAACATGTGCAAAAAGTCCGAGGGCAACATCATGTCCCCTACATTGGCAGGACGC AATGGAGTCTTCTCCTGGTCACCCTGCAGCCGCCAGTATCTACACAAATTTCTAAGCACCGCTCAAGCTATCTGCCTTGCTGATCAGCCA AAGCCTGTGAAGGAATACAAGTATCCTGAGAAATTGCCAGGAGAATTATATGATGCAAACACACAGTGCAAGTGGCAGTTCGGAGAGAAA GCCAAGCTCTGCATGCTGGACTTTAAAAAGGACATCTGTAAAGCCCTGTGGTGCCATCGTATTGGAAGGAAATGTGAGACTAAATTTATG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_IRX1_ENST00000302006_chr5_3596495_+_ADAMTS16_ENST00000274181_chr5_5182157_+_4668nt CTCCCCGCGCCTTTAATACTCGCCCGCTGCGGCGGTCGCCGAGTCCGCGGACATGTCCTTCCCGCAGCTGGGCTACCCGCAGTACCTGAG CGCCGCGGGGCCGGGCGCCTACGGCGGCGAGCGCCCGGGGGTGCTGGCCGCGGCCGCTGCGGCGGCTGCCGCCGCCTCGTCGGGCCGACC GGGGGCCGCGGAGCTGGGCGGCGGGGCAGGCGCGGCTGCAGTCACCTCGGTGCTGGGCATGTACGCGGCGGCGGGGCCGTACGCGGGCGC GCCCAACTACAGCGCCTTCCTGCCCTACGCCGCGGATCTCAGCCTCTTCTCGCAGATGTCAGGCATGATACGAACAGAAGAGGCAGATTA CTTCCTAAGGCCACTTCCTTCACACCTCTCATGGAAACTCGGCAGAGCTGCCCAAGGCAGCTCGCCATCCCACGTACTGTACAAGAGATC CACAGAGCCCCATGCTCCTGGGGCCAGTGAGGTCCTGGTGACCTCAAGGACATGGGAGCTGGCACATCAACCCCTGCACAGCAGCGACCT TCGCCTGGGACTGCCACAAAAGCAGCATTTCTGTGGAAGACGCAAGAAATACATGCCCCAGCCTCCCAAGGAAGACCTCTTCATCTTGCC AGATGAGTATAAGTCTTGCTTACGGCATAAGCGCTCTCTTCTGAGGTCCCATAGAAATGAAGAACTGAACGTGGAGACCTTGGTGGTGGT CGACAAAAAGATGATGCAAAACCATGGCCATGAAAATATCACCACCTACGTGCTCACGATACTCAACATGGTATCTGCTTTATTCAAAGA TGGAACAATAGGAGGAAACATCAACATTGCAATTGTAGGTCTGATTCTTCTAGAAGATGAACAGCCAGGACTGGTGATAAGTCACCACGC AGACCACACCTTAAGTAGCTTCTGCCAGTGGCAGTCTGGATTGATGGGGAAAGATGGGACTCGTCATGACCACGCCATCTTACTGACTGG TCTGGATATATGTTCCTGGAAGAATGAGCCCTGTGACACTTTGGGATTTGCACCCATAAGTGGAATGTGTAGTAAATATCGCAGCTGCAC GATTAATGAAGATACAGGTCTTGGACTGGCCTTCACCATTGCCCATGAGTCTGGACACAACTTTGGCATGATTCATGATGGAGAAGGGAA CATGTGCAAAAAGTCCGAGGGCAACATCATGTCCCCTACATTGGCAGGACGCAATGGAGTCTTCTCCTGGTCACCCTGCAGCCGCCAGTA TCTACACAAATTTCTAAGCACCGCTCAAGCTATCTGCCTTGCTGATCAGCCAAAGCCTGTGAAGGAATACAAGTATCCTGAGAAATTGCC AGGAGAATTATATGATGCAAACACACAGTGCAAGTGGCAGTTCGGAGAGAAAGCCAAGCTCTGCATGCTGGACTTTAAAAAGGACATCTG TAAAGCCCTGTGGTGCCATCGTATTGGAAGGAAATGTGAGACTAAATTTATGCCAGCAGCAGAAGGCACAATTTGTGGGCATGACATGTG GTGCCGGGGAGGACAGTGTGTGAAATATGGTGATGAAGGCCCCAAGCCCACCCATGGCCACTGGTCGGACTGGTCTTCTTGGTCCCCATG CTCCAGGACCTGCGGAGGGGGAGTATCTCATAGGAGTCGCCTCTGCACCAACCCCAAGCCATCGCATGGAGGGAAGTTCTGTGAGGGCTC CACTCGCACTCTGAAGCTCTGCAACAGTCAGAAATGTCCCCGGGACAGTGTTGACTTCCGTGCTGCTCAGTGTGCCGAGCACAACAGCAG ACGATTCAGAGGGCGGCACTACAAGTGGAAGCCTTACACTCAAGTAGAAGATCAGGACTTATGCAAACTCTACTGTATCGCAGAAGGATT TGATTTCTTCTTTTCTTTGTCAAATAAAGTCAAAGATGGGACTCCATGCTCGGAGGATAGCCGTAATGTTTGTATAGATGGGATATGTGA GAGAGTTGGATGTGACAATGTCCTTGGATCTGATGCTGTTGAAGACGTCTGTGGGGTGTGTAACGGGAATAACTCAGCCTGCACGATTCA CAGGGGTCTCTACACCAAGCACCACCACACCAACCAGTATTATCACATGGTCACCATTCCTTCTGGAGCCCGGAGTATCCGCATCTATGA AATGAACGTCTCTACCTCCTACATTTCTGTGCGCAATGCCCTCAGAAGGTACTACCTGAATGGGCACTGGACCGTGGACTGGCCCGGCCG GTACAAATTTTCGGGCACTACTTTCGACTACAGACGGTCCTATAATGAGCCCGAGAACTTAATCGCTACTGGACCAACCAACGAGACACT GATTGTGGAGCTGCTGTTTCAGGGAAGGAACCCGGGTGTTGCCTGGGAATACTCCATGCCTCGCTTGGGGACCGAGAAGCAGCCCCCTGC CCAGCCCAGCTACACTTGGGCCATCGTGCGCTCTGAGTGCTCCGTGTCCTGCGGAGGGGGACAGATGACCGTGAGAGAGGGCTGCTACAG AGACCTGAAGTTTCAAGTAAATATGTCCTTCTGCAATCCCAAGACACGACCTGTCACGGGGCTGGTGCCTTGCAAAGTATCTGCCTGTCC TCCCAGCTGGTCCGTGGGGAACTGGAGTGCCTGCAGTCGGACGTGTGGCGGGGGTGCCCAGAGCCGCCCCGTGCAGTGCACACGGCGGGT GCACTATGACTCGGAGCCAGTCCCGGCCAGCCTGTGCCCTCAGCCTGCTCCCTCCAGCAGGCAGGCCTGCAACTCTCAGAGCTGCCCACC TGCATGGAGCGCCGGGCCCTGGGCAGAGTGCTCACACACCTGTGGGAAGGGGTGGAGGAAGCGGGCAGTGGCCTGTAAGAGCACCAACCC CTCGGCCAGAGCGCAGCTGCTGCCCGACGCTGTCTGCACCTCCGAGCCCAAGCCCAGGATGCATGAAGCCTGTCTGCTTCAGCGCTGCCA CAAGCCCAAGAAGCTGCAGTGGCTGGTGTCCGCCTGGTCCCAGTGCTCTGTGACATGTGAAAGAGGAACACAGAAAAGATTCTTAAAATG TGCTGAAAAGTATGTTTCTGGAAAGTATCGAGAGCTGGCCTCAAAGAAGTGCTCACATTTGCCGAAGCCCAGCCTGGAGCTGGAACGTGC CTGCGCCCCGCTTCCATGCCCCAGGCACCCCCCATTTGCTGCTGCGGGACCCTCGAGGGGCAGCTGGTTTGCCTCACCCTGGTCTCAGTG CACGGCCAGCTGTGGGGGAGGCGTTCAGACGAGGTCCGTGCAGTGCCTGGCTGGGGGCCGGCCGGCCTCAGGCTGCCTCCTGCACCAGAA GCCTTCGGCCTCCCTGGCCTGCAACACTCACTTCTGCCCCATTGCAGAGAAGAAAGATGCCTTCTGCAAAGACTACTTCCACTGGTGCTA CCTGGTACCCCAGCACGGGATGTGCAGCCACAAGTTCTACGGCAAGCAGTGCTGCAAGACTTGCTCTAAGTCCAACTTGTGAGTTGGGAC CGCTCTCCGTAGCAGAGAAAGTGCCTGCGTGGCACAGAAATTTCCCACAAATGAGCTGTGCAATCTACGTCGGAATACATCCAAGGAAGA GCAAAGCCAAAAGAAGAAAACCGTGTTAGGCTCTTTGACCAGGAGTGTATGTATGTGTTTCACTGTGAGCCTGGGTGCAGACCTGTGTCC CCATGCACACAGTGTCTCCTGTCAGGCTGAAATGTGGCACCCTGGCAGACAGAGCTGTGGCTCGTGAGGCAGAAGGCAGGCACCACAACG GGAGAGGCAGCACTCACCCCTGCCTGTTGCAGCTAAATCAAGTCAAAAAGACAGGCGAGGCTGAACTTGCTAAATGTCTGGTGCCTTAGA AAAAGAAGGAAAGGCCATGAAATAAGGAAAACATACAAAATATGTACCCCCTAGTTCACCAGCCTCCCCTCCCACTAGGAGGGCCCCTCG AGCCATCAGGAGTGACCAACTTCCTGGGTGGAGGTCAGGGGAGCTCCAGGAGGCTGCCCAGGCTCCTCCTCCTCCTCCCCAGCGGCCGAG CATCTCTTACCAGGAACCTGGAGCCACCGCCGGAGCCAGCGTCATCTCTAGGGTCACTGGCCAGGGGACTGCATTCTGGTTTGGGACTTT GCCTATGGAAATGGGAAAAATGAAATTCCTGCTAAGGTGCTTCTATCTCTTTCAGATTCATGCATTGAAGGAGAGATTTTTTATACTTTA TGTTTTATCTTTCTCAGTTATTTGCAAGTGAGTGTCCTTTTAAAAACACACTTCTTCATGCTTTTCTTTGTAAATGACAGATCGAAGTAT AGGTTACATCAAAACCCTACCATCCTGAGAAGAGTTATGGTTCTATTATAGCAGACGTCAGCCACACAGCCTATGTGACAATAACCTTAG AGTCCTGTGTTTTGTTTTTGTGTGTTGTGAGATTTTAATCTTTTTTTTTTCGGTGAGTCTGGCCATTTCTATAATGCCAGGTGGGAAGCC AGGCTGCGGGTGTTAGGGTGGGAATCTGCCCGGCGTCTCTGGCACCCTCCCTGCCATCCTCAGTGCGGCTGCTGTTCTCCTGTCCGGTGC >In-frame_IRX1_ENST00000302006_chr5_3596495_+_ADAMTS16_ENST00000511368_chr5_5182157_+_2371nt CTCCCCGCGCCTTTAATACTCGCCCGCTGCGGCGGTCGCCGAGTCCGCGGACATGTCCTTCCCGCAGCTGGGCTACCCGCAGTACCTGAG CGCCGCGGGGCCGGGCGCCTACGGCGGCGAGCGCCCGGGGGTGCTGGCCGCGGCCGCTGCGGCGGCTGCCGCCGCCTCGTCGGGCCGACC GGGGGCCGCGGAGCTGGGCGGCGGGGCAGGCGCGGCTGCAGTCACCTCGGTGCTGGGCATGTACGCGGCGGCGGGGCCGTACGCGGGCGC GCCCAACTACAGCGCCTTCCTGCCCTACGCCGCGGATCTCAGCCTCTTCTCGCAGATGTCAGGCATGATACGAACAGAAGAGGCAGATTA CTTCCTAAGGCCACTTCCTTCACACCTCTCATGGAAACTCGGCAGAGCTGCCCAAGGCAGCTCGCCATCCCACGTACTGTACAAGAGATC CACAGAGCCCCATGCTCCTGGGGCCAGTGAGGTCCTGGTGACCTCAAGGACATGGGAGCTGGCACATCAACCCCTGCACAGCAGCGACCT TCGCCTGGGACTGCCACAAAAGCAGCATTTCTGTGGAAGACGCAAGAAATACATGCCCCAGCCTCCCAAGGAAGACCTCTTCATCTTGCC AGATGAGTATAAGTCTTGCTTACGGCATAAGCGCTCTCTTCTGAGGTCCCATAGAAATGAAGAACTGAACGTGGAGACCTTGGTGGTGGT CGACAAAAAGATGATGCAAAACCATGGCCATGAAAATATCACCACCTACGTGCTCACGATACTCAACATGGTATCTGCTTTATTCAAAGA TGGAACAATAGGAGGAAACATCAACATTGCAATTGTAGGTCTGATTCTTCTAGAAGATGAACAGCCAGGACTGGTGATAAGTCACCACGC AGACCACACCTTAAGTAGCTTCTGCCAGTGGCAGTCTGGATTGATGGGGAAAGATGGGACTCGTCATGACCACGCCATCTTACTGACTGG TCTGGATATATGTTCCTGGAAGAATGAGCCCTGTGACACTTTGGGATTTGCACCCATAAGTGGAATGTGTAGTAAATATCGCAGCTGCAC GATTAATGAAGATACAGGTCTTGGACTGGCCTTCACCATTGCCCATGAGTCTGGACACAACTTTGGCATGATTCATGATGGAGAAGGGAA CATGTGCAAAAAGTCCGAGGGCAACATCATGTCCCCTACATTGGCAGGACGCAATGGAGTCTTCTCCTGGTCACCCTGCAGCCGCCAGTA TCTACACAAATTTCTAAGCACCGCTCAAGCTATCTGCCTTGCTGATCAGCCAAAGCCTGTGAAGGAATACAAGTATCCTGAGAAATTGCC AGGAGAATTATATGATGCAAACACACAGTGCAAGTGGCAGTTCGGAGAGAAAGCCAAGCTCTGCATGCTGGACTTTAAAAAGGACATCTG TAAAGCCCTGTGGTGCCATCGTATTGGAAGGAAATGTGAGACTAAATTTATGCCAGCAGCAGAAGGCACAATTTGTGGGCATGACATGGT AAGAAGCTAACTGTAGGTACAGCATCGTATTCAGATGCTAGTCTTTCAACCCATGCATCTTTGCTCCTCTTGCATAGGTATTTTTAAAAC ATGTATTTCTCATATACATATGCATACCCATGCTCCTATCAAACACTGTGTTTATTTTATATTGATAATGTGAAGAGGAATCCTTTTCTC ACTTTTGTGAAAATAAAATTGATGAGCTACCTGGAATTCATAGACATAGAAATCAGACAACAGGTGATGACAGATTCAGTCTATTGAGGG GAAACATTAAGCCATTGACCACCATTTATCATGGAAAGGACCAGCATTAAACAGTGCTGTGAAAGCCACAGAACATCGGTTTGAAGACCC TGGAGCACATCATTTTCACCTATTGTTGCCTCTGTGAGAAGAGAGAGAGCTATGGTAGAGAAAAGAAGAAGTATACAAGATGTTGCAGCA ATGTGGACGTAGTTGGAGGCCATTCATTATCCTAGGCAAACTAATGCAGGAACAGAAAACCAAATACTGCATGTTGTTACTTATAAGCAG GAGCTAAACACTGAGTACACATGGACACAAAGATGGGAACCATAGACCCCGGGGACTACTTAAGGGGGGATGGTGGGAGGGGGCAAGGGT TGAAACACTATCCCATATTGTGCTTGCTGCATGGGTGATGAGGTTATTCGAATGCCAAACTTTAGTGACACGTAATCTACCCATGTAACA AATCTGCACATGTACCCCTGAACCTAAAACAAAAGTCGGAAAAAAAAGAAATATACAAGATAACAAGTTTATTACTAAATGGTAAAGAAT |
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FusionGenePPI for IRX1_ADAMTS16 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| IRX1 | ELAVL1, TP53 | ADAMTS16 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for IRX1_ADAMTS16 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for IRX1_ADAMTS16 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | IRX1 | C0024115 | Lung diseases | 1 | CTD_human |
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