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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17723

FusionGeneSummary for IRF2_EMP1

check button Fusion gene summary
Fusion gene informationFusion gene name: IRF2_EMP1
Fusion gene ID: 17723
HgeneTgene
Gene symbol

IRF2

EMP1

Gene ID

3660

2012

Gene nameinterferon regulatory factor 2epithelial membrane protein 1
SynonymsIRF-2CL-20|EMP-1|TMP
Cytomap

4q35.1

12p13.1

Type of geneprotein-codingprotein-coding
Descriptioninterferon regulatory factor 2epithelial membrane protein 1tumor-associated membrane protein
Modification date2018051920180523
UniProtAcc

P14316

P54849

Ensembl transtripts involved in fusion geneENST00000393593, ENST00000512020, 
ENST00000256951, ENST00000537612, 
ENST00000431267, ENST00000544053, 
ENST00000542289, ENST00000396301, 
Fusion gene scores* DoF score3 X 2 X 5=303 X 3 X 2=18
# samples 53
** MAII scorelog2(5/30*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: IRF2 [Title/Abstract] AND EMP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIRF2

GO:0051607

defense response to virus

21478870

TgeneEMP1

GO:0008219

cell death

12107182

TgeneEMP1

GO:0032060

bleb assembly

12107182


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI355548IRF2chr4

185309119

+EMP1chr12

13369520

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000393593ENST00000256951IRF2chr4

185309119

+EMP1chr12

13369520

+
intron-3UTRENST00000393593ENST00000537612IRF2chr4

185309119

+EMP1chr12

13369520

+
intron-intronENST00000393593ENST00000431267IRF2chr4

185309119

+EMP1chr12

13369520

+
intron-intronENST00000393593ENST00000544053IRF2chr4

185309119

+EMP1chr12

13369520

+
intron-intronENST00000393593ENST00000542289IRF2chr4

185309119

+EMP1chr12

13369520

+
intron-intronENST00000393593ENST00000396301IRF2chr4

185309119

+EMP1chr12

13369520

+
intron-3UTRENST00000512020ENST00000256951IRF2chr4

185309119

+EMP1chr12

13369520

+
intron-3UTRENST00000512020ENST00000537612IRF2chr4

185309119

+EMP1chr12

13369520

+
intron-intronENST00000512020ENST00000431267IRF2chr4

185309119

+EMP1chr12

13369520

+
intron-intronENST00000512020ENST00000544053IRF2chr4

185309119

+EMP1chr12

13369520

+
intron-intronENST00000512020ENST00000542289IRF2chr4

185309119

+EMP1chr12

13369520

+
intron-intronENST00000512020ENST00000396301IRF2chr4

185309119

+EMP1chr12

13369520

+

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FusionProtFeatures for IRF2_EMP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IRF2

P14316

EMP1

P54849

Specifically binds to the upstream regulatory region oftype I IFN and IFN-inducible MHC class I genes (the interferonconsensus sequence (ICS)) and represses those genes. Also acts asan activator for several genes including H4 and IL7.Constitutively binds to the ISRE promoter to activate IL7.Involved in cell cycle regulation through binding the site II(HiNF-M) promoter region of H4 and activating transcription duringcell growth. Antagonizes IRF1 transcriptional activation.{ECO:0000269|PubMed:12738767, ECO:0000269|PubMed:15226432,ECO:0000269|PubMed:18514056, ECO:0000269|PubMed:9540062}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for IRF2_EMP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for IRF2_EMP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for IRF2_EMP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for IRF2_EMP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIRF2C2239176Liver carcinoma1CTD_human
TgeneEMP1C0000786Spontaneous abortion1CTD_human
TgeneEMP1C0023893Liver Cirrhosis, Experimental1CTD_human
TgeneEMP1C0033578Prostatic Neoplasms1CTD_human
TgeneEMP1C0041696Unipolar Depression1PSYGENET
TgeneEMP1C1269683Major Depressive Disorder1PSYGENET