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Fusion gene ID: 17746 |
FusionGeneSummary for IRS2_MYO16 |
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Fusion gene information | Fusion gene name: IRS2_MYO16 | Fusion gene ID: 17746 | Hgene | Tgene | Gene symbol | IRS2 | MYO16 | Gene ID | 8660 | 23026 |
Gene name | insulin receptor substrate 2 | myosin XVI | |
Synonyms | IRS-2 | MYAP3|MYR8|Myo16b|NYAP3|PPP1R107 | |
Cytomap | 13q34 | 13q33.3 | |
Type of gene | protein-coding | protein-coding | |
Description | insulin receptor substrate 2 | unconventional myosin-XVIMYO16 variant proteinmyosin heavy chain Myr 8neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 3protein phosphatase 1, regulatory subunit 10 | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q9Y4H2 | Q9Y6X6 | |
Ensembl transtripts involved in fusion gene | ENST00000375856, | ENST00000356711, ENST00000251041, ENST00000357550, ENST00000457511, ENST00000467639, | |
Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 10 X 8 X 9=720 |
# samples | 4 | 10 | |
** MAII score | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(10/720*10)=-2.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: IRS2 [Title/Abstract] AND MYO16 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | PRAD | TCGA-XJ-A83G-01A | IRS2 | chr13 | 110434389 | - | MYO16 | chr13 | 109858957 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000375856 | ENST00000356711 | IRS2 | chr13 | 110434389 | - | MYO16 | chr13 | 109858957 | + |
5CDS-intron | ENST00000375856 | ENST00000251041 | IRS2 | chr13 | 110434389 | - | MYO16 | chr13 | 109858957 | + |
5CDS-intron | ENST00000375856 | ENST00000357550 | IRS2 | chr13 | 110434389 | - | MYO16 | chr13 | 109858957 | + |
5CDS-intron | ENST00000375856 | ENST00000457511 | IRS2 | chr13 | 110434389 | - | MYO16 | chr13 | 109858957 | + |
5CDS-intron | ENST00000375856 | ENST00000467639 | IRS2 | chr13 | 110434389 | - | MYO16 | chr13 | 109858957 | + |
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FusionProtFeatures for IRS2_MYO16 |
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Hgene | Tgene |
IRS2 | MYO16 |
May mediate the control of various cellular processes byinsulin. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for IRS2_MYO16 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for IRS2_MYO16 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
IRS2 | YWHAB, YWHAG, YWHAQ, SFN, SOCS1, PIK3R1, PTPN11, PIK3R3, INSR, EPOR, BCL2, JAK1, NISCH, PLCG1, TYK2, IRS1, UBTF, ESR1, ELAVL1, MYC, GRB10, PIK3CA, SOCS3, RPTOR, EGFR, COPS2, GRB2, YWHAE, DVL2, SIRT1, FBXW11, NTRK1, SRPK2, XPO1, YWHAH, YWHAZ, MRPL1, NETO2, NEDD4, EPN1, USP15, USP7 | MYO16 | NRXN1, NCKAP1, CYFIP2, CYFIP1, PIK3R1, ARHGAP26, ACOT9 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for IRS2_MYO16 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for IRS2_MYO16 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | IRS2 | C0020456 | Hyperglycemia | 2 | CTD_human |
Hgene | IRS2 | C0011853 | Diabetes Mellitus, Experimental | 1 | CTD_human |
Hgene | IRS2 | C0021655 | Insulin Resistance | 1 | CTD_human |
Hgene | IRS2 | C0025149 | Medulloblastoma | 1 | CTD_human |
Hgene | IRS2 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Hgene | IRS2 | C2239176 | Liver carcinoma | 1 | CTD_human |
Tgene | MYO16 | C0036341 | Schizophrenia | 1 | PSYGENET |