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Fusion gene ID: 17723 |
FusionGeneSummary for IRF2_EMP1 |
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Fusion gene information | Fusion gene name: IRF2_EMP1 | Fusion gene ID: 17723 | Hgene | Tgene | Gene symbol | IRF2 | EMP1 | Gene ID | 3660 | 2012 |
Gene name | interferon regulatory factor 2 | epithelial membrane protein 1 | |
Synonyms | IRF-2 | CL-20|EMP-1|TMP | |
Cytomap | 4q35.1 | 12p13.1 | |
Type of gene | protein-coding | protein-coding | |
Description | interferon regulatory factor 2 | epithelial membrane protein 1tumor-associated membrane protein | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | P14316 | P54849 | |
Ensembl transtripts involved in fusion gene | ENST00000393593, ENST00000512020, | ENST00000256951, ENST00000537612, ENST00000431267, ENST00000544053, ENST00000542289, ENST00000396301, | |
Fusion gene scores | * DoF score | 3 X 2 X 5=30 | 3 X 3 X 2=18 |
# samples | 5 | 3 | |
** MAII score | log2(5/30*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: IRF2 [Title/Abstract] AND EMP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | IRF2 | GO:0051607 | defense response to virus | 21478870 |
Tgene | EMP1 | GO:0008219 | cell death | 12107182 |
Tgene | EMP1 | GO:0032060 | bleb assembly | 12107182 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AI355548 | IRF2 | chr4 | 185309119 | + | EMP1 | chr12 | 13369520 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000393593 | ENST00000256951 | IRF2 | chr4 | 185309119 | + | EMP1 | chr12 | 13369520 | + |
intron-3UTR | ENST00000393593 | ENST00000537612 | IRF2 | chr4 | 185309119 | + | EMP1 | chr12 | 13369520 | + |
intron-intron | ENST00000393593 | ENST00000431267 | IRF2 | chr4 | 185309119 | + | EMP1 | chr12 | 13369520 | + |
intron-intron | ENST00000393593 | ENST00000544053 | IRF2 | chr4 | 185309119 | + | EMP1 | chr12 | 13369520 | + |
intron-intron | ENST00000393593 | ENST00000542289 | IRF2 | chr4 | 185309119 | + | EMP1 | chr12 | 13369520 | + |
intron-intron | ENST00000393593 | ENST00000396301 | IRF2 | chr4 | 185309119 | + | EMP1 | chr12 | 13369520 | + |
intron-3UTR | ENST00000512020 | ENST00000256951 | IRF2 | chr4 | 185309119 | + | EMP1 | chr12 | 13369520 | + |
intron-3UTR | ENST00000512020 | ENST00000537612 | IRF2 | chr4 | 185309119 | + | EMP1 | chr12 | 13369520 | + |
intron-intron | ENST00000512020 | ENST00000431267 | IRF2 | chr4 | 185309119 | + | EMP1 | chr12 | 13369520 | + |
intron-intron | ENST00000512020 | ENST00000544053 | IRF2 | chr4 | 185309119 | + | EMP1 | chr12 | 13369520 | + |
intron-intron | ENST00000512020 | ENST00000542289 | IRF2 | chr4 | 185309119 | + | EMP1 | chr12 | 13369520 | + |
intron-intron | ENST00000512020 | ENST00000396301 | IRF2 | chr4 | 185309119 | + | EMP1 | chr12 | 13369520 | + |
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FusionProtFeatures for IRF2_EMP1 |
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Hgene | Tgene |
IRF2 | EMP1 |
Specifically binds to the upstream regulatory region oftype I IFN and IFN-inducible MHC class I genes (the interferonconsensus sequence (ICS)) and represses those genes. Also acts asan activator for several genes including H4 and IL7.Constitutively binds to the ISRE promoter to activate IL7.Involved in cell cycle regulation through binding the site II(HiNF-M) promoter region of H4 and activating transcription duringcell growth. Antagonizes IRF1 transcriptional activation.{ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:15226432,ECO:0000269|PubMed:18514056, ECO:0000269|PubMed:9540062}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for IRF2_EMP1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for IRF2_EMP1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for IRF2_EMP1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for IRF2_EMP1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | IRF2 | C2239176 | Liver carcinoma | 1 | CTD_human |
Tgene | EMP1 | C0000786 | Spontaneous abortion | 1 | CTD_human |
Tgene | EMP1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | EMP1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | EMP1 | C0041696 | Unipolar Depression | 1 | PSYGENET |
Tgene | EMP1 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |