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Fusion gene ID: 17641 |
FusionGeneSummary for IPO7_WEE1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: IPO7_WEE1 | Fusion gene ID: 17641 | Hgene | Tgene | Gene symbol | IPO7 | WEE1 | Gene ID | 10527 | 7465 |
| Gene name | importin 7 | WEE1 G2 checkpoint kinase | |
| Synonyms | Imp7|RANBP7 | WEE1A|WEE1hu | |
| Cytomap | 11p15.4 | 11p15.4 | |
| Type of gene | protein-coding | protein-coding | |
| Description | importin-7RAN-binding protein 7 | wee1-like protein kinaseWEE1 homologWEE1+ homologwee1A kinase | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O95373 | P30291 | |
| Ensembl transtripts involved in fusion gene | ENST00000379719, ENST00000533680, | ENST00000450114, ENST00000299613, | |
| Fusion gene scores | * DoF score | 8 X 5 X 5=200 | 4 X 3 X 5=60 |
| # samples | 9 | 5 | |
| ** MAII score | log2(9/200*10)=-1.15200309344505 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: IPO7 [Title/Abstract] AND WEE1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-22-4593-01A | IPO7 | chr11 | 9406394 | + | WEE1 | chr11 | 9597435 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000379719 | ENST00000450114 | IPO7 | chr11 | 9406394 | + | WEE1 | chr11 | 9597435 | + |
| 5CDS-5UTR | ENST00000379719 | ENST00000299613 | IPO7 | chr11 | 9406394 | + | WEE1 | chr11 | 9597435 | + |
| intron-3CDS | ENST00000533680 | ENST00000450114 | IPO7 | chr11 | 9406394 | + | WEE1 | chr11 | 9597435 | + |
| intron-5UTR | ENST00000533680 | ENST00000299613 | IPO7 | chr11 | 9406394 | + | WEE1 | chr11 | 9597435 | + |
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FusionProtFeatures for IPO7_WEE1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| IPO7 | WEE1 |
| Functions in nuclear protein import, either by acting asautonomous nuclear transport receptor or as an adapter-likeprotein in association with the importin-beta subunit KPNB1.Acting autonomously, is thought to serve itself as receptor fornuclear localization signals (NLS) and to promote translocation ofimport substrates through the nuclear pore complex (NPC) by anenergy requiring, Ran-dependent mechanism. At the nucleoplasmicside of the NPC, Ran binds to importin, the importin/substratecomplex dissociates and importin is re-exported from the nucleusto the cytoplasm where GTP hydrolysis releases Ran. Thedirectionality of nuclear import is thought to be conferred by anasymmetric distribution of the GTP- and GDP-bound forms of Ranbetween the cytoplasm and nucleus. Mediates autonomously thenuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Bindsto a beta-like import receptor binding (BIB) domain of RPL23A. Inassociation with KPNB1 mediates the nuclear import of H1 histoneand the Ran-binding site of IPO7 is not required but synergizeswith that of KPNB1 in importin/substrate complex dissociation. Invitro, mediates nuclear import of H2A, H2B, H3 and H4 histones.{ECO:0000269|PubMed:10228156, ECO:0000269|PubMed:9687515}. (Microbial infection) Mediates the nuclear import ofHIV-1 reverse transcription complex (RTC) integrase. Binds andmediates the nuclear import of HIV-1 Rev.{ECO:0000269|PubMed:12853482, ECO:0000269|PubMed:16704975}. | Acts as a negative regulator of entry into mitosis (G2to M transition) by protecting the nucleus from cytoplasmicallyactivated cyclin B1-complexed CDK1 before the onset of mitosis bymediating phosphorylation of CDK1 on 'Tyr-15'. Specificallyphosphorylates and inactivates cyclin B1-complexed CDK1 reaching amaximum during G2 phase and a minimum as cells enter M phase.Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15'and phosphorylation of monomeric CDK1 does not occur. Its activityincreases during S and G2 phases and decreases at M phase when itis hyperphosphorylated. A correlated decrease in protein leveloccurs at M/G1 phase, probably due to its degradation. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >WEE1 | chr11:9406394 | chr11:9597435 | ENST00000299613 | + | 0 | 11 | 34_43 | -22 | 433 | Compositional bias | Note=Poly-Glu |
| Tgene | >WEE1 | chr11:9406394 | chr11:9597435 | ENST00000299613 | + | 0 | 11 | 9_12 | -22 | 433 | Compositional bias | Note=Poly-Pro |
| Tgene | >WEE1 | chr11:9406394 | chr11:9597435 | ENST00000299613 | + | 0 | 11 | 299_569 | -22 | 433 | Domain | Protein kinase |
| Tgene | >WEE1 | chr11:9406394 | chr11:9597435 | ENST00000450114 | + | 0 | 11 | 299_569 | 192 | 647 | Domain | Protein kinase |
| Tgene | >WEE1 | chr11:9406394 | chr11:9597435 | ENST00000299613 | + | 0 | 11 | 305_313 | -22 | 433 | Nucleotide binding | ATP |
| Tgene | >WEE1 | chr11:9406394 | chr11:9597435 | ENST00000450114 | + | 0 | 11 | 305_313 | 192 | 647 | Nucleotide binding | ATP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >IPO7 | chr11:9406394 | chr11:9597435 | ENST00000379719 | + | 1 | 25 | 885_957 | 28 | 1039 | Compositional bias | Note=Asp-rich |
| Hgene | >IPO7 | chr11:9406394 | chr11:9597435 | ENST00000379719 | + | 1 | 25 | 22_101 | 28 | 1039 | Domain | Importin N-terminal |
| Tgene | WEE1 | chr11:9406394 | chr11:9597435 | ENST00000450114 | + | 0 | 11 | 34_43 | 192 | 647 | Compositional bias | Note=Poly-Glu |
| Tgene | WEE1 | chr11:9406394 | chr11:9597435 | ENST00000450114 | + | 0 | 11 | 9_12 | 192 | 647 | Compositional bias | Note=Poly-Pro |
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FusionGeneSequence for IPO7_WEE1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_IPO7_ENST00000379719_chr11_9406394_+_WEE1_ENST00000450114_chr11_9597435_+_483aa MDPNTIIEALRGTMDPALREAAERQLNESLLSKARGIDSSSVKLRGSSLFMDTEKSGKREFDVRQTPQVNINPFTPDSLLLHSSGQCRRR KRTYWNDSCGEDMEASDYELEDETRPAKRITITESNMKSRYTTEFHELEKIGSGEFGSVFKCVKRLDGCIYAIKRSKKPLAGSVDEQNAL REVYAHAVLGQHSHVVRYFSAWAEDDHMLIQNEYCNGGSLADAISENYRIMSYFKEAELKDLLLQVGRGLRYIHSMSLVHMDIKPSNIFI SRTSIPNAASEEGDEDDWASNKVMFKIGDLGHVTRISSPQVEEGDSRFLANEVLQENYTHLPKADIFALALTVVCAAGAEPLPRNGDQWH EIRQGRLPRIPQVLSQEFTELLKVMIHPDPERRPSAMALVKHSVLLSASRKSAEQLRIELNAEKFKNSLLQKELKKAQMAKAAAEERALF |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_IPO7_ENST00000379719_chr11_9406394_+_WEE1_ENST00000450114_chr11_9597435_+_1449nt ATGGACCCCAACACCATTATCGAGGCCCTGCGGGGCACTATGGACCCAGCCCTGCGTGAGGCCGCGGAGCGCCAGCTCAATGAAAGTTTG CTCTCCAAAGCTCGGGGAATTGATTCCAGCTCTGTTAAACTCCGGGGTAGTTCTCTCTTCATGGATACAGAAAAATCAGGAAAAAGGGAA TTTGATGTGCGACAGACTCCTCAAGTGAATATTAATCCTTTTACTCCGGATTCTTTGTTGCTTCATTCCTCAGGACAGTGTCGTCGTAGA AAGAGAACGTATTGGAATGATTCCTGTGGTGAAGACATGGAAGCCAGTGATTATGAGCTTGAAGATGAAACAAGACCTGCTAAGAGAATT ACAATTACTGAAAGCAATATGAAGTCCCGGTATACAACAGAATTTCATGAGCTAGAGAAAATCGGCTCTGGAGAATTTGGTTCTGTATTT AAGTGTGTGAAGAGGCTGGATGGATGCATTTATGCCATTAAGCGATCAAAAAAGCCATTGGCGGGCTCTGTTGATGAGCAGAACGCTTTG AGAGAAGTATATGCTCATGCAGTGCTTGGACAGCATTCTCATGTAGTTCGATATTTCTCTGCGTGGGCAGAAGATGATCATATGCTTATA CAGAATGAATATTGTAATGGTGGAAGTTTAGCTGATGCTATAAGTGAAAACTACAGAATCATGAGTTACTTTAAAGAAGCAGAGTTGAAG GATCTCCTTTTGCAAGTTGGCCGAGGCTTGAGGTATATTCATTCAATGTCTTTGGTTCACATGGATATAAAACCTAGTAATATTTTCATA TCTCGAACCTCAATCCCAAATGCTGCCTCTGAAGAAGGAGACGAAGATGATTGGGCATCCAACAAAGTTATGTTTAAAATAGGTGATCTT GGGCATGTAACAAGGATCTCCAGTCCACAAGTTGAAGAGGGCGATAGTCGTTTTCTTGCAAATGAAGTTTTACAGGAGAATTATACCCAT CTACCAAAAGCAGATATTTTTGCGCTTGCCCTCACAGTGGTATGTGCTGCTGGTGCTGAACCTCTTCCGAGAAATGGAGATCAATGGCAT GAAATCAGACAGGGTAGATTACCTCGGATACCACAAGTGCTTTCCCAAGAATTTACAGAGTTGCTAAAAGTTATGATTCATCCAGATCCA GAGAGAAGACCTTCAGCAATGGCACTGGTAAAGCATTCAGTATTGCTGTCCGCTTCTAGAAAGAGTGCAGAACAATTACGAATAGAATTG AATGCCGAAAAGTTCAAAAATTCACTTTTACAAAAAGAACTCAAGAAAGCACAGATGGCAAAAGCTGCAGCTGAGGAAAGAGCACTCTTC ACTGACCGGATGGCCACTAGGTCCACCACCCAGAGTAATAGAACATCTCGACTTATTGGAAAGAAAATGAACCGCTCTGTCAGCCTTACT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_IPO7_ENST00000379719_chr11_9406394_+_WEE1_ENST00000450114_chr11_9597435_+_2196nt GTTCTATCCGGGGCCTTGGCGCTTCTCTTTCCTTTCGCGCCGGTTGCCGCTGCGGAGCGCGGCGGGTCCATGTGCGCAGTGAGTGGCGCT ATTCCTGGCCCAGTAGCACCCGAGCCCCGGGTTTGACCGAGTCCGCGCTGCGATGGACCCCAACACCATTATCGAGGCCCTGCGGGGCAC TATGGACCCAGCCCTGCGTGAGGCCGCGGAGCGCCAGCTCAATGAAAGTTTGCTCTCCAAAGCTCGGGGAATTGATTCCAGCTCTGTTAA ACTCCGGGGTAGTTCTCTCTTCATGGATACAGAAAAATCAGGAAAAAGGGAATTTGATGTGCGACAGACTCCTCAAGTGAATATTAATCC TTTTACTCCGGATTCTTTGTTGCTTCATTCCTCAGGACAGTGTCGTCGTAGAAAGAGAACGTATTGGAATGATTCCTGTGGTGAAGACAT GGAAGCCAGTGATTATGAGCTTGAAGATGAAACAAGACCTGCTAAGAGAATTACAATTACTGAAAGCAATATGAAGTCCCGGTATACAAC AGAATTTCATGAGCTAGAGAAAATCGGCTCTGGAGAATTTGGTTCTGTATTTAAGTGTGTGAAGAGGCTGGATGGATGCATTTATGCCAT TAAGCGATCAAAAAAGCCATTGGCGGGCTCTGTTGATGAGCAGAACGCTTTGAGAGAAGTATATGCTCATGCAGTGCTTGGACAGCATTC TCATGTAGTTCGATATTTCTCTGCGTGGGCAGAAGATGATCATATGCTTATACAGAATGAATATTGTAATGGTGGAAGTTTAGCTGATGC TATAAGTGAAAACTACAGAATCATGAGTTACTTTAAAGAAGCAGAGTTGAAGGATCTCCTTTTGCAAGTTGGCCGAGGCTTGAGGTATAT TCATTCAATGTCTTTGGTTCACATGGATATAAAACCTAGTAATATTTTCATATCTCGAACCTCAATCCCAAATGCTGCCTCTGAAGAAGG AGACGAAGATGATTGGGCATCCAACAAAGTTATGTTTAAAATAGGTGATCTTGGGCATGTAACAAGGATCTCCAGTCCACAAGTTGAAGA GGGCGATAGTCGTTTTCTTGCAAATGAAGTTTTACAGGAGAATTATACCCATCTACCAAAAGCAGATATTTTTGCGCTTGCCCTCACAGT GGTATGTGCTGCTGGTGCTGAACCTCTTCCGAGAAATGGAGATCAATGGCATGAAATCAGACAGGGTAGATTACCTCGGATACCACAAGT GCTTTCCCAAGAATTTACAGAGTTGCTAAAAGTTATGATTCATCCAGATCCAGAGAGAAGACCTTCAGCAATGGCACTGGTAAAGCATTC AGTATTGCTGTCCGCTTCTAGAAAGAGTGCAGAACAATTACGAATAGAATTGAATGCCGAAAAGTTCAAAAATTCACTTTTACAAAAAGA ACTCAAGAAAGCACAGATGGCAAAAGCTGCAGCTGAGGAAAGAGCACTCTTCACTGACCGGATGGCCACTAGGTCCACCACCCAGAGTAA TAGAACATCTCGACTTATTGGAAAGAAAATGAACCGCTCTGTCAGCCTTACTATATACTGAGCTACTCCTTTCCCACCTCCCCCTGAACA CTGTGACAAGAGGAAGCTAGGTTGAAATCACTGATAGAATCCAGTTTGCAATTACTTTCTCGATTGGTGTCAGTAGTTTTACTGATTAGG ACTTTTATTGTGAATTACAGTTGAAAGCTGTATTTTGATGATTGCTATGTCAGGCTTTCATCTAATCTTACCAGTCTGTCTTCTGTAGGA TGTGTCACTGTTGGATGTTACACCAGCCTTTCCAGGGTTAACCACTGTGGTGGTGTGCTGCTTATAGTTTGCTGTTGCATTGTAATAAAA GGTGTCTTTCCCTGTAGTGACCTGTAAAAAGTACTCAAGGGCTTTATTACAGACATACCCTCCCTTTGAAAAGGGACATGCTAAAAGACT CATTACTACTCAGCCTTCAATGTACCTGTGTGTCCATCTTATATTTCTTTTTTTTTTAATTGTGAATTAGACTTGTATATCCCACTGGGA GCACTTTGTAGGCATTGCATGAACCATGGGATGATGATTCTGTGGAGGTATTGCCTTGTGAATTTGCTGCTATTTTAGTTTTGTCTTTGC |
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FusionGenePPI for IPO7_WEE1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| IPO7 | SRP19, RPL23A, KPNB1, USP49, AIRE, UBC, MYC, RNF146, RAN, SIRT7, FBXO25, CDK2, IGBP1, CA9, METTL18, CFTR, SOX2, EGFR, FBXO6, APEH, CAND1, ELAC2, HARS, HSPA1L, HSPA4L, KARS, NFRKB, PFDN5, RNASEH2A, TNPO1, TRMT112, STAU1, MDM2, CCDC8, RNF2, ILK, RIC3, NUSAP1, VTI1B, COMTD1, CD274, TNFSF13B, ZBTB38, VSIG2, PNKD, RP2, EDA, PTGER3, RPS6KB2, UNK, HSP90AB1, HSPA8, HSPB1, IPO5, IPO9, SLC25A3, MPHOSPH10, PPM1G, NTRK1, IFI16, CEP162, LCA5, RPGRIP1L, SSX2IP, SPICE1, DCTN1, CEP19, RPGRIP1, CAPZA2, MAD2L1, NUP153, HDAC6, LIMA1, NUP107, VPS16, ASPM, MCM2, CDC5L, DUSP5, SIGLECL1, HP1BP3, AURKAIP1, FZD10, TMEM206, HTR2C, UXS1, CHRM3, PTPRE, TRIM25, G3BP1, BRCA1, TES | WEE1 | SFN, CDCA3, YWHAB, PIN1, CRK, FBXW11, BTRC, SKP2, NEDD4, ARRB2, MYC, MUS81, CSNK2B, CSNK2A1, BRSK2, PLK1, CDK1, PAXIP1, YWHAQ, CNBP, EEF2, PCBP1, SPTBN1, YEATS4, NUP160, XPO1, RUSC2, CEP350, WDFY3, BRPF3, CCNYL1, BRCA1, KDM5C, SMAD4, GATA3, RRM2, PIK3R1, HSP90AA1, CSNK1A1, KCTD3, BCR, USP15, KIF13B, SPAG9, MCM2, MCM4, CGN, DENND4C, CBY1, CHEK2, CHEK1, ADA, TOP1, TOP2A, TOP3A, DHFR, CDC73, TTN, RB1, ING4, FZR1, WRN, BLM, ATAD5, BRD4, FH, WEE1, CDKN1B, XRCC3, CDK12, CDC6, IMPDH1, TUBA1A, MTOR, TRIM25 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for IPO7_WEE1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for IPO7_WEE1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | IPO7 | C0019693 | HIV Infections | 1 | CTD_human |
| Tgene | WEE1 | C1168401 | Squamous cell carcinoma of the head and neck | 1 | CTD_human |
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