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Fusion gene ID: 17717 |
FusionGeneSummary for IREB2_OXR1 |
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Fusion gene information | Fusion gene name: IREB2_OXR1 | Fusion gene ID: 17717 | Hgene | Tgene | Gene symbol | IREB2 | OXR1 | Gene ID | 3658 | 55074 |
Gene name | iron responsive element binding protein 2 | oxidation resistance 1 | |
Synonyms | ACO3|IRE-BP 2|IRE-BP2|IRP2|IRP2AD | Nbla00307|TLDC3 | |
Cytomap | 15q25.1 | 8q23.1 | |
Type of gene | protein-coding | protein-coding | |
Description | iron-responsive element-binding protein 2iron regulatory protein 2 | oxidation resistance protein 1TBC/LysM-associated domain containing 3putative protein product of Nbla00307 | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | P48200 | Q8N573 | |
Ensembl transtripts involved in fusion gene | ENST00000258886, ENST00000560440, ENST00000559427, | ENST00000445937, ENST00000531443, ENST00000517566, ENST00000452423, ENST00000442977, ENST00000521963, ENST00000312046, ENST00000449762, ENST00000297447, ENST00000521592, ENST00000497705, | |
Fusion gene scores | * DoF score | 5 X 3 X 3=45 | 11 X 10 X 4=440 |
# samples | 6 | 12 | |
** MAII score | log2(6/45*10)=0.415037499278844 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(12/440*10)=-1.87446911791614 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: IREB2 [Title/Abstract] AND OXR1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | DA444134 | IREB2 | chr15 | 78732223 | + | OXR1 | chr8 | 107718609 | + | ||
ChiTaRS3.1 | AK127563 | IREB2 | chr15 | 78732223 | + | OXR1 | chr8 | 107718609 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000258886 | ENST00000445937 | IREB2 | chr15 | 78732223 | + | OXR1 | chr8 | 107718609 | + |
Frame-shift | ENST00000258886 | ENST00000531443 | IREB2 | chr15 | 78732223 | + | OXR1 | chr8 | 107718609 | + |
Frame-shift | ENST00000258886 | ENST00000517566 | IREB2 | chr15 | 78732223 | + | OXR1 | chr8 | 107718609 | + |
5CDS-5UTR | ENST00000258886 | ENST00000452423 | IREB2 | chr15 | 78732223 | + | OXR1 | chr8 | 107718609 | + |
5CDS-5UTR | ENST00000258886 | ENST00000442977 | IREB2 | chr15 | 78732223 | + | OXR1 | chr8 | 107718609 | + |
5CDS-intron | ENST00000258886 | ENST00000521963 | IREB2 | chr15 | 78732223 | + | OXR1 | chr8 | 107718609 | + |
5CDS-intron | ENST00000258886 | ENST00000312046 | IREB2 | chr15 | 78732223 | + | OXR1 | chr8 | 107718609 | + |
5CDS-intron | ENST00000258886 | ENST00000449762 | IREB2 | chr15 | 78732223 | + | OXR1 | chr8 | 107718609 | + |
5CDS-intron | ENST00000258886 | ENST00000297447 | IREB2 | chr15 | 78732223 | + | OXR1 | chr8 | 107718609 | + |
5CDS-intron | ENST00000258886 | ENST00000521592 | IREB2 | chr15 | 78732223 | + | OXR1 | chr8 | 107718609 | + |
5CDS-intron | ENST00000258886 | ENST00000497705 | IREB2 | chr15 | 78732223 | + | OXR1 | chr8 | 107718609 | + |
Frame-shift | ENST00000560440 | ENST00000445937 | IREB2 | chr15 | 78732223 | + | OXR1 | chr8 | 107718609 | + |
Frame-shift | ENST00000560440 | ENST00000531443 | IREB2 | chr15 | 78732223 | + | OXR1 | chr8 | 107718609 | + |
Frame-shift | ENST00000560440 | ENST00000517566 | IREB2 | chr15 | 78732223 | + | OXR1 | chr8 | 107718609 | + |
5CDS-5UTR | ENST00000560440 | ENST00000452423 | IREB2 | chr15 | 78732223 | + | OXR1 | chr8 | 107718609 | + |
5CDS-5UTR | ENST00000560440 | ENST00000442977 | IREB2 | chr15 | 78732223 | + | OXR1 | chr8 | 107718609 | + |
5CDS-intron | ENST00000560440 | ENST00000521963 | IREB2 | chr15 | 78732223 | + | OXR1 | chr8 | 107718609 | + |
5CDS-intron | ENST00000560440 | ENST00000312046 | IREB2 | chr15 | 78732223 | + | OXR1 | chr8 | 107718609 | + |
5CDS-intron | ENST00000560440 | ENST00000449762 | IREB2 | chr15 | 78732223 | + | OXR1 | chr8 | 107718609 | + |
5CDS-intron | ENST00000560440 | ENST00000297447 | IREB2 | chr15 | 78732223 | + | OXR1 | chr8 | 107718609 | + |
5CDS-intron | ENST00000560440 | ENST00000521592 | IREB2 | chr15 | 78732223 | + | OXR1 | chr8 | 107718609 | + |
5CDS-intron | ENST00000560440 | ENST00000497705 | IREB2 | chr15 | 78732223 | + | OXR1 | chr8 | 107718609 | + |
intron-3CDS | ENST00000559427 | ENST00000445937 | IREB2 | chr15 | 78732223 | + | OXR1 | chr8 | 107718609 | + |
intron-3CDS | ENST00000559427 | ENST00000531443 | IREB2 | chr15 | 78732223 | + | OXR1 | chr8 | 107718609 | + |
intron-3CDS | ENST00000559427 | ENST00000517566 | IREB2 | chr15 | 78732223 | + | OXR1 | chr8 | 107718609 | + |
intron-5UTR | ENST00000559427 | ENST00000452423 | IREB2 | chr15 | 78732223 | + | OXR1 | chr8 | 107718609 | + |
intron-5UTR | ENST00000559427 | ENST00000442977 | IREB2 | chr15 | 78732223 | + | OXR1 | chr8 | 107718609 | + |
intron-intron | ENST00000559427 | ENST00000521963 | IREB2 | chr15 | 78732223 | + | OXR1 | chr8 | 107718609 | + |
intron-intron | ENST00000559427 | ENST00000312046 | IREB2 | chr15 | 78732223 | + | OXR1 | chr8 | 107718609 | + |
intron-intron | ENST00000559427 | ENST00000449762 | IREB2 | chr15 | 78732223 | + | OXR1 | chr8 | 107718609 | + |
intron-intron | ENST00000559427 | ENST00000297447 | IREB2 | chr15 | 78732223 | + | OXR1 | chr8 | 107718609 | + |
intron-intron | ENST00000559427 | ENST00000521592 | IREB2 | chr15 | 78732223 | + | OXR1 | chr8 | 107718609 | + |
intron-intron | ENST00000559427 | ENST00000497705 | IREB2 | chr15 | 78732223 | + | OXR1 | chr8 | 107718609 | + |
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FusionProtFeatures for IREB2_OXR1 |
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Hgene | Tgene |
IREB2 | OXR1 |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for IREB2_OXR1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for IREB2_OXR1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
IREB2 | YBX1, VHL, RBCK1, FBXL5, PSMA3, APP, TERT, USP53, CBS, TNPO1, UBA2, FAM96A, FAM96B, CIAO1, CAMKMT, CCNL2, INSL3, SLC9A3R1, SF1, KRAS, ARL15, ELAVL2, ENSA, ALDH3B1 | OXR1 | LIG4, GTF2E1, NMI, RPL24, TOLLIP, VPS35, KEAP1, MYO1C, IQGAP1, DUSP8 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for IREB2_OXR1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for IREB2_OXR1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | IREB2 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |