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Fusion gene ID: 17635 |
FusionGeneSummary for IPO7_CTR9 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: IPO7_CTR9 | Fusion gene ID: 17635 | Hgene | Tgene | Gene symbol | IPO7 | CTR9 | Gene ID | 10527 | 9646 |
| Gene name | importin 7 | CTR9 homolog, Paf1/RNA polymerase II complex component | |
| Synonyms | Imp7|RANBP7 | SH2BP1|TSBP|p150|p150TSP | |
| Cytomap | 11p15.4 | 11p15.4 | |
| Type of gene | protein-coding | protein-coding | |
| Description | importin-7RAN-binding protein 7 | RNA polymerase-associated protein CTR9 homologCtr9, Paf1/RNA polymerase II complex component, homologSH2 domain binding protein 1 (tetratricopeptide repeat containing)TPR-containing, SH2-binding phosphoprotein | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O95373 | Q6PD62 | |
| Ensembl transtripts involved in fusion gene | ENST00000379719, ENST00000533680, | ENST00000361367, | |
| Fusion gene scores | * DoF score | 8 X 5 X 5=200 | 2 X 2 X 2=8 |
| # samples | 9 | 2 | |
| ** MAII score | log2(9/200*10)=-1.15200309344505 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: IPO7 [Title/Abstract] AND CTR9 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CTR9 | GO:0010390 | histone monoubiquitination | 16307923 |
| Tgene | CTR9 | GO:0019827 | stem cell population maintenance | 19345177 |
| Tgene | CTR9 | GO:0032968 | positive regulation of transcription elongation from RNA polymerase II promoter | 20178742 |
| Tgene | CTR9 | GO:0033523 | histone H2B ubiquitination | 16307923 |
| Tgene | CTR9 | GO:0045638 | negative regulation of myeloid cell differentiation | 20541477 |
| Tgene | CTR9 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 20178742 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-WE-A8K5-06A | IPO7 | chr11 | 9406394 | + | CTR9 | chr11 | 10774219 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000379719 | ENST00000361367 | IPO7 | chr11 | 9406394 | + | CTR9 | chr11 | 10774219 | + |
| intron-3CDS | ENST00000533680 | ENST00000361367 | IPO7 | chr11 | 9406394 | + | CTR9 | chr11 | 10774219 | + |
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FusionProtFeatures for IPO7_CTR9 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| IPO7 | CTR9 |
| Functions in nuclear protein import, either by acting asautonomous nuclear transport receptor or as an adapter-likeprotein in association with the importin-beta subunit KPNB1.Acting autonomously, is thought to serve itself as receptor fornuclear localization signals (NLS) and to promote translocation ofimport substrates through the nuclear pore complex (NPC) by anenergy requiring, Ran-dependent mechanism. At the nucleoplasmicside of the NPC, Ran binds to importin, the importin/substratecomplex dissociates and importin is re-exported from the nucleusto the cytoplasm where GTP hydrolysis releases Ran. Thedirectionality of nuclear import is thought to be conferred by anasymmetric distribution of the GTP- and GDP-bound forms of Ranbetween the cytoplasm and nucleus. Mediates autonomously thenuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Bindsto a beta-like import receptor binding (BIB) domain of RPL23A. Inassociation with KPNB1 mediates the nuclear import of H1 histoneand the Ran-binding site of IPO7 is not required but synergizeswith that of KPNB1 in importin/substrate complex dissociation. Invitro, mediates nuclear import of H2A, H2B, H3 and H4 histones.{ECO:0000269|PubMed:10228156, ECO:0000269|PubMed:9687515}. (Microbial infection) Mediates the nuclear import ofHIV-1 reverse transcription complex (RTC) integrase. Binds andmediates the nuclear import of HIV-1 Rev.{ECO:0000269|PubMed:12853482, ECO:0000269|PubMed:16704975}. | Component of the PAF1 complex (PAF1C) which has multiplefunctions during transcription by RNA polymerase II and isimplicated in regulation of development and maintenance ofembryonic stem cell pluripotency. PAF1C associates with RNApolymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms andis involved in transcriptional elongation, acting bothindepentently and synergistically with TCEA1 and in cooperationwith the DSIF complex and HTATSF1. PAF1C is required fortranscription of Hox and Wnt target genes. PAF1C is involved inhematopoiesis and stimulates transcriptional activity ofKMT2A/MLL1; it promotes leukemogenesis through association withKMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histonemodifications such as ubiquitination of histone H2B andmethylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits theRNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzymeUBE2A or UBE2B to chromatin which mediate monoubiquitination of'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2Bubiquitination is proposed to be coupled to transcription. PAF1Cis involved in mRNA 3' end formation probably through associationwith cleavage and poly(A) factors. In case of infection byinfluenza A strain H3N2, PAF1C associates with viral NS1 protein,thereby regulating gene transcription. Required for mono- andtrimethylation on histone H3 'Lys-4' (H3K4me3) and dimethylationon histone H3 'Lys-79' (H3K4me3). Required for Hox genetranscription. Required for the trimethylation of histone H3 'Lys-4' (H3K4me3) on genes involved in stem cell pluripotency; thisfunction is synergistic with CXXC1 indicative for an involvementof the SET1 complex. Involved in transcriptional regulation ofIL6-responsive genes and in JAK-STAT pathway; may regulate DNA-association of STAT3 (By similarity). {ECO:0000250,ECO:0000269|PubMed:16024656, ECO:0000269|PubMed:16307923,ECO:0000269|PubMed:19345177, ECO:0000269|PubMed:19952111,ECO:0000269|PubMed:20178742, ECO:0000269|PubMed:20541477,ECO:0000269|PubMed:21329879}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >CTR9 | chr11:9406394 | chr11:10774219 | ENST00000361367 | + | 0 | 25 | 1015_1172 | 15 | 1174 | Compositional bias | Note=Ser-rich |
| Tgene | >CTR9 | chr11:9406394 | chr11:10774219 | ENST00000361367 | + | 0 | 25 | 844_1011 | 15 | 1174 | Compositional bias | Note=Lys-rich |
| Tgene | >CTR9 | chr11:9406394 | chr11:10774219 | ENST00000361367 | + | 0 | 25 | 904_908 | 15 | 1174 | Compositional bias | Note=Poly-Gly |
| Tgene | >CTR9 | chr11:9406394 | chr11:10774219 | ENST00000361367 | + | 0 | 25 | 933_936 | 15 | 1174 | Compositional bias | Note=Poly-Lys |
| Tgene | >CTR9 | chr11:9406394 | chr11:10774219 | ENST00000361367 | + | 0 | 25 | 956_959 | 15 | 1174 | Compositional bias | Note=Poly-Lys |
| Tgene | >CTR9 | chr11:9406394 | chr11:10774219 | ENST00000361367 | + | 0 | 25 | 129_162 | 15 | 1174 | Repeat | Note=TPR 2 |
| Tgene | >CTR9 | chr11:9406394 | chr11:10774219 | ENST00000361367 | + | 0 | 25 | 163_196 | 15 | 1174 | Repeat | Note=TPR 3 |
| Tgene | >CTR9 | chr11:9406394 | chr11:10774219 | ENST00000361367 | + | 0 | 25 | 198_231 | 15 | 1174 | Repeat | Note=TPR 4 |
| Tgene | >CTR9 | chr11:9406394 | chr11:10774219 | ENST00000361367 | + | 0 | 25 | 235_268 | 15 | 1174 | Repeat | Note=TPR 5 |
| Tgene | >CTR9 | chr11:9406394 | chr11:10774219 | ENST00000361367 | + | 0 | 25 | 306_339 | 15 | 1174 | Repeat | Note=TPR 6 |
| Tgene | >CTR9 | chr11:9406394 | chr11:10774219 | ENST00000361367 | + | 0 | 25 | 341_374 | 15 | 1174 | Repeat | Note=TPR 7 |
| Tgene | >CTR9 | chr11:9406394 | chr11:10774219 | ENST00000361367 | + | 0 | 25 | 412_444 | 15 | 1174 | Repeat | Note=TPR 8 |
| Tgene | >CTR9 | chr11:9406394 | chr11:10774219 | ENST00000361367 | + | 0 | 25 | 41_75 | 15 | 1174 | Repeat | Note=TPR 1 |
| Tgene | >CTR9 | chr11:9406394 | chr11:10774219 | ENST00000361367 | + | 0 | 25 | 451_484 | 15 | 1174 | Repeat | Note=TPR 9 |
| Tgene | >CTR9 | chr11:9406394 | chr11:10774219 | ENST00000361367 | + | 0 | 25 | 497_530 | 15 | 1174 | Repeat | Note=TPR 10 |
| Tgene | >CTR9 | chr11:9406394 | chr11:10774219 | ENST00000361367 | + | 0 | 25 | 531_564 | 15 | 1174 | Repeat | Note=TPR 11 |
| Tgene | >CTR9 | chr11:9406394 | chr11:10774219 | ENST00000361367 | + | 0 | 25 | 566_598 | 15 | 1174 | Repeat | Note=TPR 12 |
| Tgene | >CTR9 | chr11:9406394 | chr11:10774219 | ENST00000361367 | + | 0 | 25 | 613_646 | 15 | 1174 | Repeat | Note=TPR 13 |
| Tgene | >CTR9 | chr11:9406394 | chr11:10774219 | ENST00000361367 | + | 0 | 25 | 647_680 | 15 | 1174 | Repeat | Note=TPR 14 |
| Tgene | >CTR9 | chr11:9406394 | chr11:10774219 | ENST00000361367 | + | 0 | 25 | 681_714 | 15 | 1174 | Repeat | Note=TPR 15 |
| Tgene | >CTR9 | chr11:9406394 | chr11:10774219 | ENST00000361367 | + | 0 | 25 | 717_750 | 15 | 1174 | Repeat | Note=TPR 16 |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >IPO7 | chr11:9406394 | chr11:10774219 | ENST00000379719 | + | 1 | 25 | 885_957 | 28 | 1039 | Compositional bias | Note=Asp-rich |
| Hgene | >IPO7 | chr11:9406394 | chr11:10774219 | ENST00000379719 | + | 1 | 25 | 22_101 | 28 | 1039 | Domain | Importin N-terminal |
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FusionGeneSequence for IPO7_CTR9 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_IPO7_ENST00000379719_chr11_9406394_+_CTR9_ENST00000361367_chr11_10774219_+_1187aa MDPNTIIEALRGTMDPALREAAERQLNEVIELDFDQLPEGDEVISILKQEHTQLHIWIALALEYYKQGKTEEFVKLLEAARIDGNLDYRD HEKDQMTCLDTLAAYYVQQARKEKNKDNKKDLITQATLLYTMADKIIMYDQNHLLGRACFCLLEGDKMDQADAQFHFVLNQSPNNIPALL GKACISFNKKDYRGALAYYKKALRTNPGCPAEVRLGMGHCFVKLNKLEKARLAFSRALELNSKCVGALVGLAVLELNNKEADSIKNGVQL LSRAYTIDPSNPMVLNHLANHFFFKKDYSKVQHLALHAFHNTEVEAMQAESCYQLARSFHVQEDYDQAFQYYYQATQFASSSFVLPFFGL GQMYIYRGDKENASQCFEKVLKAYPNNYETMKILGSLYAASEDQEKRDIAKGHLKKVTEQYPDDVEAWIELAQILEQTDIQGALSAYGTA TRILQEKVQADVPPEILNNVGALHFRLGNLGEAKKYFLASLDRAKAEAEHDEHYYNAISVTTSYNLARLYEAMCEFHEAEKLYKNILREH PNYVDCYLRLGAMARDKGNFYEASDWFKEALQINQDHPDAWSLIGNLHLAKQEWGPGQKKFERILKQPSTQSDTYSMLALGNVWLQTLHQ PTRDREKEKRHQDRALAIYKQVLRNDAKNLYAANGIGAVLAHKGYFREARDVFAQVREATADISDVWLNLAHIYVEQKQYISAVQMYENC LRKFYKHQNTEVVLYLARALFKCGKLQECKQTLLKARHVAPSDTVLMFNVALVLQRLATSVLKDEKSNLKEVLNAVKELELAHRYFSYLS KVGDKMRFDLALAATEARQCSDLLSQAQYHVARARKQDEEERELRAKQEQEKELLRQKLLKEQEEKRLREKEEQKKLLEQRAQYVEKTKN ILMFTGETEATKEKKRGGGGGRRSKKGGEFDEFVNDDTDDDLPISKKKKRRKGSGSEQEGEDEEGGERKKKKRRRHPKGEEGSDDDETEN GPKPKKRRPPKAEKKKAPKPERLPPSMKGKIKSKAIISSSDDSSDEDKLKIADEGHPRNSNSNSDSDEDEQRKKCASSESDSDENQNKSG SEAGSPRRPRRQRSDQDSDSDQPSRKRRPSGSEQSDNESVQSGRSHSGVSENDSRPASPSAESDHESERGSDNEGSGQGSGNESEPEGSN |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_IPO7_ENST00000379719_chr11_9406394_+_CTR9_ENST00000361367_chr11_10774219_+_3561nt ATGGACCCCAACACCATTATCGAGGCCCTGCGGGGCACTATGGACCCAGCCCTGCGTGAGGCCGCGGAGCGCCAGCTCAATGAAGTCATT GAACTTGACTTCGATCAGTTACCGGAGGGAGATGAAGTTATCAGTATTCTGAAACAGGAACACACACAACTGCACATATGGATTGCTTTG GCGCTGGAATACTACAAGCAAGGAAAAACAGAAGAGTTTGTAAAATTGTTGGAAGCAGCACGTATAGATGGCAATTTGGACTATAGAGAC CATGAAAAAGACCAGATGACTTGCTTGGATACATTGGCAGCGTATTATGTACAACAGGCTCGGAAAGAAAAGAATAAGGACAATAAAAAG GATCTTATTACACAGGCCACCTTGTTGTATACAATGGCCGATAAAATTATTATGTATGATCAGAACCATTTGTTGGGAAGAGCCTGCTTC TGCCTACTTGAGGGTGACAAAATGGATCAAGCTGATGCACAGTTTCATTTTGTACTCAATCAGTCTCCAAATAATATTCCAGCCCTTCTT GGTAAAGCTTGCATTTCCTTCAACAAGAAGGATTACAGAGGAGCTCTTGCTTACTATAAGAAAGCATTGCGTACTAACCCAGGATGTCCA GCGGAAGTTCGTTTAGGAATGGGTCATTGCTTTGTGAAACTTAACAAACTGGAAAAAGCTCGTCTGGCATTCAGCAGAGCCCTGGAACTC AATTCCAAATGCGTGGGAGCATTGGTTGGACTGGCTGTTCTAGAACTCAACAATAAAGAGGCTGATTCCATTAAAAATGGTGTCCAGCTT CTTTCCAGAGCCTATACTATTGATCCTAGCAACCCTATGGTATTGAACCATTTGGCAAATCACTTTTTCTTCAAAAAGGATTATAGTAAA GTCCAGCATCTGGCCCTCCATGCATTCCATAATACAGAAGTGGAAGCTATGCAAGCAGAGAGCTGCTATCAGCTAGCTAGATCATTCCAT GTTCAGGAAGATTATGACCAAGCTTTTCAGTACTATTATCAAGCCACACAGTTTGCCTCATCCTCTTTTGTGCTCCCATTTTTTGGTTTG GGACAAATGTATATTTATCGAGGTGACAAAGAAAATGCATCTCAGTGCTTTGAGAAGGTTTTGAAAGCTTATCCTAATAATTACGAAACT ATGAAAATTCTCGGCTCTCTCTATGCTGCCTCAGAAGATCAAGAAAAACGAGATATTGCCAAGGGCCATTTGAAGAAGGTCACAGAACAG TATCCCGATGATGTTGAAGCTTGGATTGAATTGGCACAAATCTTAGAACAGACTGATATACAGGGTGCCCTTTCAGCCTATGGAACAGCA ACACGAATCCTTCAGGAGAAAGTGCAGGCCGATGTTCCTCCAGAGATTCTCAATAATGTGGGTGCCCTCCATTTTAGACTTGGAAACCTA GGGGAGGCTAAGAAATATTTTTTGGCGTCATTGGACCGTGCAAAAGCAGAAGCGGAACACGATGAGCATTACTATAACGCCATTTCCGTT ACCACGTCATATAATCTCGCCAGGCTATATGAGGCGATGTGTGAATTCCATGAAGCAGAAAAACTGTATAAAAACATCTTACGCGAACAT CCTAATTATGTTGACTGCTATTTGCGCCTAGGAGCCATGGCTAGAGATAAGGGAAACTTTTATGAGGCTTCAGATTGGTTTAAGGAAGCT CTTCAGATTAATCAGGATCATCCAGATGCTTGGTCTTTGATTGGCAATCTTCATTTGGCAAAACAAGAATGGGGTCCTGGGCAGAAGAAG TTTGAGAGGATATTAAAACAGCCATCCACACAGAGTGATACCTATTCTATGCTAGCCCTTGGCAACGTGTGGCTCCAAACTTTACATCAG CCCACCCGAGATCGAGAAAAGGAAAAGCGTCATCAAGATCGTGCTCTGGCCATCTACAAACAAGTACTCAGAAATGATGCAAAGAATCTG TATGCTGCCAATGGCATAGGAGCTGTTTTGGCCCACAAAGGATATTTTCGTGAAGCTCGTGATGTATTTGCCCAAGTAAGAGAAGCAACA GCAGATATTAGTGATGTGTGGCTGAACTTAGCACACATCTATGTGGAGCAAAAGCAGTACATCAGCGCCGTTCAGATGTATGAAAACTGC CTCCGAAAGTTCTATAAGCACCAAAACACTGAAGTTGTACTCTATTTGGCCCGGGCCCTCTTCAAGTGTGGCAAGTTACAGGAATGCAAA CAGACTTTGCTGAAGGCTAGACATGTGGCACCCAGTGATACAGTTCTTATGTTTAATGTGGCCTTGGTCCTGCAAAGATTAGCTACCTCT GTCCTGAAAGATGAAAAAAGTAATCTGAAGGAAGTACTTAATGCTGTGAAAGAACTGGAGCTTGCACATAGATACTTCAGTTATTTGAGT AAAGTGGGAGATAAAATGAGATTTGATTTGGCCCTTGCTGCTACAGAAGCCAGGCAGTGTTCTGACTTACTGAGCCAGGCCCAGTACCAT GTGGCCCGGGCACGCAAACAAGATGAAGAAGAGCGGGAGCTGCGGGCCAAGCAAGAGCAAGAAAAGGAGCTGTTAAGGCAGAAACTTCTT AAAGAACAGGAAGAGAAACGTCTCAGAGAAAAGGAAGAGCAAAAGAAACTTTTGGAACAGCGGGCCCAGTATGTGGAGAAGACCAAAAAT ATTCTTATGTTTACTGGTGAGACTGAAGCAACAAAAGAGAAGAAAAGAGGTGGTGGTGGTGGACGGCGTTCTAAGAAGGGAGGAGAGTTT GATGAATTTGTCAATGATGACACTGATGATGACCTACCTATATCCAAAAAGAAGAAGAGAAGAAAGGGTAGTGGCAGTGAACAAGAAGGT GAAGATGAGGAGGGTGGTGAGAGAAAGAAGAAAAAGAGGAGAAGACATCCAAAGGGAGAAGAAGGATCTGATGATGATGAAACAGAAAAT GGCCCCAAACCAAAAAAACGACGTCCACCAAAAGCAGAGAAGAAAAAGGCTCCCAAGCCAGAACGTCTGCCTCCATCAATGAAGGGAAAA ATAAAATCCAAAGCCATAATTTCATCAAGTGATGACTCTTCGGATGAGGATAAACTTAAAATTGCTGATGAAGGACATCCCAGGAACAGC AACAGCAACAGTGACTCAGACGAGGACGAACAACGAAAGAAATGTGCCTCATCAGAGAGTGATTCCGATGAGAACCAGAACAAGTCTGGC AGCGAGGCCGGCAGTCCCCGGAGGCCACGAAGACAGCGGTCAGATCAGGACTCAGACAGTGACCAGCCATCCAGAAAGAGAAGGCCCTCC GGTTCTGAGCAGTCTGACAATGAATCTGTGCAGTCAGGGAGAAGCCACTCAGGAGTTTCTGAGAACGACTCTCGCCCAGCTTCTCCAAGT GCCGAATCAGATCACGAATCGGAGAGAGGATCTGATAATGAGGGTTCTGGCCAAGGCTCTGGAAATGAATCGGAACCAGAGGGATCCAAC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_IPO7_ENST00000379719_chr11_9406394_+_CTR9_ENST00000361367_chr11_10774219_+_4341nt GTTCTATCCGGGGCCTTGGCGCTTCTCTTTCCTTTCGCGCCGGTTGCCGCTGCGGAGCGCGGCGGGTCCATGTGCGCAGTGAGTGGCGCT ATTCCTGGCCCAGTAGCACCCGAGCCCCGGGTTTGACCGAGTCCGCGCTGCGATGGACCCCAACACCATTATCGAGGCCCTGCGGGGCAC TATGGACCCAGCCCTGCGTGAGGCCGCGGAGCGCCAGCTCAATGAAGTCATTGAACTTGACTTCGATCAGTTACCGGAGGGAGATGAAGT TATCAGTATTCTGAAACAGGAACACACACAACTGCACATATGGATTGCTTTGGCGCTGGAATACTACAAGCAAGGAAAAACAGAAGAGTT TGTAAAATTGTTGGAAGCAGCACGTATAGATGGCAATTTGGACTATAGAGACCATGAAAAAGACCAGATGACTTGCTTGGATACATTGGC AGCGTATTATGTACAACAGGCTCGGAAAGAAAAGAATAAGGACAATAAAAAGGATCTTATTACACAGGCCACCTTGTTGTATACAATGGC CGATAAAATTATTATGTATGATCAGAACCATTTGTTGGGAAGAGCCTGCTTCTGCCTACTTGAGGGTGACAAAATGGATCAAGCTGATGC ACAGTTTCATTTTGTACTCAATCAGTCTCCAAATAATATTCCAGCCCTTCTTGGTAAAGCTTGCATTTCCTTCAACAAGAAGGATTACAG AGGAGCTCTTGCTTACTATAAGAAAGCATTGCGTACTAACCCAGGATGTCCAGCGGAAGTTCGTTTAGGAATGGGTCATTGCTTTGTGAA ACTTAACAAACTGGAAAAAGCTCGTCTGGCATTCAGCAGAGCCCTGGAACTCAATTCCAAATGCGTGGGAGCATTGGTTGGACTGGCTGT TCTAGAACTCAACAATAAAGAGGCTGATTCCATTAAAAATGGTGTCCAGCTTCTTTCCAGAGCCTATACTATTGATCCTAGCAACCCTAT GGTATTGAACCATTTGGCAAATCACTTTTTCTTCAAAAAGGATTATAGTAAAGTCCAGCATCTGGCCCTCCATGCATTCCATAATACAGA AGTGGAAGCTATGCAAGCAGAGAGCTGCTATCAGCTAGCTAGATCATTCCATGTTCAGGAAGATTATGACCAAGCTTTTCAGTACTATTA TCAAGCCACACAGTTTGCCTCATCCTCTTTTGTGCTCCCATTTTTTGGTTTGGGACAAATGTATATTTATCGAGGTGACAAAGAAAATGC ATCTCAGTGCTTTGAGAAGGTTTTGAAAGCTTATCCTAATAATTACGAAACTATGAAAATTCTCGGCTCTCTCTATGCTGCCTCAGAAGA TCAAGAAAAACGAGATATTGCCAAGGGCCATTTGAAGAAGGTCACAGAACAGTATCCCGATGATGTTGAAGCTTGGATTGAATTGGCACA AATCTTAGAACAGACTGATATACAGGGTGCCCTTTCAGCCTATGGAACAGCAACACGAATCCTTCAGGAGAAAGTGCAGGCCGATGTTCC TCCAGAGATTCTCAATAATGTGGGTGCCCTCCATTTTAGACTTGGAAACCTAGGGGAGGCTAAGAAATATTTTTTGGCGTCATTGGACCG TGCAAAAGCAGAAGCGGAACACGATGAGCATTACTATAACGCCATTTCCGTTACCACGTCATATAATCTCGCCAGGCTATATGAGGCGAT GTGTGAATTCCATGAAGCAGAAAAACTGTATAAAAACATCTTACGCGAACATCCTAATTATGTTGACTGCTATTTGCGCCTAGGAGCCAT GGCTAGAGATAAGGGAAACTTTTATGAGGCTTCAGATTGGTTTAAGGAAGCTCTTCAGATTAATCAGGATCATCCAGATGCTTGGTCTTT GATTGGCAATCTTCATTTGGCAAAACAAGAATGGGGTCCTGGGCAGAAGAAGTTTGAGAGGATATTAAAACAGCCATCCACACAGAGTGA TACCTATTCTATGCTAGCCCTTGGCAACGTGTGGCTCCAAACTTTACATCAGCCCACCCGAGATCGAGAAAAGGAAAAGCGTCATCAAGA TCGTGCTCTGGCCATCTACAAACAAGTACTCAGAAATGATGCAAAGAATCTGTATGCTGCCAATGGCATAGGAGCTGTTTTGGCCCACAA AGGATATTTTCGTGAAGCTCGTGATGTATTTGCCCAAGTAAGAGAAGCAACAGCAGATATTAGTGATGTGTGGCTGAACTTAGCACACAT CTATGTGGAGCAAAAGCAGTACATCAGCGCCGTTCAGATGTATGAAAACTGCCTCCGAAAGTTCTATAAGCACCAAAACACTGAAGTTGT ACTCTATTTGGCCCGGGCCCTCTTCAAGTGTGGCAAGTTACAGGAATGCAAACAGACTTTGCTGAAGGCTAGACATGTGGCACCCAGTGA TACAGTTCTTATGTTTAATGTGGCCTTGGTCCTGCAAAGATTAGCTACCTCTGTCCTGAAAGATGAAAAAAGTAATCTGAAGGAAGTACT TAATGCTGTGAAAGAACTGGAGCTTGCACATAGATACTTCAGTTATTTGAGTAAAGTGGGAGATAAAATGAGATTTGATTTGGCCCTTGC TGCTACAGAAGCCAGGCAGTGTTCTGACTTACTGAGCCAGGCCCAGTACCATGTGGCCCGGGCACGCAAACAAGATGAAGAAGAGCGGGA GCTGCGGGCCAAGCAAGAGCAAGAAAAGGAGCTGTTAAGGCAGAAACTTCTTAAAGAACAGGAAGAGAAACGTCTCAGAGAAAAGGAAGA GCAAAAGAAACTTTTGGAACAGCGGGCCCAGTATGTGGAGAAGACCAAAAATATTCTTATGTTTACTGGTGAGACTGAAGCAACAAAAGA GAAGAAAAGAGGTGGTGGTGGTGGACGGCGTTCTAAGAAGGGAGGAGAGTTTGATGAATTTGTCAATGATGACACTGATGATGACCTACC TATATCCAAAAAGAAGAAGAGAAGAAAGGGTAGTGGCAGTGAACAAGAAGGTGAAGATGAGGAGGGTGGTGAGAGAAAGAAGAAAAAGAG GAGAAGACATCCAAAGGGAGAAGAAGGATCTGATGATGATGAAACAGAAAATGGCCCCAAACCAAAAAAACGACGTCCACCAAAAGCAGA GAAGAAAAAGGCTCCCAAGCCAGAACGTCTGCCTCCATCAATGAAGGGAAAAATAAAATCCAAAGCCATAATTTCATCAAGTGATGACTC TTCGGATGAGGATAAACTTAAAATTGCTGATGAAGGACATCCCAGGAACAGCAACAGCAACAGTGACTCAGACGAGGACGAACAACGAAA GAAATGTGCCTCATCAGAGAGTGATTCCGATGAGAACCAGAACAAGTCTGGCAGCGAGGCCGGCAGTCCCCGGAGGCCACGAAGACAGCG GTCAGATCAGGACTCAGACAGTGACCAGCCATCCAGAAAGAGAAGGCCCTCCGGTTCTGAGCAGTCTGACAATGAATCTGTGCAGTCAGG GAGAAGCCACTCAGGAGTTTCTGAGAACGACTCTCGCCCAGCTTCTCCAAGTGCCGAATCAGATCACGAATCGGAGAGAGGATCTGATAA TGAGGGTTCTGGCCAAGGCTCTGGAAATGAATCGGAACCAGAGGGATCCAACAATGAGGCCTCAGATAGAGGCTCAGAACATGGGTCAGA TGATAGTGACTAGGTTTTATTTCATCAATAAGCTTCATCTCTGGAGGAAACTTTTTTAATATATGAAAGCTGTGATAAAAATGTTTCAGA TGTTTAGTCAATTGTGAAATTTTTCTTAAGGCAATTTTCTTTTCTATCAGTTTGTATATTACTAAGCCCCAAGAGACATTTCCTGTGCTA GAGTCCAATATTTGAGTCTCTCGTGCAAATGAGACTATTCTTTGTGGTACAATTCCACCTATCATATGTGAAAACTGCAGTAAAAATAAA CCCAGATGCTAAATCATTCCTACAAAGGTTTGACTGAAACTGTGGCAGATGTCTCATCTTCTTTATATGTTAAGCAGCATACTCTTCTGA TTTTTATTGCAATCTTTTACCAAGTGGTGCACAAACTTGGTATTGATGTCTTTATTCCATTTTGAGTTTAGATTGAGAATATTTTTATTT TCTGAAGGCAGAGATATCTACTGTATAATTGCACCAAAGTACATTTGAAAGGAAGGTTTTCAATAGTGTAATACTGCAGCGATGTAGATA AAATCACAAATGTATAATGTGTTAGGTTGAATAAGGTGTGGAAAATGCTTTTCTGTTAGTAGAATGCAAAAACCTACCTAAGCCACATAA |
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FusionGenePPI for IPO7_CTR9 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| IPO7 | SRP19, RPL23A, KPNB1, USP49, AIRE, UBC, MYC, RNF146, RAN, SIRT7, FBXO25, CDK2, IGBP1, CA9, METTL18, CFTR, SOX2, EGFR, FBXO6, APEH, CAND1, ELAC2, HARS, HSPA1L, HSPA4L, KARS, NFRKB, PFDN5, RNASEH2A, TNPO1, TRMT112, STAU1, MDM2, CCDC8, RNF2, ILK, RIC3, NUSAP1, VTI1B, COMTD1, CD274, TNFSF13B, ZBTB38, VSIG2, PNKD, RP2, EDA, PTGER3, RPS6KB2, UNK, HSP90AB1, HSPA8, HSPB1, IPO5, IPO9, SLC25A3, MPHOSPH10, PPM1G, NTRK1, IFI16, CEP162, LCA5, RPGRIP1L, SSX2IP, SPICE1, DCTN1, CEP19, RPGRIP1, CAPZA2, MAD2L1, NUP153, HDAC6, LIMA1, NUP107, VPS16, ASPM, MCM2, CDC5L, DUSP5, SIGLECL1, HP1BP3, AURKAIP1, FZD10, TMEM206, HTR2C, UXS1, CHRM3, PTPRE, TRIM25, G3BP1, BRCA1, TES | CTR9 | CDC73, LEO1, STAT3, POLR2C, PAF1, RTF1, KMT2A, TCEA1, WDR61, CNTNAP2, HIST1H3A, PTPN11, UBE2E1, CSNK2A1, SUPT16H, SSRP1, RPL12, SMAD9, SOX2, DNMT3B, DNMT3A, HECW2, COG3, MYH14, RABL6, CIAO1, NXF1, HIST1H1A, HIST1H1C, MBIP, SOX4, CHD1, CHD2, CDK11A, IWS1, SUPT5H, NTRK1, XPO1, ADRBK1, ALDH3B1, CCNT1, CDK9, CETN2, FN1, G6PD, FOXK2, NFIC, PMS2, POLR2A, POLR2B, POLR2D, POLR2G, PPP1R10, PPP2R5D, SHMT2, SUPT6H, TCEB1, TCEB2, TCEB3, VEZF1, ELL, AKR7A2, EIF4G3, NFS1, GAR1, TOX4, ATP9A, RPP38, TACC2, PRSS23, ELL2, RPRD2, FKBP15, TMEM131, PRPF31, AFF4, TAOK3, DGCR8, FGD6, ACSS2, ERGIC1, ANO3, MAPKAP1, ZFP91, NDEL1, KLF16, FAM161A, ING5, TJAP1, ACTBL2, MYC, TULP2, MYLIP, APBA3, HIST1H1E, NCAPH2, LYZL1, SUGP1, TCEANC2, YAF2, LYPD4, ZC3H18, ARHGAP26 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for IPO7_CTR9 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for IPO7_CTR9 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | IPO7 | C0019693 | HIV Infections | 1 | CTD_human |
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