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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 17629

FusionGeneSummary for IPO11_SAP30BP

check button Fusion gene summary
Fusion gene informationFusion gene name: IPO11_SAP30BP
Fusion gene ID: 17629
HgeneTgene
Gene symbol

IPO11

SAP30BP

Gene ID

51194

29115

Gene nameimportin 11SAP30 binding protein
SynonymsRanBP11HCNGP|HTRG|HTRP
Cytomap

5q12.1

17q25.1

Type of geneprotein-codingprotein-coding
Descriptionimportin-11Ran binding protein 11imp11ran-binding protein 11SAP30-binding proteinHSV-1 bindingtranscriptional regulator protein HCNGP
Modification date2018052320180523
UniProtAcc

Q9UI26

Q9UHR5

Ensembl transtripts involved in fusion geneENST00000325324, ENST00000409296, 
ENST00000409534, ENST00000512177, 
ENST00000584667, ENST00000355423, 
ENST00000579864, 
Fusion gene scores* DoF score6 X 6 X 4=1449 X 9 X 5=405
# samples 612
** MAII scorelog2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(12/405*10)=-1.75488750216347
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IPO11 [Title/Abstract] AND SAP30BP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSAP30BP

GO:0010942

positive regulation of cell death

15496587


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CB155026IPO11chr5

61819528

+SAP30BPchr17

73663450

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000325324ENST00000584667IPO11chr5

61819528

+SAP30BPchr17

73663450

+
intron-5UTRENST00000325324ENST00000355423IPO11chr5

61819528

+SAP30BPchr17

73663450

+
intron-5UTRENST00000325324ENST00000579864IPO11chr5

61819528

+SAP30BPchr17

73663450

+
intron-5UTRENST00000409296ENST00000584667IPO11chr5

61819528

+SAP30BPchr17

73663450

+
intron-5UTRENST00000409296ENST00000355423IPO11chr5

61819528

+SAP30BPchr17

73663450

+
intron-5UTRENST00000409296ENST00000579864IPO11chr5

61819528

+SAP30BPchr17

73663450

+
intron-5UTRENST00000409534ENST00000584667IPO11chr5

61819528

+SAP30BPchr17

73663450

+
intron-5UTRENST00000409534ENST00000355423IPO11chr5

61819528

+SAP30BPchr17

73663450

+
intron-5UTRENST00000409534ENST00000579864IPO11chr5

61819528

+SAP30BPchr17

73663450

+
intron-5UTRENST00000512177ENST00000584667IPO11chr5

61819528

+SAP30BPchr17

73663450

+
intron-5UTRENST00000512177ENST00000355423IPO11chr5

61819528

+SAP30BPchr17

73663450

+
intron-5UTRENST00000512177ENST00000579864IPO11chr5

61819528

+SAP30BPchr17

73663450

+

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FusionProtFeatures for IPO11_SAP30BP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
IPO11

Q9UI26

SAP30BP

Q9UHR5

Functions in nuclear protein import as nuclear transportreceptor. Serves as receptor for nuclear localization signals(NLS) in cargo substrates. Is thought to mediate docking of theimportin/substrate complex to the nuclear pore complex (NPC)through binding to nucleoporin and the complex is subsequentlytranslocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ranbinds to the importin, the importin/substrate complex dissociatesand importin is re-exported from the nucleus to the cytoplasmwhere GTP hydrolysis releases Ran. The directionality of nuclearimport is thought to be conferred by an asymmetric distribution ofthe GTP- and GDP-bound forms of Ran between the cytoplasm andnucleus (By similarity). Mediates the nuclear import of UBE2E3,and of RPL12 (By similarity). {ECO:0000250,ECO:0000269|PubMed:11032817}. Induces cell death. May act as a transcriptionalcorepressor of a gene related to cell survival. May be involved inthe regulation of beta-2-microglobulin genes.{ECO:0000250|UniProtKB:Q02614, ECO:0000269|PubMed:15496587}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for IPO11_SAP30BP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for IPO11_SAP30BP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for IPO11_SAP30BP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for IPO11_SAP30BP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneIPO11C0001973Alcoholic Intoxication, Chronic1PSYGENET
HgeneIPO11C0043094Weight Gain1CTD_human
TgeneSAP30BPC0036341Schizophrenia1CTD_human