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Fusion gene ID: 17566 |
FusionGeneSummary for INTS12_PPA2 |
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Fusion gene information | Fusion gene name: INTS12_PPA2 | Fusion gene ID: 17566 | Hgene | Tgene | Gene symbol | INTS12 | PPA2 | Gene ID | 57117 | 27068 |
Gene name | integrator complex subunit 12 | pyrophosphatase (inorganic) 2 | |
Synonyms | INT12|PHF22|SBBI22 | HSPC124|SCFAI|SCFI|SID6-306 | |
Cytomap | 4q24 | 4q24 | |
Type of gene | protein-coding | protein-coding | |
Description | integrator complex subunit 12PHD finger protein 22hypothetical nuclear factor SBBI22 | inorganic pyrophosphatase 2, mitochondrialPPase 2pyrophosphatase SID6-306pyrophosphate phospho-hydrolase 2 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q96CB8 | Q9H2U2 | |
Ensembl transtripts involved in fusion gene | ENST00000394735, ENST00000340139, ENST00000451321, | ENST00000341695, ENST00000348706, ENST00000432483, ENST00000354147, ENST00000380004, ENST00000357415, ENST00000509426, ENST00000310267, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 3 X 3 X 3=27 |
# samples | 2 | 4 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(4/27*10)=0.567040592723894 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: INTS12 [Title/Abstract] AND PPA2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | INTS12 | GO:0016180 | snRNA processing | 16239144 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | STAD | TCGA-CD-A487-01A | INTS12 | chr4 | 106629795 | - | PPA2 | chr4 | 106377902 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000394735 | ENST00000341695 | INTS12 | chr4 | 106629795 | - | PPA2 | chr4 | 106377902 | - |
intron-3CDS | ENST00000394735 | ENST00000348706 | INTS12 | chr4 | 106629795 | - | PPA2 | chr4 | 106377902 | - |
intron-3CDS | ENST00000394735 | ENST00000432483 | INTS12 | chr4 | 106629795 | - | PPA2 | chr4 | 106377902 | - |
intron-intron | ENST00000394735 | ENST00000354147 | INTS12 | chr4 | 106629795 | - | PPA2 | chr4 | 106377902 | - |
intron-intron | ENST00000394735 | ENST00000380004 | INTS12 | chr4 | 106629795 | - | PPA2 | chr4 | 106377902 | - |
intron-intron | ENST00000394735 | ENST00000357415 | INTS12 | chr4 | 106629795 | - | PPA2 | chr4 | 106377902 | - |
intron-5UTR | ENST00000394735 | ENST00000509426 | INTS12 | chr4 | 106629795 | - | PPA2 | chr4 | 106377902 | - |
intron-intron | ENST00000394735 | ENST00000310267 | INTS12 | chr4 | 106629795 | - | PPA2 | chr4 | 106377902 | - |
5UTR-3CDS | ENST00000340139 | ENST00000341695 | INTS12 | chr4 | 106629795 | - | PPA2 | chr4 | 106377902 | - |
5UTR-3CDS | ENST00000340139 | ENST00000348706 | INTS12 | chr4 | 106629795 | - | PPA2 | chr4 | 106377902 | - |
5UTR-3CDS | ENST00000340139 | ENST00000432483 | INTS12 | chr4 | 106629795 | - | PPA2 | chr4 | 106377902 | - |
5UTR-intron | ENST00000340139 | ENST00000354147 | INTS12 | chr4 | 106629795 | - | PPA2 | chr4 | 106377902 | - |
5UTR-intron | ENST00000340139 | ENST00000380004 | INTS12 | chr4 | 106629795 | - | PPA2 | chr4 | 106377902 | - |
5UTR-intron | ENST00000340139 | ENST00000357415 | INTS12 | chr4 | 106629795 | - | PPA2 | chr4 | 106377902 | - |
5UTR-5UTR | ENST00000340139 | ENST00000509426 | INTS12 | chr4 | 106629795 | - | PPA2 | chr4 | 106377902 | - |
5UTR-intron | ENST00000340139 | ENST00000310267 | INTS12 | chr4 | 106629795 | - | PPA2 | chr4 | 106377902 | - |
5UTR-3CDS | ENST00000451321 | ENST00000341695 | INTS12 | chr4 | 106629795 | - | PPA2 | chr4 | 106377902 | - |
5UTR-3CDS | ENST00000451321 | ENST00000348706 | INTS12 | chr4 | 106629795 | - | PPA2 | chr4 | 106377902 | - |
5UTR-3CDS | ENST00000451321 | ENST00000432483 | INTS12 | chr4 | 106629795 | - | PPA2 | chr4 | 106377902 | - |
5UTR-intron | ENST00000451321 | ENST00000354147 | INTS12 | chr4 | 106629795 | - | PPA2 | chr4 | 106377902 | - |
5UTR-intron | ENST00000451321 | ENST00000380004 | INTS12 | chr4 | 106629795 | - | PPA2 | chr4 | 106377902 | - |
5UTR-intron | ENST00000451321 | ENST00000357415 | INTS12 | chr4 | 106629795 | - | PPA2 | chr4 | 106377902 | - |
5UTR-5UTR | ENST00000451321 | ENST00000509426 | INTS12 | chr4 | 106629795 | - | PPA2 | chr4 | 106377902 | - |
5UTR-intron | ENST00000451321 | ENST00000310267 | INTS12 | chr4 | 106629795 | - | PPA2 | chr4 | 106377902 | - |
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FusionProtFeatures for INTS12_PPA2 |
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Hgene | Tgene |
INTS12 | PPA2 |
Component of the Integrator complex, a complex involvedin the small nuclear RNAs (snRNA) U1 and U2 transcription and intheir 3'-box-dependent processing. The Integrator complex isassociated with the C-terminal domain (CTD) of RNA polymerase IIlargest subunit (POLR2A) and is recruited to the U1 and U2 snRNAsgenes (PubMed:16239144). Mediates recruitment of cytoplasmicdynein to the nuclear envelope, probably as component of the INTcomplex (PubMed:23904267). {ECO:0000269|PubMed:16239144,ECO:0000269|PubMed:23904267}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for INTS12_PPA2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for INTS12_PPA2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
INTS12 | INTS1, INTS3, INTS5, INTS6, INTS10, APP, POLR2C, BSG, TAS2R7, KIR2DS2, SLAMF1, ST8SIA1, TGOLN2, ALDH3A2, PPP2CA, PPP2CB, PPP2R1A, VWA9, NELFA, FOXJ2, USP37, APLNR, IL13RA2, EDNRB, ILVBL, ARL13A, MAS1, F2RL1, FZD10, ST6GAL1, DKKL1, KDELR3, GTF2IRD1 | PPA2 | VKORC1, BAG3, MTIF2, HIST1H1D, ACSF2, CLUH, ACADVL, ACSS1, GLS, PNPT1, CLPP, PCCB, NNT, ARPIN, LYRM7, NIPSNAP3A, MECR, PDPR, CAT, CD2AP, DUT, HIBCH, NEDD8, AIP, CHCHD2, EZR, FKBP14, METTL1, NAV1, PLIN3, UFM1, PPP1R11, SCPEP1, TANGO2, COMT, ZWINT, DUSP13, SYNC, NDUFAF5 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for INTS12_PPA2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for INTS12_PPA2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |