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Fusion gene ID: 17626 |
FusionGeneSummary for IPO11_CENPJ |
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Fusion gene information | Fusion gene name: IPO11_CENPJ | Fusion gene ID: 17626 | Hgene | Tgene | Gene symbol | IPO11 | CENPJ | Gene ID | 51194 | 55835 |
Gene name | importin 11 | centromere protein J | |
Synonyms | RanBP11 | BM032|CENP-J|CPAP|LAP|LIP1|MCPH6|SASS4|SCKL4|Sas-4 | |
Cytomap | 5q12.1 | 13q12.12-q12.13 | |
Type of gene | protein-coding | protein-coding | |
Description | importin-11Ran binding protein 11imp11ran-binding protein 11 | centromere protein JLAG-3-associated proteinLYST-interacting protein 1LYST-interacting protein LIP1LYST-interacting protein LIP7centrosomal P4.1-associated protein | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q9UI26 | Q9HC77 | |
Ensembl transtripts involved in fusion gene | ENST00000325324, ENST00000409296, ENST00000409534, ENST00000512177, | ENST00000381884, ENST00000545981, ENST00000493190, | |
Fusion gene scores | * DoF score | 6 X 6 X 4=144 | 1 X 1 X 1=1 |
# samples | 6 | 1 | |
** MAII score | log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: IPO11 [Title/Abstract] AND CENPJ [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | CENPJ | GO:0061511 | centriole elongation | 22020124 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-B6-A0I8-01A | IPO11 | chr5 | 61708756 | + | CENPJ | chr13 | 25459524 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000325324 | ENST00000381884 | IPO11 | chr5 | 61708756 | + | CENPJ | chr13 | 25459524 | - |
5UTR-3UTR | ENST00000325324 | ENST00000545981 | IPO11 | chr5 | 61708756 | + | CENPJ | chr13 | 25459524 | - |
5UTR-5UTR | ENST00000325324 | ENST00000493190 | IPO11 | chr5 | 61708756 | + | CENPJ | chr13 | 25459524 | - |
intron-3CDS | ENST00000409296 | ENST00000381884 | IPO11 | chr5 | 61708756 | + | CENPJ | chr13 | 25459524 | - |
intron-3UTR | ENST00000409296 | ENST00000545981 | IPO11 | chr5 | 61708756 | + | CENPJ | chr13 | 25459524 | - |
intron-5UTR | ENST00000409296 | ENST00000493190 | IPO11 | chr5 | 61708756 | + | CENPJ | chr13 | 25459524 | - |
intron-3CDS | ENST00000409534 | ENST00000381884 | IPO11 | chr5 | 61708756 | + | CENPJ | chr13 | 25459524 | - |
intron-3UTR | ENST00000409534 | ENST00000545981 | IPO11 | chr5 | 61708756 | + | CENPJ | chr13 | 25459524 | - |
intron-5UTR | ENST00000409534 | ENST00000493190 | IPO11 | chr5 | 61708756 | + | CENPJ | chr13 | 25459524 | - |
intron-3CDS | ENST00000512177 | ENST00000381884 | IPO11 | chr5 | 61708756 | + | CENPJ | chr13 | 25459524 | - |
intron-3UTR | ENST00000512177 | ENST00000545981 | IPO11 | chr5 | 61708756 | + | CENPJ | chr13 | 25459524 | - |
intron-5UTR | ENST00000512177 | ENST00000493190 | IPO11 | chr5 | 61708756 | + | CENPJ | chr13 | 25459524 | - |
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FusionProtFeatures for IPO11_CENPJ |
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Hgene | Tgene |
IPO11 | CENPJ |
Functions in nuclear protein import as nuclear transportreceptor. Serves as receptor for nuclear localization signals(NLS) in cargo substrates. Is thought to mediate docking of theimportin/substrate complex to the nuclear pore complex (NPC)through binding to nucleoporin and the complex is subsequentlytranslocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ranbinds to the importin, the importin/substrate complex dissociatesand importin is re-exported from the nucleus to the cytoplasmwhere GTP hydrolysis releases Ran. The directionality of nuclearimport is thought to be conferred by an asymmetric distribution ofthe GTP- and GDP-bound forms of Ran between the cytoplasm andnucleus (By similarity). Mediates the nuclear import of UBE2E3,and of RPL12 (By similarity). {ECO:0000250,ECO:0000269|PubMed:11032817}. | Plays an important role in cell division and centrosomefunction by participating in centriole duplication(PubMed:17681131, PubMed:20531387). Inhibits microtubulenucleation from the centrosome. Involved in the regulation of slowprocessive growth of centriolar microtubules. Acts as microtubuleplus-end tracking protein that stabilizes centriolar microtubulesand inhibits microtubule polymerization and extension from thedistal ends of centrioles (PubMed:15047868, PubMed:27219064,PubMed:27306797). Required for centriole elongation and for STIL-mediated centriole amplification (PubMed:22020124). Required forthe recruitment of CEP295 to the proximal end of new-borncentrioles at the centriolar microtubule wall during early S phasein a PLK4-dependent manner (PubMed:27185865). May be involved inthe control of centriolar-microtubule growth by acting as aregulator of tubulin release (PubMed:27306797).{ECO:0000269|PubMed:15047868, ECO:0000269|PubMed:17681131,ECO:0000269|PubMed:20531387, ECO:0000269|PubMed:22020124,ECO:0000269|PubMed:27185865, ECO:0000269|PubMed:27219064,ECO:0000305|PubMed:27306797}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for IPO11_CENPJ |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for IPO11_CENPJ |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
IPO11 | TRAF2, PLCD4, C20orf24, RPL12, DDX5, KEAP1, RAN, UBE2E1, UBE2E3, UBE2E2, NXF1, SH3GL2, CFTR, PHB, EGFR, FBXO6, MOB1A, MOB1B, AARS, CACYBP, DR1, EIF4A3, HNRNPD, HNRNPH1, AGFG1, ARPC1B, CALU, HSF1, LPP, METTL1, TPD52L2, TTLL12, UBE3A, PDLIM5, PKM, PLIN3, PRDX2, RANGAP1, SRP9, TPRKB, EIF4A2, C1orf94, ADORA3, COMTD1, BSG, TNFSF13B, PNKD, LPAR6, P2RY12, PTGER3, ARL13B, SCN2B, XPO1, NTRK1, CEP128, SIGLECL1, IL13RA2, HTR2C, FZD10, CHRM4, TMEM206, OPRM1, CD70, SLC15A1, APLNR, STOM, AAR2, TRIM25 | CENPJ | LYST, TUBG1, EPB41, YWHAG, YWHAZ, ATN1, CIC, GFI1B, HDAC6, LATS2, SLMAP, MOV10, NXF1, RELA, CREBBP, PLEKHO2, CEP55, CEP131, NEDD1, PLK1, CEP120, CCP110, CEP85, CLASP1, CKAP2, MIB1, STIL, TTK, LZTS2, KIAA1671, CEP97, IQSEC1, KIF14, PCNT, KIF7, KIAA0586, ALMS1, CEP192, C2CD3, CDC7, CEP152, PCM1, ABCE1, ABLIM1, ADSL, AP3B1, AP3D1, ATXN10, BAIAP2L1, BTF3, AAR2, C5orf51, C6orf211, RABL6, CALM2, CAMSAP1, CAMSAP2, CCDC138, CCDC85C, CENPH, CEP170, CEP76, CKB, CNOT1, CNOT10, COMMD4, COPS3, CRTC3, CSPP1, DCP1B, DDX54, DVL3, ENO2, FAM21A, FBXO22, FERMT2, GPATCH1, GPX1, HAUS1, HAUS3, HAUS6, HAUS7, HAUS8, IBTK, IPO9, KIAA0753, LRRC49, MAPRE2, MB21D2, MLLT10, MOB4, MPHOSPH9, NAA10, OFD1, PALLD, PFDN4, PKN2, PSMC4, PTPN12, RAB18, RFC5, RIOK2, SDCCAG3, SEC16A, SEC23A, SEC23B, SEC24B, SMG7, SNX27, SSX2IP, TCHP, TNIP1, TNRC6A, TNRC6B, TP53BP2, TPGS1, TRIO, UNC45A, VCPIP1, WRAP73, XRN1, YWHAE, YWHAH, SPICE1, NINL, SASS6, NAB1, YWHAB, CLASP2, GEMIN5, PPHLN1, NABP2, KLC2, PRR3, DYNLRB1, PHLDB3, MRPL12, SH3RF2, TUBB3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for IPO11_CENPJ |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for IPO11_CENPJ |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | IPO11 | C0001973 | Alcoholic Intoxication, Chronic | 1 | PSYGENET |
Hgene | IPO11 | C0043094 | Weight Gain | 1 | CTD_human |
Tgene | CENPJ | C1842109 | Microcephaly, Primary Autosomal Recessive, 6 | 1 | CTD_human;UNIPROT |