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Fusion gene ID: 17675 |
FusionGeneSummary for IQCK_BCAR4 |
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Fusion gene information | Fusion gene name: IQCK_BCAR4 | Fusion gene ID: 17675 | Hgene | Tgene | Gene symbol | IQCK | BCAR4 | Gene ID | 124152 | 400500 |
Gene name | IQ motif containing K | breast cancer anti-estrogen resistance 4 | |
Synonyms | - | - | |
Cytomap | 16p12.3 | 16p13.13 | |
Type of gene | protein-coding | ncRNA | |
Description | IQ domain-containing protein K | breast cancer anti-estrogen resistance 4 (non-protein coding)breast cancer antiestrogen resistance 4 protein | |
Modification date | 20180519 | 20180517 | |
UniProtAcc | Q8N0W5 | ||
Ensembl transtripts involved in fusion gene | ENST00000320394, ENST00000564186, ENST00000541926, ENST00000433597, ENST00000562762, | ENST00000573319, | |
Fusion gene scores | * DoF score | 4 X 6 X 3=72 | 15 X 4 X 8=480 |
# samples | 7 | 15 | |
** MAII score | log2(7/72*10)=-0.0406419844973459 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(15/480*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: IQCK [Title/Abstract] AND BCAR4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BLCA | TCGA-4Z-AA84-01A | IQCK | chr16 | 19745150 | + | BCAR4 | chr16 | 11914322 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000320394 | ENST00000573319 | IQCK | chr16 | 19745150 | + | BCAR4 | chr16 | 11914322 | - |
5CDS-intron | ENST00000564186 | ENST00000573319 | IQCK | chr16 | 19745150 | + | BCAR4 | chr16 | 11914322 | - |
5CDS-intron | ENST00000541926 | ENST00000573319 | IQCK | chr16 | 19745150 | + | BCAR4 | chr16 | 11914322 | - |
5CDS-intron | ENST00000433597 | ENST00000573319 | IQCK | chr16 | 19745150 | + | BCAR4 | chr16 | 11914322 | - |
intron-intron | ENST00000562762 | ENST00000573319 | IQCK | chr16 | 19745150 | + | BCAR4 | chr16 | 11914322 | - |
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FusionProtFeatures for IQCK_BCAR4 |
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Hgene | Tgene |
IQCK | BCAR4 |
Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for IQCK_BCAR4 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for IQCK_BCAR4 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
IQCK | NCOA3 | BCAR4 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for IQCK_BCAR4 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for IQCK_BCAR4 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | BCAR4 | C1458155 | Mammary Neoplasms | 2 | CTD_human |