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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17713

FusionGeneSummary for IREB2_C6orf52

check button Fusion gene summary
Fusion gene informationFusion gene name: IREB2_C6orf52
Fusion gene ID: 17713
HgeneTgene
Gene symbol

IREB2

C6orf52

Gene ID

3658

347744

Gene nameiron responsive element binding protein 2chromosome 6 open reading frame 52
SynonymsACO3|IRE-BP 2|IRE-BP2|IRP2|IRP2AD-
Cytomap

15q25.1

6p24.2

Type of geneprotein-codingprotein-coding
Descriptioniron-responsive element-binding protein 2iron regulatory protein 2putative uncharacterized protein C6orf52
Modification date2018051920180402
UniProtAcc

P48200

Q5T4I8

Ensembl transtripts involved in fusion geneENST00000258886, ENST00000560440, 
ENST00000559427, 		ENST00000460742, 
ENST00000259983, ENST00000426700, 
ENST00000467832, ENST00000379586, 
ENST00000503680, 
Fusion gene scores* DoF score5 X 3 X 3=454 X 4 X 4=64
# samples 64
** MAII scorelog2(6/45*10)=0.415037499278844
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IREB2 [Title/Abstract] AND C6orf52 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSKCMTCGA-D3-A2J6-06AIREB2chr15

78786606

+C6orf52chr6

10687397

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000258886ENST00000460742IREB2chr15

78786606

+C6orf52chr6

10687397

-
5CDS-5UTRENST00000258886ENST00000259983IREB2chr15

78786606

+C6orf52chr6

10687397

-
5CDS-5UTRENST00000258886ENST00000426700IREB2chr15

78786606

+C6orf52chr6

10687397

-
5CDS-intronENST00000258886ENST00000467832IREB2chr15

78786606

+C6orf52chr6

10687397

-
5CDS-intronENST00000258886ENST00000379586IREB2chr15

78786606

+C6orf52chr6

10687397

-
5CDS-5UTRENST00000258886ENST00000503680IREB2chr15

78786606

+C6orf52chr6

10687397

-
intron-5UTRENST00000560440ENST00000460742IREB2chr15

78786606

+C6orf52chr6

10687397

-
intron-5UTRENST00000560440ENST00000259983IREB2chr15

78786606

+C6orf52chr6

10687397

-
intron-5UTRENST00000560440ENST00000426700IREB2chr15

78786606

+C6orf52chr6

10687397

-
intron-intronENST00000560440ENST00000467832IREB2chr15

78786606

+C6orf52chr6

10687397

-
intron-intronENST00000560440ENST00000379586IREB2chr15

78786606

+C6orf52chr6

10687397

-
intron-5UTRENST00000560440ENST00000503680IREB2chr15

78786606

+C6orf52chr6

10687397

-
intron-5UTRENST00000559427ENST00000460742IREB2chr15

78786606

+C6orf52chr6

10687397

-
intron-5UTRENST00000559427ENST00000259983IREB2chr15

78786606

+C6orf52chr6

10687397

-
intron-5UTRENST00000559427ENST00000426700IREB2chr15

78786606

+C6orf52chr6

10687397

-
intron-intronENST00000559427ENST00000467832IREB2chr15

78786606

+C6orf52chr6

10687397

-
intron-intronENST00000559427ENST00000379586IREB2chr15

78786606

+C6orf52chr6

10687397

-
intron-5UTRENST00000559427ENST00000503680IREB2chr15

78786606

+C6orf52chr6

10687397

-

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FusionProtFeatures for IREB2_C6orf52


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IREB2

P48200

C6orf52

Q5T4I8


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for IREB2_C6orf52


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for IREB2_C6orf52


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
IREB2YBX1, VHL, RBCK1, FBXL5, PSMA3, APP, TERT, USP53, CBS, TNPO1, UBA2, FAM96A, FAM96B, CIAO1, CAMKMT, CCNL2, INSL3, SLC9A3R1, SF1, KRAS, ARL15, ELAVL2, ENSA, ALDH3B1C6orf52


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for IREB2_C6orf52


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for IREB2_C6orf52


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIREB2C0027626Neoplasm Invasiveness1CTD_human