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Fusion gene ID: 17685 |
FusionGeneSummary for IQGAP1_RASGRF1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: IQGAP1_RASGRF1 | Fusion gene ID: 17685 | Hgene | Tgene | Gene symbol | IQGAP1 | RASGRF1 | Gene ID | 8826 | 5923 |
| Gene name | IQ motif containing GTPase activating protein 1 | Ras protein specific guanine nucleotide releasing factor 1 | |
| Synonyms | HUMORFA01|SAR1|p195 | CDC25|CDC25L|GNRP|GRF1|GRF55|H-GRF55|PP13187|ras-GRF1 | |
| Cytomap | 15q26.1 | 15q25.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ras GTPase-activating-like protein IQGAP1RasGAP-like with IQ motifs | ras-specific guanine nucleotide-releasing factor 1Ras-specific guanine nucleotide-releasing factor, CDC25 homologRas-specific nucleotide exchange factor CDC25guanine nucleotide exchange factorguanine nucleotide-releasing factor 1guanine nucleotide-re | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | P46940 | Q13972 | |
| Ensembl transtripts involved in fusion gene | ENST00000268182, ENST00000560738, ENST00000560020, | ENST00000558480, ENST00000419573, ENST00000560334, ENST00000394745, | |
| Fusion gene scores | * DoF score | 13 X 8 X 13=1352 | 3 X 4 X 3=36 |
| # samples | 21 | 3 | |
| ** MAII score | log2(21/1352*10)=-2.68663391861606 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/36*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: IQGAP1 [Title/Abstract] AND RASGRF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | IQGAP1 | GO:0071277 | cellular response to calcium ion | 18567582 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-FX-A3TO-01A | IQGAP1 | chr15 | 90934105 | + | RASGRF1 | chr15 | 79298776 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000268182 | ENST00000558480 | IQGAP1 | chr15 | 90934105 | + | RASGRF1 | chr15 | 79298776 | - |
| In-frame | ENST00000268182 | ENST00000419573 | IQGAP1 | chr15 | 90934105 | + | RASGRF1 | chr15 | 79298776 | - |
| 5CDS-5UTR | ENST00000268182 | ENST00000560334 | IQGAP1 | chr15 | 90934105 | + | RASGRF1 | chr15 | 79298776 | - |
| 5CDS-intron | ENST00000268182 | ENST00000394745 | IQGAP1 | chr15 | 90934105 | + | RASGRF1 | chr15 | 79298776 | - |
| intron-3CDS | ENST00000560738 | ENST00000558480 | IQGAP1 | chr15 | 90934105 | + | RASGRF1 | chr15 | 79298776 | - |
| intron-3CDS | ENST00000560738 | ENST00000419573 | IQGAP1 | chr15 | 90934105 | + | RASGRF1 | chr15 | 79298776 | - |
| intron-5UTR | ENST00000560738 | ENST00000560334 | IQGAP1 | chr15 | 90934105 | + | RASGRF1 | chr15 | 79298776 | - |
| intron-intron | ENST00000560738 | ENST00000394745 | IQGAP1 | chr15 | 90934105 | + | RASGRF1 | chr15 | 79298776 | - |
| intron-3CDS | ENST00000560020 | ENST00000558480 | IQGAP1 | chr15 | 90934105 | + | RASGRF1 | chr15 | 79298776 | - |
| intron-3CDS | ENST00000560020 | ENST00000419573 | IQGAP1 | chr15 | 90934105 | + | RASGRF1 | chr15 | 79298776 | - |
| intron-5UTR | ENST00000560020 | ENST00000560334 | IQGAP1 | chr15 | 90934105 | + | RASGRF1 | chr15 | 79298776 | - |
| intron-intron | ENST00000560020 | ENST00000394745 | IQGAP1 | chr15 | 90934105 | + | RASGRF1 | chr15 | 79298776 | - |
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FusionProtFeatures for IQGAP1_RASGRF1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| IQGAP1 | RASGRF1 |
| Plays a crucial role in regulating the dynamics andassembly of the actin cytoskeleton. Binds to activated CDC42 butdoes not stimulate its GTPase activity. It associates withcalmodulin. Could serve as an assembly scaffold for theorganization of a multimolecular complex that would interfaceincoming signals to the reorganization of the actin cytoskeletonat the plasma membrane. May promote neurite outgrowth(PubMed:15695813). May play a possible role in cell cycleregulation by contributing to cell cycle progression after DNAreplication arrest (PubMed:20883816).{ECO:0000269|PubMed:15695813, ECO:0000269|PubMed:20883816}. | Promotes the exchange of Ras-bound GDP by GTP.{ECO:0000269|PubMed:11389730}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >RASGRF1 | chr15:90934105 | chr15:79298776 | ENST00000394745 | - | 0 | 14 | 1038_1270 | -393 | 490 | Domain | Ras-GEF |
| Tgene | >RASGRF1 | chr15:90934105 | chr15:79298776 | ENST00000394745 | - | 0 | 14 | 204_229 | -393 | 490 | Domain | IQ |
| Tgene | >RASGRF1 | chr15:90934105 | chr15:79298776 | ENST00000394745 | - | 0 | 14 | 22_129 | -393 | 490 | Domain | PH 1 |
| Tgene | >RASGRF1 | chr15:90934105 | chr15:79298776 | ENST00000394745 | - | 0 | 14 | 240_426 | -393 | 490 | Domain | DH |
| Tgene | >RASGRF1 | chr15:90934105 | chr15:79298776 | ENST00000394745 | - | 0 | 14 | 467_584 | -393 | 490 | Domain | PH 2 |
| Tgene | >RASGRF1 | chr15:90934105 | chr15:79298776 | ENST00000394745 | - | 0 | 14 | 644_761 | -393 | 490 | Domain | N-terminal Ras-GEF |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >IQGAP1 | chr15:90934105 | chr15:79298776 | ENST00000268182 | + | 2 | 38 | 1004_1237 | 51 | 1658 | Domain | Ras-GAP |
| Hgene | >IQGAP1 | chr15:90934105 | chr15:79298776 | ENST00000268182 | + | 2 | 38 | 44_159 | 51 | 1658 | Domain | Calponin-homology (CH) |
| Hgene | >IQGAP1 | chr15:90934105 | chr15:79298776 | ENST00000268182 | + | 2 | 38 | 679_712 | 51 | 1658 | Domain | WW |
| Hgene | >IQGAP1 | chr15:90934105 | chr15:79298776 | ENST00000268182 | + | 2 | 38 | 745_774 | 51 | 1658 | Domain | IQ 1 |
| Hgene | >IQGAP1 | chr15:90934105 | chr15:79298776 | ENST00000268182 | + | 2 | 38 | 775_804 | 51 | 1658 | Domain | IQ 2 |
| Hgene | >IQGAP1 | chr15:90934105 | chr15:79298776 | ENST00000268182 | + | 2 | 38 | 805_834 | 51 | 1658 | Domain | IQ 3 |
| Hgene | >IQGAP1 | chr15:90934105 | chr15:79298776 | ENST00000268182 | + | 2 | 38 | 835_864 | 51 | 1658 | Domain | IQ 4 |
| Hgene | >IQGAP1 | chr15:90934105 | chr15:79298776 | ENST00000268182 | + | 2 | 38 | 1276_1657 | 51 | 1658 | Region | Note=C2 |
| Hgene | >IQGAP1 | chr15:90934105 | chr15:79298776 | ENST00000268182 | + | 2 | 38 | 956_1274 | 51 | 1658 | Region | Note=C1 |
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FusionGeneSequence for IQGAP1_RASGRF1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_IQGAP1_ENST00000268182_chr15_90934105_+_RASGRF1_ENST00000558480_chr15_79298776_-_701aa MSAADEVDGLGVARPHYGSVLDNERLTAEEMDERRRQNVAYEYLCHLEEAKRSDASLYCDDVDIRFSKTMNSCKVLQIRYASVERLLERL TDLRFLSIDFLNTFLHSYRVFTTAIVVLDKLITIYKKPISAIPARSLELLFASGQNNKLLYGEPPKSPRATRKFSSPPPLSITKTSSPSR RRKLSLNIPIITGGKALDLAALSCNSNGYTSMYSAMSPFSKATLDTSKLYVSSSFTNKIPDEGDTTPEKPEDPSALSKQSSEVSMREESD IDQNQSDDGDTETSPTKSPTTPKSVKNKNSSEFPLFSYNNGVVMTSCRELDNNRSALSAASAFAIATAGANEGTPNKEKYRRMSLASAGF PPDQRNGDKEFVIRRAATNRVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDPGDNQITLEEIT QMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKW VAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEG >In-frame_IQGAP1_ENST00000268182_chr15_90934105_+_RASGRF1_ENST00000419573_chr15_79298776_-_704aa MSAADEVDGLGVARPHYGSVLDNERLTAEEMDERRRQNVAYEYLCHLEEAKRSDASLYCDDVDIRFSKTMNSCKVLQIRYASVERLLERL TDLRFLSIDFLNTFLHSYRVFTTAIVVLDKLITIYKKPISAIPARWLRSLELLFASGQNNKLLYGEPPKSPRATRKFSSPPPLSITKTSS PSRRRKLSLNIPIITGGKALDLAALSCNSNGYTSMYSAMSPFSKATLDTSKLYVSSSFTNKIPDEGDTTPEKPEDPSALSKQSSEVSMRE ESDIDQNQSDDGDTETSPTKSPTTPKSVKNKNSSEFPLFSYNNGVVMTSCRELDNNRSALSAASAFAIATAGANEGTPNKEKYRRMSLAS AGFPPDQRNGDKEFVIRRAATNRVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDPGDNQITLE EITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAI EKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFI |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_IQGAP1_ENST00000268182_chr15_90934105_+_RASGRF1_ENST00000558480_chr15_79298776_-_2103nt ATGTCCGCCGCAGACGAGGTTGACGGGCTGGGCGTGGCCCGGCCGCACTATGGCTCTGTCCTGGATAATGAAAGACTTACTGCAGAGGAG ATGGATGAAAGGAGACGTCAGAACGTGGCTTATGAGTACCTTTGTCATTTGGAAGAAGCGAAGAGGTCCGACGCCTCCTTATATTGTGAT GATGTTGACATTCGCTTCAGCAAAACCATGAACTCCTGCAAAGTGCTGCAGATCCGCTACGCCAGTGTGGAGCGGCTGCTGGAGAGGCTG ACGGACCTGCGCTTCCTGAGCATCGACTTCCTCAACACCTTCCTGCACTCCTACCGCGTCTTCACCACCGCCATCGTGGTCCTGGACAAG CTCATTACCATCTACAAGAAGCCTATCAGTGCCATTCCTGCCAGGTCGCTGGAGCTCCTGTTTGCCAGTGGCCAGAACAATAAGCTCCTG TACGGTGAACCCCCCAAGTCCCCGCGCGCCACCCGCAAGTTCTCCTCGCCGCCACCTCTGTCCATCACCAAGACATCGTCACCGAGCCGC CGGCGGAAGCTCTCCCTGAACATCCCCATCATCACTGGCGGCAAGGCCCTGGACCTGGCCGCCCTCAGCTGCAACTCCAATGGCTACACC AGCATGTACTCGGCCATGTCACCCTTCAGCAAGGCCACGCTGGACACCAGCAAGCTCTATGTGTCCAGCAGCTTCACCAACAAGATTCCA GATGAGGGCGATACGACCCCTGAGAAGCCCGAAGACCCTTCAGCGCTCAGCAAGCAGAGCTCAGAAGTCTCCATGAGAGAGGAGTCAGAT ATTGATCAAAACCAGAGTGATGATGGTGATACTGAAACATCACCAACTAAATCTCCAACAACACCCAAATCAGTCAAAAACAAAAATTCT TCAGAGTTCCCACTCTTTTCCTATAACAATGGAGTCGTCATGACCTCCTGTCGTGAACTGGACAATAACCGCAGTGCCTTGTCGGCCGCC TCTGCCTTTGCCATAGCAACCGCCGGGGCCAACGAGGGCACCCCAAACAAGGAGAAGTACCGGAGGATGTCCTTAGCCAGTGCAGGGTTT CCCCCAGACCAGAGGAATGGAGACAAGGAGTTTGTGATCCGCAGAGCAGCCACCAATCGTGTCTTGAACGTGCTCCGCCACTGGGTGTCC AAGCACTCTCAGGACTTTGAGACCAACGATGAGCTCAAATGCAAGGTGATCGGCTTCCTGGAAGAAGTCATGCACGACCCGGAGCTCCTG ACCCAGGAGCGGAAGGCTGCAGCCAACATCATCAGGACTCTGACCCAGGAGGACCCAGGTGACAACCAGATCACGCTGGAGGAGATCACG CAGATGGCTGAAGGCGTGAAGGCTGAGCCCTTTGAAAACCACTCAGCCCTGGAGATCGCGGAGCAGCTGACCCTGCTAGATCACCTCGTC TTCAAGAAGATTCCTTATGAGGAGTTCTTCGGACAAGGATGGATGAAACTGGAAAAGAATGAAAGGACCCCTTATATCATGAAAACCACT AAGCACTTCAATGACATCAGTAACTTGATTGCTTCAGAAATCATCCGCAATGAGGACATCAACGCCAGGGTGAGCGCCATCGAGAAGTGG GTGGCCGTAGCTGACATATGCCGCTGCCTCCACAACTACAATGCCGTACTGGAGATCACCTCGTCCATGAACCGCAGTGCAATCTTCCGG CTCAAAAAGACGTGGCTCAAAGTCTCTAAGCAGACTAAAGCTTTGATTGATAAGCTCCAAAAGCTTGTGTCATCTGAGGGCAGATTTAAG AATCTCAGAGAAGCTCTGAAAAATTGTGACCCACCCTGTGTCCCTTACCTGGGGATGTACCTCACCGACCTGGCCTTCATCGAGGAGGGG ACGCCCAATTACACGGAAGACGGCCTGGTCAACTTCTCCAAGATGAGGATGATATCCCATATTATCCGAGAGATTCGCCAGTTTCAACAA ACTGCCTACAAAATAGAGCACCAAGCAAAGGTAACGCAATATTTACTGGACCAATCTTTTGTAATGGATGAAGAAAGCCTCTACGAGTCT >In-frame_IQGAP1_ENST00000268182_chr15_90934105_+_RASGRF1_ENST00000419573_chr15_79298776_-_2112nt ATGTCCGCCGCAGACGAGGTTGACGGGCTGGGCGTGGCCCGGCCGCACTATGGCTCTGTCCTGGATAATGAAAGACTTACTGCAGAGGAG ATGGATGAAAGGAGACGTCAGAACGTGGCTTATGAGTACCTTTGTCATTTGGAAGAAGCGAAGAGGTCCGACGCCTCCTTATATTGTGAT GATGTTGACATTCGCTTCAGCAAAACCATGAACTCCTGCAAAGTGCTGCAGATCCGCTACGCCAGTGTGGAGCGGCTGCTGGAGAGGCTG ACGGACCTGCGCTTCCTGAGCATCGACTTCCTCAACACCTTCCTGCACTCCTACCGCGTCTTCACCACCGCCATCGTGGTCCTGGACAAG CTCATTACCATCTACAAGAAGCCTATCAGTGCCATTCCTGCCAGGTGGCTGAGGTCGCTGGAGCTCCTGTTTGCCAGTGGCCAGAACAAT AAGCTCCTGTACGGTGAACCCCCCAAGTCCCCGCGCGCCACCCGCAAGTTCTCCTCGCCGCCACCTCTGTCCATCACCAAGACATCGTCA CCGAGCCGCCGGCGGAAGCTCTCCCTGAACATCCCCATCATCACTGGCGGCAAGGCCCTGGACCTGGCCGCCCTCAGCTGCAACTCCAAT GGCTACACCAGCATGTACTCGGCCATGTCACCCTTCAGCAAGGCCACGCTGGACACCAGCAAGCTCTATGTGTCCAGCAGCTTCACCAAC AAGATTCCAGATGAGGGCGATACGACCCCTGAGAAGCCCGAAGACCCTTCAGCGCTCAGCAAGCAGAGCTCAGAAGTCTCCATGAGAGAG GAGTCAGATATTGATCAAAACCAGAGTGATGATGGTGATACTGAAACATCACCAACTAAATCTCCAACAACACCCAAATCAGTCAAAAAC AAAAATTCTTCAGAGTTCCCACTCTTTTCCTATAACAATGGAGTCGTCATGACCTCCTGTCGTGAACTGGACAATAACCGCAGTGCCTTG TCGGCCGCCTCTGCCTTTGCCATAGCAACCGCCGGGGCCAACGAGGGCACCCCAAACAAGGAGAAGTACCGGAGGATGTCCTTAGCCAGT GCAGGGTTTCCCCCAGACCAGAGGAATGGAGACAAGGAGTTTGTGATCCGCAGAGCAGCCACCAATCGTGTCTTGAACGTGCTCCGCCAC TGGGTGTCCAAGCACTCTCAGGACTTTGAGACCAACGATGAGCTCAAATGCAAGGTGATCGGCTTCCTGGAAGAAGTCATGCACGACCCG GAGCTCCTGACCCAGGAGCGGAAGGCTGCAGCCAACATCATCAGGACTCTGACCCAGGAGGACCCAGGTGACAACCAGATCACGCTGGAG GAGATCACGCAGATGGCTGAAGGCGTGAAGGCTGAGCCCTTTGAAAACCACTCAGCCCTGGAGATCGCGGAGCAGCTGACCCTGCTAGAT CACCTCGTCTTCAAGAAGATTCCTTATGAGGAGTTCTTCGGACAAGGATGGATGAAACTGGAAAAGAATGAAAGGACCCCTTATATCATG AAAACCACTAAGCACTTCAATGACATCAGTAACTTGATTGCTTCAGAAATCATCCGCAATGAGGACATCAACGCCAGGGTGAGCGCCATC GAGAAGTGGGTGGCCGTAGCTGACATATGCCGCTGCCTCCACAACTACAATGCCGTACTGGAGATCACCTCGTCCATGAACCGCAGTGCA ATCTTCCGGCTCAAAAAGACGTGGCTCAAAGTCTCTAAGCAGACTAAAGCTTTGATTGATAAGCTCCAAAAGCTTGTGTCATCTGAGGGC AGATTTAAGAATCTCAGAGAAGCTCTGAAAAATTGTGACCCACCCTGTGTCCCTTACCTGGGGATGTACCTCACCGACCTGGCCTTCATC GAGGAGGGGACGCCCAATTACACGGAAGACGGCCTGGTCAACTTCTCCAAGATGAGGATGATATCCCATATTATCCGAGAGATTCGCCAG TTTCAACAAACTGCCTACAAAATAGAGCACCAAGCAAAGGTAACGCAATATTTACTGGACCAATCTTTTGTAATGGATGAAGAAAGCCTC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_IQGAP1_ENST00000268182_chr15_90934105_+_RASGRF1_ENST00000558480_chr15_79298776_-_4424nt GACGGCACGGGGCGGGGCCTCGGGGACCCCGGCAAGCCCGCGCACTTGGCAGGAGCTGTAGCTACCGCCGTCCGCGCCTCCAAGGTTTCA CGGCTTCCTCAGCAGAGACTCGGGCTCGTCCGCCATGTCCGCCGCAGACGAGGTTGACGGGCTGGGCGTGGCCCGGCCGCACTATGGCTC TGTCCTGGATAATGAAAGACTTACTGCAGAGGAGATGGATGAAAGGAGACGTCAGAACGTGGCTTATGAGTACCTTTGTCATTTGGAAGA AGCGAAGAGGTCCGACGCCTCCTTATATTGTGATGATGTTGACATTCGCTTCAGCAAAACCATGAACTCCTGCAAAGTGCTGCAGATCCG CTACGCCAGTGTGGAGCGGCTGCTGGAGAGGCTGACGGACCTGCGCTTCCTGAGCATCGACTTCCTCAACACCTTCCTGCACTCCTACCG CGTCTTCACCACCGCCATCGTGGTCCTGGACAAGCTCATTACCATCTACAAGAAGCCTATCAGTGCCATTCCTGCCAGGTCGCTGGAGCT CCTGTTTGCCAGTGGCCAGAACAATAAGCTCCTGTACGGTGAACCCCCCAAGTCCCCGCGCGCCACCCGCAAGTTCTCCTCGCCGCCACC TCTGTCCATCACCAAGACATCGTCACCGAGCCGCCGGCGGAAGCTCTCCCTGAACATCCCCATCATCACTGGCGGCAAGGCCCTGGACCT GGCCGCCCTCAGCTGCAACTCCAATGGCTACACCAGCATGTACTCGGCCATGTCACCCTTCAGCAAGGCCACGCTGGACACCAGCAAGCT CTATGTGTCCAGCAGCTTCACCAACAAGATTCCAGATGAGGGCGATACGACCCCTGAGAAGCCCGAAGACCCTTCAGCGCTCAGCAAGCA GAGCTCAGAAGTCTCCATGAGAGAGGAGTCAGATATTGATCAAAACCAGAGTGATGATGGTGATACTGAAACATCACCAACTAAATCTCC AACAACACCCAAATCAGTCAAAAACAAAAATTCTTCAGAGTTCCCACTCTTTTCCTATAACAATGGAGTCGTCATGACCTCCTGTCGTGA ACTGGACAATAACCGCAGTGCCTTGTCGGCCGCCTCTGCCTTTGCCATAGCAACCGCCGGGGCCAACGAGGGCACCCCAAACAAGGAGAA GTACCGGAGGATGTCCTTAGCCAGTGCAGGGTTTCCCCCAGACCAGAGGAATGGAGACAAGGAGTTTGTGATCCGCAGAGCAGCCACCAA TCGTGTCTTGAACGTGCTCCGCCACTGGGTGTCCAAGCACTCTCAGGACTTTGAGACCAACGATGAGCTCAAATGCAAGGTGATCGGCTT CCTGGAAGAAGTCATGCACGACCCGGAGCTCCTGACCCAGGAGCGGAAGGCTGCAGCCAACATCATCAGGACTCTGACCCAGGAGGACCC AGGTGACAACCAGATCACGCTGGAGGAGATCACGCAGATGGCTGAAGGCGTGAAGGCTGAGCCCTTTGAAAACCACTCAGCCCTGGAGAT CGCGGAGCAGCTGACCCTGCTAGATCACCTCGTCTTCAAGAAGATTCCTTATGAGGAGTTCTTCGGACAAGGATGGATGAAACTGGAAAA GAATGAAAGGACCCCTTATATCATGAAAACCACTAAGCACTTCAATGACATCAGTAACTTGATTGCTTCAGAAATCATCCGCAATGAGGA CATCAACGCCAGGGTGAGCGCCATCGAGAAGTGGGTGGCCGTAGCTGACATATGCCGCTGCCTCCACAACTACAATGCCGTACTGGAGAT CACCTCGTCCATGAACCGCAGTGCAATCTTCCGGCTCAAAAAGACGTGGCTCAAAGTCTCTAAGCAGACTAAAGCTTTGATTGATAAGCT CCAAAAGCTTGTGTCATCTGAGGGCAGATTTAAGAATCTCAGAGAAGCTCTGAAAAATTGTGACCCACCCTGTGTCCCTTACCTGGGGAT GTACCTCACCGACCTGGCCTTCATCGAGGAGGGGACGCCCAATTACACGGAAGACGGCCTGGTCAACTTCTCCAAGATGAGGATGATATC CCATATTATCCGAGAGATTCGCCAGTTTCAACAAACTGCCTACAAAATAGAGCACCAAGCAAAGGTAACGCAATATTTACTGGACCAATC TTTTGTAATGGATGAAGAAAGCCTCTACGAGTCTTCTCTCCGAATAGAACCAAAACTCCCCACCTGAAGCTGAGCCCAGCCCAGACCCAG CTGCTCCCGGGGACATGTGCTAGATGATACTGTACATATTCGTTTGGTTTCACTGGATTTTCTTCTTCAGTATGTGCTTCTCCAAGAATA CAAATCGTCCTTGTTCTTAGATTCCTGTAGAACCGGAATATGAATTTCTGCACCGTTTCAGACTTCGCCCACCCATCCCTCCCCTCGTCT CCTGCAGTGCCTGTTTCTTTTAAACAGCTGTACTCTTGGTCCCTCTTCCCTAGACTCCTCACTCTTCTCAGAGGGGAAACAGCACCCTTG CATACAAGAATCTTAGACTCCAGTCCTGCTTCCGTCCCTCCCCAGCCCAGGCTCCTGGGTTGAGGTGGCCACCCAGGCATCCTCCCAGCA TGTTCCATGTAGTTGTTATAACTGGGTGGGGGGTGGGGGGCGGCGGGAGGGGGAAACCATACCCTGAAGTCCAGTCATTGACAAATCTTC CCGCTGATGGTGATGTCAATTTCCAAAGCAGCTTCTCCAGCCAAAATCGCAGGTCTCAAAACTCCCCATGTGTCTCCCAGTAACCTGGAC GGAAGGGAGTCCTCTCTGCTCAGAACCACACCCCTCGTACCAATGCTGCCATCTCGTTCAGGCCCCACGTCGCTCCTTGCTCTAGGATTA ACACCAGATAGCATGAATAGCAGTCTCAATACAACTGGATGAGGCCCTAGACTTCCCGAGGAAATGGAGTCACAAACACCAAGCCACGTC GACTCTTGCCGACCACTGGCCCAGCATCCACTGAAAGTCGGGAACACAAAAATGTCACTTTTCCTCTTTAAGCTGCCTAACGGTCACTAC AAGCTTACATTGAGATGCTCTAAGTCTGTATACCTTGTGATAATTAGTACCACACTGTAGAATTAGGAAATCAATAACCAAGTGTTTTTA TTGCATATACTGTAGTCCTGTCTAAATGCCTTCTAGCAGGAATATAGTAATGTAGTGCTTATTCTGTGAATATTACCATGTATTTTTTAC ACTGTACAGTATAGAAAACACAGGTTAACTCCGAAGTGGCAGGCATGCTCCACTACAACAGACAGACAACTTTTGCTGTAAGCAATACCT AGTGGTATGAGAATTCTATTTCAAGTCCTAAAATATTTCAACTTACAGCTTGTTTGGAAAAAAATTTCCATTTTTGTAAAAATATATGTT TCCTGATTACCTCTTGCTAATAAATCTATTCTATCTCAGGGTGAACAGCGAGTTTTGATGGGTTTCATTCGTTCAGTCAAGGAATATTTG ATGAGCACTTGCTCCTTACCCAGCCCAGCCTGGGACCGGAGATCCAGAGTGTCAAGGACACCATACCTGCTTTTTAGGCACCAACAGTTT GGTGGGGAAGACTGTTTCAGTTGCCTATTGCACCAAGAACAAGCCACTCCAAAACATAATGGCTTAAAACCATTTTTGTTACCTTTCACA GTTCTATGGGTTGACTGGGTCCAGCTGTCAGTTCTTATTTGGAGTCTCTCATGAAGTTTCAGTCACTCAGCAACTGGGACTGGAGTCATC TGAAGGCTCAACTGGACCGGGTGGTGCTCTAGTTGGTGCACCAAGATGGCGCTGTCACATGGCTGGATGTTGATGTCTGCTGGGCTGCAC TGGGGCTGTTCATGGGAGCATCCACACGTGGCCTCTCTGTGTGGCTTGGGCTCCTCACAGTCCGGAAGCTGGGTTCCAAGAGCGACTGTT CCAGCAGCCTCAGGCAGAAGCTACAAGGCTGCCCAGATGCCATCCTGCCCAGATGTGTCCTCACTGTCACCCAGGAAGGGAAGCCCCGGA ACACCACCCTCAGTCACAGGCATGGGGCCCACTGCAAGGCACAACCCACTCCAGAGCTCCCAAGGCCGCCTCCCCTGGGACCTGCAGCCA GCTGGCTCCATAACTGCTTTTCCGTTTCCTCCAGGCATTTTCATCCTAGCCCTACTTTGTGCTGGGATCTGAGGGGGATAGCAAGCGGAG AAAGAAGGGATCTAGAGGGAGAAGATTCTAGATCCTTCTTTTGACTGCCAGCTGATTTTGATTGCCAGCTTTACCTGCTTCATGAGCTCA GCCAAGTCACTTAACCTCTCAGAGCTTCACTGTTCTCATCTGAAAAATGGGGATGAAAATGGTATCTCATTACAGAGTAGAATTAAATGA >In-frame_IQGAP1_ENST00000268182_chr15_90934105_+_RASGRF1_ENST00000419573_chr15_79298776_-_4433nt GACGGCACGGGGCGGGGCCTCGGGGACCCCGGCAAGCCCGCGCACTTGGCAGGAGCTGTAGCTACCGCCGTCCGCGCCTCCAAGGTTTCA CGGCTTCCTCAGCAGAGACTCGGGCTCGTCCGCCATGTCCGCCGCAGACGAGGTTGACGGGCTGGGCGTGGCCCGGCCGCACTATGGCTC TGTCCTGGATAATGAAAGACTTACTGCAGAGGAGATGGATGAAAGGAGACGTCAGAACGTGGCTTATGAGTACCTTTGTCATTTGGAAGA AGCGAAGAGGTCCGACGCCTCCTTATATTGTGATGATGTTGACATTCGCTTCAGCAAAACCATGAACTCCTGCAAAGTGCTGCAGATCCG CTACGCCAGTGTGGAGCGGCTGCTGGAGAGGCTGACGGACCTGCGCTTCCTGAGCATCGACTTCCTCAACACCTTCCTGCACTCCTACCG CGTCTTCACCACCGCCATCGTGGTCCTGGACAAGCTCATTACCATCTACAAGAAGCCTATCAGTGCCATTCCTGCCAGGTGGCTGAGGTC GCTGGAGCTCCTGTTTGCCAGTGGCCAGAACAATAAGCTCCTGTACGGTGAACCCCCCAAGTCCCCGCGCGCCACCCGCAAGTTCTCCTC GCCGCCACCTCTGTCCATCACCAAGACATCGTCACCGAGCCGCCGGCGGAAGCTCTCCCTGAACATCCCCATCATCACTGGCGGCAAGGC CCTGGACCTGGCCGCCCTCAGCTGCAACTCCAATGGCTACACCAGCATGTACTCGGCCATGTCACCCTTCAGCAAGGCCACGCTGGACAC CAGCAAGCTCTATGTGTCCAGCAGCTTCACCAACAAGATTCCAGATGAGGGCGATACGACCCCTGAGAAGCCCGAAGACCCTTCAGCGCT CAGCAAGCAGAGCTCAGAAGTCTCCATGAGAGAGGAGTCAGATATTGATCAAAACCAGAGTGATGATGGTGATACTGAAACATCACCAAC TAAATCTCCAACAACACCCAAATCAGTCAAAAACAAAAATTCTTCAGAGTTCCCACTCTTTTCCTATAACAATGGAGTCGTCATGACCTC CTGTCGTGAACTGGACAATAACCGCAGTGCCTTGTCGGCCGCCTCTGCCTTTGCCATAGCAACCGCCGGGGCCAACGAGGGCACCCCAAA CAAGGAGAAGTACCGGAGGATGTCCTTAGCCAGTGCAGGGTTTCCCCCAGACCAGAGGAATGGAGACAAGGAGTTTGTGATCCGCAGAGC AGCCACCAATCGTGTCTTGAACGTGCTCCGCCACTGGGTGTCCAAGCACTCTCAGGACTTTGAGACCAACGATGAGCTCAAATGCAAGGT GATCGGCTTCCTGGAAGAAGTCATGCACGACCCGGAGCTCCTGACCCAGGAGCGGAAGGCTGCAGCCAACATCATCAGGACTCTGACCCA GGAGGACCCAGGTGACAACCAGATCACGCTGGAGGAGATCACGCAGATGGCTGAAGGCGTGAAGGCTGAGCCCTTTGAAAACCACTCAGC CCTGGAGATCGCGGAGCAGCTGACCCTGCTAGATCACCTCGTCTTCAAGAAGATTCCTTATGAGGAGTTCTTCGGACAAGGATGGATGAA ACTGGAAAAGAATGAAAGGACCCCTTATATCATGAAAACCACTAAGCACTTCAATGACATCAGTAACTTGATTGCTTCAGAAATCATCCG CAATGAGGACATCAACGCCAGGGTGAGCGCCATCGAGAAGTGGGTGGCCGTAGCTGACATATGCCGCTGCCTCCACAACTACAATGCCGT ACTGGAGATCACCTCGTCCATGAACCGCAGTGCAATCTTCCGGCTCAAAAAGACGTGGCTCAAAGTCTCTAAGCAGACTAAAGCTTTGAT TGATAAGCTCCAAAAGCTTGTGTCATCTGAGGGCAGATTTAAGAATCTCAGAGAAGCTCTGAAAAATTGTGACCCACCCTGTGTCCCTTA CCTGGGGATGTACCTCACCGACCTGGCCTTCATCGAGGAGGGGACGCCCAATTACACGGAAGACGGCCTGGTCAACTTCTCCAAGATGAG GATGATATCCCATATTATCCGAGAGATTCGCCAGTTTCAACAAACTGCCTACAAAATAGAGCACCAAGCAAAGGTAACGCAATATTTACT GGACCAATCTTTTGTAATGGATGAAGAAAGCCTCTACGAGTCTTCTCTCCGAATAGAACCAAAACTCCCCACCTGAAGCTGAGCCCAGCC CAGACCCAGCTGCTCCCGGGGACATGTGCTAGATGATACTGTACATATTCGTTTGGTTTCACTGGATTTTCTTCTTCAGTATGTGCTTCT CCAAGAATACAAATCGTCCTTGTTCTTAGATTCCTGTAGAACCGGAATATGAATTTCTGCACCGTTTCAGACTTCGCCCACCCATCCCTC CCCTCGTCTCCTGCAGTGCCTGTTTCTTTTAAACAGCTGTACTCTTGGTCCCTCTTCCCTAGACTCCTCACTCTTCTCAGAGGGGAAACA GCACCCTTGCATACAAGAATCTTAGACTCCAGTCCTGCTTCCGTCCCTCCCCAGCCCAGGCTCCTGGGTTGAGGTGGCCACCCAGGCATC CTCCCAGCATGTTCCATGTAGTTGTTATAACTGGGTGGGGGGTGGGGGGCGGCGGGAGGGGGAAACCATACCCTGAAGTCCAGTCATTGA CAAATCTTCCCGCTGATGGTGATGTCAATTTCCAAAGCAGCTTCTCCAGCCAAAATCGCAGGTCTCAAAACTCCCCATGTGTCTCCCAGT AACCTGGACGGAAGGGAGTCCTCTCTGCTCAGAACCACACCCCTCGTACCAATGCTGCCATCTCGTTCAGGCCCCACGTCGCTCCTTGCT CTAGGATTAACACCAGATAGCATGAATAGCAGTCTCAATACAACTGGATGAGGCCCTAGACTTCCCGAGGAAATGGAGTCACAAACACCA AGCCACGTCGACTCTTGCCGACCACTGGCCCAGCATCCACTGAAAGTCGGGAACACAAAAATGTCACTTTTCCTCTTTAAGCTGCCTAAC GGTCACTACAAGCTTACATTGAGATGCTCTAAGTCTGTATACCTTGTGATAATTAGTACCACACTGTAGAATTAGGAAATCAATAACCAA GTGTTTTTATTGCATATACTGTAGTCCTGTCTAAATGCCTTCTAGCAGGAATATAGTAATGTAGTGCTTATTCTGTGAATATTACCATGT ATTTTTTACACTGTACAGTATAGAAAACACAGGTTAACTCCGAAGTGGCAGGCATGCTCCACTACAACAGACAGACAACTTTTGCTGTAA GCAATACCTAGTGGTATGAGAATTCTATTTCAAGTCCTAAAATATTTCAACTTACAGCTTGTTTGGAAAAAAATTTCCATTTTTGTAAAA ATATATGTTTCCTGATTACCTCTTGCTAATAAATCTATTCTATCTCAGGGTGAACAGCGAGTTTTGATGGGTTTCATTCGTTCAGTCAAG GAATATTTGATGAGCACTTGCTCCTTACCCAGCCCAGCCTGGGACCGGAGATCCAGAGTGTCAAGGACACCATACCTGCTTTTTAGGCAC CAACAGTTTGGTGGGGAAGACTGTTTCAGTTGCCTATTGCACCAAGAACAAGCCACTCCAAAACATAATGGCTTAAAACCATTTTTGTTA CCTTTCACAGTTCTATGGGTTGACTGGGTCCAGCTGTCAGTTCTTATTTGGAGTCTCTCATGAAGTTTCAGTCACTCAGCAACTGGGACT GGAGTCATCTGAAGGCTCAACTGGACCGGGTGGTGCTCTAGTTGGTGCACCAAGATGGCGCTGTCACATGGCTGGATGTTGATGTCTGCT GGGCTGCACTGGGGCTGTTCATGGGAGCATCCACACGTGGCCTCTCTGTGTGGCTTGGGCTCCTCACAGTCCGGAAGCTGGGTTCCAAGA GCGACTGTTCCAGCAGCCTCAGGCAGAAGCTACAAGGCTGCCCAGATGCCATCCTGCCCAGATGTGTCCTCACTGTCACCCAGGAAGGGA AGCCCCGGAACACCACCCTCAGTCACAGGCATGGGGCCCACTGCAAGGCACAACCCACTCCAGAGCTCCCAAGGCCGCCTCCCCTGGGAC CTGCAGCCAGCTGGCTCCATAACTGCTTTTCCGTTTCCTCCAGGCATTTTCATCCTAGCCCTACTTTGTGCTGGGATCTGAGGGGGATAG CAAGCGGAGAAAGAAGGGATCTAGAGGGAGAAGATTCTAGATCCTTCTTTTGACTGCCAGCTGATTTTGATTGCCAGCTTTACCTGCTTC ATGAGCTCAGCCAAGTCACTTAACCTCTCAGAGCTTCACTGTTCTCATCTGAAAAATGGGGATGAAAATGGTATCTCATTACAGAGTAGA |
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FusionGenePPI for IQGAP1_RASGRF1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| IQGAP1 | ARF6, PRKACA, AKAP5, GRB2, CALM1, S100B, CDC42, RAC1, CLIP1, EZR, CTNNB1, CDH1, USP46, KBTBD7, PPARGC1A, MYL6B, RPTOR, AKT1, SIRT7, NRD1, TSG101, ISG15, FBXO25, CDK2, KDR, SRC, WHSC1, INPPL1, CBL, UBASH3B, PIK3R2, SHC1, EPS15, AP2M1, ACTB, CYBB, MYH10, HSPA5, SDHB, MAPK3, MAPK1, CD44, LRRK2, NFATC2, VCAM1, FN1, PEX14, TGFBR2, ITGA4, MEN1, BRAF, MAPK14, YWHAQ, GAPVD1, AIMP1, AIMP2, CCT2, DNAJA1, EEF1E1, EIF2S3, EIF4G1, HNRNPA1, CCAR2, LRRC47, PRPSAP2, PSMA1, PTBP1, QARS, RPLP0, SYNCRIP, RUVBL1, RPA3, RPA2, RPA1, LGR4, LRP6, DVL2, MAP2K1, MAP2K2, PTK2, WASL, PXN, DIAPH1, STAU1, CEP57, CEP76, TP53, TUBGCP3, VCP, PDLIM7, NXF1, CUL7, OBSL1, CCDC8, UBE2I, RNF2, MYL1, ABCE1, MYL10, HOXB5, MAGEA4, GGPS1, ECH1, PARVA, DDX19B, PPP2R2C, CYP1A1, NAP1L5, RPS6KB2, ANXA5, NDUFA9, TRAP1, UQCRQ, USP7, WDR3, NTRK1, OFD1, NPHP1, PPME1, ACTG1, ACTN4, ACTN1, ADD1, AP2A1, AP2A2, ANXA2, DST, CAMK2G, CAPZA2, CAPZB, CDK4, CDKN2A, CFL1, CFL2, CLIC1, CLTA, CLTB, CLTC, DAB2, DAPK3, DBN1, DSG1, DSG2, CTTN, FLII, FLNA, FLNB, GSN, HSP90AB1, ABLIM1, LMO7, MYO1B, MYL6, MYO1C, MYO1E, MYO5A, MYO5B, PPP1R12A, PPP1R12B, PIK3C2A, PLEC, PPP1CA, PPP1CB, PPP1CC, TWF1, RAP1A, SIPA1, SPTAN1, SPTBN1, SPTBN2, SSFA2, SVIL, TMOD1, TPM1, TPM2, TPM3, TPM4, CORO2A, LUZP1, SORBS2, MYH9, SMC3, LIMA1, MYO19, LRRFIP1, LRRFIP2, TJP2, CLINT1, ARHGAP11A, ARHGEF17, SEC16A, WDR1, ARPC4, ARPC3, ACTR3, ACTR2, ARPC2, CEPT1, BASP1, GAS2L1, ASCC3, TRIOBP, AKAP2, SYNPO, LIMCH1, SIPA1L3, MPRIP, COBL, SPECC1L, CORO1C, ZDHHC5, PLEKHG3, SIPA1L1, RAI14, TES, ZBTB20, RPS6KC1, GOLIM4, PACSIN3, TMOD3, KCTD3, GTSE1, NCKIPSD, OXR1, BMP2K, MYO5C, CORO1B, CGN, ARHGAP21, AFAP1, INF2, CYBRD1, ARPC5L, LZTS2, PPP1R9B, SSH2, NEXN, SPECC1, MISP, PTGR2, PPP1R18, TPRN, MYO18A, MROH6, RCC2, MCM2, SNW1, CDC5L, EID1, U2AF2, EGFR, AHSA1, C1orf131, HECTD1, MYL3, PPP2R2D, CDK15, TRPC4AP, DNM1L, SOD1, TRIM25, BRCA1 | RASGRF1 | MARK3, YWHAB, HRAS, PPP1R9B, MYC, EHD4, ADRBK1, CEBPA, SNRNP70, SRC, SRPK2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for IQGAP1_RASGRF1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | IQGAP1 | P46940 | DB11638 | Artenimol | Ras GTPase-activating-like protein IQGAP1 | small molecule | approved|investigational |
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RelatedDiseases for IQGAP1_RASGRF1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | IQGAP1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Hgene | IQGAP1 | C0043094 | Weight Gain | 1 | CTD_human |
| Hgene | IQGAP1 | C2239176 | Liver carcinoma | 1 | CTD_human |
| Tgene | RASGRF1 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Tgene | RASGRF1 | C0013386 | Dyskinesia, Drug-Induced | 1 | CTD_human |
| Tgene | RASGRF1 | C0027092 | Myopia | 1 | CTD_human |
| Tgene | RASGRF1 | C0034951 | Refractive Errors | 1 | CTD_human |
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