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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17746

FusionGeneSummary for IRS2_MYO16

check button Fusion gene summary
Fusion gene informationFusion gene name: IRS2_MYO16
Fusion gene ID: 17746
HgeneTgene
Gene symbol

IRS2

MYO16

Gene ID

8660

23026

Gene nameinsulin receptor substrate 2myosin XVI
SynonymsIRS-2MYAP3|MYR8|Myo16b|NYAP3|PPP1R107
Cytomap

13q34

13q33.3

Type of geneprotein-codingprotein-coding
Descriptioninsulin receptor substrate 2unconventional myosin-XVIMYO16 variant proteinmyosin heavy chain Myr 8neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 3protein phosphatase 1, regulatory subunit 10
Modification date2018052320180519
UniProtAcc

Q9Y4H2

Q9Y6X6

Ensembl transtripts involved in fusion geneENST00000375856, ENST00000356711, 
ENST00000251041, ENST00000357550, 
ENST00000457511, ENST00000467639, 
Fusion gene scores* DoF score3 X 3 X 2=1810 X 8 X 9=720
# samples 410
** MAII scorelog2(4/18*10)=1.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(10/720*10)=-2.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IRS2 [Title/Abstract] AND MYO16 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPRADTCGA-XJ-A83G-01AIRS2chr13

110434389

-MYO16chr13

109858957

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000375856ENST00000356711IRS2chr13

110434389

-MYO16chr13

109858957

+
5CDS-intronENST00000375856ENST00000251041IRS2chr13

110434389

-MYO16chr13

109858957

+
5CDS-intronENST00000375856ENST00000357550IRS2chr13

110434389

-MYO16chr13

109858957

+
5CDS-intronENST00000375856ENST00000457511IRS2chr13

110434389

-MYO16chr13

109858957

+
5CDS-intronENST00000375856ENST00000467639IRS2chr13

110434389

-MYO16chr13

109858957

+

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FusionProtFeatures for IRS2_MYO16


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IRS2

Q9Y4H2

MYO16

Q9Y6X6

May mediate the control of various cellular processes byinsulin.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for IRS2_MYO16


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for IRS2_MYO16


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
IRS2YWHAB, YWHAG, YWHAQ, SFN, SOCS1, PIK3R1, PTPN11, PIK3R3, INSR, EPOR, BCL2, JAK1, NISCH, PLCG1, TYK2, IRS1, UBTF, ESR1, ELAVL1, MYC, GRB10, PIK3CA, SOCS3, RPTOR, EGFR, COPS2, GRB2, YWHAE, DVL2, SIRT1, FBXW11, NTRK1, SRPK2, XPO1, YWHAH, YWHAZ, MRPL1, NETO2, NEDD4, EPN1, USP15, USP7MYO16NRXN1, NCKAP1, CYFIP2, CYFIP1, PIK3R1, ARHGAP26, ACOT9


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for IRS2_MYO16


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for IRS2_MYO16


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIRS2C0020456Hyperglycemia2CTD_human
HgeneIRS2C0011853Diabetes Mellitus, Experimental1CTD_human
HgeneIRS2C0021655Insulin Resistance1CTD_human
HgeneIRS2C0025149Medulloblastoma1CTD_human
HgeneIRS2C0038356Stomach Neoplasms1CTD_human
HgeneIRS2C2239176Liver carcinoma1CTD_human
TgeneMYO16C0036341Schizophrenia1PSYGENET