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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17737

FusionGeneSummary for IRF7_RCC1

check button Fusion gene summary
Fusion gene informationFusion gene name: IRF7_RCC1
Fusion gene ID: 17737
HgeneTgene
Gene symbol

IRF7

RCC1

Gene ID

3665

1104

Gene nameinterferon regulatory factor 7regulator of chromosome condensation 1
SynonymsIMD39|IRF-7H|IRF7A|IRF7B|IRF7C|IRF7HCHC1|RCC1-I|SNHG3-RCC1
Cytomap

11p15.5

1p35.3

Type of geneprotein-codingprotein-coding
Descriptioninterferon regulatory factor 7IRF-7interferon regulatory factor 7G isoforminterferon regulatory factor-7Hregulator of chromosome condensationSNHG3-RCC1 readthroughcell cycle regulatory proteinguanine nucleotide-releasing protein
Modification date2018051920180522
UniProtAcc

Q92985

P18754

Ensembl transtripts involved in fusion geneENST00000525445, ENST00000348655, 
ENST00000397566, ENST00000397570, 
ENST00000397574, ENST00000397562, 
ENST00000330243, 		ENST00000398958, 
ENST00000373833, ENST00000373832, 
ENST00000373831, ENST00000429051, 
Fusion gene scores* DoF score2 X 2 X 2=85 X 5 X 5=125
# samples 26
** MAII scorelog2(2/8*10)=1.32192809488736log2(6/125*10)=-1.05889368905357
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IRF7 [Title/Abstract] AND RCC1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIRF7

GO:0002819

regulation of adaptive immune response

17404045

HgeneIRF7

GO:0032727

positive regulation of interferon-alpha production

16127453

HgeneIRF7

GO:0045944

positive regulation of transcription by RNA polymerase II

16127453|17404045

HgeneIRF7

GO:0051607

defense response to virus

21478870

TgeneRCC1

GO:0007052

mitotic spindle organization

15014043

TgeneRCC1

GO:0007088

regulation of mitotic nuclear division

15014043

TgeneRCC1

GO:0051290

protein heterotetramerization

11336674


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVESCATCGA-2H-A9GJ-01AIRF7chr11

615345

-RCC1chr1

28843237

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000525445ENST00000398958IRF7chr11

615345

-RCC1chr1

28843237

+
intron-5UTRENST00000525445ENST00000373833IRF7chr11

615345

-RCC1chr1

28843237

+
intron-intronENST00000525445ENST00000373832IRF7chr11

615345

-RCC1chr1

28843237

+
intron-intronENST00000525445ENST00000373831IRF7chr11

615345

-RCC1chr1

28843237

+
intron-intronENST00000525445ENST00000429051IRF7chr11

615345

-RCC1chr1

28843237

+
5CDS-intronENST00000348655ENST00000398958IRF7chr11

615345

-RCC1chr1

28843237

+
5CDS-5UTRENST00000348655ENST00000373833IRF7chr11

615345

-RCC1chr1

28843237

+
5CDS-intronENST00000348655ENST00000373832IRF7chr11

615345

-RCC1chr1

28843237

+
5CDS-intronENST00000348655ENST00000373831IRF7chr11

615345

-RCC1chr1

28843237

+
5CDS-intronENST00000348655ENST00000429051IRF7chr11

615345

-RCC1chr1

28843237

+
intron-intronENST00000397566ENST00000398958IRF7chr11

615345

-RCC1chr1

28843237

+
intron-5UTRENST00000397566ENST00000373833IRF7chr11

615345

-RCC1chr1

28843237

+
intron-intronENST00000397566ENST00000373832IRF7chr11

615345

-RCC1chr1

28843237

+
intron-intronENST00000397566ENST00000373831IRF7chr11

615345

-RCC1chr1

28843237

+
intron-intronENST00000397566ENST00000429051IRF7chr11

615345

-RCC1chr1

28843237

+
5CDS-intronENST00000397570ENST00000398958IRF7chr11

615345

-RCC1chr1

28843237

+
5CDS-5UTRENST00000397570ENST00000373833IRF7chr11

615345

-RCC1chr1

28843237

+
5CDS-intronENST00000397570ENST00000373832IRF7chr11

615345

-RCC1chr1

28843237

+
5CDS-intronENST00000397570ENST00000373831IRF7chr11

615345

-RCC1chr1

28843237

+
5CDS-intronENST00000397570ENST00000429051IRF7chr11

615345

-RCC1chr1

28843237

+
5CDS-intronENST00000397574ENST00000398958IRF7chr11

615345

-RCC1chr1

28843237

+
5CDS-5UTRENST00000397574ENST00000373833IRF7chr11

615345

-RCC1chr1

28843237

+
5CDS-intronENST00000397574ENST00000373832IRF7chr11

615345

-RCC1chr1

28843237

+
5CDS-intronENST00000397574ENST00000373831IRF7chr11

615345

-RCC1chr1

28843237

+
5CDS-intronENST00000397574ENST00000429051IRF7chr11

615345

-RCC1chr1

28843237

+
5UTR-intronENST00000397562ENST00000398958IRF7chr11

615345

-RCC1chr1

28843237

+
5UTR-5UTRENST00000397562ENST00000373833IRF7chr11

615345

-RCC1chr1

28843237

+
5UTR-intronENST00000397562ENST00000373832IRF7chr11

615345

-RCC1chr1

28843237

+
5UTR-intronENST00000397562ENST00000373831IRF7chr11

615345

-RCC1chr1

28843237

+
5UTR-intronENST00000397562ENST00000429051IRF7chr11

615345

-RCC1chr1

28843237

+
intron-intronENST00000330243ENST00000398958IRF7chr11

615345

-RCC1chr1

28843237

+
intron-5UTRENST00000330243ENST00000373833IRF7chr11

615345

-RCC1chr1

28843237

+
intron-intronENST00000330243ENST00000373832IRF7chr11

615345

-RCC1chr1

28843237

+
intron-intronENST00000330243ENST00000373831IRF7chr11

615345

-RCC1chr1

28843237

+
intron-intronENST00000330243ENST00000429051IRF7chr11

615345

-RCC1chr1

28843237

+

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FusionProtFeatures for IRF7_RCC1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IRF7

Q92985

RCC1

P18754

Key transcriptional regulator of type I interferon(IFN)-dependent immune responses and plays a critical role in theinnate immune response against DNA and RNA viruses. Regulates thetranscription of type I IFN genes (IFN-alpha and IFN-beta) andIFN-stimulated genes (ISG) by binding to an interferon-stimulatedresponse element (ISRE) in their promoters. Can efficientlyactivate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genesand mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependentpathway. Required during both the early and late phases of the IFNgene induction but is more critical for the late than for theearly phase. Exists in an inactive form in the cytoplasm ofuninfected cells and following viral infection, double-strandedRNA (dsRNA), or toll-like receptor (TLR) signaling, becomesphosphorylated by IKBKE and TBK1 kinases. This induces aconformational change, leading to its dimerization and nuclearlocalization where along with other coactivators it can activatetranscription of the type I IFN and ISG genes. Can also play arole in regulating adaptive immune responses by inducingPSMB9/LMP2 expression, either directly or through induction ofIRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a(EBNA1) and may play a role in the regulation of EBV latency. Canactivate distinct gene expression programs in macrophages andregulate the anti-tumor properties of primary macrophages.{ECO:0000269|PubMed:11073981, ECO:0000269|PubMed:12374802,ECO:0000269|PubMed:15361868, ECO:0000269|PubMed:17404045}. Guanine-nucleotide releasing factor that promotes theexchange of Ran-bound GDP by GTP, and thereby plays an importantrole in RAN-mediated functions in nuclear import and mitosis(PubMed:1944575, PubMed:17435751, PubMed:20668449,PubMed:22215983, PubMed:11336674). Contributes to the generationof high levels of chromosome-associated, GTP-bound RAN, which isimportant for mitotic spindle assembly and normal progress throughmitosis (PubMed:12194828, PubMed:17435751, PubMed:22215983). Viaits role in maintaining high levels of GTP-bound RAN in thenucleus, contributes to the release of cargo proteins fromimportins after nuclear import (PubMed:22215983). Involved in theregulation of onset of chromosome condensation in the S phase(PubMed:3678831). Binds both to the nucleosomes and double-stranded DNA (PubMed:17435751, PubMed:18762580).{ECO:0000269|PubMed:11336674, ECO:0000269|PubMed:12194828,ECO:0000269|PubMed:17435751, ECO:0000269|PubMed:18762580,ECO:0000269|PubMed:1944575, ECO:0000269|PubMed:20668449,ECO:0000269|PubMed:22215983, ECO:0000269|PubMed:3678831}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for IRF7_RCC1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for IRF7_RCC1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
IRF7IRF3, IRF7, TANK, ALK, MYD88, TRAF6, FADD, TNFAIP3, TRIM21, ARAF, CCDC47, IRAK1, TRMT2A, LTN1, AIP, HACE1, IQSEC1, P4HA1, PALD1, TLK2, TRMT61B, EP300, CREBBP, TRIM28, TBK1, MAVS, PIAS4, SMAD3, SMAD4, SMAD2, MAFB, DEAF1, NMI, GCLM, ACADS, INSR, SUMO2, SUMO3, TP53, RNF31RCC1CSNK1A1, RAN, TAL1, KPNA3, RANBP3, XPO1, H2AFY, KPNA4, KPNB1, NTMT1, HIST1H3A, HIST2H2AC, HIST2H2BE, HIST1H4A, NUDT21, CHGB, SPRED1, USP4, TP53, CSAD, PKM, NGFR, DYNC1I1, PDHB, GNB2, SDF4, RPA1, FLAD1, DDAH2, APLP1, UNC119, HADHB, ZNF135, WIZ, TLE1, KMT2B, TRMT2A, ACTB, CCT7, BAG6, HOXD8, LRIF1, FAF1, TUBB3, CDK2AP2, HDGF, RANBP1, NCSTN, U2AF1, HNRNPM, SF3B6, RBM14, LUC7L3, ACIN1, HNRNPK, FN1, VCAM1, ITGA4, HMGA1, HDAC9, PTMA, ENO1, SHMT2, MOV10, NXF1, CUL7, OBSL1, SUZ12, RNF2, NUSAP1, RGPD3, RGPD8, RANBP2, RGPD5, RANGAP1, NAV1, DIS3, GLYR1, UBE2I, NUP153, NUP107, RBPJ, TEAD2, FOXA1, FOXB1, FOXE1, FOXH1, FOXI2, FOXP1, FOXQ1, OTUB1, PPM1G, DLGAP5, DNM1L, TRIM25, G3BP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for IRF7_RCC1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for IRF7_RCC1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIRF7C0021368Inflammation1CTD_human
HgeneIRF7C0021400Influenza1CTD_human
HgeneIRF7C0041696Unipolar Depression1PSYGENET
HgeneIRF7C1269683Major Depressive Disorder1PSYGENET
HgeneIRF7C4225358IMMUNODEFICIENCY 391UNIPROT