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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionGeneSequence

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Fusion gene ID: 17692

FusionGeneSummary for IQGAP2_ATRNL1

check button Fusion gene summary
Fusion gene informationFusion gene name: IQGAP2_ATRNL1
Fusion gene ID: 17692
HgeneTgene
Gene symbol

IQGAP2

ATRNL1

Gene ID

10788

26033

Gene nameIQ motif containing GTPase activating protein 2attractin like 1
Synonyms-ALP|bA338L11.1|bA454H24.1
Cytomap

5q13.3

10q25.3

Type of geneprotein-codingprotein-coding
Descriptionras GTPase-activating-like protein IQGAP2attractin-like protein 1
Modification date2018052220180519
UniProtAcc

Q13576

Q5VV63

Ensembl transtripts involved in fusion geneENST00000274364, ENST00000379730, 
ENST00000396234, ENST00000502745, 
ENST00000508410, 		ENST00000355044, 
ENST00000423111, ENST00000303745, 
ENST00000529665, ENST00000527407, 
Fusion gene scores* DoF score4 X 3 X 3=366 X 4 X 4=96
# samples 46
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IQGAP2 [Title/Abstract] AND ATRNL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneIQGAP2

GO:0034314

Arp2/3 complex-mediated actin nucleation

12515716

HgeneIQGAP2

GO:0070493

thrombin-activated receptor signaling pathway

12515716


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVHNSCTCGA-CV-7243-01AIQGAP2chr5

75866482

+ATRNL1chr10

117278773

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000274364ENST00000355044IQGAP2chr5

75866482

+ATRNL1chr10

117278773

+
In-frameENST00000274364ENST00000423111IQGAP2chr5

75866482

+ATRNL1chr10

117278773

+
In-frameENST00000274364ENST00000303745IQGAP2chr5

75866482

+ATRNL1chr10

117278773

+
5CDS-intronENST00000274364ENST00000529665IQGAP2chr5

75866482

+ATRNL1chr10

117278773

+
5CDS-intronENST00000274364ENST00000527407IQGAP2chr5

75866482

+ATRNL1chr10

117278773

+
5UTR-3CDSENST00000379730ENST00000355044IQGAP2chr5

75866482

+ATRNL1chr10

117278773

+
5UTR-3CDSENST00000379730ENST00000423111IQGAP2chr5

75866482

+ATRNL1chr10

117278773

+
5UTR-3CDSENST00000379730ENST00000303745IQGAP2chr5

75866482

+ATRNL1chr10

117278773

+
5UTR-intronENST00000379730ENST00000529665IQGAP2chr5

75866482

+ATRNL1chr10

117278773

+
5UTR-intronENST00000379730ENST00000527407IQGAP2chr5

75866482

+ATRNL1chr10

117278773

+
intron-3CDSENST00000396234ENST00000355044IQGAP2chr5

75866482

+ATRNL1chr10

117278773

+
intron-3CDSENST00000396234ENST00000423111IQGAP2chr5

75866482

+ATRNL1chr10

117278773

+
intron-3CDSENST00000396234ENST00000303745IQGAP2chr5

75866482

+ATRNL1chr10

117278773

+
intron-intronENST00000396234ENST00000529665IQGAP2chr5

75866482

+ATRNL1chr10

117278773

+
intron-intronENST00000396234ENST00000527407IQGAP2chr5

75866482

+ATRNL1chr10

117278773

+
intron-3CDSENST00000502745ENST00000355044IQGAP2chr5

75866482

+ATRNL1chr10

117278773

+
intron-3CDSENST00000502745ENST00000423111IQGAP2chr5

75866482

+ATRNL1chr10

117278773

+
intron-3CDSENST00000502745ENST00000303745IQGAP2chr5

75866482

+ATRNL1chr10

117278773

+
intron-intronENST00000502745ENST00000529665IQGAP2chr5

75866482

+ATRNL1chr10

117278773

+
intron-intronENST00000502745ENST00000527407IQGAP2chr5

75866482

+ATRNL1chr10

117278773

+
intron-3CDSENST00000508410ENST00000355044IQGAP2chr5

75866482

+ATRNL1chr10

117278773

+
intron-3CDSENST00000508410ENST00000423111IQGAP2chr5

75866482

+ATRNL1chr10

117278773

+
intron-3CDSENST00000508410ENST00000303745IQGAP2chr5

75866482

+ATRNL1chr10

117278773

+
intron-intronENST00000508410ENST00000529665IQGAP2chr5

75866482

+ATRNL1chr10

117278773

+
intron-intronENST00000508410ENST00000527407IQGAP2chr5

75866482

+ATRNL1chr10

117278773

+

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FusionProtFeatures for IQGAP2_ATRNL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IQGAP2

Q13576

ATRNL1

Q5VV63

Binds to activated CDC42 and RAC1 but does not seem tostimulate their GTPase activity. Associates with calmodulin. May play a role in melanocortin signaling pathways thatregulate energy homeostasis. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneATRNL1chr5:75866482chr10:117278773ENST00000355044+23291252_137912181380Topological domainCytoplasmic
TgeneATRNL1chr5:75866482chr10:117278773ENST00000355044+23291231_125112181380TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIQGAP2chr5:75866482chr10:117278773ENST00000274364+436263_2661271576Compositional biasNote=Poly-Lys
HgeneIQGAP2chr5:75866482chr10:117278773ENST00000396234+124263_266-231072Compositional biasNote=Poly-Lys
HgeneIQGAP2chr5:75866482chr10:117278773ENST00000274364+43641_1561271576DomainCalponin-homology (CH)
HgeneIQGAP2chr5:75866482chr10:117278773ENST00000274364+436594_6271271576DomainWW
HgeneIQGAP2chr5:75866482chr10:117278773ENST00000274364+436690_7191271576DomainIQ 1
HgeneIQGAP2chr5:75866482chr10:117278773ENST00000274364+436720_7491271576DomainIQ 2
HgeneIQGAP2chr5:75866482chr10:117278773ENST00000274364+436750_7791271576DomainIQ 3
HgeneIQGAP2chr5:75866482chr10:117278773ENST00000274364+436917_11501271576DomainRas-GAP
HgeneIQGAP2chr5:75866482chr10:117278773ENST00000396234+12441_156-231072DomainCalponin-homology (CH)
HgeneIQGAP2chr5:75866482chr10:117278773ENST00000396234+124594_627-231072DomainWW
HgeneIQGAP2chr5:75866482chr10:117278773ENST00000396234+124690_719-231072DomainIQ 1
HgeneIQGAP2chr5:75866482chr10:117278773ENST00000396234+124720_749-231072DomainIQ 2
HgeneIQGAP2chr5:75866482chr10:117278773ENST00000396234+124750_779-231072DomainIQ 3
HgeneIQGAP2chr5:75866482chr10:117278773ENST00000396234+124917_1150-231072DomainRas-GAP
TgeneATRNL1chr5:75866482chr10:117278773ENST00000355044+23291014_105912181380DomainLaminin EGF-like 1
TgeneATRNL1chr5:75866482chr10:117278773ENST00000355044+23291060_110812181380DomainLaminin EGF-like 2
TgeneATRNL1chr5:75866482chr10:117278773ENST00000355044+2329207_24512181380DomainEGF-like 2
TgeneATRNL1chr5:75866482chr10:117278773ENST00000355044+232953_9112181380DomainEGF-like 1
TgeneATRNL1chr5:75866482chr10:117278773ENST00000355044+2329614_65712181380DomainNote=PSI 1
TgeneATRNL1chr5:75866482chr10:117278773ENST00000355044+2329666_70912181380DomainNote=PSI 2
TgeneATRNL1chr5:75866482chr10:117278773ENST00000355044+2329715_76012181380DomainNote=PSI 3
TgeneATRNL1chr5:75866482chr10:117278773ENST00000355044+2329755_87312181380DomainC-type lectin
TgeneATRNL1chr5:75866482chr10:117278773ENST00000355044+2329889_93912181380DomainNote=PSI 4
TgeneATRNL1chr5:75866482chr10:117278773ENST00000355044+232993_20912181380DomainCUB
TgeneATRNL1chr5:75866482chr10:117278773ENST00000355044+2329942_101212181380DomainNote=PSI 5
TgeneATRNL1chr5:75866482chr10:117278773ENST00000355044+2329316_36512181380RepeatNote=Kelch 1
TgeneATRNL1chr5:75866482chr10:117278773ENST00000355044+2329367_41512181380RepeatNote=Kelch 2
TgeneATRNL1chr5:75866482chr10:117278773ENST00000355044+2329427_47512181380RepeatNote=Kelch 3
TgeneATRNL1chr5:75866482chr10:117278773ENST00000355044+2329480_53112181380RepeatNote=Kelch 4
TgeneATRNL1chr5:75866482chr10:117278773ENST00000355044+2329533_59112181380RepeatNote=Kelch 5
TgeneATRNL1chr5:75866482chr10:117278773ENST00000355044+2329592_63812181380RepeatNote=Kelch 6
TgeneATRNL1chr5:75866482chr10:117278773ENST00000355044+232953_123012181380Topological domainExtracellular


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FusionGeneSequence for IQGAP2_ATRNL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_IQGAP2_ENST00000274364_chr5_75866482_+_ATRNL1_ENST00000355044_chr10_117278773_+_289aa
MPHEELPSLQRPRYGSIVDDERLSAEEMDERRRQNIAYEYLCHLEEAKRWMEVCLVEELPPTTELEEGLRNGVYLAKLAKFFAPKMVSEK
KIYDVEQTRYKKSGLHFRHTDNTVQWLRAMESIGLPKIAFSQHNTIMDLVQFFVTFFSCFLSLLLVAAVVWKIKQTCWASRRREQLLRER
QQMASRPFASVDVALEVGAEQTEFLRGPLEGAPKPIAIEPCAGNRAAVLTVFLCLPRGSSGAPPPGQSGLAIASALIDISQQKASDSKDK

>In-frame_IQGAP2_ENST00000274364_chr5_75866482_+_ATRNL1_ENST00000423111_chr10_117278773_+_289aa
MPHEELPSLQRPRYGSIVDDERLSAEEMDERRRQNIAYEYLCHLEEAKRWMEVCLVEELPPTTELEEGLRNGVYLAKLAKFFAPKMVSEK
KIYDVEQTRYKKSGLHFRHTDNTVQWLRAMESIGLPKIAFSQHNTIMDLVQFFVTFFSCFLSLLLVAAVVWKIKQTCWASRRREQLLRER
QQMASRPFASVDVALEVGAEQTEFLRGPLEGAPKPIAIEPCAGNRAAVLTVFLCLPRGSSGAPPPGQSGLAIASALIDISQQKASDSKDK

>In-frame_IQGAP2_ENST00000274364_chr5_75866482_+_ATRNL1_ENST00000303745_chr10_117278773_+_289aa
MPHEELPSLQRPRYGSIVDDERLSAEEMDERRRQNIAYEYLCHLEEAKRWMEVCLVEELPPTTELEEGLRNGVYLAKLAKFFAPKMVSEK
KIYDVEQTRYKKSGLHFRHTDNTVQWLRAMESIGLPKIAFSQHNTIMDLVQFFVTFFSCFLSLLLVAAVVWKIKQTCWASRRREQLLRER
QQMASRPFASVDVALEVGAEQTEFLRGPLEGAPKPIAIEPCAGNRAAVLTVFLCLPRGSSGAPPPGQSGLAIASALIDISQQKASDSKDK


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_IQGAP2_ENST00000274364_chr5_75866482_+_ATRNL1_ENST00000355044_chr10_117278773_+_867nt
ATGCCACACGAAGAGCTGCCGTCGCTGCAGAGACCCCGCTATGGCTCTATTGTGGACGATGAAAGGCTCTCTGCAGAGGAGATGGATGAG
AGGAGGCGGCAGAACATTGCTTATGAATATCTGTGCCACTTAGAGGAAGCCAAAAGGTGGATGGAAGTTTGCTTAGTTGAAGAATTGCCA
CCAACCACTGAATTGGAAGAAGGGCTCCGGAATGGAGTTTACCTTGCAAAGTTAGCCAAGTTCTTTGCCCCGAAAATGGTATCAGAGAAA
AAGATCTATGATGTGGAACAAACACGTTATAAGAAGTCTGGCCTTCATTTTCGACACACAGATAATACCGTCCAGTGGTTAAGAGCGATG
GAGTCTATTGGTCTACCCAAGATTGCATTCTCACAACACAATACAATCATGGACCTTGTGCAGTTTTTTGTCACCTTCTTCAGTTGTTTC
CTATCCTTATTGCTGGTGGCTGCTGTGGTATGGAAGATCAAACAAACTTGTTGGGCTTCTCGACGGAGAGAGCAACTGCTTCGAGAACGA
CAGCAGATGGCCAGCCGTCCCTTTGCTTCTGTTGATGTAGCTCTGGAAGTGGGAGCTGAACAAACAGAGTTTCTGCGAGGGCCATTAGAG
GGGGCACCCAAGCCAATTGCCATTGAACCATGTGCTGGGAACAGAGCTGCTGTTCTGACTGTGTTTCTTTGTCTACCACGAGGATCATCA
GGTGCCCCTCCCCCTGGGCAGTCAGGCCTTGCAATTGCCAGTGCCCTAATAGATATTTCACAACAGAAAGCTTCAGATAGTAAAGATAAG

>In-frame_IQGAP2_ENST00000274364_chr5_75866482_+_ATRNL1_ENST00000423111_chr10_117278773_+_867nt
ATGCCACACGAAGAGCTGCCGTCGCTGCAGAGACCCCGCTATGGCTCTATTGTGGACGATGAAAGGCTCTCTGCAGAGGAGATGGATGAG
AGGAGGCGGCAGAACATTGCTTATGAATATCTGTGCCACTTAGAGGAAGCCAAAAGGTGGATGGAAGTTTGCTTAGTTGAAGAATTGCCA
CCAACCACTGAATTGGAAGAAGGGCTCCGGAATGGAGTTTACCTTGCAAAGTTAGCCAAGTTCTTTGCCCCGAAAATGGTATCAGAGAAA
AAGATCTATGATGTGGAACAAACACGTTATAAGAAGTCTGGCCTTCATTTTCGACACACAGATAATACCGTCCAGTGGTTAAGAGCGATG
GAGTCTATTGGTCTACCCAAGATTGCATTCTCACAACACAATACAATCATGGACCTTGTGCAGTTTTTTGTCACCTTCTTCAGTTGTTTC
CTATCCTTATTGCTGGTGGCTGCTGTGGTATGGAAGATCAAACAAACTTGTTGGGCTTCTCGACGGAGAGAGCAACTGCTTCGAGAACGA
CAGCAGATGGCCAGCCGTCCCTTTGCTTCTGTTGATGTAGCTCTGGAAGTGGGAGCTGAACAAACAGAGTTTCTGCGAGGGCCATTAGAG
GGGGCACCCAAGCCAATTGCCATTGAACCATGTGCTGGGAACAGAGCTGCTGTTCTGACTGTGTTTCTTTGTCTACCACGAGGATCATCA
GGTGCCCCTCCCCCTGGGCAGTCAGGCCTTGCAATTGCCAGTGCCCTAATAGATATTTCACAACAGAAAGCTTCAGATAGTAAAGATAAG

>In-frame_IQGAP2_ENST00000274364_chr5_75866482_+_ATRNL1_ENST00000303745_chr10_117278773_+_867nt
ATGCCACACGAAGAGCTGCCGTCGCTGCAGAGACCCCGCTATGGCTCTATTGTGGACGATGAAAGGCTCTCTGCAGAGGAGATGGATGAG
AGGAGGCGGCAGAACATTGCTTATGAATATCTGTGCCACTTAGAGGAAGCCAAAAGGTGGATGGAAGTTTGCTTAGTTGAAGAATTGCCA
CCAACCACTGAATTGGAAGAAGGGCTCCGGAATGGAGTTTACCTTGCAAAGTTAGCCAAGTTCTTTGCCCCGAAAATGGTATCAGAGAAA
AAGATCTATGATGTGGAACAAACACGTTATAAGAAGTCTGGCCTTCATTTTCGACACACAGATAATACCGTCCAGTGGTTAAGAGCGATG
GAGTCTATTGGTCTACCCAAGATTGCATTCTCACAACACAATACAATCATGGACCTTGTGCAGTTTTTTGTCACCTTCTTCAGTTGTTTC
CTATCCTTATTGCTGGTGGCTGCTGTGGTATGGAAGATCAAACAAACTTGTTGGGCTTCTCGACGGAGAGAGCAACTGCTTCGAGAACGA
CAGCAGATGGCCAGCCGTCCCTTTGCTTCTGTTGATGTAGCTCTGGAAGTGGGAGCTGAACAAACAGAGTTTCTGCGAGGGCCATTAGAG
GGGGCACCCAAGCCAATTGCCATTGAACCATGTGCTGGGAACAGAGCTGCTGTTCTGACTGTGTTTCTTTGTCTACCACGAGGATCATCA
GGTGCCCCTCCCCCTGGGCAGTCAGGCCTTGCAATTGCCAGTGCCCTAATAGATATTTCACAACAGAAAGCTTCAGATAGTAAAGATAAG


* Fusion transcript sequences (Full-length transcript).
>In-frame_IQGAP2_ENST00000274364_chr5_75866482_+_ATRNL1_ENST00000355044_chr10_117278773_+_5377nt
CGCGGTGAATAACGGGGCCTGGCTGGAGGAGAAAGGAAACCTGCTGCGGGAGGCGGCGGCGACCGGCCAGGGAGCGAGGGAGGAGAGTTC
ACTTTTACTTCAGTGTCAGCGCGCGGCGGCCGTGGCTGGCTCTGGCGAGAGAGCACCGAGGGAGTGGGTCGCAGATCTTCGGGCGGCTAG
GGGAAATCGGCGAGAGGCGGGATCCGAGCGCGCCGGCGGGGCGCAGAGCCCGCGAGCCTGGCCAGCGAGGGTAGCCGCGGGGGGCGCGCC
CCGGGCGGGCCCCCGGAGACGCGCAGGATGCCACACGAAGAGCTGCCGTCGCTGCAGAGACCCCGCTATGGCTCTATTGTGGACGATGAA
AGGCTCTCTGCAGAGGAGATGGATGAGAGGAGGCGGCAGAACATTGCTTATGAATATCTGTGCCACTTAGAGGAAGCCAAAAGGTGGATG
GAAGTTTGCTTAGTTGAAGAATTGCCACCAACCACTGAATTGGAAGAAGGGCTCCGGAATGGAGTTTACCTTGCAAAGTTAGCCAAGTTC
TTTGCCCCGAAAATGGTATCAGAGAAAAAGATCTATGATGTGGAACAAACACGTTATAAGAAGTCTGGCCTTCATTTTCGACACACAGAT
AATACCGTCCAGTGGTTAAGAGCGATGGAGTCTATTGGTCTACCCAAGATTGCATTCTCACAACACAATACAATCATGGACCTTGTGCAG
TTTTTTGTCACCTTCTTCAGTTGTTTCCTATCCTTATTGCTGGTGGCTGCTGTGGTATGGAAGATCAAACAAACTTGTTGGGCTTCTCGA
CGGAGAGAGCAACTGCTTCGAGAACGACAGCAGATGGCCAGCCGTCCCTTTGCTTCTGTTGATGTAGCTCTGGAAGTGGGAGCTGAACAA
ACAGAGTTTCTGCGAGGGCCATTAGAGGGGGCACCCAAGCCAATTGCCATTGAACCATGTGCTGGGAACAGAGCTGCTGTTCTGACTGTG
TTTCTTTGTCTACCACGAGGATCATCAGGTGCCCCTCCCCCTGGGCAGTCAGGCCTTGCAATTGCCAGTGCCCTAATAGATATTTCACAA
CAGAAAGCTTCAGATAGTAAAGATAAGACTTCTGGAGTCCGGAATCGAAAACACCTTTCAACACGTCAAGGAACTTGTGTCTGAGAAATG
GAAACCGCTCCTGTATATTCTGTACTGTTTTACTTCGGGCTTCTGTTAAAGCTGTTCTATGGCCTTGGATTTTATGGAGGCAGATCTCTG
TATCATCCAGAGCCTGAGTACAGTTTCCTTCCAAATGGACAATGACCCAGGTGGCCAAAGAATGTTCATGAGTTTTATAAAAGTATTGAT
GGTCACAGGTGATAAAGTCAGTTTTTACCACTATCTTAGGCTTATTATAGCTAACATTAAATTACTCTGGAAAAAGATGTATATTGTTTC
TTAATGAAGATGAAAAATATGTAATTCATATAAATCAACTGTTTATATCCCAAGACTTGAAAGAAAGACATTTTTTAATGCCTGAATGAT
GAGAATTGTACAGTTTTTGCCTCATAAGCAAACTTGAATCACCTGTGTATGAACAGGGAATGAACACATTGCAATGGCTTTAAATGCTCT
TTTATCTCGTTGTAAAGGTAAGGCAAGATTTTGATGTAGTAGGATGTAGGTAATGTATTTAAATATTTCATATGACCATATCGTGTCCAA
ACTCAGTCTGAGAATGTGACAGCTTTCCGCCTAACTAGAATGCAGACCAGAATGAGTTCAACTCATTCTGTGCAACTTCACAGGGGGTTT
ATTAGAATGCTCAGTGTAGAGGACATTCCTGTCATCCATGCCAACTACCTAACTCGTTATCAGAGCTGATAGAGCATGGAAAAGTCTGTC
CAGCGATCAGTTGTTCCCCTCCTTCCAAAAACAGCCTCCAATACCACAACCTGAAAAGAGCCGAAATGGTTATTTTACAGCATACAAGCT
TCTGCTCCAGTATGATAATTTTTAATTGCCTAAGAATCATTGGATCAGACCTAAATGATCCATCTGCATTTTTATAAGAATGGATCTTTC
TTTGCCCTTCCTCTCCTAGCTGCTAGATTTTAACTACCTTTTACAAATGTTACAAAATGTATTTTAGAGGCGACATCTCTCAAGATGACC
TGAGTTCCTTCCTGCCAACTGTTCCACCTAGAATACAAGTAGAGAAGAGCACTGGCTGGCAAGCATCAACAGGAGTCTTCTTCCCAACAC
GAGCGCATCCATGTCCTGAGAAAAAGTCTGTGGTTTAGAAAATATGTCCATGGTTGCCCACAGTCAGCACACTCTTAGTGACTCAAAATT
CTGAATTATGGCAGAAAGGAAAAATAAAACATACTTCACATTAGAACACAGAATCATTTACATCCTAATACTGACCACAGTTCACTAAAG
CTCAGTAGCATTAACAGATATAGTTTGGAATTGCAGTTTCCTCACTTCAGGGTGACAAGATATGTATAACAGTGACAGAAATCTCCAAAG
CTGCTGTATATGATATAGCTTTGTTAAATATGAAGGTCCTTTAAATACAATTGATGTTTAGTACTATATATGTACTTTTCACATTCTTTG
GATTTCTGGAAGGTTATGACACTTTACTGTTTACAGCTAATGCATAGTTACTTGCATGCCATGGTTGTACAGTAGCAGACTATGACCCTA
TTGTGATATTAAGTGTTTATTTCATAATGCCATTTATACATAGCTGAATTTGATGAGGATTGAATGTCATATATAAGAGGAATGATCATA
CAATATGTAGTTGCATCTTATATAAGATTTCTAGGTTGCATCTAACCATGACTATGTCATTATTTTGATAATTAGGCATTTATGAATTAT
AGTATATATTCCTCATGTTGGCATGATAATTTTGCTATTTTCCATGCATTAAAAATAAGACAAATTCTTAGAGTAATTTTAGTAATTTTA
TCTATAATCTGTGGGGTTTTTTTGGAGGGGGAGGCCACTGGTTGTTTCTACTTCCCTGTGATATTTTCTCTCTCATTAAAGGAATGAGCT
AAGTTTGTAAATATCTCCTAAAAACAATCAAGTAATTTTATTAGCTTCTTTTGGACCCTCTAAATATTGACTTCTCTCATGAAAAAATAA
ATTGATGAAACTAATGATTACAAAGATATAATCATTTTTTAAAAAGTGATTGCCCAATGTATTTCTCTAACAATTGTCACAAGAGAAAGC
ATAACAATAAAAATACAAAAACATACAGATTTAGATGTAAAATCTATATAAGCTATATTTTTAGGGAGGCTAAGCAGATAGTATTACTGT
GGAAGAATTATCAAGTTTTATTCACCTCAAATCCCACTGGGTTCTTAAAACTTGAAAATTCAAATTGTAGAGAATTATGAGACACAATGT
GATGTTTAGTTAAAGTCATGCTATACCTTTCTGGGCCACATATTGCTAACTCTGTGGCTAATTATGCAATTAATTCTCAACGTATCAAAG
CTTTTCACTGGCAGTAAATTCTTTGCCCTCAGGTGAAGTGGATTGAAAAGACATCAAGGATCAAGGATAATCACTTTGAATCTGTTGGTT
TTTCCCCCTACATTCCAGACACTTTAAATTTGGATGCTTTCATTTTTTTTAAATCAAACCACACAAATATGCAGATACTTTCCCAGAATT
TCGCAGTTAAATGGCTGATCCTCTTGAAAACTAACCTTAATGGAATTCTAAACATTTCAGTTTAGAATGACTTTGAAAAATTCCTTAGAT
TTTTAGGATGTTTTATTCTGCCAAGTATGAAAAAAAAATGGTTAAATACAATGGAGTTTTAAAAATTAACCTGGGGATTCTATTTGAACT
AGAAAATTCCTATTGGAAAAGAATTTGCACATACTTACAGATTCAGCTAATAAATTTTAAGAGGATTAGGATTCTCATAATTCTTTAAAT
GAAAATTTGTTTTAGTGATACACAGAGATGCCGTATACTATAGTGTTATGTTCAGTAGGAAAACTTCAAATAGTTCGTATTTAAAAAGGT
AATTGATCCTTGCTGTACTTCCCAACATCTCATCTTCTTTTAGCTGCAGTAAGATAGAGGTGACTGTATGGCTACAGTTCATGGTATAAG
GTCATTTAGGGTGCACACTGGCACACAGGCTGGAAAACGGGCACTGGACCCAGCTTTCAGGTGTGTGGTGCTGGGTAAGTTTCACCTTTG
AAGCCTCAGCCTTCCATCTGTAAAGGGCGGTAATGGTGCCCACCTTTCGAGGCATTGCGAGGCTAGATGGTAACACACAGAAAGCTCCCA
CAGTGGGACCTTGATGCAGCGTAGCTGGTATTAACAACCGTGGGGACACCAGGCCACTCTTTTTCTACCAGTTGTTTTATGAATCCACCT
ATTAATTTTCATCCATCTTTTGGTCGTAGGTAAAGGTCAATCAGGTTTTTCAAAAAGACTCCCTGAATAACTTAAGTTCCTGTATTTCTA
AGATATAGGGATTTCTACAAAACGACTTTGACATTTAGTCAATAAAGACTTAAACTCTTCTTAAATCTATAGTTTTAGGAGAGTTTTTCT
TAAAATTACTGACTGATGACATTGAGACAAGAGCATCAATGATCACCTTTCACGTACAAACTAGGCAAGACAGGGTCAGTGCTTACATTT
TGTGGTTATACATGATACATCTTTTCTCAGTGAACATAAAACTATGATTTGAAAGGTGTCTTATATTTAAAAAAGATTGTAAAATGAAAA
CTGACCAAATGAACTAATTCTACCCACCTATGGTCTTTTTAAATGTCGAGTTTCAAAACCCATTTGCCGTATACTAGAGTGAGCTTGGAA
ACTTACCTGATTACAGGAATTGCTTGGGTTCAGGCAGATTCCCACTTTCACCTCTAGAGATTTAGATTCAGAAACACTGGGGTAGGCCCT
GGAGAGCAGTACTCTTAACAAGCTCCTCAGTGCTTCTTACCATTAGGCAAATTAGGGAAACACTGCATTGGGTCAAAGTGCTGCCTTTAA
TCGACCATTAGAGGGAGTTCTCTAAATAACAAAGTTATTACTCTAATTCAAAATGCTTTAAAGAATTTTCCAAGGAATACAAGCCATCTG
GTTGGTGTTAGTTATAGCAGTGATTTCATTAGAGTGTACATTTAACATTTTAGTTTTATCAAAATTTTTTGAAATTAAGAATTAGAACCA
GAGCTCCTATCAGTATATATGTACACAGGTGTGCATGCCAGTGTTCAAAAGATTGTGTAAAAGTTCAAGCCCGTTTTAGAAAGCCAACAT

>In-frame_IQGAP2_ENST00000274364_chr5_75866482_+_ATRNL1_ENST00000423111_chr10_117278773_+_1420nt
CGCGGTGAATAACGGGGCCTGGCTGGAGGAGAAAGGAAACCTGCTGCGGGAGGCGGCGGCGACCGGCCAGGGAGCGAGGGAGGAGAGTTC
ACTTTTACTTCAGTGTCAGCGCGCGGCGGCCGTGGCTGGCTCTGGCGAGAGAGCACCGAGGGAGTGGGTCGCAGATCTTCGGGCGGCTAG
GGGAAATCGGCGAGAGGCGGGATCCGAGCGCGCCGGCGGGGCGCAGAGCCCGCGAGCCTGGCCAGCGAGGGTAGCCGCGGGGGGCGCGCC
CCGGGCGGGCCCCCGGAGACGCGCAGGATGCCACACGAAGAGCTGCCGTCGCTGCAGAGACCCCGCTATGGCTCTATTGTGGACGATGAA
AGGCTCTCTGCAGAGGAGATGGATGAGAGGAGGCGGCAGAACATTGCTTATGAATATCTGTGCCACTTAGAGGAAGCCAAAAGGTGGATG
GAAGTTTGCTTAGTTGAAGAATTGCCACCAACCACTGAATTGGAAGAAGGGCTCCGGAATGGAGTTTACCTTGCAAAGTTAGCCAAGTTC
TTTGCCCCGAAAATGGTATCAGAGAAAAAGATCTATGATGTGGAACAAACACGTTATAAGAAGTCTGGCCTTCATTTTCGACACACAGAT
AATACCGTCCAGTGGTTAAGAGCGATGGAGTCTATTGGTCTACCCAAGATTGCATTCTCACAACACAATACAATCATGGACCTTGTGCAG
TTTTTTGTCACCTTCTTCAGTTGTTTCCTATCCTTATTGCTGGTGGCTGCTGTGGTATGGAAGATCAAACAAACTTGTTGGGCTTCTCGA
CGGAGAGAGCAACTGCTTCGAGAACGACAGCAGATGGCCAGCCGTCCCTTTGCTTCTGTTGATGTAGCTCTGGAAGTGGGAGCTGAACAA
ACAGAGTTTCTGCGAGGGCCATTAGAGGGGGCACCCAAGCCAATTGCCATTGAACCATGTGCTGGGAACAGAGCTGCTGTTCTGACTGTG
TTTCTTTGTCTACCACGAGGATCATCAGGTGCCCCTCCCCCTGGGCAGTCAGGCCTTGCAATTGCCAGTGCCCTAATAGATATTTCACAA
CAGAAAGCTTCAGATAGTAAAGATAAGACTTCTGGAGTCCGGAATCGAAAACACCTTTCAACACGTCAAGGAACTTGTGTCTGAGAAATG
GAAACCGCTCCTGTATATTCTGTACTGTTTTACTTCGGGCTTCTGTTAAAGCTGTTCTATGGCCTTGGATTTTATGGAGGCAGATCTCTG
TATCATCCAGAGCCTGAGTACAGTTTCCTTCCAAATGGACAATGACCCAGGTGGCCAAAGAATGTTCATGAGTTTTATAAAAGTATTGAT

>In-frame_IQGAP2_ENST00000274364_chr5_75866482_+_ATRNL1_ENST00000303745_chr10_117278773_+_1571nt
CGCGGTGAATAACGGGGCCTGGCTGGAGGAGAAAGGAAACCTGCTGCGGGAGGCGGCGGCGACCGGCCAGGGAGCGAGGGAGGAGAGTTC
ACTTTTACTTCAGTGTCAGCGCGCGGCGGCCGTGGCTGGCTCTGGCGAGAGAGCACCGAGGGAGTGGGTCGCAGATCTTCGGGCGGCTAG
GGGAAATCGGCGAGAGGCGGGATCCGAGCGCGCCGGCGGGGCGCAGAGCCCGCGAGCCTGGCCAGCGAGGGTAGCCGCGGGGGGCGCGCC
CCGGGCGGGCCCCCGGAGACGCGCAGGATGCCACACGAAGAGCTGCCGTCGCTGCAGAGACCCCGCTATGGCTCTATTGTGGACGATGAA
AGGCTCTCTGCAGAGGAGATGGATGAGAGGAGGCGGCAGAACATTGCTTATGAATATCTGTGCCACTTAGAGGAAGCCAAAAGGTGGATG
GAAGTTTGCTTAGTTGAAGAATTGCCACCAACCACTGAATTGGAAGAAGGGCTCCGGAATGGAGTTTACCTTGCAAAGTTAGCCAAGTTC
TTTGCCCCGAAAATGGTATCAGAGAAAAAGATCTATGATGTGGAACAAACACGTTATAAGAAGTCTGGCCTTCATTTTCGACACACAGAT
AATACCGTCCAGTGGTTAAGAGCGATGGAGTCTATTGGTCTACCCAAGATTGCATTCTCACAACACAATACAATCATGGACCTTGTGCAG
TTTTTTGTCACCTTCTTCAGTTGTTTCCTATCCTTATTGCTGGTGGCTGCTGTGGTATGGAAGATCAAACAAACTTGTTGGGCTTCTCGA
CGGAGAGAGCAACTGCTTCGAGAACGACAGCAGATGGCCAGCCGTCCCTTTGCTTCTGTTGATGTAGCTCTGGAAGTGGGAGCTGAACAA
ACAGAGTTTCTGCGAGGGCCATTAGAGGGGGCACCCAAGCCAATTGCCATTGAACCATGTGCTGGGAACAGAGCTGCTGTTCTGACTGTG
TTTCTTTGTCTACCACGAGGATCATCAGGTGCCCCTCCCCCTGGGCAGTCAGGCCTTGCAATTGCCAGTGCCCTAATAGATATTTCACAA
CAGAAAGCTTCAGATAGTAAAGATAAGACTTCTGGAGTCCGGAATCGAAAACACCTTTCAACACGTCAAGGAACTTGTGTCTGAGAAATG
GAAACCGCTCCTGTATATTCTGTACTGTTTTACTTCGGGCTTCTGTTAAAGCTGTTCTATGGCCTTGGATTTTATGGAGGCAGATCTCTG
TATCATCCAGAGCCTGAGTACAGTTTCCTTCCAAATGGACAATGACCCAGGTGGCCAAAGAATGTTCATGAGTTTTATAAAAGTATTGAT
GGTCACAGGTGATAAAGTCAGTTTTTACCACTATCTTAGGCTTATTATAGCTAACATTAAATTACTCTGGAAAAAGATGTATATTGTTTC
TTAATGAAGATGAAAAATATGTAATTCATATAAATCAACTGTTTATATCCCAAGACTTGAAAGAAAGACATTTTTTAATGCCTGAATGAT


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FusionGenePPI for IQGAP2_ATRNL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
IQGAP2UBAC1, RELA, RAC1, CDC42, RHOG, CAMKK2, MYC, PEX14, TSHR, MAGEA1, GNAI2, SDF4, DTNBP1, TXNDC12, FOXB1, SUCLA2, CALM1, VCPATRNL1MC4R


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for IQGAP2_ATRNL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for IQGAP2_ATRNL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIQGAP2C2239176Liver carcinoma1CTD_human