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Fusion gene ID: 17714 |
FusionGeneSummary for IREB2_CTSH |
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Fusion gene information | Fusion gene name: IREB2_CTSH | Fusion gene ID: 17714 | Hgene | Tgene | Gene symbol | IREB2 | CTSH | Gene ID | 3658 | 1512 |
Gene name | iron responsive element binding protein 2 | cathepsin H | |
Synonyms | ACO3|IRE-BP 2|IRE-BP2|IRP2|IRP2AD | ACC-4|ACC-5|ACC4|ACC5|CPSB | |
Cytomap | 15q25.1 | 15q25.1 | |
Type of gene | protein-coding | protein-coding | |
Description | iron-responsive element-binding protein 2iron regulatory protein 2 | pro-cathepsin HN-benzoylarginine-beta-naphthylamide hydrolasealeuraincathepsin B3cathepsin BA | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | P48200 | P09668 | |
Ensembl transtripts involved in fusion gene | ENST00000258886, ENST00000560440, ENST00000559427, | ENST00000220166, ENST00000534533, | |
Fusion gene scores | * DoF score | 5 X 3 X 3=45 | 3 X 2 X 3=18 |
# samples | 6 | 3 | |
** MAII score | log2(6/45*10)=0.415037499278844 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: IREB2 [Title/Abstract] AND CTSH [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CTSH | GO:0002764 | immune response-regulating signaling pathway | 16822283 |
Tgene | CTSH | GO:0006508 | proteolysis | 6203523|8811434 |
Tgene | CTSH | GO:0010628 | positive regulation of gene expression | 21217776 |
Tgene | CTSH | GO:0010813 | neuropeptide catabolic process | 15127951 |
Tgene | CTSH | GO:0010815 | bradykinin catabolic process | 15127951 |
Tgene | CTSH | GO:0010952 | positive regulation of peptidase activity | 20435891 |
Tgene | CTSH | GO:0030335 | positive regulation of cell migration | 21217776 |
Tgene | CTSH | GO:0031638 | zymogen activation | 20435891 |
Tgene | CTSH | GO:0033619 | membrane protein proteolysis | 14766755 |
Tgene | CTSH | GO:0043129 | surfactant homeostasis | 18216060 |
Tgene | CTSH | GO:0070371 | ERK1 and ERK2 cascade | 21217776 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | PRAD | TCGA-J4-AATZ-01A | IREB2 | chr15 | 78732223 | + | CTSH | chr15 | 79231513 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000258886 | ENST00000220166 | IREB2 | chr15 | 78732223 | + | CTSH | chr15 | 79231513 | - |
5CDS-intron | ENST00000258886 | ENST00000534533 | IREB2 | chr15 | 78732223 | + | CTSH | chr15 | 79231513 | - |
In-frame | ENST00000560440 | ENST00000220166 | IREB2 | chr15 | 78732223 | + | CTSH | chr15 | 79231513 | - |
5CDS-intron | ENST00000560440 | ENST00000534533 | IREB2 | chr15 | 78732223 | + | CTSH | chr15 | 79231513 | - |
intron-3CDS | ENST00000559427 | ENST00000220166 | IREB2 | chr15 | 78732223 | + | CTSH | chr15 | 79231513 | - |
intron-intron | ENST00000559427 | ENST00000534533 | IREB2 | chr15 | 78732223 | + | CTSH | chr15 | 79231513 | - |
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FusionProtFeatures for IREB2_CTSH |
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Hgene | Tgene |
IREB2 | CTSH |
Important for the overall degradation of proteins inlysosomes. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for IREB2_CTSH |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_IREB2_ENST00000258886_chr15_78732223_+_CTSH_ENST00000220166_chr15_79231513_-_341aa MDAPKAGYAFEYLIETLNDSSHKKFFDVSKLGTKYEKFHFKSWMSKHRKTYSTEEYHHRLQTFASNWRKINAHNNGNHTFKMALNQFSDM SFAEIKHKYLWSEPQNCSATKSNYLRGTGPYPPSVDWRKKGNFVSPVKNQGACGSCWTFSTTGALESAIAIATGKMLSLAEQQLVDCAQD FNNHGCQGGLPSQAFEYILYNKGIMGEDTYPYQGKDGYCKFQPGKAIGFVKDVANITIYDEEAMVEAVALYNPVSFAFEVTQDFMMYRTG >In-frame_IREB2_ENST00000560440_chr15_78732223_+_CTSH_ENST00000220166_chr15_79231513_-_341aa MDAPKAGYAFEYLIETLNDSSHKKFFDVSKLGTKYEKFHFKSWMSKHRKTYSTEEYHHRLQTFASNWRKINAHNNGNHTFKMALNQFSDM SFAEIKHKYLWSEPQNCSATKSNYLRGTGPYPPSVDWRKKGNFVSPVKNQGACGSCWTFSTTGALESAIAIATGKMLSLAEQQLVDCAQD FNNHGCQGGLPSQAFEYILYNKGIMGEDTYPYQGKDGYCKFQPGKAIGFVKDVANITIYDEEAMVEAVALYNPVSFAFEVTQDFMMYRTG |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_IREB2_ENST00000258886_chr15_78732223_+_CTSH_ENST00000220166_chr15_79231513_-_1023nt ATGGACGCCCCAAAAGCAGGATACGCCTTTGAGTACCTTATTGAAACATTAAATGACAGTTCACATAAGAAGTTCTTCGATGTATCTAAA CTTGGCACCAAGTATGAGAAGTTTCACTTCAAGTCATGGATGTCTAAGCACCGTAAGACCTACAGTACGGAGGAGTACCACCACAGGCTG CAGACGTTTGCCAGCAACTGGAGGAAGATAAACGCCCACAACAATGGGAACCACACATTTAAAATGGCACTGAACCAATTTTCAGACATG AGCTTTGCTGAAATAAAACACAAGTATCTCTGGTCAGAGCCTCAGAATTGCTCAGCCACCAAAAGTAACTACCTTCGAGGTACTGGTCCC TACCCACCTTCCGTGGACTGGCGGAAAAAAGGAAATTTTGTCTCACCTGTGAAAAATCAGGGTGCCTGCGGCAGTTGCTGGACTTTCTCC ACCACTGGGGCCCTGGAGTCTGCGATCGCCATCGCAACCGGAAAGATGCTGTCCTTGGCGGAACAGCAGCTGGTGGACTGCGCCCAGGAC TTCAATAATCACGGCTGCCAAGGGGGTCTCCCCAGCCAGGCTTTCGAGTATATCCTGTACAACAAGGGGATCATGGGTGAAGACACCTAC CCCTACCAGGGCAAGGATGGTTATTGCAAGTTCCAACCTGGAAAGGCCATCGGCTTTGTCAAGGATGTAGCCAACATCACAATCTATGAC GAGGAAGCGATGGTGGAGGCTGTGGCCCTCTACAACCCTGTGAGCTTTGCCTTTGAGGTGACTCAGGACTTCATGATGTATAGAACCGGC ATCTACTCCAGTACTTCCTGCCATAAAACTCCAGATAAAGTAAACCATGCAGTACTGGCTGTTGGGTATGGAGAAAAAAATGGGATCCCT TACTGGATCGTGAAAAACTCTTGGGGTCCCCAGTGGGGAATGAACGGGTACTTCCTCATCGAGCGCGGAAAGAACATGTGTGGCCTGGCT >In-frame_IREB2_ENST00000560440_chr15_78732223_+_CTSH_ENST00000220166_chr15_79231513_-_1023nt ATGGACGCCCCAAAAGCAGGATACGCCTTTGAGTACCTTATTGAAACATTAAATGACAGTTCACATAAGAAGTTCTTCGATGTATCTAAA CTTGGCACCAAGTATGAGAAGTTTCACTTCAAGTCATGGATGTCTAAGCACCGTAAGACCTACAGTACGGAGGAGTACCACCACAGGCTG CAGACGTTTGCCAGCAACTGGAGGAAGATAAACGCCCACAACAATGGGAACCACACATTTAAAATGGCACTGAACCAATTTTCAGACATG AGCTTTGCTGAAATAAAACACAAGTATCTCTGGTCAGAGCCTCAGAATTGCTCAGCCACCAAAAGTAACTACCTTCGAGGTACTGGTCCC TACCCACCTTCCGTGGACTGGCGGAAAAAAGGAAATTTTGTCTCACCTGTGAAAAATCAGGGTGCCTGCGGCAGTTGCTGGACTTTCTCC ACCACTGGGGCCCTGGAGTCTGCGATCGCCATCGCAACCGGAAAGATGCTGTCCTTGGCGGAACAGCAGCTGGTGGACTGCGCCCAGGAC TTCAATAATCACGGCTGCCAAGGGGGTCTCCCCAGCCAGGCTTTCGAGTATATCCTGTACAACAAGGGGATCATGGGTGAAGACACCTAC CCCTACCAGGGCAAGGATGGTTATTGCAAGTTCCAACCTGGAAAGGCCATCGGCTTTGTCAAGGATGTAGCCAACATCACAATCTATGAC GAGGAAGCGATGGTGGAGGCTGTGGCCCTCTACAACCCTGTGAGCTTTGCCTTTGAGGTGACTCAGGACTTCATGATGTATAGAACCGGC ATCTACTCCAGTACTTCCTGCCATAAAACTCCAGATAAAGTAAACCATGCAGTACTGGCTGTTGGGTATGGAGAAAAAAATGGGATCCCT TACTGGATCGTGAAAAACTCTTGGGGTCCCCAGTGGGGAATGAACGGGTACTTCCTCATCGAGCGCGGAAAGAACATGTGTGGCCTGGCT |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_IREB2_ENST00000258886_chr15_78732223_+_CTSH_ENST00000220166_chr15_79231513_-_2244nt GCTCTGCTGCTCTCGCGATATTTGCGCGAGCCTGCTTCCTTCTTTCCTCCCTTGCCAGTCCGCCTGTCTTCCTCCCCGTCTTCCCTGCCC GGCCTCCCCCTTCTTCCCCCGCTGGCCCCCTCCCCGGAGGGATAATATGGTCTCCGGCGATGGACGCCCCAAAAGCAGGATACGCCTTTG AGTACCTTATTGAAACATTAAATGACAGTTCACATAAGAAGTTCTTCGATGTATCTAAACTTGGCACCAAGTATGAGAAGTTTCACTTCA AGTCATGGATGTCTAAGCACCGTAAGACCTACAGTACGGAGGAGTACCACCACAGGCTGCAGACGTTTGCCAGCAACTGGAGGAAGATAA ACGCCCACAACAATGGGAACCACACATTTAAAATGGCACTGAACCAATTTTCAGACATGAGCTTTGCTGAAATAAAACACAAGTATCTCT GGTCAGAGCCTCAGAATTGCTCAGCCACCAAAAGTAACTACCTTCGAGGTACTGGTCCCTACCCACCTTCCGTGGACTGGCGGAAAAAAG GAAATTTTGTCTCACCTGTGAAAAATCAGGGTGCCTGCGGCAGTTGCTGGACTTTCTCCACCACTGGGGCCCTGGAGTCTGCGATCGCCA TCGCAACCGGAAAGATGCTGTCCTTGGCGGAACAGCAGCTGGTGGACTGCGCCCAGGACTTCAATAATCACGGCTGCCAAGGGGGTCTCC CCAGCCAGGCTTTCGAGTATATCCTGTACAACAAGGGGATCATGGGTGAAGACACCTACCCCTACCAGGGCAAGGATGGTTATTGCAAGT TCCAACCTGGAAAGGCCATCGGCTTTGTCAAGGATGTAGCCAACATCACAATCTATGACGAGGAAGCGATGGTGGAGGCTGTGGCCCTCT ACAACCCTGTGAGCTTTGCCTTTGAGGTGACTCAGGACTTCATGATGTATAGAACCGGCATCTACTCCAGTACTTCCTGCCATAAAACTC CAGATAAAGTAAACCATGCAGTACTGGCTGTTGGGTATGGAGAAAAAAATGGGATCCCTTACTGGATCGTGAAAAACTCTTGGGGTCCCC AGTGGGGAATGAACGGGTACTTCCTCATCGAGCGCGGAAAGAACATGTGTGGCCTGGCTGCCTGCGCCTCCTACCCCATCCCTCTGGTGT GAGCCGTGGCAGCCGCAGCGCAGACTGGCGGAGAAGGAGAGGAACGGGCAGCCTGGGCCTGGGTGGAAATCCTGCCCTGGAGGAAGTTGT GGGGAGATCCACTGGGACCCCCAACATTCTGCCCTCACCTCTGTGCCCAGCCTGGAAACCTACAGACAAGGAGGAGTTCCACCATGAGCT CACCCGTGTCTATGACGCAAAGATCACCAGCCATGTGCCTTAGTGTCCTTCTTAACAGACTCAAACCACATGGACCACGAATATTCTTTC TGTCCAGAAGGGCTACTTTCCACATATAGAGCTCCAGGGACTGTCTTTTCTGTATTCGCTGTTCAATAAACATTGAGTGAGCACCTCCCC AGATGGAGCATGCTGGTCCTGGGCCATGACTCAAACCAGGTCTGTCCTCGCCACTCAGTCTCCCAGGAGGGAGGCATCAGGGGGTGTCCA GGCTCTGGCTGGGAGGATGGTGGGGGTGCTGGCGGTATTATCCACCAGATGGGGTATCCAGGATGAAGAGCAGGCTTAATTTGAGATCTT GACTATTTGTCCCAAACCTGAGTGGAGAGGTGGGGAGGAAGGAGAAAAACGGGCCAAGCTGCGGCAGAGGCAGGATTCAAACCCACAATG TCAGCCCAGAAGCCTGTACTTCTCTGTGTGGCCTCCCCAGTCTCAGCTGCCTACTCCTACTCAGACTCTGCCCCCCACCTCCACATGAGA CTGCCCACCCCTTCCTCACCAACCCCTTATTTATTTCAAACGTGCCCAGATGCTCCTGTCGTTTCCACACCATCCCTTCCCTTATCTTGC CTTTTGAGAAATCTTGATCTCTGTTTAGAGGGCGGCCATGAAGTTGCTGCTGCTTCCTGAAGCCTCCGGGCTCTGGGATGTCTGTAGAAC AAGCTGGAGTCCACCAGCTCTTTGTCCTATGGCTCACAGACTTTCTTAATGATAAAAGCTGTCATCTTATTTGGGCTTCCTGAAAAGCTA >In-frame_IREB2_ENST00000560440_chr15_78732223_+_CTSH_ENST00000220166_chr15_79231513_-_2149nt CCCCCTTCTTCCCCCGCTGGCCCCCTCCCCGGAGGGATAATATGGTCTCCGGCGATGGACGCCCCAAAAGCAGGATACGCCTTTGAGTAC CTTATTGAAACATTAAATGACAGTTCACATAAGAAGTTCTTCGATGTATCTAAACTTGGCACCAAGTATGAGAAGTTTCACTTCAAGTCA TGGATGTCTAAGCACCGTAAGACCTACAGTACGGAGGAGTACCACCACAGGCTGCAGACGTTTGCCAGCAACTGGAGGAAGATAAACGCC CACAACAATGGGAACCACACATTTAAAATGGCACTGAACCAATTTTCAGACATGAGCTTTGCTGAAATAAAACACAAGTATCTCTGGTCA GAGCCTCAGAATTGCTCAGCCACCAAAAGTAACTACCTTCGAGGTACTGGTCCCTACCCACCTTCCGTGGACTGGCGGAAAAAAGGAAAT TTTGTCTCACCTGTGAAAAATCAGGGTGCCTGCGGCAGTTGCTGGACTTTCTCCACCACTGGGGCCCTGGAGTCTGCGATCGCCATCGCA ACCGGAAAGATGCTGTCCTTGGCGGAACAGCAGCTGGTGGACTGCGCCCAGGACTTCAATAATCACGGCTGCCAAGGGGGTCTCCCCAGC CAGGCTTTCGAGTATATCCTGTACAACAAGGGGATCATGGGTGAAGACACCTACCCCTACCAGGGCAAGGATGGTTATTGCAAGTTCCAA CCTGGAAAGGCCATCGGCTTTGTCAAGGATGTAGCCAACATCACAATCTATGACGAGGAAGCGATGGTGGAGGCTGTGGCCCTCTACAAC CCTGTGAGCTTTGCCTTTGAGGTGACTCAGGACTTCATGATGTATAGAACCGGCATCTACTCCAGTACTTCCTGCCATAAAACTCCAGAT AAAGTAAACCATGCAGTACTGGCTGTTGGGTATGGAGAAAAAAATGGGATCCCTTACTGGATCGTGAAAAACTCTTGGGGTCCCCAGTGG GGAATGAACGGGTACTTCCTCATCGAGCGCGGAAAGAACATGTGTGGCCTGGCTGCCTGCGCCTCCTACCCCATCCCTCTGGTGTGAGCC GTGGCAGCCGCAGCGCAGACTGGCGGAGAAGGAGAGGAACGGGCAGCCTGGGCCTGGGTGGAAATCCTGCCCTGGAGGAAGTTGTGGGGA GATCCACTGGGACCCCCAACATTCTGCCCTCACCTCTGTGCCCAGCCTGGAAACCTACAGACAAGGAGGAGTTCCACCATGAGCTCACCC GTGTCTATGACGCAAAGATCACCAGCCATGTGCCTTAGTGTCCTTCTTAACAGACTCAAACCACATGGACCACGAATATTCTTTCTGTCC AGAAGGGCTACTTTCCACATATAGAGCTCCAGGGACTGTCTTTTCTGTATTCGCTGTTCAATAAACATTGAGTGAGCACCTCCCCAGATG GAGCATGCTGGTCCTGGGCCATGACTCAAACCAGGTCTGTCCTCGCCACTCAGTCTCCCAGGAGGGAGGCATCAGGGGGTGTCCAGGCTC TGGCTGGGAGGATGGTGGGGGTGCTGGCGGTATTATCCACCAGATGGGGTATCCAGGATGAAGAGCAGGCTTAATTTGAGATCTTGACTA TTTGTCCCAAACCTGAGTGGAGAGGTGGGGAGGAAGGAGAAAAACGGGCCAAGCTGCGGCAGAGGCAGGATTCAAACCCACAATGTCAGC CCAGAAGCCTGTACTTCTCTGTGTGGCCTCCCCAGTCTCAGCTGCCTACTCCTACTCAGACTCTGCCCCCCACCTCCACATGAGACTGCC CACCCCTTCCTCACCAACCCCTTATTTATTTCAAACGTGCCCAGATGCTCCTGTCGTTTCCACACCATCCCTTCCCTTATCTTGCCTTTT GAGAAATCTTGATCTCTGTTTAGAGGGCGGCCATGAAGTTGCTGCTGCTTCCTGAAGCCTCCGGGCTCTGGGATGTCTGTAGAACAAGCT GGAGTCCACCAGCTCTTTGTCCTATGGCTCACAGACTTTCTTAATGATAAAAGCTGTCATCTTATTTGGGCTTCCTGAAAAGCTAAAGGC |
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FusionGenePPI for IREB2_CTSH |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
IREB2 | YBX1, VHL, RBCK1, FBXL5, PSMA3, APP, TERT, USP53, CBS, TNPO1, UBA2, FAM96A, FAM96B, CIAO1, CAMKMT, CCNL2, INSL3, SLC9A3R1, SF1, KRAS, ARL15, ELAVL2, ENSA, ALDH3B1 | CTSH | CSTA, CSTB, XRN1, SLC25A41, TCTN3, CTSL, MMRN1, CST1, ZIC1, AIRE, SLCO6A1, TBC1D22B, POC5, SF3A1, CCDC103, NONO, BPNT1, HSPD1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for IREB2_CTSH |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for IREB2_CTSH |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | IREB2 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Tgene | CTSH | C0011854 | Diabetes Mellitus, Insulin-Dependent | 1 | CTD_human |
Tgene | CTSH | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |