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Fusion gene ID: 17629 |
FusionGeneSummary for IPO11_SAP30BP |
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Fusion gene information | Fusion gene name: IPO11_SAP30BP | Fusion gene ID: 17629 | Hgene | Tgene | Gene symbol | IPO11 | SAP30BP | Gene ID | 51194 | 29115 |
Gene name | importin 11 | SAP30 binding protein | |
Synonyms | RanBP11 | HCNGP|HTRG|HTRP | |
Cytomap | 5q12.1 | 17q25.1 | |
Type of gene | protein-coding | protein-coding | |
Description | importin-11Ran binding protein 11imp11ran-binding protein 11 | SAP30-binding proteinHSV-1 bindingtranscriptional regulator protein HCNGP | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9UI26 | Q9UHR5 | |
Ensembl transtripts involved in fusion gene | ENST00000325324, ENST00000409296, ENST00000409534, ENST00000512177, | ENST00000584667, ENST00000355423, ENST00000579864, | |
Fusion gene scores | * DoF score | 6 X 6 X 4=144 | 9 X 9 X 5=405 |
# samples | 6 | 12 | |
** MAII score | log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/405*10)=-1.75488750216347 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: IPO11 [Title/Abstract] AND SAP30BP [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | SAP30BP | GO:0010942 | positive regulation of cell death | 15496587 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | CB155026 | IPO11 | chr5 | 61819528 | + | SAP30BP | chr17 | 73663450 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-5UTR | ENST00000325324 | ENST00000584667 | IPO11 | chr5 | 61819528 | + | SAP30BP | chr17 | 73663450 | + |
intron-5UTR | ENST00000325324 | ENST00000355423 | IPO11 | chr5 | 61819528 | + | SAP30BP | chr17 | 73663450 | + |
intron-5UTR | ENST00000325324 | ENST00000579864 | IPO11 | chr5 | 61819528 | + | SAP30BP | chr17 | 73663450 | + |
intron-5UTR | ENST00000409296 | ENST00000584667 | IPO11 | chr5 | 61819528 | + | SAP30BP | chr17 | 73663450 | + |
intron-5UTR | ENST00000409296 | ENST00000355423 | IPO11 | chr5 | 61819528 | + | SAP30BP | chr17 | 73663450 | + |
intron-5UTR | ENST00000409296 | ENST00000579864 | IPO11 | chr5 | 61819528 | + | SAP30BP | chr17 | 73663450 | + |
intron-5UTR | ENST00000409534 | ENST00000584667 | IPO11 | chr5 | 61819528 | + | SAP30BP | chr17 | 73663450 | + |
intron-5UTR | ENST00000409534 | ENST00000355423 | IPO11 | chr5 | 61819528 | + | SAP30BP | chr17 | 73663450 | + |
intron-5UTR | ENST00000409534 | ENST00000579864 | IPO11 | chr5 | 61819528 | + | SAP30BP | chr17 | 73663450 | + |
intron-5UTR | ENST00000512177 | ENST00000584667 | IPO11 | chr5 | 61819528 | + | SAP30BP | chr17 | 73663450 | + |
intron-5UTR | ENST00000512177 | ENST00000355423 | IPO11 | chr5 | 61819528 | + | SAP30BP | chr17 | 73663450 | + |
intron-5UTR | ENST00000512177 | ENST00000579864 | IPO11 | chr5 | 61819528 | + | SAP30BP | chr17 | 73663450 | + |
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FusionProtFeatures for IPO11_SAP30BP |
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Hgene | Tgene |
IPO11 | SAP30BP |
Functions in nuclear protein import as nuclear transportreceptor. Serves as receptor for nuclear localization signals(NLS) in cargo substrates. Is thought to mediate docking of theimportin/substrate complex to the nuclear pore complex (NPC)through binding to nucleoporin and the complex is subsequentlytranslocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ranbinds to the importin, the importin/substrate complex dissociatesand importin is re-exported from the nucleus to the cytoplasmwhere GTP hydrolysis releases Ran. The directionality of nuclearimport is thought to be conferred by an asymmetric distribution ofthe GTP- and GDP-bound forms of Ran between the cytoplasm andnucleus (By similarity). Mediates the nuclear import of UBE2E3,and of RPL12 (By similarity). {ECO:0000250,ECO:0000269|PubMed:11032817}. | Induces cell death. May act as a transcriptionalcorepressor of a gene related to cell survival. May be involved inthe regulation of beta-2-microglobulin genes.{ECO:0000250|UniProtKB:Q02614, ECO:0000269|PubMed:15496587}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for IPO11_SAP30BP |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for IPO11_SAP30BP |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for IPO11_SAP30BP |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for IPO11_SAP30BP |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | IPO11 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
Hgene | IPO11 | C0043094 | Weight Gain | 1 | CTD_human |
Tgene | SAP30BP | C0036341 | Schizophrenia | 1 | CTD_human |