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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17645

FusionGeneSummary for IPO9_CSRP1

check button Fusion gene summary
Fusion gene informationFusion gene name: IPO9_CSRP1
Fusion gene ID: 17645
HgeneTgene
Gene symbol

IPO9

CSRP1

Gene ID

55705

1465

Gene nameimportin 9cysteine and glycine rich protein 1
SynonymsImp9CRP|CRP1|CSRP|CYRP|D1S181E|HEL-141|HEL-S-286
Cytomap

1q32.1

1q32.1

Type of geneprotein-codingprotein-coding
Descriptionimportin-9ran-binding protein 9ranBP9cysteine and glycine-rich protein 1LIM-domain proteincysteine-rich protein 1epididymis luminal protein 141epididymis secretory protein Li 286
Modification date2018052320180519
UniProtAcc

Q96P70

P21291

Ensembl transtripts involved in fusion geneENST00000361565, ENST00000464348, 
ENST00000367306, ENST00000340006, 
ENST00000531916, ENST00000532460, 
ENST00000533432, ENST00000526723, 
ENST00000458271, 
Fusion gene scores* DoF score4 X 4 X 3=484 X 6 X 4=96
# samples 46
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IPO9 [Title/Abstract] AND CSRP1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDHNSCTCGA-CV-5979-01AIPO9chr1

201840455

+CSRP1chr1

201465432

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000361565ENST00000367306IPO9chr1

201840455

+CSRP1chr1

201465432

-
5CDS-5UTRENST00000361565ENST00000340006IPO9chr1

201840455

+CSRP1chr1

201465432

-
5CDS-5UTRENST00000361565ENST00000531916IPO9chr1

201840455

+CSRP1chr1

201465432

-
5CDS-5UTRENST00000361565ENST00000532460IPO9chr1

201840455

+CSRP1chr1

201465432

-
5CDS-5UTRENST00000361565ENST00000533432IPO9chr1

201840455

+CSRP1chr1

201465432

-
5CDS-5UTRENST00000361565ENST00000526723IPO9chr1

201840455

+CSRP1chr1

201465432

-
5CDS-5UTRENST00000361565ENST00000458271IPO9chr1

201840455

+CSRP1chr1

201465432

-
intron-5UTRENST00000464348ENST00000367306IPO9chr1

201840455

+CSRP1chr1

201465432

-
intron-5UTRENST00000464348ENST00000340006IPO9chr1

201840455

+CSRP1chr1

201465432

-
intron-5UTRENST00000464348ENST00000531916IPO9chr1

201840455

+CSRP1chr1

201465432

-
intron-5UTRENST00000464348ENST00000532460IPO9chr1

201840455

+CSRP1chr1

201465432

-
intron-5UTRENST00000464348ENST00000533432IPO9chr1

201840455

+CSRP1chr1

201465432

-
intron-5UTRENST00000464348ENST00000526723IPO9chr1

201840455

+CSRP1chr1

201465432

-
intron-5UTRENST00000464348ENST00000458271IPO9chr1

201840455

+CSRP1chr1

201465432

-

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FusionProtFeatures for IPO9_CSRP1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IPO9

Q96P70

CSRP1

P21291

Could play a role in neuronal development.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for IPO9_CSRP1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for IPO9_CSRP1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
IPO9USP49, MEPCE, RPAP1, PMS1, MYC, APP, NAP1L1, KPNB1, ECT2, CA9, CFTR, NPM1, EGFR, GNPDA1, HMGB3, HEXB, MCTS1, PDCD6IP, SRP14, TNPO3, TUFM, TWF1, USP5, NOL3, PLIN3, TNPO1, FAF2, ADORA3, VTI1B, COMTD1, TNFSF13B, PNKD, PTGER3, HIST1H2BA, UNK, IPO7, CAND1, CANX, COPB1, EPRS, HSP90B1, IDH3A, IPO5, IPO8, KPNA3, KPNA4, POLR3A, POLR3B, PRKCSH, PSMD2, RAB1A, RAN, RCN1, RPN2, SMARCA5, SSR4, XPO1, RPN1, NTRK1, HIST1H2BG, RPGRIP1L, DCTN1, CEP19, RPGRIP1, CENPJ, SORT1, XRCC3, USP37, SNW1, CDC5L, ZNF746, PTPMT1, H2AFX, SIGLECL1, H2AFY2, TMEM206, AKIRIN2, CHRM4, CHRM3, FZD10, HTR2C, KLHDC2, BROX, PTPRE, STOM, MTNR1A, MTNR1BCSRP1CSRP1, EGFR, APP, GRB2, ACTN1, BAG3, YBX3, MACF1, PRKAR2A, SUZ12, RNF2, BMI1, ACAA2, CFL1, HSPB1, NUP214, UFM1, FUBP3, TALDO1, ESR1, CNTRL, ASCC2, ASCC1, TRIP4, TES


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for IPO9_CSRP1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneCSRP1P21291DB11638ArtenimolCysteine and glycine-rich protein 1small moleculeapproved|investigational

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RelatedDiseases for IPO9_CSRP1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCSRP1C0005586Bipolar Disorder1PSYGENET
TgeneCSRP1C0014173Endometrial Hyperplasia1CTD_human
TgeneCSRP1C0033578Prostatic Neoplasms1CTD_human
TgeneCSRP1C0746402manic symptom1PSYGENET