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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17677

FusionGeneSummary for IQCK_IQCK

check button Fusion gene summary
Fusion gene informationFusion gene name: IQCK_IQCK
Fusion gene ID: 17677
HgeneTgene
Gene symbol

IQCK

IQCK

Gene ID

124152

124152

Gene nameIQ motif containing KIQ motif containing K
Synonyms--
Cytomap

16p12.3

16p12.3

Type of geneprotein-codingprotein-coding
DescriptionIQ domain-containing protein KIQ domain-containing protein K
Modification date2018051920180519
UniProtAcc

Q8N0W5

Q8N0W5

Ensembl transtripts involved in fusion geneENST00000320394, ENST00000564186, 
ENST00000541926, ENST00000433597, 
ENST00000562762, 		ENST00000320394, 
ENST00000564186, ENST00000541926, 
ENST00000433597, ENST00000562762, 
Fusion gene scores* DoF score4 X 6 X 3=723 X 5 X 3=45
# samples 76
** MAII scorelog2(7/72*10)=-0.0406419844973459
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/45*10)=0.415037499278844
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: IQCK [Title/Abstract] AND IQCK [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI520470IQCKchr16

19729632

-IQCKchr16

19745027

+
ChiTaRS3.1BI520472IQCKchr16

19729630

-IQCKchr16

19745024

+
ChiTaRS3.1BU673976IQCKchr16

19868392

-IQCKchr16

19868251

+
ChiTaRS3.1CN478643IQCKchr16

19868392

-IQCKchr16

19868251

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000320394ENST00000320394IQCKchr16

19729632

-IQCKchr16

19745027

+
Frame-shiftENST00000320394ENST00000564186IQCKchr16

19729632

-IQCKchr16

19745027

+
Frame-shiftENST00000320394ENST00000541926IQCKchr16

19729632

-IQCKchr16

19745027

+
5CDS-5UTRENST00000320394ENST00000433597IQCKchr16

19729632

-IQCKchr16

19745027

+
5CDS-intronENST00000320394ENST00000562762IQCKchr16

19729632

-IQCKchr16

19745027

+
Frame-shiftENST00000564186ENST00000320394IQCKchr16

19729632

-IQCKchr16

19745027

+
Frame-shiftENST00000564186ENST00000564186IQCKchr16

19729632

-IQCKchr16

19745027

+
Frame-shiftENST00000564186ENST00000541926IQCKchr16

19729632

-IQCKchr16

19745027

+
5CDS-5UTRENST00000564186ENST00000433597IQCKchr16

19729632

-IQCKchr16

19745027

+
5CDS-intronENST00000564186ENST00000562762IQCKchr16

19729632

-IQCKchr16

19745027

+
Frame-shiftENST00000541926ENST00000320394IQCKchr16

19729632

-IQCKchr16

19745027

+
Frame-shiftENST00000541926ENST00000564186IQCKchr16

19729632

-IQCKchr16

19745027

+
Frame-shiftENST00000541926ENST00000541926IQCKchr16

19729632

-IQCKchr16

19745027

+
5CDS-5UTRENST00000541926ENST00000433597IQCKchr16

19729632

-IQCKchr16

19745027

+
5CDS-intronENST00000541926ENST00000562762IQCKchr16

19729632

-IQCKchr16

19745027

+
intron-3CDSENST00000433597ENST00000320394IQCKchr16

19729632

-IQCKchr16

19745027

+
intron-3CDSENST00000433597ENST00000564186IQCKchr16

19729632

-IQCKchr16

19745027

+
intron-3CDSENST00000433597ENST00000541926IQCKchr16

19729632

-IQCKchr16

19745027

+
intron-5UTRENST00000433597ENST00000433597IQCKchr16

19729632

-IQCKchr16

19745027

+
intron-intronENST00000433597ENST00000562762IQCKchr16

19729632

-IQCKchr16

19745027

+
intron-3CDSENST00000562762ENST00000320394IQCKchr16

19729632

-IQCKchr16

19745027

+
intron-3CDSENST00000562762ENST00000564186IQCKchr16

19729632

-IQCKchr16

19745027

+
intron-3CDSENST00000562762ENST00000541926IQCKchr16

19729632

-IQCKchr16

19745027

+
intron-5UTRENST00000562762ENST00000433597IQCKchr16

19729632

-IQCKchr16

19745027

+
intron-intronENST00000562762ENST00000562762IQCKchr16

19729632

-IQCKchr16

19745027

+
Frame-shiftENST00000320394ENST00000320394IQCKchr16

19729630

-IQCKchr16

19745024

+
Frame-shiftENST00000320394ENST00000564186IQCKchr16

19729630

-IQCKchr16

19745024

+
Frame-shiftENST00000320394ENST00000541926IQCKchr16

19729630

-IQCKchr16

19745024

+
5CDS-5UTRENST00000320394ENST00000433597IQCKchr16

19729630

-IQCKchr16

19745024

+
5CDS-intronENST00000320394ENST00000562762IQCKchr16

19729630

-IQCKchr16

19745024

+
Frame-shiftENST00000564186ENST00000320394IQCKchr16

19729630

-IQCKchr16

19745024

+
Frame-shiftENST00000564186ENST00000564186IQCKchr16

19729630

-IQCKchr16

19745024

+
Frame-shiftENST00000564186ENST00000541926IQCKchr16

19729630

-IQCKchr16

19745024

+
5CDS-5UTRENST00000564186ENST00000433597IQCKchr16

19729630

-IQCKchr16

19745024

+
5CDS-intronENST00000564186ENST00000562762IQCKchr16

19729630

-IQCKchr16

19745024

+
Frame-shiftENST00000541926ENST00000320394IQCKchr16

19729630

-IQCKchr16

19745024

+
Frame-shiftENST00000541926ENST00000564186IQCKchr16

19729630

-IQCKchr16

19745024

+
Frame-shiftENST00000541926ENST00000541926IQCKchr16

19729630

-IQCKchr16

19745024

+
5CDS-5UTRENST00000541926ENST00000433597IQCKchr16

19729630

-IQCKchr16

19745024

+
5CDS-intronENST00000541926ENST00000562762IQCKchr16

19729630

-IQCKchr16

19745024

+
intron-3CDSENST00000433597ENST00000320394IQCKchr16

19729630

-IQCKchr16

19745024

+
intron-3CDSENST00000433597ENST00000564186IQCKchr16

19729630

-IQCKchr16

19745024

+
intron-3CDSENST00000433597ENST00000541926IQCKchr16

19729630

-IQCKchr16

19745024

+
intron-5UTRENST00000433597ENST00000433597IQCKchr16

19729630

-IQCKchr16

19745024

+
intron-intronENST00000433597ENST00000562762IQCKchr16

19729630

-IQCKchr16

19745024

+
intron-3CDSENST00000562762ENST00000320394IQCKchr16

19729630

-IQCKchr16

19745024

+
intron-3CDSENST00000562762ENST00000564186IQCKchr16

19729630

-IQCKchr16

19745024

+
intron-3CDSENST00000562762ENST00000541926IQCKchr16

19729630

-IQCKchr16

19745024

+
intron-5UTRENST00000562762ENST00000433597IQCKchr16

19729630

-IQCKchr16

19745024

+
intron-intronENST00000562762ENST00000562762IQCKchr16

19729630

-IQCKchr16

19745024

+
3UTR-3UTRENST00000320394ENST00000320394IQCKchr16

19868392

-IQCKchr16

19868251

+
3UTR-intronENST00000320394ENST00000564186IQCKchr16

19868392

-IQCKchr16

19868251

+
3UTR-intronENST00000320394ENST00000541926IQCKchr16

19868392

-IQCKchr16

19868251

+
3UTR-intronENST00000320394ENST00000433597IQCKchr16

19868392

-IQCKchr16

19868251

+
3UTR-intronENST00000320394ENST00000562762IQCKchr16

19868392

-IQCKchr16

19868251

+
intron-3UTRENST00000564186ENST00000320394IQCKchr16

19868392

-IQCKchr16

19868251

+
intron-intronENST00000564186ENST00000564186IQCKchr16

19868392

-IQCKchr16

19868251

+
intron-intronENST00000564186ENST00000541926IQCKchr16

19868392

-IQCKchr16

19868251

+
intron-intronENST00000564186ENST00000433597IQCKchr16

19868392

-IQCKchr16

19868251

+
intron-intronENST00000564186ENST00000562762IQCKchr16

19868392

-IQCKchr16

19868251

+
intron-3UTRENST00000541926ENST00000320394IQCKchr16

19868392

-IQCKchr16

19868251

+
intron-intronENST00000541926ENST00000564186IQCKchr16

19868392

-IQCKchr16

19868251

+
intron-intronENST00000541926ENST00000541926IQCKchr16

19868392

-IQCKchr16

19868251

+
intron-intronENST00000541926ENST00000433597IQCKchr16

19868392

-IQCKchr16

19868251

+
intron-intronENST00000541926ENST00000562762IQCKchr16

19868392

-IQCKchr16

19868251

+
intron-3UTRENST00000433597ENST00000320394IQCKchr16

19868392

-IQCKchr16

19868251

+
intron-intronENST00000433597ENST00000564186IQCKchr16

19868392

-IQCKchr16

19868251

+
intron-intronENST00000433597ENST00000541926IQCKchr16

19868392

-IQCKchr16

19868251

+
intron-intronENST00000433597ENST00000433597IQCKchr16

19868392

-IQCKchr16

19868251

+
intron-intronENST00000433597ENST00000562762IQCKchr16

19868392

-IQCKchr16

19868251

+
intron-3UTRENST00000562762ENST00000320394IQCKchr16

19868392

-IQCKchr16

19868251

+
intron-intronENST00000562762ENST00000564186IQCKchr16

19868392

-IQCKchr16

19868251

+
intron-intronENST00000562762ENST00000541926IQCKchr16

19868392

-IQCKchr16

19868251

+
intron-intronENST00000562762ENST00000433597IQCKchr16

19868392

-IQCKchr16

19868251

+
intron-intronENST00000562762ENST00000562762IQCKchr16

19868392

-IQCKchr16

19868251

+

Top

FusionProtFeatures for IQCK_IQCK


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IQCK

Q8N0W5

IQCK

Q8N0W5


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for IQCK_IQCK


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for IQCK_IQCK


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
IQCKNCOA3IQCKNCOA3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for IQCK_IQCK


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for IQCK_IQCK


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource